Primary Site >> Stomach Cancer
Gene >> EPHB2
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Ref: Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer. PMID: 7688222 |
Ref: Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. PMID: 8033077 |
Ref: Gastrin and phorbol 12-myristate 13-acetate regulate the human histidine decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric cancer cells. PMID: 9341140 |
Ref: Oxidative stress activates the human histidine decarboxylase promoter in AGS gastric cancer cells. PMID: 9722530 |
Ref: Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells. PMID: 11413105 Ref: Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways. PMID: 11686835 |
Ref: Extracellular signal-regulated protein kinases mediate H(+),K(+)-ATPase alpha-subunit gene expression. PMID: 11812003 Ref: Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer. PMID: 12136247 Ref: [Inhibition of activator protein-1 on the growth of gastric cancer by octreotide]. PMID: 12478891 |
Ref: Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. PMID: 12555068 Ref: Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. PMID: 12618892 Ref: Tyrosine-kinase expression profiles in human gastric cancer cell lines and their modulations with retinoic acids. PMID: 12671705 Ref: Transcriptional regulation of the human trefoil factor, TFF1, by gastrin. PMID: 12891554 Ref: Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. PMID: 14531897 Ref: [Roles of ERK1/2 MAPK in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells]. PMID: 14963907 |
Ref: Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. PMID: 14699500 Ref: TGF-beta1 (transforming growth factor-beta1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity. PMID: 14720123 Ref: Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. PMID: 14963045 Ref: Increased tyrosine kinase activites may lead to the phenotypic differences of gastric cancer cells. PMID: 15161014 Ref: Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2. PMID: 15319299 Ref: Regulation of vascular endothelial growth factor expression in human gastric cancer cells by interleukin-1beta. PMID: 15349119 Ref: Selenomethionine stimulates MAPK (ERK) phosphorylation, protein oxidation, and DNA synthesis in gastric cancer cells. PMID: 15489202 |
Ref: Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer. PMID: 15655810 Ref: A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad. PMID: 15751984 Ref: Orchestration of aberrant epithelial signaling by Helicobacter pylori CagA. PMID: 15798102 Ref: [The function of ERK on Fas-mediated apoptotic signaling pathway of human gastric carcinoma cells]. PMID: 15949415 Ref: Urokinase plasminogen activator receptor is upregulated by Helicobacter pylori in human gastric cancer AGS cells via ERK, JNK, and AP-1. PMID: 15963460 Ref: Immuno-regulatory effects of CKBM on the activities of mitogen-activated protein kinases and the release of cytokines in THP-1 monocytic cells. PMID: 16141532 Ref: Analysis on the mechanism of Helicobacter pylori-induced apoptosis in gastric cancer cell line BGC-823. PMID: 16142414 Ref: Helicobacter pylori and gastric epithelial cells: from gastritis to cancer. PMID: 16270519 |
Ref: Topological and functional discovery in a gene coexpression meta-network of gastric cancer. PMID: 16397236 Ref: Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. PMID: 16441665 Ref: Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines. PMID: 16520550 Ref: Cellular components involved in the cell death induced by cisplatin in the absence of p53 activation. PMID: 16596182 Ref: CAGE, a novel cancer/testis antigen gene, promotes cell motility by activation ERK and p38 MAPK and downregulating ROS. PMID: 16819299 Ref: Erk is involved in the differentiation induced by diallyl disulfide in the human gastric cancer cell line MGC803. PMID: 16874458 Ref: CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model. PMID: 16933206 Ref: The role of Helicobacter pylori CagA in gastric carcinogenesis. PMID: 17118755 |
Ref: High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability. PMID: 16819508 Ref: Rebamipide inhibits gastric cancer cell growth. PMID: 17171453 Ref: Genetic and epigenetic analysis of the EPHB2 gene in gastric cancers. PMID: 17295683 Ref: Apoptotic effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation. PMID: 17304508 Ref: Hypoxia induced overexpression of PrP(C) in gastric cancer cell lines. PMID: 17387271 Ref: Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer. PMID: 17568183 Ref: IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric adenocarcinoma cells. PMID: 17644350 Ref: 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer. PMID: 17680560 |
