Primary Site >> Colorectal Cancer
Gene >> DCC
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Ref: The genetics of colorectal cancer. PMID: 2101725 Ref: Lessons from the genetics of colon cancer. PMID: 2173130 Ref: Identification of a chromosome 18q gene that is altered in colorectal cancers. PMID: 2294591 |
Ref: Are there molecular targets for therapy of colon cancer? PMID: 1664228 Ref: Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18. PMID: 1670965 Ref: Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic disease. PMID: 1680575 Ref: Tumor suppressor genes involved in metastasis of lung and colorectal carcinomas. PMID: 1844253 Ref: [Diagnosis of colorectal cancer from DNA level]. PMID: 1846282 Ref: Evidence supporting exclusion of the DCC gene and a portion of chromosome 18q as the locus for susceptibility to hereditary nonpolyposis colorectal carcinoma in five kindreds. PMID: 1868434 |
Ref: Colorectal carcinoma as a genetic phenomenon. PMID: 1294935 Ref: Mutations of the p53 gene and other genes involving in human colorectal carcinogenesis. PMID: 1306299 Ref: Multistage carcinogenesis in paediatric and adult cancers. PMID: 1314630 Ref: Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. PMID: 1314700 Ref: [Genetic analysis of adenomatous polyposis coli: analysis of alterations of oncogenes and tumor suppressor genes in colorectal tumors]. PMID: 1317336 Ref: Loss of expression of the DCC gene during progression of colorectal carcinomas in familial adenomatous polyposis and non-familial adenomatous polyposis patients. PMID: 1319833 Ref: Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. PMID: 1347643 Ref: Suppressor genes in breast cancer: an overview. PMID: 1360244 Ref: Persistent expression of the tumor suppressor gene DCC is essential for neuronal differentiation. PMID: 1419911 Ref: Suppressor gene alterations in the colorectal adenoma-carcinoma sequence. PMID: 1469893 Ref: Molecular genetics of colorectal carcinoma. PMID: 1511369 Ref: Genetic alterations in the adenoma--carcinoma sequence. PMID: 1516027 Ref: [DCC gene and leukemia]. PMID: 1518158 Ref: Molecular genetic alterations as potential prognostic indicators in colorectal carcinoma. PMID: 1540900 Ref: Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts. PMID: 1549369 Ref: Frequent loss of heterozygosity on chromosome 18 in ovarian adenocarcinoma which does not always include the DCC locus. PMID: 1594239 |
Ref: Decreased expression of DCC mRNA in human colorectal cancers. PMID: 7678832 Ref: Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma. PMID: 8094072 Ref: [Metastasis related genes and malignancy in human esophageal, gastric and colorectal cancers]. PMID: 8094950 Ref: [Molecular genetics of colorectal cancer and carcinogenesis]. PMID: 8134731 Ref: Genetic events responsible for colorectal tumorigenesis: achievements and challenges. PMID: 8249174 Ref: Genetic alteration in gastrointestinal cancer. A molecular and cytogenetic study. PMID: 8297153 Ref: Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer. PMID: 8318422 Ref: Biological consequences of the genetic changes which occur during human colorectal carcinogenesis. PMID: 8318691 Ref: Alteration of the DCC tumor-suppressor gene in tumorigenic HPV-18 immortalized human keratinocytes transformed by nitrosomethylurea. PMID: 8380923 Ref: Lack of correlation between the gap junctional communication capacity of human colon cancer cell lines and expression of the DCC gene, a homologue of a cell adhesion molecule (N-CAM). PMID: 8396566 Ref: Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma. PMID: 8414507 Ref: Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas. PMID: 8437850 Ref: Molecular mechanism of stomach carcinogenesis. PMID: 8440743 Ref: [Analysis of molecular mechanism in colorectal tumorigenesis]. PMID: 8458595 Ref: Tumour suppressor genes and colorectal neoplasia. PMID: 8471756 Ref: DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18. PMID: 8490178 |
Ref: Esophageal cancer. PMID: 7533069 Ref: [Etiology of colorectal cancer]. PMID: 7557283 Ref: Studies of the deleted in colorectal cancer gene in normal and neoplastic tissues. PMID: 7587124 Ref: Expression of the DCC gene in human hematological malignancies. PMID: 7696919 Ref: Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. PMID: 7806578 Ref: Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos. PMID: 7813784 Ref: [Genes, heredity and colorectal cancer]. PMID: 7878358 Ref: Molecular genetics for clinical management of colorectal carcinoma. 17p, 18q, and 22q loss of heterozygosity and decreased DCC expression are correlated with the metastatic potential. PMID: 7906606 Ref: The DCC gene product in cellular differentiation and colorectal tumorigenesis. PMID: 7926722 Ref: Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. PMID: 7947085 Ref: The capacity for growth stimulation by TGF beta 1 seen only in advanced colon cancers cannot be ascribed to mutations in APC, DCC, p53 or ras. PMID: 7970729 Ref: Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues. PMID: 8044801 Ref: Loss of heterozygosity of tumour suppressor gene loci in human colorectal carcinoma. PMID: 8080684 Ref: DNA alterations in cells from hereditary non-polyposis colorectal cancer patients. PMID: 8108146 Ref: [Genetic alterations of human colorectal cancer]. PMID: 8109990 Ref: NIH3T3 cells expressing the deleted in colorectal cancer tumor suppressor gene product stimulate neurite outgrowth in rat PC12 pheochromocytoma cells. PMID: 8132705 Ref: A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene. PMID: 8132740 Ref: The DCC gene: structural analysis and mutations in colorectal carcinomas. PMID: 8188295 Ref: Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma. PMID: 8194712 Ref: Allelic losses associated with the metastatic potential of colorectal-carcinoma. PMID: 21559585 |
Ref: Contribution of molecular oncology in the detection of colorectal carcinomas. PMID: 7491839 Ref: The deleted in colorectal cancer (DCC) gene: a candidate tumour suppressor gene encoding a cell surface protein with similarity to neural cell adhesion molecules. PMID: 7553661 Ref: Inactivation of the DCC tumor suppressor gene in a B-cell lymphoma cell line with the alteration of chromosome 18. PMID: 7572991 Ref: The distribution of the deleted in colon cancer (DCC) protein in human tissues. PMID: 7585645 Ref: Platelet-derived growth factor-B increases colon cancer cell growth in vivo by a paracrine effect. PMID: 7593201 Ref: The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma. PMID: 7674088 Ref: The DCC gene suppresses the malignant phenotype of transformed human epithelial cells. PMID: 7731713 Ref: Genetic alterations of microsatellites on chromosome 18 in human breast carcinoma. PMID: 7735559 Ref: Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. PMID: 7743515 Ref: DCC: linking tumor suppressor genes and altered cell surface interactions in cancer? PMID: 7749329 Ref: The genetic basis of colorectal cancer--clinical implications. PMID: 7851569 Ref: Low frequency and late occurrence of p53 and dcc aberrations in colorectal tumours. PMID: 7860623 Ref: DCC expression is altered by multiple mechanisms in brain tumours. PMID: 8570191 Ref: DCC (deleted in colorectal cancer) inactivation in hematological malignancies. PMID: 8580831 Ref: Molecular biology of colon polyps and colon cancer. PMID: 8607008 Ref: Multistep carcinogenesis in colorectal cancers. PMID: 8629105 Ref: Decreased expression of DCC mRNA in gastric and colorectal cancer. PMID: 8645930 Ref: Genetic and cellular changes in colorectal cancer: proposed targets of chemopreventive agents. PMID: 8672984 |
