Primary Site >> Colorectal Cancer
Gene >> DUSP4
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Ref: Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas. PMID: 20725992 |
Ref: MAP kinase genes and colon and rectal cancer. PMID: 23027623 |
Ref: Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition. PMID: 22430215 Ref: Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation. PMID: 22965873 Ref: A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. PMID: 23350875 Ref: Decreased expression of DUSP4 is associated with liver and lung metastases in colorectal cancer. PMID: 23749251 Ref: DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype. PMID: 23875912 |
Ref: Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer. PMID: 24609463 |
Ref: Genetic variants identified by GWAS was associated with colorectal cancer in the Han Chinese population. PMID: 26148620 |
Ref: Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas. PMID: 29150975 |