Ref: 12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway. PMID: 17522976 Ref: Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. PMID: 18097546 Ref: Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. PMID: 18339873 Ref: Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. PMID: 18378261 Ref: Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. PMID: 18395088 Ref: Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration. PMID: 18400571 Ref: Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways. PMID: 18805435 Ref: EGF stimulates uPAR expression and cell invasiveness through ERK, AP-1, and NF-kappaB signaling in human gastric carcinoma cells. PMID: 19020743 |
Ref: Inhibition of MEK blocks GRP78 up-regulation and enhances apoptosis induced by ER stress in gastric cancer cells. PMID: 18829155 Ref: Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. PMID: 19140230 Ref: Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells. PMID: 19281788 Ref: Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation. PMID: 19473897 Ref: Ubiquitin ligase Cbl-b sensitizes leukemia and gastric cancer cells to anthracyclines by activating the mitochondrial pathway and modulating Akt and ERK survival signals. PMID: 19508871 Ref: TGF-beta promotes invasion and metastasis of gastric cancer cells by increasing fascin1 expression via ERK and JNK signal pathways. PMID: 19657566 Ref: Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer. PMID: 20066900 |
Ref: Early antiallergic inflammatory effects of Rhus verniciflua Stokes on human mast cells. PMID: 19653191 Ref: Overexpression of protein phosphatase non-receptor type 11 (PTPN11) in gastric carcinomas. PMID: 19690960 Ref: Rapamycin enhances chemotherapy-induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells. PMID: 19856312 Ref: Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells. PMID: 20087064 Ref: Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. PMID: 20179222 Ref: Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation. PMID: 20198349 Ref: Intracellular chloride regulates cell proliferation through the activation of stress-activated protein kinases in MKN28 human gastric cancer cells. PMID: 20205250 Ref: Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells. PMID: 20348091 Ref: Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages. PMID: 20410304 Ref: Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines. PMID: 20428833 Ref: gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line. PMID: 20452389 Ref: Hypoxia promotes metastasis in human gastric cancer by up-regulating the 67-kDa laminin receptor. PMID: 20491781 Ref: Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells. PMID: 20522955 Ref: Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics. PMID: 20836672 Ref: Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice. PMID: 20842125 Ref: [Effects of EGFR inhibitor AG1478 in combination with celecoxib on the growth of gastric cancer cells]. PMID: 20848776 Ref: [Helicobacter pylori cytotoxin associated protein CagA regulates gastrin gene promoter activity]. PMID: 21029692 Ref: Hepatoma-derived growth factor regulates the bad-mediated apoptotic pathway and induction of vascular endothelial growth factor in stomach cancer cells. PMID: 21302807 Ref: Phosphoinositide 3-kinase/Akt and nuclear factor kappaB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells. PMID: 21472268 |
Ref: Low-dose taxotere enhances the ability of sorafenib to induce apoptosis in gastric cancer models. PMID: 20015197 Ref: Reduced expression of EphB2 is significantly associated with nodal metastasis in Chinese patients with gastric cancer. PMID: 20238226 Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways. PMID: 20498032 Ref: Human ZNF312b oncogene is regulated by Sp1 binding to its promoter region through DNA demethylation and histone acetylation in gastric cancer. PMID: 21170990 Ref: Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. PMID: 21266357 Ref: Involvement of MAPK and PI3K signaling pathway in sterigmatocystin-induced G2 phase arrest in human gastric epithelium cells. PMID: 21287681 Ref: Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells. PMID: 21312237 Ref: Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis. PMID: 21346147 Ref: Flagellin promotes the proliferation of gastric cancer cells via the Toll-like receptor 5. PMID: 21455558 Ref: Human gastrin mRNA expression up-regulated by Helicobacter pylori CagA through MEK/ERK and JAK2-signaling pathways in gastric cancer cells. PMID: 21509655 Ref: