Primary Site >> Colorectal Cancer
Gene >> CYP1A1
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Ref: Aryl hydrocarbon hydroxylase and 16alpha-hydroxylase in cultured human lymphocytes. PMID: 10885 |
Ref: Mixed function oxidase activities of established human colon carcinoma cell lines in the activation of cyclophosphamide. PMID: 4053018 |
Ref: Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol. PMID: 3459919 |
Ref: Large-bowel mucosal biotransformation activity in persons at high risk for colorectal cancer. A preliminary report. PMID: 8284630 |
Ref: CYP1A1 genetic polymorphisms and in situ colorectal cancer. PMID: 7913406 |
Ref: A comparative study of hepatic and colonic metabolic enzymes in inbred mouse lines before and after treatment with the colon carcinogen, 1,2-dimethylhydrazine. PMID: 8801055 Ref: Effect of cytochrome P450 inducers on expression of oncogenes and a tumor suppressor gene in human colon cancer cells. PMID: 21541530 |
Ref: Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3. PMID: 9145912 Ref: Polymorphisms of CYP1A1 and GSTM1 influence the in vivo function of CYP1A2. PMID: 9202749 Ref: The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. PMID: 9202751 |
Ref: Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene. PMID: 9783729 Ref: Polymorphisms in xenobiotic conjugation and disease predisposition. PMID: 10022251 Ref: Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. PMID: 10026993 |
Ref: Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. PMID: 9973208 Ref: Meat, metabolic genotypes and risk for colorectal cancer. PMID: 10443949 Ref: Chemoprevention of 2-amino-1-methyl-6-phenyli-midazo 4,5-b pyridine-induced carcinogen-DNA adducts by Chinese cabbage in rats. PMID: 11819413 |
Ref: N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs. PMID: 10755318 Ref: Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-transferase M1 enzymes. PMID: 10769717 Ref: Prenatal toxicity and lack of carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) following transplacental exposure. PMID: 10828274 Ref: Postmitotic differentiation of colon carcinoma caco-2 cells does not prevent reentry in the cell cycle and tumorigenicity. PMID: 10891291 Ref: A prospective study of cytochrome P450 1A1 polymorphisms and colorectal cancer risk in men. PMID: 10952105 Ref: Molecular genetics of cancer susceptibility. PMID: 10971208 Ref: Antimutagenic effects of wheat bran diet through modification of xenobiotic metabolising enzymes. PMID: 11035162 Ref: Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer. PMID: 11059519 Ref: Differential sensitivity to lung tumorigenesis following transplacental exposure of mice to polycyclic hydrocarbons, heterocyclic amines, and lung tumor promoters. PMID: 11195466 |
Ref: Metabolic genotypes and risk for colorectal cancer. PMID: 11422615 Ref: Molecular epidemiologic studies within the Selenium and Vitamin E Cancer Prevention Trial (SELECT). PMID: 11552710 |
Ref: Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences. PMID: 12107646 Ref: Genetic polymorphisms in the cytochrome P450 1A1, glutathione S-transferase M1 and T1, and susceptibility to colon cancer. PMID: 12210502 Ref: Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis. PMID: 12210751 Ref: A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. PMID: 12419832 |
Ref: Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer. PMID: 15352038 Ref: CYP1A1, cigarette smoking, and colon and rectal cancer. PMID: 15496536 |
Ref: Relationship between metabolic enzyme polymorphism and colorectal cancer. PMID: 15637738 Ref: The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women. PMID: 15671210 Ref: CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma. PMID: 15731166 Ref: Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic. PMID: 16000231 Ref: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. PMID: 16006997 Ref: Ten polymorphisms of estrogen-metabolizing genes and a family history of colon cancer--an association study of multiple gene-gene interactions. PMID: 16202920 Ref: [A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]. PMID: 16471212 |
Ref: Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone. PMID: 16581943 Ref: [Association between genetic polymorphisms of metabolic enzymes and susceptibility of colorectal cancer]. PMID: 16620591 Ref: Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland. PMID: 16823842 Ref: Genetic polymorphisms in xenobiotic clearance genes and their influence on disease expression in hereditary nonpolyposis colorectal cancer patients. PMID: 17119063 Ref: Toxicological aspects of flavonoid interaction with biomacromolecules. PMID: 17159770 Ref: Cytochrome P450 1A1 expression and activity in Caco-2 cells: modulation by apple juice extract and certain apple polyphenols. PMID: 17177569 |
Ref: Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. PMID: 16926176 Ref: Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan. PMID: 17191090 Ref: Metabolism of a heterocyclic amine colon carcinogen in young and old rats. PMID: 17251306 Ref: Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary. PMID: 17695473 Ref: Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking. PMID: 18159984 |
Ref: Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. PMID: 17985343 Ref: Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer. PMID: 18409146 Ref: Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. PMID: 18768509 |
Ref: CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers. PMID: 19287966 Ref: Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: a hospital-based case-control study in Japan. PMID: 19452301 Ref: Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1. PMID: 19469472 |
