Primary Site >> Colorectal Cancer
Gene >> EGR1
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Ref: Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells. PMID: 10344756 |
Ref: Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes. PMID: 11751871 |
Ref: Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity. PMID: 12475986 Ref: Differential gene expression profiles and identification of the genes relevant to clinicopathologic factors in colorectal cancer selected by cDNA array method in combination with principal component analysis. PMID: 12792775 |
Ref: Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. PMID: 14662774 Ref: The colon mitosis inhibitor pyroglutamyl-histidyl-glycine inhibits growth of non-tumorigenic colonic epithelial cells. PMID: 15160998 Ref: Chemoinducible gene therapy: a strategy to enhance doxorubicin antitumor activity. PMID: 15367711 |
Ref: Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene. PMID: 16079301 Ref: Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells. PMID: 16093249 Ref: 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-infl PMID: 16155208 |
Ref: Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. PMID: 16170359 Ref: Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway. PMID: 16489044 Ref: NSAID activated gene (NAG-1), a modulator of tumorigenesis. PMID: 17129398 |
Ref: NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells. PMID: 17191121 Ref: Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. PMID: 17230532 Ref: The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. PMID: 17631291 Ref: Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation. PMID: 17764926 Ref: The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis. PMID: 18075315 |
Ref: Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells. PMID: 18583030 Ref: Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil. PMID: 18757417 Ref: [Alteration of early growth response 1 expression in gastroenterological cancers and its biological significance]. PMID: 18953875 Ref: ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells. PMID: 19074849 |
Ref: A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene. PMID: 19384947 Ref: Suppression of cancer growth by nonviral gene therapy based on a novel reactive oxygen species-responsive promoter. PMID: 19436270 Ref: Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes. PMID: 19608733 Ref: Enhanced radiosensitivity of SW480 cells via TRAIL up-regulation mediated by Egr-1 promoter. PMID: 19724854 Ref: Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli. PMID: 19834918 |
Ref: Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. PMID: 20068171 Ref: Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells. PMID: 20087343 Ref: MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration. PMID: 21118966 |
Ref: Resveratrol-induced apoptosis is mediated by early growth response-1, Kruppel-like factor 4, and activating transcription factor 3. PMID: 21205742 Ref: A gene signature distinguishing CD133hi from CD133- colorectal cancer cells: essential role for EGR1 and downstream factors. PMID: 21436631 |
Ref: DIF-1 inhibits the Wnt/beta-catenin signaling pathway by inhibiting TCF7L2 expression in colon cancer cell lines. PMID: 22005519 Ref: Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK. PMID: 22228178 Ref: Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation. PMID: 22230687 Ref: 2'-Hydroxyflavanone induces apoptosis through Egr-1 involving expression of Bax, p21, and NAG-1 in colon cancer cells. PMID: 22648623 Ref: Inhibition of GSK-3beta reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells. PMID: 22683934 |
Ref: Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation. PMID: 22965873 Ref: Expression and functions of galectin-7 in human and murine melanomas. PMID: 23658821 Ref: Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction. PMID: 23660334 Ref: Phosphoglycerate kinase 1 as a promoter of metastasis in colon cancer. PMID: 23727790 Ref: Heterogeneous nuclear ribonucleoprotein (HnRNP) K genome-wide binding survey reveals its role in regulating 3'-end RNA processing and transcription termination at the early growth response 1 (EGR1) gene through XRN2 exonuclease. PMID: 23857582 Ref: Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation. PMID: 23872169 Ref: Effects of anti-miR-182 on TSP-1 expression in human colon cancer cells: there is a sense in antisense? PMID: 24053448 |
Ref: Downregulation of PAK5 inhibits glioma cell migration and invasion potentially through the PAK5-Egr1-MMP2 signaling pathway. PMID: 24062079 Ref: Expression of early growth response-1 in colorectal cancer and its relation to tumor cell proliferation and apoptosis. PMID: 24297681 Ref: Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. PMID: 24440808 Ref: Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents. PMID: 24530873 Ref: DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3beta and expressions of cyclin D1 and TCF7L2 in cancer model mice. PMID: 24670930 Ref: EGR1-dependent PTEN upregulation by 2-benzoyloxycinnamaldehyde attenuates cell invasion and EMT in colon cancer. PMID: 24704156 Ref: Egr-1 regulates the transcription of NGX6 gene through a Sp1/Egr-1 overlapping site in the promoter. PMID: 25029911 Ref: Egr-1 activation by cancer-derived extracellular vesicles promotes endothelial cell migration via ERK1/2 and JNK signaling pathways. PMID: 25502753 |
Ref: Retroviral cyclin controls cyclin-dependent kinase 8-mediated transcription elongation and reinitiation. PMID: 25741012 Ref: Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth. PMID: 26206332 Ref: Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. PMID: 26343742 Ref: Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression. PMID: 26498686 |
Ref: ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer. PMID: 26621868 Ref: Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells. PMID: 26809095 Ref: Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers. PMID: 26880583 Ref: Kruppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1. PMID: 27442508 Ref: p53-dependent and -independent mechanisms are involved in (E)-1-(2-hydroxyphenyl)-3-(2-methoxynaphthalen-1-yl)prop-2-en-1-one (HMP)-induced apoptosis in HCT116 colon cancer cells. PMID: 27641669 Ref: gamma-Aminobutyric acid inhibits the proliferation and increases oxaliplatin sensitivity in human colon cancer cells. PMID: 27644246 Ref: Putative Tumor Suppressor Genes EGR1 and BRSK1 Are Mutated in Gastric and Colorectal Cancers. PMID: 27677186 |
Ref: High early growth response 1 (EGR1) expression correlates with resistance to anti-EGFR treatment in vitro and with poorer outcome in metastatic colorectal cancer patients treated with cetuximab. PMID: 28005260 Ref: Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway. PMID: 28107519 Ref: Haploinsufficient tumor suppressor genes. PMID: 28680740 |
Ref: The extracellular matrix protein mindin attenuates colon cancer progression by blocking angiogenesis via Egr-1-mediated regulation. PMID: 28991232 Ref: Soluble CD80 Protein Delays Tumor Growth and Promotes Tumor-Infiltrating Lymphocytes. PMID: 29122838 Ref: Transcriptional regulation of CacyBP/SIP gene and the influence of increased CacyBP/SIP level on gene expression pattern in colorectal cancer HCT116 cells. PMID: 29197151 Ref: Sex-dependent correlation between survival and expression of genes related to the circadian oscillator in patients with colorectal cancer. PMID: 29953268 |