Metastatic function of BMP-2 in gastric cancer cells: the role of PI3K/AKT, MAPK, the NF-kappaB pathway, and MMP-9 expression. PMID: 21570392 Ref: FW523-3, a novel lipopeptide compound, induces apoptosis in cancer cells. PMID: 21584500 Ref: Proteasome particle-rich structures are widely present in human epithelial neoplasms: correlative light, confocal and electron microscopy study. PMID: 21695063 Ref: Oncogenic CagA promotes gastric cancer risk via activating ERK signaling pathways: a nested case-control study. PMID: 21698158 Ref: Interferon-alpha sensitizes human gastric cancer cells to TRAIL-induced apoptosis via activation of the c-CBL-dependent MAPK/ERK pathway. PMID: 21725207 Ref: Nitric oxide inhibits gastric cancer cell growth through the modulation of the Akt pathway. PMID: 21769431 Ref: Co-expression of erythropoietin receptor with human epidermal growth factor 2 may counteract trastuzumab inhibition in gastric cancer. PMID: 21944379 |
Ref: Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells. PMID: 21676900 Ref: Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells. PMID: 22012247 Ref: NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. PMID: 22159814 Ref: Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism. PMID: 22207169 Ref: c-Met upregulates aquaporin 3 expression in human gastric carcinoma cells via the ERK signalling pathway. PMID: 22261330 Ref: Helicobacter pylori CagA inhibits the expression of Runx3 via Src/MEK/ERK and p38 MAPK pathways in gastric epithelial cell. PMID: 22266963 Ref: Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. PMID: 22285823 Ref: P21-activated protein kinase 1 is overexpressed in gastric cancer and induces cancer metastasis. PMID: 22293972 Ref: Regulation of SHP2 by PTEN/AKT/GSK-3beta signaling facilitates IFN-gamma resistance in hyperproliferating gastric cancer. PMID: 22325465 Ref: Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration. PMID: 22328534 Ref: Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. PMID: 22344252 Ref: Midkine confers Adriamycin resistance in human gastric cancer cells. PMID: 22576950 Ref: Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. PMID: 22634261 Ref: A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation. PMID: 22745804 Ref: ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-kappaB-dependent and Notch-independent mechanism. PMID: 22781708 Ref: Pro-apoptotic role of the MEK/ERK pathway in ursodeoxycholic acid-induced apoptosis in SNU601 gastric cancer cells. PMID: 22824956 Ref: Type II cGMP-dependent protein kinase inhibits ERK/JNK-mediated activation of transcription factors in gastric cancer cells. PMID: 22940826 Ref: Protein inhibitor of activated STAT-1 is downregulated in gastric cancer tissue and involved in cell metastasis. PMID: 22972521 Ref: Role of integrin-linked kinase in multi-drug resistance of human gastric carcinoma SGC7901/DDP cells. PMID: 23317227 |
Ref: A systematic approach to therapeutic target selection in oesophago-gastric cancer. PMID: 22773546 Ref: Preclinical evaluation of a novel c-Met inhibitor in a gastric cancer xenograft model using small animal PET. PMID: 22864665 Ref: Critical role of aquaporin-3 in epidermal growth factor-induced migration of colorectal carcinoma cells and its clinical significance. PMID: 23165320 Ref: CD81 is a candidate tumor suppressor gene in human gastric cancer. PMID: 23264205 Ref: Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells. PMID: 23292941 Ref: KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer. PMID: 23348694 Ref: Inhibition of gastric tumor growth by a novel Hsp90 inhibitor. PMID: 23415900 Ref: Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo via downregulating the ERK-MAPK pathway. PMID: 23587796 Ref: PKG II inhibits EGF/EGFR-induced migration of gastric cancer cells. PMID: 23613900 Ref: Catecholamine-Induced beta2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression. PMID: 23630346 Ref: Association between phosphorylated AMP-activated protein kinase and MAPK3/1 expression and prognosis for patients with gastric cancer. PMID: 23860205 Ref: Ribonucleotide reductase large subunit M1 predicts poor survival due to modulation of proliferative and invasive ability of gastric cancer. PMID: 23922955 Ref: Interferon-alpha enhances 5'-deoxy-5-fluorouridine-induced apoptosis by ERK-dependant upregulation of thymidine phosphorylase. PMID: 24027750 Ref: Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. PMID: 24104608 Ref: Combination of the FGFR4 inhibitor PD173074 and 5-fluorouracil reduces proliferation and promotes apoptosis in gastric cancer. PMID: 24126887 Ref: 14-3-3sigma attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells. PMID: 24185104 Ref: The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer. PMID: 24244023 Ref: Type II cGMP-dependent protein kinase inhibits epidermal growth factor-induced phosphatidylinositol-3-kinase/Akt signal transduction in gastric cancer cells. PMID: 24273605 Ref: Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis. PMID: 24340024 Ref: Cbl-b enhances sensitivity to 5-fluorouracil via EGFR- and mitochondria-mediated pathways in gastric cancer cells. PMID: 24351824 Ref: Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells. PMID: 24648957 |