Ref: Contributions of molecular genetics to the clinical management of colorectal cancer. PMID: 8554121 Ref: Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer. PMID: 8577718 Ref: Detection of DCC and Ki-ras gene alterations in colorectal carcinoma tissue as prognostic markers for liver metastatic recurrence. PMID: 8608570 Ref: DCC protein expression in hematopoietic cell populations and its relation to leukemogenesis. PMID: 8609244 Ref: Synergy between Apc min and an activated ras mutation is sufficient to induce colon carcinomas. PMID: 8622690 Ref: Genetic heterogeneity and unmapped genes for colorectal cancer. PMID: 8640829 Ref: Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. PMID: 8673134 Ref: [Prognostic factors of colon cancer from a molecular biology standpoint]. PMID: 8687233 Ref: Bcl-2 expression and allelic loss of the p53 gene in gastric carcinomas. PMID: 8690754 Ref: [Genetic diagnosis of colorectal cancer]. PMID: 8727369 Ref: The deleted in colon cancer (DCC) gene is consistently expressed in colorectal cancers and metastases. PMID: 8761300 Ref: Numerical chromosome alterations in colorectal carcinomas detected by fluorescence in situ hybridization. Relationship to 17p and 18q allelic losses. PMID: 8764933 Ref: Loss of 18q and homozygosity for the DCC locus: possible markers for clinically aggressive squamous cell carcinoma. PMID: 8816836 Ref: Synthesis of a new class of isothiocyanatopeptide bifunctional chelating agents for coupling to monoclonal antibodies. PMID: 8844266 Ref: Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors. PMID: 8846166 Ref: UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. PMID: 8861903 Ref: DCC: is there a connection between tumorigenesis and cell guidance molecules? PMID: 8876630 Ref: Genetic aspects of colorectal cancer: the surgeon's view. PMID: 8898451 Ref: [Structure and function of DCC (deleted in colorectal cancer) gene and its product]. PMID: 8920659 Ref: [Genetic steps in colorectal cancer]. PMID: 8920676 Ref: Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules. PMID: 8921253 Ref: The DCC protein and prognosis in colorectal cancer. PMID: 8929264 Ref: Decreased expression of the DCC gene in human breast carcinoma. PMID: 8931221 Ref: Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse. PMID: 8946200 Ref: The cellular and molecular pathogenesis of colorectal cancer. PMID: 8960890 Ref: Molecular pathogenesis of adenoma and differentiated adenocarcinoma of the stomach. PMID: 8970192 Ref: Allelotype of adenoma and differentiated adenocarcinoma of the stomach. PMID: 9014856 Ref: DNA alterations in sporadic colorectal tumors do not correlate with tumor staging diagnosed by the TNM system. PMID: 9020916 Ref: Loss of heterozygosity at the DCC gene locus is not crucial for the acquisition of metastatic potential in oesophageal squamous cell carcinoma. PMID: 9081374 Ref: [Loss of heterozygosity involving DCC gene in human colorectal cancers is correlated with the metastatic potential]. PMID: 9387312 Ref: [A study on the loss of heterozygosity at the APC/MCC and DCC genetic loci in colorectal cancers]. PMID: 9592312 Ref: [A study on the changes of DCC and MCC genes in colorectal carcinoma and adenoma]. PMID: 9592313 Ref: Genetics of colorectal cancer (Review). PMID: 21541519 |
Ref: Loss of DCC expression and glioma progression. PMID: 9012460 Ref: DCC genetic alterations and expression in endometrial carcinoma. PMID: 9021725 Ref: DCC's function takes shape in the nervous system. PMID: 9024638 Ref: Assessment of microsatellite alterations in young patients with gastric adenocarcinoma. PMID: 9024705 Ref: Advances in molecular genetics. PMID: 9046882 Ref: Loss of heterozygosity and microsatellite instability at the DCC and nm23 loci in Duke's B colorectal carcinoma. PMID: 9057038 Ref: DCC expression and prognosis in colorectal cancer. PMID: 9100619 Ref: [Molecular-pathological problems of genetic diagnosis for colorectal cancer]. PMID: 9101543 Ref: Analysis of the DCC tumor suppressor gene in testicular germ cell tumors: mutations and loss of expression. PMID: 9112574 Ref: Identification and characterization of neogenin, a DCC-related gene. PMID: 9121761 Ref: Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression. PMID: 9126347 Ref: Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. PMID: 9126737 Ref: Genetic alterations in gastric cancer: relation to histological subtypes, tumor stage, and Helicobacter pylori infection. PMID: 9136822 Ref: The DCC protein and colon cancer. PMID: 9148153 Ref: The DCC protein and colon cancer. PMID: 9148154 Ref: The DCC protein and colon cancer. PMID: 9148155 Ref: Frequent reduction or loss of DCC gene expression in human osteosarcoma. PMID: 9155051 Ref: Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma. PMID: 9288786 Ref: Microsatellite instability in sporadic-colon-cancer patients with and without liver metastases. PMID: 9291442 Ref: Tumor suppressor activity of neural cell adhesion molecule in colon carcinoma. PMID: 9324132 Ref: Concordance of genetic alterations in poorly differentiated colorectal neuroendocrine carcinomas and associated adenocarcinomas. PMID: 9326914 Ref: Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. PMID: 9331350 Ref: Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. PMID: 9334332 Ref: Expression of two Ig family adhesion molecules in the murine hair cycle: DCC in the bulge epithelia and NCAM in the follicular papilla. PMID: 9347798 Ref: Critical issues in the evolving management of rectal cancer. PMID: 9422268 Ref: Molecular biology of colorectal cancer. PMID: 9438104 Ref: Codon 201Arg/Gly polymorphism of DCC (deleted in colorectal carcinoma) gene in flat- and polypoid-type colorectal tumors. PMID: 9440618 Ref: [Colorectal carcinogenesis, frequency and significance of genetic alterations: deletion of the short arm of chromosome 1, and initiating event]. PMID: 9554124 Ref: [The molecular biology and genetics of colorectal carcinoma]. PMID: 9739886 Ref: Synthesis, rhenium-188 labeling and biodistribution studies of a phenolic ester derivative of trisuccin PMID: 10851491 Ref: Evaluation of DNA polymerase beta gene mutation as a genetic marker for colorectal carcinoma. PMID: 21590066 Ref: Loss of heterozygosity and mRNA expression at deleted in colorectal cancer gene locus in gastric cancer. PMID: 27239131 Ref: The DCC protein -- neural development and the malignant process. PMID: 28481205 |
