Primary Site >> Colorectal Cancer
Gene >> F2
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Ref: Microangiopathic hemolytic anemia, thrombocytopenia, and renal failure in patients treated for adenocarcinoma. PMID: 7284973 |
Ref: A new mechanism for tumor induced platelet aggregation. Comparison with mechanisms shared by other tumor with possible pharmacologic strategy toward prevention of metastases. PMID: 6299977 |
Ref: Formation of tight junctions in epithelial cells. I. Induction by proteases in a human colon carcinoma cell line. PMID: 3880701 Ref: A new serine protease which preferentially recognizes p-guanidino-L-phenylalanyl residue in ascitic plasma from Ehrlich ascites tumor-bearing mice. PMID: 3890849 Ref: Hepatic resection for metastatic colon and rectal cancer. An evaluation of preoperative and postoperative factors. PMID: 4015224 Ref: Tumor cell generation of thrombin via functional prothrombinase assembly. PMID: 4053025 |
Ref: Plasma-dependent and -independent mechanisms of platelet aggregation induced by human tumour cell lines. PMID: 3629545 |
Ref: Mechanisms of platelet activation by cultured human cancer cells and cells freshly isolated from tumor tissues. PMID: 2767927 |
Ref: Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo. PMID: 1845869 Ref: Cellular localization of activated factor X by Xa-specific probes. PMID: 1871716 |
Ref: Pathways of coagulation/fibrinolysis activation in malignancy. PMID: 1574711 Ref: Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo. PMID: 1596884 |
Ref: Tumor cells induce platelet aggregation and intraplatelet calcium ion movements. PMID: 21043751 |
Ref: Inhibition of HT-29 human colon cancer growth under the renal capsule of severe combined immunodeficient mice by an analogue of 1,25-dihydroxyvitamin D3, DD-003. PMID: 7923132 Ref: Evaluation of the potential role of class II histocompatibility antigen HLA-DR in platelet/tumor cell interaction. PMID: 8306320 |
Ref: Cellular localization of enzymatically active thrombin in intact human tissues by hirudin binding. PMID: 7482405 |
Ref: Pre- and postoperative state of coagulation and fibrinolysis in plasma of patients with benign and malignant colorectal disease--a preliminary study. PMID: 8902990 |
Ref: Raised prostate-specific antigen in adenocarcinoma of the colon. PMID: 9241551 |
Ref: Plasma thrombospondin levels in patients with colorectal carcinoma. PMID: 9477093 Ref: Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis. PMID: 9808563 |
Ref: Fibrinogen Matsumoto III: a variant with gamma275 Arg-->Cys (CGC-->TGC)--comparison of fibrin polymerization properties with those of Matsumoto I (gamma364 Asp-->His) and Matsumoto II (gamma308 Asn-->Lys). PMID: 10365751 Ref: Factor XIII modulates intestinal epithelial wound healing in vitro. PMID: 10423064 |
Ref: IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling. PMID: 10638662 Ref: Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells. PMID: 10807779 |
Ref: Coagulative system activation and fibrinolytic system inhibition activities arise from tumoral draining vein in colon carcinoma. PMID: 11755952 |
Ref: Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells. PMID: 12124268 Ref: Resistance to activated protein C, factor V leiden and the prothrombin G20210A variant in patients with colorectal cancer. PMID: 12214157 |
Ref: Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells. PMID: 12707033 Ref: MAP kinase-mediated proliferation of DLD-1 carcinoma by the stimulation of protease-activated receptor 2. PMID: 14511767 |
Ref: Novel CD43 specific phage antibodies react with early stage colorectal tumours. PMID: 14719063 Ref: Platelet-induced enhancement of LS174T colon carcinoma and THP-1 monocytoid cell adhesion to vascular endothelium under flow. PMID: 15084476 Ref: Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation. PMID: 15383630 Ref: PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism. PMID: 15559761 |
Ref: Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment. PMID: 16091733 Ref: [Expression evaluation of in loco coagulation system in colorectal cancer]. PMID: 17877125 |
Ref: Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: A multicentric phase II study. PMID: 16414206 Ref: Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells. PMID: 16440418 Ref: Defective arachidonate release and PGE2 production in Gi alpha2-deficient intestinal and colonic subepithelial myofibroblasts. PMID: 16534415 Ref: Thrombomodulin expression in colorectal carcinoma is protective and correlates with survival. PMID: 16622452 |
Ref: Detection of protein biomarkers using RNA aptamer microarrays and enzymatically amplified surface plasmon resonance imaging. PMID: 17263339 Ref: Recombinant C-terminal fragments of the gastrin-releasing peptide precursor are bioactive. PMID: 17395367 |
