Primary Site >> Colorectal Cancer

Gene >> DUT

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Ref: Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase.
PMID: 8162567
 Ref: Lack of dependence of 5-fluorodeoxyuridine-mediated radiosensitization on cytotoxicity.
PMID: 7652165
Ref: Lack of radiosensitization after paclitaxel treatment of three human carcinoma cell lines.
PMID: 7712434
 Ref: Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours.
PMID: 10567908
 Ref: dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer.
PMID: 10910061
 Ref: The role of dUTPase and uracil-DNA repair in cancer chemotherapy.
PMID: 12374095
 Ref: Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
PMID: 16518869
 Ref: Novel opportunities for thymidylate metabolism as a therapeutic target.
PMID: 18790783
 Ref: Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer.
PMID: 19052026
 Ref: Identification of potential pharmacogenomic markers of clinical efficacy of 5-fluorouracil in colorectal cancer.
PMID: 20560137
Ref: Pharmacokinetic and metabolism determinants of fluoropyrimidines and oxaliplatin activity in treatment of colorectal patients.
PMID: 21787270
 Ref: The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis.
PMID: 26208523