Primary Site >> Colorectal Cancer
Gene >> EIF2AK4
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Ref: The non-steroidal anti-inflammatory drug indomethacin activates the eIF2alpha kinase PKR, causing a translational block in human colorectal cancer cells. PMID: 22268531 Ref: AMPK and GCN2-ATF4 signal the repression of mitochondria in colon cancer cells. PMID: 22435535 |
Ref: Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1. PMID: 24113185 |
Ref: Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2alpha kinase PKR. PMID: 25856684 Ref: Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases. PMID: 25892863 Ref: KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism. PMID: 26709701 |
Ref: Arginine starvation in colorectal carcinoma cells: Sensing, impact on translation control and cell cycle distribution. PMID: 26751966 |
Ref: BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib. PMID: 27965097 Ref: Smad7 knockdown activates protein kinase RNA-associated eIF2alpha pathway leading to colon cancer cell death. PMID: 28300830 Ref: The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab. PMID: 28632725 |