Ref: Molecular changes during the genesis of human gliomas. PMID: 9407626 Ref: Reduced expression of deleted colorectal carcinoma (DCC) protein in established colon cancers. PMID: 9472645 Ref: Detection of the DCC gene product in normal and malignant colorectal tissues and its relation to a codon 201 mutation. PMID: 9484816 Ref: [The study of genetic changes in colorectal cancer accompanied with ulcerative colitis]. PMID: 9513564 Ref: A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer. PMID: 9602705 Ref: Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. PMID: 9609755 Ref: Allelic imbalance and microsatellite instability of the DCC gene in colorectal cancer in patients under the age of 35 using fluorescent DNA technology. PMID: 9624418 Ref: [DCC changes and prognosis in colorectal carcinoma]. PMID: 9628983 Ref: Alterations in the colorectal carcinoma gene and protein in a novel human myeloid leukemia cell line with trisomy 18 established from overt leukemia after myelodysplastic syndrome. PMID: 9631582 Ref: DCC protein as a predictor of distant metastases after curative surgery for rectal cancer. PMID: 9645744 Ref: Status of deleted in colorectal cancer gene expression correlates with neuroblastoma metastasis. PMID: 9645757 Ref: K-ras codon 12 mutation determines the polypoid growth of colorectral cancer. PMID: 9699657 Ref: At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice. PMID: 9790761 Ref: The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. PMID: 9796814 Ref: Somatic alterations of the SMAD-2 gene in human colorectal cancers. PMID: 9820171 Ref: Decreased DCC mRNA expression in human gastric cancers is clinicopathologically significant. PMID: 9842974 |
Ref: Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. PMID: 9858595 Ref: Expression of DCC protein in colorectal tumors and its relationship to tumor progression and metastasis. PMID: 9949300 Ref: Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. PMID: 9950216 Ref: L-myc genotypes in Hong Kong Chinese colorectal carcinoma patients. PMID: 10023018 Ref: Loss of expression of the gene deleted in colon carcinoma (DCC) is closely related to histologic differentiation and lymph node metastasis in endometrial carcinoma. PMID: 10023715 Ref: Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer. PMID: 10090594 Ref: In vitro analysis of the role of DCC in mucus-secreting intestinal differentiation. PMID: 10328236 Ref: Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons. PMID: 10341242 Ref: Induction of apoptosis and G2/M cell cycle arrest by DCC. PMID: 10348349 Ref: Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene. PMID: 10353603 Ref: Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. PMID: 10366627 Ref: Clinicopathologic and carcinogenetic appraisal of DNA replication error in sporadic T3N0M0 stage colorectal cancer after curative resection. PMID: 10370632 Ref: Divergent properties of mouse netrins. PMID: 10381568 Ref: Genomic instability and alterations in Apc, Mcc and Dcc in Hong Kong patients with colorectal carcinoma. PMID: 10404094 Ref: Hypermethylation of the p16 gene in sporadic T3N0M0 stage colorectal cancers: association with DNA replication error and shorter survival. PMID: 10461063 Ref: Reduced expression of APC and DCC gene protein in breast cancer. PMID: 10469217 Ref: Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients. PMID: 10479724 Ref: The Deleted in Colorectal Cancer netrin guidance system: a molecular strategy for neuronal navigation. PMID: 10499167 Ref: Molecular pathology of colorectal cancer. PMID: 10545700 Ref: Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice. PMID: 10559399 Ref: Expression of the deleted in colorectal cancer gene is related to prognosis in DNA diploid and low proliferative colorectal adenocarcinoma. PMID: 10561211 Ref: A case of adenocarcinoma of the small intestine in a Japanese patient with Crohn disease: a report with immunohistochemical and oncogenic analyses. PMID: 10582770 Ref: Extension of long leading processes and neuronal migration in the mammalian brain directed by the chemoattractant netrin-1. PMID: 10595513 Ref: Frequent allelic imbalance on chromosome 18q21 in early superficial colorectal cancers. PMID: 10665650 Ref: LOH at the sites of the DCC, APC, and TP53 tumor suppressor genes occurs in Barrett's metaplasia and dysplasia adjacent to adenocarcinoma of the esophagus. PMID: 10667431 Ref: [Are there differences between ex adenoma and de novo colorectal carcinomas?]. PMID: 10714204 Ref: Netrins and netrin receptors. PMID: 11213262 Ref: The molecular basis of colorectal carcinogenesis. PMID: 17023910 |
Ref: Expression of the netrin-1 receptor, deleted in colorectal cancer (DCC), is largely confined to projecting neurons in the developing forebrain. PMID: 10581466 Ref: Aberration of p53 and DCC in gastric and colorectal cancer. PMID: 10601600 Ref: Collision tumour in the pelvic cavity: rectal leiomyosarcoma and prostate adenocarcinoma. PMID: 10664249 Ref: DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination. PMID: 10698524 Ref: Use of crypt isolation to determine loss of heterozygosity of multiple tumor suppressor genes in colorectal carcinoma. PMID: 10729918 Ref: Colonic mucin-carbohydrate components in colorectal tumors and their possible relationship to MUC2, p53 and DCC immunoreactivities. PMID: 10729920 Ref: Genetic analysis of multiple synchronous lesions of the colon adenoma-carcinoma sequence. PMID: 10755401 Ref: Axons crossing in the ventral commissure express L1 and GAD65 in the developing rat spinal cord. PMID: 10894986 Ref: Decreased expression of CD44, alpha-catenin, and deleted colon carcinoma and altered expression of beta-catenin in ulcerative colitis-associated dysplasia and carcinoma, as compared with sporadic colon neoplasms. PMID: 10951334 Ref: Function of an axonal chemoattractant modulated by metalloprotease activity. PMID: 10958786 Ref: [Dependence receptors: links between apoptosis, nervous system development and control of tumorigenesis]. PMID: 10969210 Ref: The DCC protein expression in breast carcinoma. PMID: 10969518 Ref: No SMAD4 hypermethylation in colorectal cancer. PMID: 10993648 Ref: Reduced or absent expression and codon 201Gly/Arg polymorphism of DCC gene in rhabdomyosarcoma and Ewing's sarcoma/PNET family. PMID: 10998440 Ref: The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression. PMID: 11040453 Ref: Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. PMID: 11048721 Ref: Differentially expressed genes in asbestos-induced tumorigenic human bronchial epithelial cells: implication for mechanism. PMID: 11062161 Ref: A comparative microsatellite analysis of colorectal cancer in patients <35 years and >50 years of age. PMID: 11095352 Ref: Cellular mechanisms of netrin function: long-range and short-range actions. PMID: 11103947 Ref: A double germline mutations in the APC and p53 genes. PMID: 11263856 |
