Primary Site >> Colorectal Cancer
Gene >> DNMT3B
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Ref: CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. PMID: 10344733 |
Ref: DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. PMID: 11146446 |
Ref: DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. PMID: 11932749 Ref: Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. PMID: 12438232 |
Ref: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. PMID: 12496760 Ref: Epigenetic inactivation of CHFR in human tumors. PMID: 12810945 Ref: Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases. PMID: 12915469 |
Ref: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. PMID: 15547111 Ref: The expression of de novo DNA methylase DNMT3b, of the methyl-CpG binding protein MBD2b and of 5-MCDG glycosylase shows two waves of induction during CaCO-2 cell differentiation. PMID: 15823509 Ref: Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. PMID: 16204030 Ref: Procainamide is a specific inhibitor of DNA methyltransferase 1. PMID: 16230360 |
Ref: DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. PMID: 16421593 Ref: De novo CpG island methylation in human cancer cells. PMID: 16423997 Ref: Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis. PMID: 16568088 Ref: DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset. PMID: 16702365 Ref: Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b. PMID: 16715135 Ref: Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription. PMID: 16735507 Ref: [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]. PMID: 17236547 |
Ref: DNMT3b 39179GT polymorphism and the risk of adenocarcinoma of the colon in Koreans. PMID: 17318376 Ref: Progressive up-regulation of genes encoding DNA methyltransferases in the colorectal adenoma-carcinoma sequence. PMID: 17538945 Ref: DNA methylation regulates MicroRNA expression. PMID: 17660710 Ref: Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. PMID: 18056424 Ref: Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells. PMID: 18089774 |
Ref: Association of interindividual differences in p14ARF promoter methylation with single nucleotide polymorphism in primary colorectal cancer. PMID: 18327804 Ref: Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study. PMID: 18662374 Ref: DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells. PMID: 19074829 |
Ref: Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. PMID: 18789002 Ref: 5-Aza-2'-deoxycytidine reactivates expression of RUNX3 by deletion of DNA methyltransferases leading to caspase independent apoptosis in colorectal cancer Lovo cells. PMID: 18848767 Ref: DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers. PMID: 19156137 Ref: Possible involvement of activation of P53/P21 and demethylation of RUNX 3 in the cytotoxicity against Lovo cells induced by 5-Aza-2'-deoxycytidine. PMID: 19159630 Ref: DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. PMID: 19470733 Ref: DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer. PMID: 19723660 Ref: Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. PMID: 19843671 |
Ref: Recent insights into the pathogenesis of colorectal cancer. PMID: 19786869 Ref: Epigenetic regulation of the ERbeta gene on the estrogen signal transfection pathway in colon cancer cells. PMID: 20155458 Ref: Impact of genomic methylation on radiation sensitivity of colorectal carcinoma. PMID: 20338477 Ref: Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype. PMID: 20381446 Ref: HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors. PMID: 20454457 Ref: Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells. PMID: 20543577 |
Ref: Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer. PMID: 20960050 Ref: Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. PMID: 21068132 Ref: Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines. PMID: 21408221 Ref: Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer. PMID: 21490393 Ref: Genetic variation in the promoter of DNMT3B is associated with the risk of colorectal cancer. PMID: 21519807 Ref: Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks. PMID: 21526191 Ref: Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks. PMID: 21526302 Ref: Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing. PMID: 21785137 Ref: DNA-methyltransferase 3B 39179 G > T polymorphism and risk of sporadic colorectal cancer in a subset of Iranian population. PMID: 22091311 |
Ref: DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case-control studies. PMID: 21938431 Ref: A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer. PMID: 22244828 Ref: [Correlation between polymorphism in the promoter of DNA methyltransferase-3B and the risk of colorectal cancer]. PMID: 22490141 Ref: Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation. PMID: 22563479 Ref: Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity. PMID: 22595877 Ref: MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. PMID: 22641368 Ref: The -149C>T polymorphism of DNMT3B is not associated with colorectal cancer risk: Evidence from a meta-analysis based on case-control studies. PMID: 23170134 |
Ref: Immunohistochemical analysis of the DNA methyltransferase 3b expression is associated with significant improvements in the discrimination of ulcerative colitis-associated neoplastic lesions. PMID: 23307264 Ref: Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells. PMID: 23368921 Ref: A prospective study of duration of smoking cessation and colorectal cancer risk by epigenetics-related tumor classification. PMID: 23788674 Ref: Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. PMID: 24067901 Ref: Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. PMID: 24129635 |
Ref: The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. PMID: 23708667 Ref: Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. PMID: 23946381 Ref: Genetic polymorphism of DNA methyltransferase 3B 149 C>T and risk of colorectal cancer: a meta-analysis. PMID: 24178910 Ref: Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism. PMID: 24500500 Ref: DNA methyltransferases: a novel target for prevention and therapy. PMID: 24822169 |
Ref: PHF21B as a candidate tumor suppressor gene in head and neck squamous cell carcinomas. PMID: 25454821 Ref: Systematic evaluation of cancer risk associated with DNMT3B polymorphisms. PMID: 25515408 Ref: Identification of long-range epigenetic silencing on chromosome 15q25 and its clinical implication in gastric cancer. PMID: 25576785 Ref: DNMT3b -149C/T promoter variants and methylation of colorectal cancer-associated genes. PMID: 25769449 Ref: Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study. PMID: 26108676 Ref: Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer. PMID: 26305882 Ref: Quantitative assessment of the association between DNMT3B-579G>T polymorphism and cancer risk. PMID: 26406961 Ref: Association of DNA methyltransferases expression with global and gene-specific DNA methylation in colorectal cancer cells. PMID: 26416384 Ref: Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases. PMID: 26458736 Ref: Gene-specific DNA methylation of DNMT3B and MTHFR and colorectal adenoma risk. PMID: 26485042 Ref: miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1. PMID: 26497367 Ref: Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis. PMID: 26550225 |
Ref: Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma. PMID: 26787892 Ref: Genetic and epigenetic variation in the DNMT3B and MTHFR genes and colorectal adenoma risk. PMID: 27062459 Ref: DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis. PMID: 27356727 Ref: Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer. PMID: 27666771 Ref: MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition. PMID: 27668319 |
Ref: A novel miR-203-DNMT3b-ABCG2 regulatory pathway predisposing colorectal cancer development. PMID: 27253631 Ref: Induction of Epigenetic Alteration by CPUK02, An Ent- kaurenoid Derivative of Stevioside. PMID: 28090275 Ref: Effect of evodiamine and berberine on the interaction between DNMTs and target microRNAs during malignant transformation of the colon by TGF-beta1. PMID: 28098901 Ref: Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer. PMID: 28300471 Ref: Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer. PMID: 28583846 Ref: Chemoresistance of colorectal cancer to 5-fluorouracil is associated with silencing of the BNIP3 gene through aberrant methylation. PMID: 28607593 |
Ref: Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. PMID: 29361151 |