Ref: ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis. PMID: 23686315 Ref: Overexpression of L1CAM is associated with tumor progression and prognosis via ERK signaling in gastric cancer. PMID: 24046108 Ref: ERK1/2 inhibition enhances apoptosis induced by JAK2 silencing in human gastric cancer SGC7901 cells. PMID: 24178240 Ref: Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target. PMID: 24253382 Ref: Trastuzumab and oxaliplatin exhibit a synergistic antitumor effect in HER2-postive gastric cancer cells. PMID: 24300914 Ref: The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway. PMID: 24416349 Ref: The niche component periostin is produced by cancer-associated fibroblasts, supporting growth of gastric cancer through ERK activation. PMID: 24418260 Ref: Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer. PMID: 24465527 Ref: Cetuximab inhibits gastric cancer growth in vivo, independent of KRAS status. PMID: 24467518 Ref: Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis. PMID: 24470239 Ref: RASAL1 influences the proliferation and invasion of gastric cancer cells by regulating the RAS/ERK signaling pathway. PMID: 24531877 Ref: Type II cGMP-dependent protein kinase inhibits ligandinduced activation of EGFR in gastric cancer cells. PMID: 24534906 Ref: 1,25-Dihydroxyvitamin D(3) and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells. PMID: 24573222 Ref: IL-1beta-stimulated urokinase plasminogen activator expression through NF-kappaB in gastric cancer after HGF treatment. PMID: 24626561 Ref: Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells. PMID: 24647664 Ref: MGr1-Ag/37LRP induces cell adhesion-mediated drug resistance through FAK/PI3K and MAPK pathway in gastric cancer. PMID: 24703465 Ref: Clinicopathological features and prognostic roles of KRAS, BRAF, PIK3CA and NRAS mutations in advanced gastric cancer. PMID: 24774510 Ref: AKT/ERK activation is associated with gastric cancer cell resistance to paclitaxel. PMID: 24817940 Ref: Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways. PMID: 24824325 Ref: Activation of mesenchymal stem cells by macrophages prompts human gastric cancer growth through NF-kappaB pathway. PMID: 24824968 Ref: Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells. PMID: 24885194 Ref: Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy. PMID: 24903273 Ref: Anti-tumor activity of oridonin on SNU-5 subcutaneous xenograft model via regulation of c-Met pathway. PMID: 24916572 Ref: IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling. PMID: 24937671 Ref: CDX2 can be regulated through the signalling pathways activated by IL-6 in gastric cells. PMID: 24953186 Ref: FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival. PMID: 24968263 Ref: Functional genetic approach identifies MET, HER3, IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancer. PMID: 24973425 Ref: Role of antimicrobial peptides expressed by host cells upon infection by Helicobacter pylori. PMID: 25001211 Ref: Expression of insulin-like growth factor receptor type 1 correlate with lymphatic metastases in human gastric cancer. PMID: 25119174 Ref: Sorafenib regulating ERK signals pathway in gastric cancer cell. PMID: 25136776 Ref: A triterpenoid saponin from Adenophora triphylla var. japonica suppresses the growth of human gastric cancer cells via regulation of apoptosis and autophagy. PMID: 25146681 Ref: Rabeprazole exhibits antiproliferative effects on human gastric cancer cell lines. PMID: 25202402 Ref: The regulation of ERK and p-ERK expression by cisplatin and sorafenib in gastric cancer cells. PMID: 25219752 Ref: RhoGDI2 is associated with HGF-mediated tumor invasion through VEGF in stomach cancer. PMID: 25253431 Ref: Inhibition of Vav3 could reverse the drug resistance of gastric cancer cells by downregulating JNK signaling pathway. PMID: 25430880 Ref: PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways. PMID: 27919028 |