Ref: Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells. PMID: 11121239 Ref: Truncated DCC reduces N-cadherin/catenin expression and calcium-dependent cell adhesion in neuroblastoma cells. PMID: 11232642 Ref: The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. PMID: 11248093 Ref: Multiple genetic alterations involved in the tumorigenesis of human cholangiocarcinoma: a molecular genetic and clinicopathological study. PMID: 11260864 Ref: Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. PMID: 11289147 Ref: 09/15: Comparative genomics of a conserved chromosomal region associated with a complex human phenotype. PMID: 11318607 Ref: Allelic loss of chromosome 2p21-16.3 is associated with reduced survival in sporadic colorectal cancer. PMID: 11336166 Ref: Chromosome 18 deletions are common events in classical midgut carcinoid tumors. PMID: 11351300 Ref: Upregulation of the netrin receptor (DCC) gene during activation of b lymphocytes and modulation by interleukins. PMID: 11355876 Ref: Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7. PMID: 11391794 Ref: [Genetic changes in liver metastasis of colorectal cancer and their clinical application]. PMID: 11393998 Ref: [Future scope for gene therapy for liver metastasis of colon cancer]. PMID: 11394006 Ref: [Telomere length and DCC gene mRNA expression of human large intestine cancers]. PMID: 11402446 Ref: A role of netrin-1 in the formation of the subcortical structure striatum: repulsive action on the migration of late-born striatal neurons. PMID: 11404412 Ref: Loss of p27 expression predicts poor prognosis in patients with Dukes' B stage or proximal colorectal cancer. PMID: 11408921 Ref: Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma. PMID: 11433398 Ref: SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway. PMID: 11481457 Ref: Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer. PMID: 11518545 Ref: Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells. PMID: 11527412 Ref: Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue. PMID: 11533074 Ref: Developmental expression of DCC in the rat retina. PMID: 11557102 Ref: Codon 201(Gly) polymorphic type of the DCC gene is related to disseminated neuroblastoma. PMID: 11571626 Ref: Human colon cancer cells deficient in DCC produce abnormal transcripts in progression of carcinogenesis. PMID: 11575440 Ref: Immunohistochemical localization of deleted-in-colon-cancer (DCC) protein in human epithelial, neural, and neuro-endocrine tissues in paraffin sections with antigen retrieval. PMID: 11593961 Ref: Loss of heterozygosity and HIV infection in patients with anal squamous-cell carcinoma. PMID: 11598481 Ref: A zebrafish homologue of deleted in colorectal cancer (zdcc) is expressed in the first neuronal clusters of the developing brain. PMID: 11677060 Ref: Genetic alterations in poorly differentiated endocrine colon carcinomas developing in tubulo-villous adenomas: a report of two cases. PMID: 11787850 |
Ref: The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. PMID: 11817894 Ref: Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. PMID: 11844789 Ref: Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old. PMID: 11852336 Ref: Prediction of distant metastases after curative surgery for rectal cancer. PMID: 11855920 Ref: Expression of netrin-1 and netrin-1 receptor, DCC, in the rat olfactory nerve pathway during development and axonal regeneration. PMID: 11927147 Ref: Microsatellite analysis of fecal DNA for colorectal cancer detection. PMID: 11967905 Ref: Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. PMID: 11986622 Ref: Mediation of the DCC apoptotic signal by DIP13 alpha. PMID: 12011067 Ref: Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans. PMID: 12016117 Ref: [Etiopathogenic factors in colorectal cancer. Genetic and clinical features (first of 2 parts)]. PMID: 12048974 Ref: RER and LOH association with sporadic colorectal cancer in Taiwanese patients. PMID: 12063967 Ref: Loss of heterozygosity at 18q21 region in gastric cancer involves a number of cancer-related genes and correlates with stage and histology, but lacks independent prognostic value. PMID: 12081203 Ref: Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1. PMID: 12122061 Ref: The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism. PMID: 12149262 Ref: No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice. PMID: 12183405 Ref: High resolution analysis of chromosome 18 alterations in ulcerative colitis-related colorectal cancer. PMID: 12237237 Ref: p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer. PMID: 12390383 Ref: Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region. PMID: 12397640 Ref: Early loss of deleted in colorectal carcinoma gene transcript detected in a group of benign colon adenomas. PMID: 12432238 |
Ref: Quantification of expression of netrins, slits and their receptors in human prostate tumors. PMID: 12471613 Ref: The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction. PMID: 12509857 Ref: Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus. PMID: 12584607 Ref: Mammalian BarH1 confers commissural neuron identity on dorsal cells in the spinal cord. PMID: 12657654 Ref: p53 and DCC immunohistochemistry in curative rectal cancer surgery. PMID: 12673482 Ref: Netrin-1 is a chemorepellent for oligodendrocyte precursor cells in the embryonic spinal cord. PMID: 12736344 Ref: Implications of genetic testing in the management of colorectal cancer. PMID: 12749725 Ref: Codon 201 polymorphism of DCC gene is a prognostic factor in patients with colorectal cancer. PMID: 12787729 Ref: Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. PMID: 12798294 Ref: Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin. PMID: 12810718 Ref: Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells. PMID: 12819897 Ref: Immunohistochemical analyses of colon cancer in I1307K APC mutation carriers compared with noncarriers. PMID: 12822869 Ref: Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough? PMID: 12853343 Ref: Folic acid mediated attenuation of loss of heterozygosity of DCC tumor suppressor gene in the colonic mucosa of patients with colorectal adenomas. PMID: 12893078 Ref: Prognostic significance of the deleted in colorectal cancer gene protein expression in high-risk resected gastric carcinoma. PMID: 12901278 Ref: The role of the Deleted Colon Cancer (DCC) gene in colorectal and gastric cancer. PMID: 12901294 Ref: The expression of DCC protein in female breast cancer. PMID: 12908825 Ref: Tumor suppressor function of Betaig-h3 gene in radiation carcinogenesis. PMID: 12971413 Ref: Bcl-2 expression is a prognostic factor in the subgroups of patients with colorectal cancer. PMID: 14532988 Ref: The dependence receptors DCC and UNC5H as a link between neuronal guidance and survival. PMID: 14597260 Ref: Microsatellite analysis of early stage (Ia-IIb) uterine cervical squamous carcinoma. PMID: 14615820 Ref: Genetic analysis of radiation-associated rectal cancer. PMID: 14714259 |
