Primary Site >> Stomach Cancer

Gene >> DKK1

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Ref: Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis.
PMID: 15858124
Ref: Comparative genomics on DKK2 and DKK4 orthologs.
PMID: 16077958
 Ref: WNT antagonist, SFRP1, is Hedgehog signaling target.
PMID: 16328026
Ref: Analysis of genes upregulated by the demethylating agent 5-aza-2'-deoxycytidine in gastric cancer cell lines.
PMID: 16671088
Ref: Suppressing Wnt signaling by the hedgehog pathway through sFRP-1.
PMID: 17035233
 Ref: Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.
PMID: 17273778
Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs.
PMID: 17273804
Ref: Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs.
PMID: 17390031
Ref: Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer.
PMID: 17568183
Ref: Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.
PMID: 17675336
 Ref: Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer.
PMID: 19628661
 Ref: Molecular analysis of gastric differentiated-type intramucosal and submucosal cancers.
PMID: 20178104
 Ref: A novel screening biomarker in gastric cancer: serum Dickkopf-1.
PMID: 22155860
Ref: The Wnt/beta-catenin pathway regulates self-renewal of cancer stem-like cells in human gastric cancer.
PMID: 22367735
Ref: Dickkopf-1 expression is a novel prognostic marker for gastric cancer.
PMID: 22496615
Ref: Clinical significance of serum and tissue Dickkopf-1 levels in patients with gastric cancer.
PMID: 22796372
 Ref: Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44(+) gastric cancer cells via attenuating Wnt signaling.
PMID: 23188090
Ref: Bone metastases in gastric cancer follow a RANKL-independent mechanism.
PMID: 23404437
 Ref: Prognostic significance of dickkopf-1 overexpression in solid tumors: a meta-analysis.
PMID: 24258111
Ref: Assessing the diagnostic value of serum Dickkopf-related protein 1 levels in cancer detection: a case-control study and meta-analysis.
PMID: 25422182
 Ref: Expression of serum Dickkopf-1 in gastric cancer patients.
PMID: 26522305
Ref: Serum dickkopf-1 as a biomarker in screening gastrointestinal cancers: a systematic review and meta-analysis.
PMID: 26543380
 Ref: miR-493 mediated DKK1 down-regulation confers proliferation, invasion and chemo-resistance in gastric cancer cells.
PMID: 26799283
Ref: Prognostic Significance of Dickkopf-1 in Gastric Cancer Survival: A Meta-Analysis.
PMID: 27023747
Ref: Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility.
PMID: 27457487
Ref: Upregulation of miR-501-5p activates the wnt/beta-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer.
PMID: 27846906
 Ref: Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion.
PMID: 27895076
Ref: Concurrent Hypermethylation of SFRP2 and DKK2 Activates the Wnt/beta-Catenin Pathway and Is Associated with Poor Prognosis in Patients with Gastric Cancer.
PMID: 28152305
Ref: Bioinformatic identification of candidate genes induced by trichostatin A in BGC-823 gastric cancer cells.
PMID: 28356958
 Ref: Prognostic value of Dickkopf-1 and ss-catenin expression in advanced gastric cancer.
PMID: 29720122
Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
PMID: 29786110