Ref: Pb2+ induces gastrin gene expression by extracellular signal-regulated kinases 1/2 and transcription factor activator protein 1 in human gastric carcinoma cells. PMID: 23765435 Ref: Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling. PMID: 24469046 Ref: Overexpression of Ephrin A2 receptors in cancer stromal cells is a prognostic factor for the relapse of gastric cancer. PMID: 24908114 Ref: Protein kinase Ciota is a new prognostic factor in gastric cancer. PMID: 25108825 Ref: Bone morphogenetic protein 2 mediates epithelial-mesenchymal transition via AKT and ERK signaling pathways in gastric cancer. PMID: 25448881 Ref: Ras/ERK signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma AGS cells. PMID: 25492214 Ref: Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study. PMID: 25500692 Ref: Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway. PMID: 25515760 Ref: CCR7 pathway induces epithelial-mesenchymal transition through up-regulation of Snail signaling in gastric cancer. PMID: 25572817 Ref: Sorafenib reverses resistance of gastric cancer to treatment by cisplatin through down-regulating MDR1 expression. PMID: 25579168 Ref: Aberrant EphB/ephrin-B expression in experimental gastric lesions and tumor cells. PMID: 25593460 Ref: Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. PMID: 25605238 Ref: Ara-C increases gastric cancer cell invasion by upregulating CD-147-MMP-2/MMP9 via the ERK signaling pathway. PMID: 25625234 Ref: Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer. PMID: 25638174 Ref: Asporin participates in gastric cancer cell growth and migration by influencing EGF receptor signaling. PMID: 25673058 Ref: G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro. PMID: 25673461 Ref: Helicobacter pylori FKBP-type PPIase promotes gastric epithelial cell proliferation and anchorage-independent growth through activation of ERK-mediated mitogenic signaling pathway. PMID: 25687921 Ref: Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. PMID: 25697906 Ref: Inflammation and proliferation - a causal event of host response to Helicobacter pylori infection. PMID: 25721850 Ref: RASAL1 attenuates gastric carcinogenesis in nude mice by blocking RAS/ERK signaling. PMID: 25735335 Ref: Hyperglycemia Promotes Human Gastric Carcinoma Progression via Aquaporin 3. PMID: 25777259 Ref: EGF-reduced Wnt5a transcription induces epithelial-mesenchymal transition via Arf6-ERK signaling in gastric cancer cells. PMID: 25779663 Ref: Identification of potential targets for diallyl disulfide in human gastric cancer MGC-803 cells using proteomics approaches. PMID: 25812569 Ref: Effect of REG Ialpha protein on angiogenesis in gastric cancer tissues. PMID: 25813126 Ref: Chrysin inhibits tumor promoter-induced MMP-9 expression by blocking AP-1 via suppression of ERK and JNK pathways in gastric cancer cells. PMID: 25875631 Ref: Antitumor effect and apoptosis induction of Alocasia cucullata (Lour.) G. Don in human gastric cancer cells in vitro and in vivo. PMID: 25888009 Ref: Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer. PMID: 25909166 Ref: FGF9 from cancer-associated fibroblasts is a possible mediator of invasion and anti-apoptosis of gastric cancer cells. PMID: 25925261 Ref: ZnPPIX inhibits peritoneal metastasis of gastric cancer via its antiangiogenic activity. PMID: 25960243 Ref: Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. PMID: 25981581 Ref: Epigenetic silencing of DUSP9 induces the proliferation of human gastric cancer by activating JNK signaling. PMID: 25998184 Ref: Anti-tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC-803 proliferation via phospho-extracellular signal-regulated kinase-, Src-, c-Jun N-terminal kinase- and phosphoinositide 3-kinase-associated pathways. PMID: 26063313 Ref: Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer. PMID: 26091251 Ref: Combinational Treatment of Curcumin and Quercetin against Gastric Cancer MGC-803 Cells in Vitro. PMID: 26111180 Ref: Type II cyclic guanosine monophosphate-dependent protein kinase inhibits epidermal growth factor receptor activation in different cancer cell lines. PMID: 26137146 Ref: Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas. PMID: 26147886 Ref: Cortactin promotes colon cancer progression by regulating ERK pathway. PMID: 26151562 Ref: MicroRNA-206: Effective Inhibition of Gastric Cancer Progression through the c-Met Pathway. PMID: 26186594 Ref: Macrophage Infiltration Induces Gastric Cancer Invasiveness by Activating the beta-Catenin Pathway. PMID: 26226629 Ref: WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-gamma pathways. PMID: 26291058 Ref: Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas. PMID: 