Ref: Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature. PMID: 12827409 Ref: Microsatellite analysis of the DCC gene in nephroblastomas: pathologic correlations and prognostic implications. PMID: 14631365 Ref: Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. PMID: 14688025 Ref: Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons. PMID: 14750959 Ref: Evaluation of genetic mutations of tumor suppresser genes in colorectal cancer patients. PMID: 15011843 Ref: Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma. PMID: 15014022 Ref: Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension. PMID: 15044543 Ref: DCC protein expression in clear cell renal cell carcinoma. PMID: 15050007 Ref: The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish. PMID: 15081375 Ref: Application of cycling gradient capillary electrophoresis to detection of APC, K-ras, and DCC point mutations in patients with sporadic colorectal tumors. PMID: 15095442 Ref: Deleted in colorectal cancer protein expression as a possible predictor of response to adjuvant chemotherapy in colorectal cancer patients. PMID: 15148649 Ref: Histological indicators of prognosis in glioblastomas: retinoblastoma protein expression and oligodendroglial differentiation indicate improved survival. PMID: 15186270 Ref: Netrin-1 is crucial for the establishment of the dorsal column-medial lemniscal system. PMID: 15189358 Ref: Clinical overview: adjuvant therapy of gastrointestinal cancer. PMID: 15309508 Ref: Role of the dependence receptor DCC in colorectal cancer pathogenesis. PMID: 15310786 Ref: Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. PMID: 15343335 Ref: Chemopreventive role of folic acid in colorectal cancer. PMID: 15353309 Ref: Deleted in colon cancer protein expression in colorectal cancer metastases: a major predictor of survival in patients with unresectable metastatic disease receiving palliative fluorouracil-based chemotherapy. PMID: 15365072 Ref: Systematic review of genetic influences on the prognosis of colorectal cancer. PMID: 15382104 Ref: Focal adhesion kinase in netrin-1 signaling. PMID: 15494733 Ref: Activation of FAK and Src are receptor-proximal events required for netrin signaling. PMID: 15494734 Ref: APC gene loss of heterozygosity, mutations, E1317Q, and I1307K germ-line variants in sporadic colon cancer in Croatia. PMID: 15507235 Ref: Netrin-1 and its receptors in tumorigenesis. PMID: 15573119 Ref: Tailored chemotherapy for colorectal cancer: a new approach to therapy. PMID: 15581057 Ref: Deleted-in-colon-cancer protein expression in patients with adenocarcinoma of the urinary tract and a history of colorectal cancer. PMID: 15596185 Ref: No association between the Arg201Gly polymorphism of the DCC gene and colorectal cancer. PMID: 15646429 |
Ref: Colon cancer: survival after curative surgery. PMID: 15455234 Ref: Genotype phenotype correlations in Israeli colorectal cancer patients. PMID: 15523694 Ref: Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine. PMID: 15534618 Ref: Loss of heterozygosity: an independent prognostic factor of colorectal cancer. PMID: 15682467 Ref: Prognostic significance of DCC and p27Kip1 in colorectal cancer. PMID: 15722793 Ref: Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents. PMID: 15730872 Ref: Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord. PMID: 15788454 Ref: DCC association with lipid rafts is required for netrin-1-mediated axon guidance. PMID: 15811950 Ref: Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers. PMID: 15956977 Ref: Expression of p53, DCC, and HER-2/neu in mucinous carcinoma of the breast. PMID: 15960065 Ref: Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells. PMID: 16103117 Ref: Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients. PMID: 16122883 Ref: A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis. PMID: 16125380 Ref: [The molecular screening of the stool for the colorectal carcinoma]. PMID: 16149221 Ref: Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis. PMID: 16158190 Ref: Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron. PMID: 16181408 Ref: Venous invasion and down-regulation of p21(WAF1/CIP1) are associated with metastasis in colorectal carcinomas. PMID: 16201087 Ref: Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. PMID: 16244667 Ref: Hypermethylation of the putative tumor-suppressor genes DCC, p51/63 and O6-methylguanine-DNA methyltransferase (MGMT) and loss of their expressions in cell lines of hematological malignancies. PMID: 16247226 Ref: Deletion mapping of 18q in conventional renal cell carcinoma. PMID: 16337851 Ref: [Dependence receptors DCC and UNC5H: the role of apoptosis in the control of tumorigenesis]. PMID: 16471261 Ref: Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia. PMID: 16471312 |
Ref: DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation. PMID: 16321979 Ref: Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder. PMID: 16337279 Ref: FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. PMID: 16371650 Ref: Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer. PMID: 16474178 Ref: Cross-linking tumor cells with effector cells via CD55 with a bispecific mAb induces beta-glucan-dependent CR3-dependent cellular cytotoxicity. PMID: 16525993 Ref: The dependence receptor DCC requires lipid raft localization for cell death signaling. PMID: 16537496 Ref: Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction. PMID: 16554470 Ref: Colorectal cancer: genetics of development and metastasis. PMID: 16699851 Ref: Microdissection-based allelotyping: a novel technique to determine the temporal sequence and biological aggressiveness of colorectal cancer. PMID: 16719202 Ref: DCC regulates cell adhesion in human colon cancer derived HT-29 cells and associates with ezrin. PMID: 16762451 Ref: Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain. PMID: 16908105 Ref: Netrin/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut. PMID: 16917820 Ref: Adequacy of colonoscopic biopsy specimens for molecular analysis: a comparative study with colectomy tissue. PMID: 16932072 Ref: Automated quantitative analysis of DCC tumor suppressor protein in ovarian cancer tissue microarray shows association with beta-catenin levels and outcome in patients with epithelial ovarian cancer. PMID: 16971669 Ref: The use of early and midpoint adenoma-carcinoma sequence biomarkers in prediction of neoplastic progression in patients with a history of colorectal neoplasia. PMID: 17080251 Ref: Netrin/DCC signaling controls contralateral dendrites of octavolateralis efferent neurons. PMID: 17182783 Ref: [Biomolecular prognostic factors in colorectal cancer]. PMID: 17190278 |