Ref: UDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors. PMID: 19831498 Ref: Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins. PMID: 20112993 Ref: Biochanin A induction of sulfotransferases in rats. PMID: 20391625 Ref: Metabolic bioactivation of oestradiol-17beta (E2beta) in mouse colon epithelial cells bearing ApcMin mutation. PMID: 20417221 Ref: Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. PMID: 20534171 Ref: Estrogen receptor expression is required for low-dose resveratrol-mediated repression of aryl hydrocarbon receptor activity. PMID: 20716622 Ref: Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis. PMID: 20886582 Ref: Bi-functional induction of the quinone reductase and cytochrome P450 1A1 by youngiasides via Nrf2-ARE and AhR-XRE pathways. PMID: 20930371 Ref: Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk. PMID: 20937634 |
Ref: Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. PMID: 21081470 Ref: Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. PMID: 21081473 Ref: CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis. PMID: 21246002 Ref: Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. PMID: 21256954 Ref: Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk. PMID: 21317201 Ref: Evaluation of quality indicators following implementation of total mesorectal excision in primarily resected rectal cancer changed future management. PMID: 21340717 Ref: A role of the aryl hydrocarbon receptor in attenuation of colitis. PMID: 21374063 Ref: CYP1A1, CYP2E1, and GSTM1 gene polymorphisms and susceptibility to colorectal and gastric cancer among Lebanese. PMID: 21385088 Ref: Evaluation of Lynch syndrome modifier genes in 748 MMR mutation carriers. PMID: 21407259 Ref: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. PMID: 21458546 Ref: Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes. PMID: 21490239 Ref: CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. PMID: 21831963 Ref: [Irbesartan regulates inflammatory gene expressions related to atherosclerosis in EA.hy926 cells]. PMID: 22126760 Ref: Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats. PMID: 22167211 |
Ref: Association between CYP1A1 polymorphism and colorectal cancer risk: a meta-analysis. PMID: 21710246 Ref: Cytotoxic and potent CYP1 inhibitors from the marine algae Cymopolia barbata. PMID: 22686946 |
Ref: The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. PMID: 23135549 Ref: Beta-catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells. PMID: 23174221 Ref: Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol. PMID: 23411228 Ref: Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells. PMID: 23452288 Ref: Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer. PMID: 23696052 Ref: Combination of CYP inhibitor with MEK/ERK inhibitor enhances the inhibitory effect on ERK in BRAF mutant colon cancer cells. PMID: 23749901 Ref: Expression of CYP1A1, CYP1B1 and MnSOD in a panel of human cancer cell lines. PMID: 23873331 Ref: Cytochrome P450 1A1, 2E1 and GSTM1 gene polymorphisms and susceptibility to colorectal cancer in the Saudi population. PMID: 23886179 Ref: Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue. PMID: 24055891 Ref: Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer. PMID: 24231098 Ref: Expression profile of CYP1A1 and CYP1B1 enzymes in colon and bladder tumors. PMID: 24358191 Ref: Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies. PMID: 24513335 |
Ref: Association between the CYP1A1 A2455G polymorphism and risk of cancer: evidence from 272 case-control studies. PMID: 24307623 Ref: Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies. PMID: 24498651 Ref: Genetic variations in the xenobiotic-metabolizing enzymes CYP1A1, CYP1A2, CYP2C9, CYP2C19 and susceptibility to colorectal cancer among Turkish people. PMID: 24527758 Ref: Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently. PMID: 24714741 Ref: Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice. PMID: 24853661 Ref: CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. PMID: 24939416 Ref: Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese. PMID: 24969905 Ref: Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3. PMID: 25333344 |
Ref: Analysis of the AHR gene proximal promoter GGGGC-repeat polymorphism in lung, breast, and colon cancer. PMID: 25447411 Ref: Inhibition of beta-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation. PMID: 25805023 Ref: Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes. PMID: 25873348 Ref: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases. PMID: 26233904 Ref: A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer. PMID: 26782431 Ref: Association between CYP1A1 2454A > G polymorphism and colorectal cancer risk: A meta-analysis. PMID: 26881514 |
Ref: Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells. PMID: 26514676 Ref: The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins. PMID: 26861731 Ref: The Effect of the CYP1A1*2A Allele on Colorectal Cancer Susceptibility in a British Population. PMID: 27243113 Ref: Associations between CYP1A1 rs1048943 A > G and rs4646903 T > C genetic variations and colorectal cancer risk: Proof from 26 case-control studies. PMID: 27384991 Ref: Indole-3-carbinol induces tumor cell death: function follows form. PMID: 27451867 Ref: CYP1A1, CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms. PMID: 28018104 |
Ref: Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. PMID: 27830268 Ref: Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling. PMID: 27837168 Ref: Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population. PMID: 28273931 Ref: Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells. PMID: 28860561 |
Ref: Polymorphisms of xenobiotic-metabolizing genes and colorectal cancer risk in patients with lynch syndrome: A retrospective cohort study in Taiwan. PMID: 28714190 Ref: Involvement of CYP1B1 in interferon gamma-induced alterations of epithelial barrier integrity. PMID: 29232759 Ref: Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells. PMID: 29501585 Ref: Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. PMID: 29584932 Ref: The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis. PMID: 29721061 Ref: Alteration of benzo(a)pyrene biotransformation by resveratrol in Apc (Min/+) mouse model of colon carcinogenesis. PMID: 29931584 Ref: Expression of CYP and GST in human normal and colon tumor tissues. PMID: 30092668 |