Primary Site >> Colorectal Cancer
Gene >> E2F1
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Ref: p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line. PMID: 8831553 |
Ref: Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors. PMID: 9192806 |
Ref: Expression of the E2F family in human gastrointestinal carcinomas. PMID: 10225440 Ref: Expression of cell-cycle-regulating transcription factor E2F-1 in colorectal carcinomas. PMID: 10738178 |
Ref: Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase. PMID: 10811110 Ref: Thymidylate synthase expression correlates closely with E2F1 expression in colon cancer. PMID: 10914714 Ref: Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents. PMID: 11052627 |
Ref: Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit. PMID: 11489836 Ref: E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis in colon cancer cells. PMID: 11705881 Ref: p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells. PMID: 11795482 |
Ref: Up-regulation of vitamin D3 up-regulated protein 1 gene in response to 5-fluorouracil in colon carcinoma SW620. PMID: 11748459 Ref: C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells. PMID: 11961668 Ref: Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. PMID: 12084458 Ref: Role of retinoblastoma protein and E2F-1 transcription factor in the acquisition of 5-fluorouracil resistance by colon cancer cells. PMID: 12118326 Ref: The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway. PMID: 12198702 Ref: SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells. PMID: 12234612 Ref: Expression of E2F-4 gene in colorectal adenocarcinoma and corresponding covering mucosa: an immunohistochemistry, image analysis, and immunoblot study. PMID: 12373148 Ref: Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. PMID: 12460790 |
Ref: E2F-1 overexpression sensitizes colorectal cancer cells to camptothecin. PMID: 12637937 Ref: The mitochondrial apoptosis-inducing factor plays a role in E2F-1-induced apoptosis in human colon cancer cells. PMID: 12679318 Ref: mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. PMID: 12813132 Ref: Gene expression in colorectal cancer and in vitro chemosensitivity to 5-fluorouracil: a study of 88 surgical specimens. PMID: 12841874 Ref: Chromosome arm 20q gains and other genomic alterations in esophageal squamous cell carcinoma, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. PMID: 14696419 |
Ref: Lack of correlation between immunohistochemical expression of E2F-1, thymidylate synthase expression and clinical response to 5-fluorouracil in advanced colorectal cancer. PMID: 14679120 Ref: Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification. PMID: 14726656 Ref: The nucleocytoplasmic shuttling of E2F4 is involved in the regulation of human intestinal epithelial cell proliferation and differentiation. PMID: 15040009 Ref: Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor. PMID: 15195143 Ref: Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells. PMID: 15202011 Ref: Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas. PMID: 15221933 Ref: E2F-1 transcription factor immunoexpression is inversely associated with tumor growth in colon adenocarcinomas. PMID: 15517914 Ref: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. PMID: 15604277 |
Ref: Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK. PMID: 15611081 Ref: Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway. PMID: 15867357 Ref: Real-time RT-PCR (TaqMan) of tumor mRNA to predict sensitivity of specimens to 5-fluorouracil. PMID: 15911984 |
Ref: Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer. PMID: 15885887 Ref: RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling. PMID: 16505104 Ref: Restriction of adenoviral replication to the transcriptional intersection of two different promoters for colorectal and pancreatic cancer treatment. PMID: 16505112 Ref: Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). PMID: 16820966 Ref: Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells. PMID: 17212786 |
Ref: E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation. PMID: 17263886 Ref: Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. PMID: 17656449 Ref: Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation. PMID: 17909036 |
Ref: E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. PMID: 18521084 Ref: Deregulated expression of miR-106a predicts survival in human colon cancer patients. PMID: 18521848 Ref: p73 Isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis. PMID: 18546269 Ref: Overlapping expression of microRNAs in human embryonic colon and colorectal cancer. PMID: 18607389 Ref: Adenovirus-mediated expression of spermidine/spermine N1-acetyltransferase gene induces S-phase arrest in human colorectal cancer cells. PMID: 18949426 |
Ref: Rplp1 bypasses replicative senescence and contributes to transformation. PMID: 19233166 Ref: E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. PMID: 19562678 Ref: E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. PMID: 19585502 Ref: Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. PMID: 19787257 |
Ref: The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells. PMID: 19636513 Ref: The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells. PMID: 19908241 Ref: PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells. PMID: 20372802 Ref: Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells. PMID: 20531417 Ref: Increased angiogenesis in Cdk4(R24C/R24C):Apc(+/Min) intestinal tumors. PMID: 20603602 Ref: A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells. PMID: 20615460 Ref: Irinotecan overcomes the resistance to 5-fluorouracil in human colon cancer xenografts by down-regulation of intratumoral thymidylate synthase. PMID: 20811661 |
Ref: Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. PMID: 20812030 Ref: ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence. PMID: 21223585 Ref: Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells. PMID: 21406062 |