Ref: Does immunostaining effectively upstage colorectal cancer by identifying micrometastatic nodal disease? PMID: 16528541 Ref: Colorectal cancer in a population with endemic Schistosoma mansoni: is this an at-risk population? PMID: 16786317 Ref: Neogenin: one receptor, many functions. PMID: 17137827 Ref: Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas. PMID: 17143621 Ref: Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. PMID: 17174565 Ref: Myosin X regulates netrin receptors and functions in axonal path-finding. PMID: 17237772 Ref: A simple method for the routine detection of somatic quantitative genetic alterations in colorectal cancer. PMID: 17258723 Ref: Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis. PMID: 17334389 Ref: [Netrin-1 and axonal guidance: signaling and asymmetrical translation]. PMID: 17349294 Ref: Clinical significance of p53, K-ras and DCC gene alterations in the stage I-II colorectal cancers. PMID: 17410283 Ref: Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. PMID: 17442818 Ref: A multivariate analysis of adhesion molecules expression in assessment of colorectal cancer. PMID: 17443723 Ref: Dependence receptors: when apoptosis controls tumor progression. PMID: 17449433 Ref: Chromosomal alteration in Chinese sporadic colorectal carcinomas detected by comparative genomic hybridization. PMID: 17525679 Ref: Pontine tegmental cap dysplasia: a novel brain malformation with a defect in axonal guidance. PMID: 17690130 Ref: Netrin inhibits regenerative axon growth of adult dorsal root ganglion neurons in vitro. PMID: 17728502 Ref: Netrin-1 induces proliferation of Schwann cells through Unc5b receptor. PMID: 17825258 Ref: Diffusion tensor magnetic resonance imaging and tract-tracing analysis of Probst bundle structure in Netrin1- and DCC-deficient mice. PMID: 17898206 Ref: Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. PMID: 17916735 Ref: Netrin-1 receptor-deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine. PMID: 18005074 Ref: From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy. PMID: 18043553 Ref: Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. PMID: 18054557 Ref: Netrins and their receptors. PMID: 18269208 |
Ref: Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer. PMID: 18205772 Ref: Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance. PMID: 18212043 Ref: Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. PMID: 18253061 Ref: The DCC gene and colorectal cancer: the story is more complex. PMID: 18266884 Ref: DCC promoter hypermethylation in esophageal squamous cell carcinoma. PMID: 18302152 Ref: MUC1 and colorectal cancer pathophysiology considerations. PMID: 18407586 Ref: Laminin terminates the Netrin/DCC mediated attraction of vagal sensory axons. PMID: 18418846 Ref: CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40-mediated axon outgrowth and promotes presynaptic development in Caenorhabditis elegans. PMID: 18434533 Ref: NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors. PMID: 18692059 Ref: Netrin-1 is a survival factor during commissural neuron navigation. PMID: 18796601 Ref: Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. PMID: 18922894 Ref: Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. PMID: 18945908 Ref: Microsatellite instability and loss of heterozygosity of tumor suppressor genes in Bosnian patients with sporadic colorectal cancer. PMID: 19125701 Ref: Netrin-1 specifically enhances cell spreading on fibronectin in human glioblastoma cells. PMID: 19967060 |
Ref: Compartmentalized DCC signalling is distinct from DCC localized to lipid rafts. PMID: 18616430 Ref: Netrin-4 enhances angiogenesis and neurologic outcome after cerebral ischemia. PMID: 18985053 Ref: Interference with netrin-1 and tumor cell death in non-small cell lung cancer. PMID: 19211441 Ref: Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer. PMID: 19242752 Ref: Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. PMID: 19303019 Ref: Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinoma. PMID: 19304403 Ref: Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21. PMID: 19329758 Ref: Expression of DCC in differentiating ameloblasts from developing tooth germs in rats. PMID: 19362703 Ref: Segment-specific expression of netrin-1 receptors in normal and ischemic mouse kidney. PMID: 19372643 Ref: Interfering with multimerization of netrin-1 receptors triggers tumor cell death. PMID: 19543238 Ref: Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease. PMID: 19543899 Ref: Netrin and DCC: axon guidance regulators at the intersection of nervous system development and cancer. PMID: 19601764 Ref: Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons. PMID: 19605629 Ref: [Familial colorectal cancer type X: clinical, pathological and molecular characterization]. PMID: 19686620 Ref: Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. PMID: 19721007 Ref: Role of deleted in colon carcinoma in osteoarthritis and in chondrocyte migration. PMID: 19745029 Ref: Post-pubertal emergence of a dopamine phenotype in netrin-1 receptor-deficient mice. PMID: 19788579 |
Ref: Intramedullary solitary fibrous tumor of dorsal spinal cord. PMID: 19751244 Ref: Characterization and expression of netrin-1 and its receptors UNC5B and DCC in human placenta. PMID: 19826074 Ref: The ratio of 'deleted in colorectal cancer' to 'uncoordinated-5A' netrin-1 receptors on the growth cone regulates mossy fibre directionality. PMID: 19858080 Ref: Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. PMID: 20065295 Ref: Methylation of the DCC gene is lost in advanced gastric cancer. PMID: 20150623 Ref: Netrin-1 elevates the level and induces cluster formation of its receptor DCC at the surface of cortical axon shafts in an exocytosis-dependent manner. PMID: 20170691 Ref: Netrin-1, a missing link between chronic inflammation and tumor progression. PMID: 20305387 Ref: Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine. PMID: 20345916 Ref: Primary cell lines: false representation or model system? a comparison of four human colorectal tumors and their coordinately established cell lines. PMID: 20369042 Ref: HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors. PMID: 20454457 Ref: Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization. PMID: 20493932 Ref: Bcl11A/CTIP1 mediates the effect of the glutamate receptor on axon branching and dendrite outgrowth. PMID: 20534004 Ref: 5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency. PMID: 20606684 Ref: Spatio-temporal deleted in colorectal cancer (DCC) and netrin-1 expression in human foetal brain development. PMID: 20609112 Ref: Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents. PMID: 20628609 |
