Primary Site >> Colorectal Cancer

Gene >> DKK4

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Ref: Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.
PMID: 17675336
Ref: DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3.
PMID: 18408752
Ref: Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes.
PMID: 19035286
Ref: Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells.
PMID: 19059704
Ref: DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer.
PMID: 19659606
Ref: Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells.
PMID: 20043299
Ref: TFAP2E-DKK4 and chemoresistance in colorectal cancer.
PMID: 22216841
Ref: TFAP2E-DKK4 and chemoresistance in colorectal cancer.
PMID: 22397669
Ref: Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4.
PMID: 22740476
Ref: beta-catenin regulates NF-kappaB activity via TNFRSF19 in colorectal cancer cells.
PMID: 24623448
Ref: Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.
PMID: 26006007
Ref: CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells.
PMID: 28229932
Ref: DKK4 enhances resistance to chemotherapeutics 5-Fu and YN968D1 in colorectal cancer cells.
PMID: 28356933
Ref: TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells.
PMID: 28450117
Ref: Identification, isolation and characterization of human LGR5-positive colon adenoma cells.
PMID: 29467240