26296355 Ref: Hexane extract from Sargassum serratifolium inhibits the cell proliferation and metastatic ability of human glioblastoma U87MG cells. PMID: 26323587 Ref: [Effects of beta-elemene on proliferation and apoptosis of SGC7901 gastric cancer cells in vitro and the underlying mechanisms]. PMID: 26403730 Ref: DBD-F induces apoptosis in gastric cancer-derived cells through suppressing HIF2alpha expression. PMID: 26526811 Ref: Targeting inhibition of extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) suppresses growth and angiogenesis of gastric cancer. PMID: 26567773 Ref: Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis. PMID: 26608463 Ref: Melatonin Induces Cell Apoptosis in AGS Cells Through the Activation of JNK and P38 MAPK and the Suppression of Nuclear Factor-Kappa B: a Novel Therapeutic Implication for Gastric Cancer. PMID: 26645893 Ref: Geldanamycin induces apoptosis in human gastric carcinomas by affecting multiple oncogenic kinases that have synergic effects with TNF-related apoptosis-inducing ligand. PMID: 26788199 |
Ref: The involvement of survivin in insulin-like growth factor 1-induced epithelial-mesenchymal transition in gastric cancer. PMID: 26271669 Ref: Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer. PMID: 26432329 Ref: Decreased expression of long non-coding RNA WT1-AS promotes cell proliferation and invasion in gastric cancer. PMID: 26449525 Ref: Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Promotes EBV Reactivation through Activation of the p38 Mitogen-Activated Protein Kinase. PMID: 26559845 Ref: Downregulation of lncRNA-MALAT1 Affects Proliferation and the Expression of Stemness Markers in Glioma Stem Cell Line SHG139S. PMID: 26649728 Ref: Sustained ERK activation-mediated proliferation inhibition of farrerol on human gastric carcinoma cell line by G0/G1-phase cell-cycle arrest. PMID: 26656929 Ref: Inhibition of Vav3 gene can promote apoptosis of human gastric cancer cell line MGC803 by regulating ERK pathway. PMID: 26695150 Ref: GNA13 as a prognostic factor and mediator of gastric cancer progression. PMID: 26735177 Ref: DCT015, a new sorafenib derivate, inhibits tumor growth and angiogenesis in gastric cancer models. PMID: 26768619 Ref: Identification of stem-like cells and clinical significance of candidate stem cell markers in gastric cancer. PMID: 26769843 Ref: Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. PMID: 26774454 Ref: Upregulation of microRNA27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2mediated ERK signaling. PMID: 26781754 Ref: Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells. PMID: 26801760 Ref: Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways. PMID: 26802142 Ref: Helicobacter pylori induces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3beta in human gastric cancer cells. PMID: 26808296 Ref: The tumor promoting roles of HSP60 and HIF2alpha in gastric cancer cells. PMID: 26810190 Ref: Lentivirus-mediated PLCgamma1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma. PMID: 26811493 Ref: CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells. PMID: 26830684 Ref: Trichostatin A potentiates TRAIL-induced antitumor effects via inhibition of ERK/FOXM1 pathway in gastric cancer. PMID: 26831669 Ref: Leptin receptor signaling is required for high-fat diet-induced atrophic gastritis in mice. PMID: 26839577 Ref: VEGF promotes gastric cancer development by upregulating CRMP4. 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PMID: 27539855 Ref: Oncogenic NanogP8 expression regulates cell proliferation and migration through the Akt/mTOR signaling pathway in human gastric cancer - SGC-7901cell line. PMID: 27563247 Ref: Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc. PMID: 27601158 Ref: DEC2 suppresses tumor proliferation and metastasis by regulating ERK/NF-kappaB pathway in gastric cancer. PMID: 27648362 Ref: JWA down-regulates HER2 expression via c-Cbl and induces lapatinib resistance in human gastric cancer cells. PMID: 27708243 Ref: Inhibition of cell proliferation and triggering of apoptosis by agrimonolide through MAP kinase (ERK and p38) pathways in human gastric cancer AGS cells. PMID: 27747355 Ref: miR-590-5p regulates gastric cancer cell growth and chemosensitivity through RECK and the AKT/ERK pathway. 