Ref: Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells. PMID: 18606591 |
Ref: Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase. PMID: 19058300 Ref: Differential effects of anticoagulants on tumor development of mouse cancer cell lines B16, K1735 and CT26 in lung. PMID: 19067186 Ref: NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells. PMID: 19234748 Ref: Coagulation factor Xa inhibits cancer cell migration via protease-activated receptor-1 activation. PMID: 19250659 Ref: Haemostatis activity in rectal cancer patients exposed to preoperative radiotherapy: a clinical prospective cohort study. PMID: 19318923 Ref: Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis. PMID: 19555470 |
Ref: Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells. PMID: 20056842 Ref: [Molecular markers in hematology and oncology]. PMID: 20859878 Ref: The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. PMID: 20942929 |
Ref: Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1alpha translational pathway in colorectal cancer cells. PMID: 20857420 Ref: The level of claudin-7 is reduced as an early event in colorectal carcinogenesis. PMID: 21310043 Ref: D-dimer, plasminogen activator inhibitor-1, prothrombin fragments and protein C - role in prothrombotic state of colorectal cancer. PMID: 21391740 Ref: Co-localization of prothrombin fragment F1+2 and VEGF-R2-bound VEGF in human colon cancer. PMID: 21498704 Ref: [Coagulation disorder and its uncommon complication in a patient with obturating sigmoid carcinoma]. PMID: 21755906 Ref: Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells. PMID: 21907696 Ref: Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas. PMID: 22866096 |
Ref: Thrombin-dependent modulation of beta1-integrin-mediated signaling up-regulates prolidase and HIF-1alpha through p-FAK in colorectal cancer cells. PMID: 21993963 Ref: Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer. PMID: 22444159 Ref: Evaluation of antiproliferative and anti-inflammatory activities of methanol extract and its fractions from the Mediterranean sponge. PMID: 22587650 Ref: Evaluating coagulation disorders in the use of bevacizumab for metastatic colorectal cancer by thrombelastography. PMID: 22696065 |
Ref: Altered plasma fibrin clot properties in patients with digestive tract cancers: links with the increased thrombin generation. PMID: 23273404 Ref: Demographic and clinical evaluation of secondaries to liver. PMID: 23416820 Ref: Evaluation of antiproliferative and antioxidant activities of the organic extract and its polar fractions from the Mediterranean gorgonian Eunicella singularis. PMID: 23712134 Ref: Antiproliferative effects of protopanaxadiol ginsenosides on human colorectal cancer cells. PMID: 24648985 |
Ref: Endoscopic tissue shielding method with polyglycolic acid sheets and fibrin glue to cover wounds after colorectal endoscopic submucosal dissection (with video). PMID: 24140128 Ref: Thrombin drives tumorigenesis in colitis-associated colon cancer. PMID: 24710407 Ref: Low molecular weight procyanidins from grape seeds enhance the impact of 5-Fluorouracil chemotherapy on Caco-2 human colon cancer cells. PMID: 24905821 |
Ref: Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen. PMID: 26238780 |
Ref: Tissue Factor Pathway Inhibitor Gene Polymorphism -33T --> C Predicts Improved Disease-Free Survival in Colorectal Cancer. PMID: 26968713 Ref: Phosphatidylserine exposing-platelets and microparticles promote procoagulant activity in colon cancer patients. PMID: 27015840 Ref: PO-51 - Expression of proteins of the tissue factor thrombin pathway is upregulated in the stroma and epithelium of colorectal cancer. PMID: 27161738 Ref: Elevated prothrombin time/international normalized ratio associated with concurrent administration of regorafenib and warfarin in a patient with advanced colorectal cancer. PMID: 27398225 |
Ref: Factors affecting the postoperative morbidity and survival of patients with liver cirrhosis following colorectal cancer surgery. PMID: 27987016 Ref: Increased thrombin generation in a mouse model of cancer cachexia is partially interleukin-6 dependent. PMID: 28058802 Ref: Rare upper gastrointestinal hemorrhage of cetuximab: A case report. PMID: 29390545 |
Ref: Platelets contribute to the initiation of colitis-associated cancer by promoting immunosuppression. PMID: 29369476 Ref: Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer. PMID: 29416788 Ref: Mechanisms coupling thrombin to metastasis and tumorigenesis. PMID: 29703481 Ref: Molecular mechanisms of platelet activation and aggregation induced by breast cancer cells. PMID: 29705335 |