Ref: Molecular development of the extrinsic sensory innervation of the gastrointestinal tract. PMID: 21147045 Ref: Molecular profiling of colon tumors: the search for clinically relevant biomarkers of progression, prognosis, therapeutics, and predisposition. PMID: 21347779 Ref: Abolition of the behavioral phenotype of adult netrin-1 receptor deficient mice by exposure to amphetamine during the juvenile period. PMID: 21523346 Ref: Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain. PMID: 21642953 Ref: The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry. PMID: 21653843 Ref: Schwann cells direct peripheral nerve regeneration through the Netrin-1 receptors, DCC and Unc5H2. PMID: 21656855 Ref: Immunohistochemical investigation of tumorigenic pathways in sinonasal intestinal-type adenocarcinoma. A tissue microarray analysis of 62 cases. PMID: 21668475 Ref: The Drosophila Netrin receptor frazzled/DCC functions as an invasive tumor suppressor. PMID: 21672235 Ref: Spatial and temporal second messenger codes for growth cone turning. PMID: 21795610 Ref: Effects of treadmill exercise on the expression of netrin-1 and its receptors in rat brain after cerebral ischemia. PMID: 21820492 Ref: Familial colorectal cancer type X syndrome: two distinct molecular entities? PMID: 21837511 Ref: Draxin inhibits axonal outgrowth through the netrin receptor DCC. PMID: 21957262 Ref: Autocrine netrin function inhibits glioma cell motility and promotes focal adhesion formation. PMID: 21980448 Ref: A signaling mechanism coupling netrin-1/deleted in colorectal cancer chemoattraction to SNARE-mediated exocytosis in axonal growth cones. PMID: 21994363 |
Ref: Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain. PMID: 22221736 Ref: Juvenile exposure to methylphenidate reduces cocaine reward and alters netrin-1 receptor expression in adulthood. PMID: 22249134 Ref: A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population. PMID: 22318345 Ref: Netrin-1 simultaneously suppresses corneal inflammation and neovascularization. PMID: 22323486 Ref: Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours. PMID: 22358843 Ref: Association between schizophrenia and genetic variation in DCC: a case-control study. PMID: 22418395 Ref: Netrin (UNC-6) mediates dendritic self-avoidance. PMID: 22426253 Ref: Netrin/DCC signaling guides olfactory sensory axons to their correct location in the olfactory bulb. PMID: 22457493 Ref: Increased cellular distribution of vimentin and Ret in the cingulum induced by developmental hypothyroidism in rat offspring maternally exposed to anti-thyroid agents. PMID: 22504374 Ref: Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1. PMID: 22512716 Ref: DCC mediated axon guidance of spinal interneurons is essential for normal locomotor central pattern generator function. PMID: 22521513 Ref: Increased expression of netrin-1 and its deleted in colorectal cancer receptor in human diseased lumbar intervertebral disc compared with autopsy control. PMID: 22588384 Ref: Dcc regulates asymmetric outgrowth of forebrain neurons in zebrafish. PMID: 22606267 Ref: [DCC, come back of a suppressor gene in colorectal cancer]. PMID: 22642996 Ref: Deleted in Colorectal Cancer (DCC) pathfinding: axon guidance gene finally turned tumor suppressor. PMID: 22876889 Ref: Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients. PMID: 22879877 Ref: Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip. PMID: 22946563 Ref: Robo2--slit and Dcc--netrin1 coordinate neuron axonal pathfinding within the embryonic axon tracts. PMID: 22956848 |
Ref: Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease. PMID: 22926168 Ref: Whole-genome methylation analysis of benign and malignant colorectal tumours. PMID: 23096130 Ref: Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth. PMID: 23230270 Ref: Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats. PMID: 23232257 Ref: DCC expression by neurons regulates synaptic plasticity in the adult brain. PMID: 23291093 Ref: Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage I esophageal squamous cell carcinoma. PMID: 23310950 Ref: AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth. PMID: 23479427 Ref: Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin alpha6beta4-dependent Akt, GSK-3beta, and HSF-1 in mesenchymal stem cells. PMID: 23538444 Ref: Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling. PMID: 23740870 Ref: Similarities of molecular genetic changes in synchronous and metachronous colorectal cancers are limited and related to the cancers' proximities to each other. PMID: 23810502 Ref: Netrin-1 receptor-deficient mice show age-specific impairment in drug-induced locomotor hyperactivity but still self-administer methamphetamine. PMID: 23820928 Ref: Toward a comprehensive and systematic methylome signature in colorectal cancers. PMID: 23975090 Ref: Prenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation. PMID: 23981041 |
Ref: Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion. PMID: 23302812 Ref: Adolescence: a time of transition for the phenotype of dcc heterozygous mice. PMID: 23572211 Ref: Piezoelectric ceramic (PZT) modulates axonal guidance growth of rat cortical neurons via RhoA, Rac1, and Cdc42 pathways. PMID: 24203571 Ref: Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor. PMID: 24400119 Ref: Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. PMID: 24876346 Ref: Netrin-1 controls sympathetic arterial innervation. PMID: 24937433 Ref: Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes. PMID: 25031414 Ref: Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion. PMID: 25056828 Ref: Dual drug delivery of 5-fluorouracil (5-FU) and methotrexate (MTX) through random copolymeric nanomicelles of PLGA and polyethylenimine demonstrating enhanced cell uptake and cytotoxicity. PMID: 25108479 Ref: The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. PMID: 25123307 |
Ref: Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy. PMID: 24928309 Ref: Association of DCC, MLH1, GSTT1, GSTM1, and TP53 gene polymorphisms with colorectal cancer in Kazakhstan. PMID: 25249451 Ref: Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a DCC-dependent manner. PMID: 25336209 Ref: Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO. PMID: 25561546 Ref: Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer). PMID: 25575591 Ref: Coordinated interaction of Down syndrome cell adhesion molecule and deleted in colorectal cancer with dynamic TUBB3 mediates Netrin-1-induced axon branching. PMID: 25754961 Ref: Correlation of gene methylation in surgical margin imprints with locoregional recurrence in head and neck squamous cell carcinoma. PMID: 25773145 Ref: Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3beta (GSK-3beta) and microtubule-associated protein 1B. PMID: 25775433 Ref: Signaling mechanism of the netrin-1 receptor DCC in axon guidance. PMID: 25881791 Ref: NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits. PMID: 25913325 Ref: Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration. PMID: 25950802 Ref: Molecular biomarkers in colorectal carcinoma. PMID: 26237292 Ref: Resilience to amphetamine in mouse models of netrin-1 haploinsufficiency: role of mesocortical dopamine. PMID: 26264903 Ref: Netrin1-DCC-Mediated Attraction Guides Post-Crossing Commissural Axons in the Hindbrain. PMID: 26290247 Ref: Influence of the DCC gene on proliferation and carcinoembryonic antigen expression in the human colorectal cancer cell line SW1116. PMID: 26345965 Ref: Netrin-1 overexpression in bone marrow mesenchymal stem cells promotes functional recovery in a rat model of peripheral nerve injury. PMID: 26445571 Ref: Large Bowel Genetic Background and Inflammatory Processes in Carcinogenesis--Systematic Review. PMID: 26469098 Ref: Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex. PMID: 26659141 |
