Primary Site >> Biliary tract Cancer
Gene >> EZH2
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Ref: Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis. PMID: 18393368 Ref: The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma. PMID: 18591938 |
Ref: Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin. PMID: 19564843 Ref: Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts. PMID: 21160963 |
Ref: Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma. PMID: 19860841 |
Ref: Overexpression of EZH2 and loss of expression of PTEN is associated with invasion, metastasis, and poor progression of gallbladder adenocarcinoma. PMID: 21719208 |
Ref: Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct. PMID: 23163606 Ref: Enhancer of zeste homolog 2 (EZH2) promotes progression of cholangiocarcinoma cells by regulating cell cycle and apoptosis. PMID: 23887863 |
Ref: Epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A inhibits the growth of cholangiocarcinoma cells. PMID: 24337160 Ref: Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. PMID: 24487593 Ref: EZH2 elevates the proliferation of human cholangiocarcinoma cells through the downregulation of RUNX3. PMID: 25280519 |
Ref: Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions. PMID: 25289642 |
Ref: Long non-coding RNA MINCR promotes gallbladder cancer progression through stimulating EZH2 expression. PMID: 27345740 |
Ref: Long non-coding RNA UCA1 promotes gallbladder cancer progression by epigenetically repressing p21 and E-cadherin expression. PMID: 28624787 Ref: Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation: Impact on Regulation of Notch Pathway. PMID: 28923203 |
Ref: Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites. PMID: 29445149 Ref: Enhancer of zeste homolog 2 (EZH2) regulates tumor angiogenesis and predicts recurrence and prognosis of intrahepatic cholangiocarcinoma. PMID: 29759640 Ref: Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma. PMID: 29970899 Ref: Long noncoding RNA MEG3 regulates LATS2 by promoting the ubiquitination of EZH2 and inhibits proliferation and invasion in gallbladder cancer. PMID: 30282996 |