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Ref: Transducin (beta)-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway. PMID: 27694893 Ref: Sprouty2 correlates with favorable prognosis of gastric adenocarcinoma via suppressing FGFR2-induced ERK phosphorylation and cancer progression. PMID: 28002800 Ref: Gastrin Enhances Autophagy and Promotes Gastric Carcinoma Proliferation via Inducing AMPKalpha. PMID: 28059052 Ref: MicroRNA-133a Inhibits Proliferation of Gastric Cancer Cells by Downregulating ERBB2 Expression. PMID: 28109082 Ref: Resistance Mechanism against Trastuzumab in HER2-Positive Cancer Cells and Its Negation by Src Inhibition. PMID: 28223426 Ref: Asparaginyl endopeptidase improves the resistance of microtubule-targeting drugs in gastric cancer through IQGAP1 modulating the EGFR/JNK/ERK signaling pathway. PMID: 28223821 Ref: MicroRNA-320 inhibits invasion and induces apoptosis by targeting CRKL and inhibiting ERK and AKT signaling in gastric cancer cells. PMID: 28255248 Ref: Long non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis. PMID: 28268166 Ref: E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells. PMID: 28334634 Ref: Reduction of miR1323p contributes to gastric cancer proliferation by targeting MUC13. PMID: 28339011 Ref: G protein subunit alpha q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways. PMID: 28350126 Ref: Cot kinase plays a critical role in Helicobacter pylori-induced IL-8 expression. PMID: 28361341 Ref: MAGI1 inhibits migration and invasion via blocking MAPK/ERK signaling pathway in gastric cancer. PMID: 28373751 Ref: Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer. PMID: 28423564 Ref: Bradykinin Promotes Cell Proliferation, Migration, Invasion, and Tumor Growth of Gastric Cancer Through ERK Signaling Pathway. PMID: 28464378 Ref: Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice. PMID: 28501767 Ref: Inhibition of cell proliferation and induction of autophagy by KDM2B/FBXL10 knockdown in gastric cancer cells. PMID: 28506929 Ref: Gastric cancer-derived exosomes promote peritoneal metastasis by destroying the mesothelial barrier. PMID: 28643334 Ref: Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/beta-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer. PMID: 28677721 Ref: Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling. 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PMID: 28963677 Ref: Clinical implications of progranulin in gastric cancer and its regulation via a positive feedback loop involving AKT and ERK signaling pathways. PMID: 29039535 Ref: B7-H3 promotes gastric cancer cell migration and invasion. PMID: 29069741 Ref: Atractylenolide II Inhibits Proliferation, Motility and Induces Apoptosis in Human Gastric Carcinoma Cell Lines HGC-27 and AGS. PMID: 29099789 Ref: Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression. PMID: 29141593 Ref: Gimatecan exerts potent antitumor activity against gastric cancer in vitro and in vivo via AKT and MAPK signaling pathways. PMID: 29237470 Ref: Glucose-derived AGEs enhance human gastric cancer metastasis through RAGE/ERK/Sp1/MMP2 cascade. PMID: 29262634 Ref: MerTK inhibition by RXDX-106 in MerTK activated gastric cancer cell lines. PMID: 29285287 Ref: Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway. PMID: 29379775 Ref: Cryptotanshinone induces ROS-mediated apoptosis in human gastric cancer cells. PMID: 29383168 Ref: Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival. PMID: 29872697 |
Ref: 4-Phenybutyric acid promotes gastric cancer cell migration via histone deacetylase inhibition-mediated HER3/HER4 up-regulation. PMID: 28851073 Ref: SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models. PMID: 28905937 Ref: Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3beta. PMID: 28978722 Ref: Selenoprotein K Mediates the Proliferation, Migration, and Invasion of Human Choriocarcinoma Cells by Negatively Regulating Human Chorionic Gonadotropin Expression via ERK, p38 MAPK, and Akt Signaling Pathway. PMID: 28983820 Ref: Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer. PMID: 29095547 Ref: 18beta-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-alpha/ERK pathway. PMID: 29098529 Ref: The screening and analysis of protein signatures and signaling associated with chemoresistance based on Protein Pathway Array technology in gastric cancer. PMID: 29115543 Ref: Chk1 activation attenuates sensitivity of lapatinib in HER2-positive gastric cancer. PMID: 29271513 Ref: Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway. PMID: 29286170 Ref: MiR-199a/b-3p inhibits gastric cancer cell proliferation via down-regulating PAK4/MEK/ERK signaling pathway. PMID: 29304764 Ref: Over-expression of ARHGAP18 suppressed cell proliferation, migration, invasion, and tumor growth in gastric cancer by restraining over-activation of MAPK signaling pathways. PMID: 29386906 Ref: Tanshinone IIA inhibits gastric carcinoma AGS cells by decreasing