Ref: USP22 acts as an oncogene by the activation of BMI-1-mediated INK4a/ARF pathway and Akt pathway. PMID: 21928107 Ref: Differential microRNA expression tracks neoplastic progression in inflammatory bowel disease-associated colorectal cancer. PMID: 22241525 Ref: Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats. PMID: 22916810 Ref: UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer. PMID: 23023523 Ref: Glycogen Synthase Kinase 3beta Inhibitor (2'Z,3'E)-6-Bromo-indirubin- 3'-Oxime Enhances Drug Resistance to 5-Fluorouracil Chemotherapy in Colon Cancer Cells. PMID: 23359767 |
Ref: Methylselenol, a selenium metabolite, modulates p53 pathway and inhibits the growth of colon cancer xenografts in Balb/c mice. PMID: 22841391 Ref: MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer. PMID: 23280316 Ref: E2F transcription factors and digestive system malignancies: how much do we know? PMID: 23745020 Ref: Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells. PMID: 24039993 |
Ref: The relationship between E2F family members and tumor growth in colorectal adenocarcinomas: A comparative immunohistochemical study of 100 cases. PMID: 22688350 Ref: Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells. PMID: 23503458 Ref: Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer. PMID: 24465681 Ref: Thymosin beta-4 knockdown in IEC-6 normal intestinal epithelial cells induces DNA re-replication via downregulating Emi1. PMID: 24615569 Ref: T-oligo as an anticancer agent in colorectal cancer. PMID: 24632202 Ref: Daurinol, a catalytic inhibitor of topoisomerase IIalpha, suppresses SNU-840 ovarian cancer cell proliferation through cell cycle arrest in S phase. PMID: 24841075 Ref: Synergistic cooperation of MDM2 and E2F1 contributes to TAp73 transcriptional activity. PMID: 24845566 Ref: HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy. PMID: 25296971 |
Ref: Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma. PMID: 25335113 Ref: Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells. PMID: 25861415 Ref: Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F. PMID: 25893635 Ref: Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis. PMID: 25934694 Ref: Radiation-induced microRNA-622 causes radioresistance in colorectal cancer cells by down-regulating Rb. PMID: 25961730 Ref: E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide reductase small subunit M2. PMID: 26093293 Ref: Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling beta-catenin signaling in cancer-initiating cells. PMID: 26122663 Ref: The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis. PMID: 26208523 Ref: Downregulation of CDK-8 inhibits colon cancer hepatic metastasis by regulating Wnt/beta-catenin pathway. PMID: 26349978 Ref: The Histone Acetyltransferase GCN5 Expression Is Elevated and Regulated by c-Myc and E2F1 Transcription Factors in Human Colon Cancer. PMID: 26637399 Ref: Adenovirus-Mediated E2F-1 Gene Transfer Augments Gemcitabine-Induced Apoptosis in Human Colon Cancer Cells. PMID: 26642705 Ref: Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation. PMID: 26704889 |
Ref: E2F1/TS Immunophenotype and Survival of Patients with Colorectal Cancer Treated with 5FU-Based Adjuvant Therapy. PMID: 26831819 Ref: The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis. PMID: 26843428 Ref: Inhibition of NF-kappaB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer. PMID: 26850372 Ref: Predictive microRNAs for lymph node metastasis in endoscopically resectable submucosal colorectal cancer. PMID: 27096956 Ref: H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-beta-Catenin Signaling in Colorectal Cancer. PMID: 27789274 |
Ref: Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. PMID: 27793841 Ref: Long noncoding RNA CRNDE functions as a competing endogenous RNA to promote metastasis and oxaliplatin resistance by sponging miR-136 in colorectal cancer. PMID: 28115855 Ref: In vitro and ex vivo delivery of tailored siRNA-nanoliposomes for E2F1 silencing as a potential therapy for colorectal cancer. PMID: 28189855 Ref: Identification of a Low-Frequency Missense Variant in E2F Transcription Factor 7 Associated with Colorectal Cancer Risk In A Chinese Population PMID: 28240846 Ref: rs35301225 polymorphism in miR-34a promotes development of human colon cancer by deregulation of 3'UTR in E2F1 in Chinese population. PMID: 28293146 Ref: The Significant Pathways and Genes Underlying the Colon Cancer Treatment by the Traditional Chinese Medicine PHY906. PMID: 28588641 Ref: E2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer. PMID: 28704519 Ref: Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/beta-Catenin and PI3K/Akt Signaling. PMID: 28939743 Ref: Prognostic value of E2F1 in rectal cancer. PMID: 28944330 |
Ref: Transcriptional regulation of CacyBP/SIP gene and the influence of increased CacyBP/SIP level on gene expression pattern in colorectal cancer HCT116 cells. PMID: 29197151 Ref: NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling. PMID: 29203250 Ref: Insulin receptor substrate-4 is overexpressed in colorectal cancer and promotes retinoblastoma-cyclin-dependent kinase activation. PMID: 29353348 Ref: Effective Timing of Surgical Resection of Colorectal Cancer Liver Metastases During Chemotherapy. PMID: 29374697 Ref: Herbal formula Huang Qin Ge Gen Tang enhances 5-fluorouracil antitumor activity through modulation of the E2F1/TS pathway. PMID: 29458395 Ref: Long noncoding RNA CCAT2 is activated by E2F1 and exerts oncogenic properties by interacting with PTTG1 in pituitary adenomas. PMID: 29511595 Ref: Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells. PMID: 29794421 Ref: Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1. PMID: 29803790 Ref: E2F1/SP3/STAT6 axis is required for IL-4-induced epithelial-mesenchymal transition of colorectal cancer cells. PMID: 29901191 Ref: Tristetraprolin activation by resveratrol inhibits the proliferation and metastasis of colorectal cancer cells. PMID: 29956753 Ref: Computational Model for Predicting the Relationship Between Micro-RNAs and Their Target Messenger RNAs in Breast and Colon Cancers. PMID: 30013305 Ref: miR-329 regulates the sensitivity of 5-FU in chemotherapy of colorectal cancer by targeting E2F1. PMID: 30127965 Ref: Follistatin-like protein 1 sustains colon cancer cell growth and survival. PMID: 30131854 Ref: CDCA3 mediates p21-dependent proliferation by regulating E2F1 expression in colorectal cancer. PMID: 30226575 Ref: Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2. PMID: 30304835 |