Ref: Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis. PMID: 26452536 Ref: Netrin-1 Contributes to Myelinated Afferent Fiber Sprouting and Neuropathic Pain. PMID: 26482371 Ref: Netrin-1 induces local translation of down syndrome cell adhesion molecule in axonal growth cones. PMID: 26518186 Ref: p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance. PMID: 26710849 Ref: Direct measurement of oscillatory RhoA activity in embryonic cortical neurons stimulated with the axon guidance cue netrin-1 using fluorescence resonance energy transfer. PMID: 26787017 Ref: Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. PMID: 26858598 Ref: Targeting netrin-1/DCC interaction in diffuse large B-cell and mantle cell lymphomas. PMID: 26882243 Ref: Copy number variants associated with 18p11.32, DCC and the promoter 1B region of APC in colorectal polyposis patients. PMID: 26909336 Ref: Copy number of the Adenomatous Polyposis Coli gene is not always neutral in sporadic colorectal cancers with loss of heterozygosity for the gene. PMID: 26970738 Ref: Dcc Mediates Functional Assembly of Peripheral Auditory Circuits. PMID: 27040640 Ref: Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression. PMID: 27096627 Ref: Associations between markers of colorectal cancer stem cells, mutation, microRNA and the clinical features of ulcerative colitis. PMID: 27153478 Ref: Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex. PMID: 27225772 Ref: A recellularized human colon model identifies cancer driver genes. PMID: 27398792 Ref: Dependence receptor involvement in subtilisin-induced long-term depression and in long-term potentiation. PMID: 27590265 Ref: A Population-Based Study of Four Genes Associated with Heroin Addiction in Han Chinese. PMID: 27676367 Ref: Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer. PMID: 27716118 Ref: [Pancreatic acinar neoplasms : Comparative molecular characterization]. PMID: 27807633 Ref: Neuronal Cell Bodies Remotely Regulate Axonal Growth Response to Localized Netrin-1 Treatment via Second Messenger and DCC Dynamics. PMID: 28105005 |
Ref: Misregulation of the dependence receptor DCC and its upstream lincRNA, LOC100287225, in colorectal cancer. PMID: 26429648 Ref: Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma Remains. PMID: 27222126 Ref: DCC Confers Susceptibility to Depression-like Behaviors in Humans and Mice and Is Regulated by miR-218. PMID: 27773352 Ref: Copy number variations in DCC/18q and ERBB2/17q are associated with disease-free survival in microsatellite stable colon cancer. PMID: 28006840 Ref: Dcc haploinsufficiency regulates dopamine receptor expression across postnatal lifespan. PMID: 28108253 Ref: Establishment of apoptotic regulatory network for genetic markers of colorectal cancer. PMID: 28386169 Ref: Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target. PMID: 28386190 Ref: Does "OPTINAB" strategy ("stop-and-go") work in treatment of advanced pancreatic cancer (APC) with nab-paclitaxel-gemcitabine? PMID: 28664225 Ref: Spatially Selective Dissection of Signal Transduction in Neurons Grown on Netrin-1 Printed Nanoarrays via Segmented Fluorescence Fluctuation Analysis. PMID: 28679208 Ref: TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching. PMID: 28701345 Ref: Wiring the Human Brain: A User's Handbook. PMID: 28772118 Ref: Uncommon somatic mutations in metastatic NUT midline carcinoma. PMID: 28967088 Ref: Effects of intra-arterial transplantation of adipose-derived stem cells on the expression of netrin-1 and its receptor DCC in the peri-infarct cortex after experimental stroke. PMID: 29017609 Ref: Making Dopamine Connections in Adolescence. PMID: 29032842 Ref: Shift in the function of netrin-1 from axon outgrowth to axon branching in developing cerebral cortical neurons. PMID: 29041904 Ref: Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway. PMID: 29321724 Ref: Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats. PMID: 29375318 Ref: Establishment of optimal regulatory network of colorectal cancer based on p42.3 protein. PMID: 29551923 |
Ref: Early genetic aberrations in patients with sporadic colorectal cancer. PMID: 28926134 Ref: DCC mutation update: Congenital mirror movements, isolated agenesis of the corpus callosum, and developmental split brain syndrome. PMID: 29068161 Ref: DCC/NTN1 complex mutations in patients with congenital hypogonadotropic hypogonadism impair GnRH neuron development. PMID: 29202173 Ref: Identification of crucial genes associated with Parkinson's disease using microarray data. PMID: 29257331 Ref: Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis. PMID: 29339781 Ref: Human TUBB3 Mutations Disrupt Netrin Attractive Signaling. PMID: 29382549 Ref: The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction. PMID: 29479476 Ref: Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC. PMID: 29503192 Ref: Protective Effect of Moderate Exogenous Electric Field Stimulation on Activating Netrin-1/DCC Expression Against Mechanical Stretch-Induced Injury in Spinal Cord Neurons. PMID: 29627918 Ref: Mesocorticolimbic Connectivity and Volumetric Alterations in DCC Mutation Carriers. PMID: 29712788 Ref: Interferon regulatory factor 1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately silence the gene for adhesion protein CEACAM1. PMID: 29720400 Ref: Circulating Free Methylated Tumor DNA Markers for Sensitive Assessment of Tumor Burden and Early Response Monitoring in Patients Receiving Systemic Chemotherapy for Colorectal Cancer Liver Metastasis. PMID: 30080722 Ref: Mir-483 inhibits colon cancer cell proliferation and migration by targeting TRAF1. PMID: 30173777 Ref: Dietary fiber intake and risks of proximal and distal colon cancers: A meta-analysis. PMID: 30200062 Ref: Netrin-1/DCC-mediated PLCgamma1 activation is required for axon guidance and brain structure development. PMID: 30224412 Ref: Neogenin in amygdala for neuronal activity and information processing. PMID: 30228230 |