Primary Site >> Colorectal Cancer
Gene >> CYSLTR1
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Ref: Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas. PMID: 12512030 Ref: The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer. PMID: 12751768 Ref: Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin. PMID: 14499635 |
Ref: A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. PMID: 15705869 |
Ref: Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. PMID: 19042113 |
Ref: Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer. PMID: 20064706 Ref: Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells. PMID: 21203429 |
Ref: The cysteinyl leukotriene 2 receptor contributes to all-trans retinoic acid-induced differentiation of colon cancer cells. PMID: 23829413 Ref: CysLT(1)R antagonists inhibit tumor growth in a xenograft model of colon cancer. PMID: 24039952 |
Ref: The inflammatory mediator leukotriene D(4) induces subcellular beta-catenin translocation and migration of colon cancer cells. PMID: 24211746 |
Ref: Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. PMID: 26216432 |
Ref: Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model. PMID: 26979937 Ref: High tumor mast cell density is associated with longer survival of colon cancer patients. PMID: 27355473 |
Ref: M2-like macrophages induce colon cancer cell invasion via matrix metalloproteinases. PMID: 28098359 Ref: Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer. PMID: 28410235 |
Ref: Cysteinyl Leukotriene Receptor Antagonists Inhibit Migration, Invasion, and Expression of MMP-2/9 in Human Glioblastoma. PMID: 28600709 Ref: Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer. PMID: 30144515 |