Primary Site >> Colorectal Cancer

Gene >> ENPP7

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Ref: Effects of ursodeoxycholate and other bile salts on levels of rat intestinal alkaline sphingomyelinase: a potential implication in tumorigenesis.
PMID: 9508530
Ref: Purification, localization, and expression of human intestinal alkaline sphingomyelinase.
PMID: 12671034
Ref: Purified intestinal alkaline sphingomyelinase inhibits proliferation without inducing apoptosis in HT-29 colon carcinoma cells.
PMID: 12920578
Ref: Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells.
PMID: 15016655
Ref: Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity.
PMID: 16255717
Ref: Alkaline sphingomyelinase: an old enzyme with novel implications.
PMID: 16631405
Ref: Identification of aberrant forms of alkaline sphingomyelinase (NPP7) associated with human liver tumorigenesis.
PMID: 17923876
Ref: Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats.
PMID: 17605045
Ref: Expression of alkaline sphingomyelinase in yeast cells and anti-inflammatory effects of the expressed enzyme in a rat colitis model.
PMID: 18989780
Ref: Changes of activity and isoforms of alkaline sphingomyelinase (nucleotide pyrophosphatase phosphodiesterase 7) in bile from patients undergoing endoscopic retrograde cholangiopancreatography.
PMID: 25100243
Ref: Enhanced colonic tumorigenesis in alkaline sphingomyelinase (NPP7) knockout mice.
PMID: 25381265