the protein expression of VEGFR and blocking Ras/Raf/MEK/ERK pathway. PMID: 29393362 Ref: Downregulation of leucine-rich repeats and immunoglobulin-like domains 1 by microRNA-20a modulates gastric cancer multidrug resistance. PMID: 29450946 Ref: TRPC1/3/6 inhibition attenuates the TGF-beta1-induced epithelial-mesenchymal transition in gastric cancer via the Ras/Raf1/ERK signaling pathway. PMID: 29570903 Ref: Dual silencing of EGFR and HER2 enhances the sensitivity of gastric cancer cells to gefitinib. PMID: 29637613 Ref: CLIC1 Promotes the Progression of Gastric Cancer by Regulating the MAPK/AKT Pathways. PMID: 29669336 Ref: Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the AktGSK3beta and MAPK/ERK signaling cascades. PMID: 29693162 Ref: Cancer-associated fibroblasts-stimulated interleukin-11 promotes metastasis of gastric cancer cells mediated by upregulation of MUC1. PMID: 29709516 Ref: Human Epidermal Growth Factor Receptor-2 Promotes Invasion and Metastasis in Gastric Cancer by Activating Mitogen-activated Protein Kinase Signaling. PMID: 29734245 Ref: Salidroside inhibits the proliferation and migration of gastric cancer cells via suppression of Srcassociated signaling pathway activation and heat shock protein 70 expression. PMID: 29749547 Ref: High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer. PMID: 29767389 Ref: NRAGE confers poor prognosis and promotes proliferation, invasion, and chemoresistance in gastric cancer. PMID: 29778424 Ref: Validation of Neurotensin Receptor 1 as a Therapeutic Target for Gastric Cancer. PMID: 29794962 Ref: Epigenetic silencing of miR-1271 enhances MEK1 and TEAD4 expression in gastric cancer. PMID: 29862663 Ref: Noncaloric Sweeteners Induce Peripheral Serotonin Secretion via the T1R3-Dependent Pathway in Human Gastric Parietal Tumor Cells (HGT-1). PMID: 29874909 Ref: siRNA Targeting of the SNCG Gene Inhibits the Growth of Gastric Carcinoma SGC7901 Cells in vitro and in vivo by Downregulating the Phosphorylation of AKT/ERK. PMID: 29902801 Ref: SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism. PMID: 29925042 Ref: PKG II inhibits PDGF-BB triggered biological activities by phosphorylating PDGFRbeta in gastric cancer cells. PMID: 29935031 Ref: MiR-592 Promotes Gastric Cancer Proliferation, Migration, and Invasion Through the PI3K/AKT and MAPK/ERK Signaling Pathways by Targeting Spry2. PMID: 29949784 Ref: Psoriasin overexpression confers drug resistance to cisplatin by activating ERK in gastric cancer. PMID: 29956751 Ref: Pro-apoptotic effects of Kangfuxin on human stomach cancer cells and its underlying mechanism. PMID: 29963166 Ref: TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation. PMID: 30015980 Ref: FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p. PMID: 30082912 Ref: Netrin1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation. PMID: 30106432 Ref: Molecular Signatures of the Insulin-like Growth Factor 1-mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers. PMID: 30111747 Ref: UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability. PMID: 30116193 Ref: Knockdown of TMPRSS3 inhibits gastric cancer cell proliferation, invasion and EMT via regulation of the ERK1/2 and PI3K/Akt pathways. PMID: 30142546 Ref: Zeylenone Induces Mitochondrial Apoptosis and Inhibits Migration and Invasion in Gastric Cancer. PMID: 30150551 Ref: Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells. PMID: 30157801 Ref: Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through beta-catenin/Erk/Akt signaling in gastric cancer. PMID: 30165890 Ref: Three types of metaplasia models through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium. PMID: 30168144 Ref: miR-17-92 functions as an oncogene and modulates NF-kappaB signaling by targeting TRAF3 in MGC-803 human gastric cancer cells. PMID: 30226589 Ref: Increasing HER2 alpha2,6 sialylation facilitates gastric cancer progression and resistance via the Akt and ERK pathways. PMID: 30226606 Ref: Upregulation of long noncoding RNA CCAT1-L promotes epithelial-mesenchymal transition in gastric adenocarcinoma. PMID: 30254457 Ref: USP14 as a novel prognostic marker promotes cisplatin resistance via Akt/ERK signaling pathways in gastric cancer. PMID: 30296012 Ref: [Aloin induces apoptosis via regulating the activation of MAPKs signaling pathway in human gastric cancer cells in vitro]. PMID: 30377097 Ref: SIX1 is upregulated in gastric cancer and regulates proliferation and invasion by targeting the ERK pathway and promoting epithelial-mesenchymal transition. PMID: 30379332 Ref: Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1. PMID: 30382763 |