Primary Site >> Colorectal Cancer
Gene >> CYP1A2
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Ref: Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. PMID: 1306111 |
Ref: Role of acetylation in colorectal cancer. PMID: 7694097 |
Ref: Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. PMID: 7881341 |
Ref: Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis. PMID: 8844812 |
Ref: Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility. PMID: 8895986 Ref: Effect of cytochrome P450 inducers on expression of oncogenes and a tumor suppressor gene in human colon cancer cells. PMID: 21541530 |
Ref: Lifestyle and nutritional correlates of cytochrome CYP1A2 activity: inverse associations with plasma lutein and alpha-tocopherol. PMID: 9110357 Ref: Polymorphisms of CYP1A1 and GSTM1 influence the in vivo function of CYP1A2. PMID: 9202749 Ref: The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. PMID: 9202751 Ref: Higher frequency of aberrant crypt foci in rapid than slow acetylator inbred rats administered the colon carcinogen 3,2'-dimethyl-4-aminobiphenyl. PMID: 9356307 |
Ref: Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas. PMID: 9682272 Ref: Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene. PMID: 9783729 |
Ref: Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. PMID: 10086330 Ref: Combined influence of genetic and dietary factors on colorectal cancer incidence in Japanese Americans. PMID: 10854493 |
Ref: The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy. PMID: 10811468 Ref: Prenatal toxicity and lack of carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) following transplacental exposure. PMID: 10828274 Ref: Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer. PMID: 11059519 Ref: DX-8951f: summary of phase I clinical trials. PMID: 11193901 |
Ref: Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk. PMID: 11751443 |
Ref: Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies. PMID: 11908637 Ref: Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences. PMID: 12107646 Ref: Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii. PMID: 12351160 Ref: A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. PMID: 12419832 |
Ref: Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism. PMID: 12534642 |
Ref: Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. PMID: 15224350 |
Ref: Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic. PMID: 16000231 Ref: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. PMID: 16006997 Ref: The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans. PMID: 16157215 Ref: [A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]. PMID: 16471212 |
Ref: Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans. PMID: 16800822 Ref: The urinary metabolite profile of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is predictive of colon DNA adducts after a low-dose exposure in humans. PMID: 17079477 |
Ref: Effects of herbal medicinal products and food supplements on induction of CYP1A2, CYP3A4 and MDR1 in the human colon carcinoma cell line LS180. PMID: 17163579 Ref: Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan. PMID: 17191090 Ref: Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer. PMID: 17603900 Ref: Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk. PMID: 17615053 Ref: Combinations of cytochrome P450 gene polymorphisms enhancing the risk for sporadic colorectal cancer related to red meat consumption. PMID: 17627011 Ref: Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary. PMID: 17695473 Ref: Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking. PMID: 18159984 |
Ref: Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity. PMID: 17851638 Ref: Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. PMID: 17985343 Ref: CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas. PMID: 18751408 |
Ref: Polymorphisms of cytochrome P450 1A2 and N-acetyltransferase genes, meat consumption, and risk of colorectal cancer. PMID: 19273964 Ref: Activation of aminoimidazole carcinogens by nitrosation: mutagenicity and nucleotide adducts. PMID: 19449459 Ref: Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: a hospital-based case-control study in Japan. PMID: 19452301 |
Ref: Metabolic bioactivation of oestradiol-17beta (E2beta) in mouse colon epithelial cells bearing ApcMin mutation. PMID: 20417221 |
Ref: Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. PMID: 21081470 Ref: Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. PMID: 21081473 Ref: Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. PMID: 21256954 Ref: Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk. PMID: 21317201 Ref: Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes. PMID: 21490239 |
Ref: Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk. PMID: 21618522 Ref: Cytotoxic and potent CYP1 inhibitors from the marine algae Cymopolia barbata. PMID: 22686946 Ref: Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk. PMID: 22724046 |
Ref: Phase I safety, pharmacokinetic and pharmacodynamic evaluation of the vascular disrupting agent ombrabulin (AVE8062) in patients with advanced solid tumors. PMID: 23833302 Ref: quantitative assessment of the influence of cytochrome P450 1A2 gene polymorphism and colorectal cancer risk. PMID: 23951174 |
Ref: Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study. PMID: 24318358 Ref: Association between the CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility: a meta-analysis. PMID: 24514875 Ref: Genetic variations in the xenobiotic-metabolizing enzymes CYP1A1, CYP1A2, CYP2C9, CYP2C19 and susceptibility to colorectal cancer among Turkish people. PMID: 24527758 Ref: Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice. PMID: 24853661 Ref: Association between CYP1A2 and CYP1B1 polymorphisms and colorectal cancer risk: a meta-analysis. PMID: 25115775 |
Ref: Isoxanthohumol--Biologically active hop flavonoid. PMID: 25771121 Ref: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases. PMID: 26233904 |
Ref: Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells. PMID: 29061341 |