Primary Site >> Colorectal Cancer
Gene >> CTSD
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Ref: Plasma activities of lysosomal enzymes after hepatic dearterialization in man. PMID: 9001 |
Ref: Enzymes as prognostic markers and therapeutic indicators in patients with cancer. PMID: 1572080 |
Ref: Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease. PMID: 8099272 |
Ref: GPI membrane anchor is determinant in intracellular accumulation of apical plasma membrane proteins in the non-polarized human colon cancer cell line HT-29 18. PMID: 7876337 Ref: The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator. PMID: 7911458 Ref: Cathepsin-d activity levels in colorectal-cancer - correlation with cathepsin-B and cathepsin-L and other biological and clinical-parameters. PMID: 21559606 |
Ref: PSA immunoreactivity detected in LNCaP cell medium, breast tumor cytosol, and female serum. PMID: 7562242 Ref: Tissue cathepsins as tumor markers. PMID: 7664480 Ref: Cathepsin D content in colorectal cancer. Correlation with cathepsin D activity and other biological parameters: a preliminary report. PMID: 7715907 |
Ref: The immunohistochemical expression of cathepsin D in colorectal cancer. PMID: 8615673 Ref: Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D. PMID: 8759615 Ref: Clinical practice guidelines for the use of tumor markers in breast and colorectal cancer. Adopted on May 17, 1996 by the American Society of Clinical Oncology. PMID: 8874347 Ref: Regulation of cathepsin D dependent on the phenotype of colon carcinoma cells. PMID: 8945619 Ref: Immunohistochemical p53 overexpression correlated to c-erbB-2 and cathepsin D proteins in colorectal cancer. PMID: 9042263 |
Ref: Immunohistochemical evaluation of cathepsin D expression in colorectal cancer. PMID: 9095205 Ref: Evaluation of cathepsin D immunostaining in colorectal adenocarcinoma. PMID: 9274788 Ref: Expression and posttranslational fate of cathepsin D in HT-29 tumor cells depend on their enterocytic differentiation state. PMID: 9300184 |
Ref: Serum proteolytic activities and antiproteases in human colorectal carcinoma. PMID: 9732103 |
Ref: An aggressive desmoid tumor in a patient with familial adenomatous polyposis: immunohistochemical findings. PMID: 10022664 Ref: Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices. PMID: 10470163 Ref: Cathepsin D cytosol content in colorectal cancer. PMID: 10569144 Ref: IGFs and human cancer: implications regarding the risk of growth hormone therapy. PMID: 10592443 Ref: Prognostic evaluation of metallothionein expression in human colorectal neoplasms. PMID: 10711249 |
Ref: Immunohistochemical localization of cathepsin D in colorectal tumors. PMID: 10733123 Ref: Secretion of extracellular matrix (fibronectin), growth factor (transforming growth factor beta) and protease (cathepsin D) by hepatoma cells. PMID: 10765130 Ref: Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines. PMID: 10838186 Ref: Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma. PMID: 10850757 Ref: A functional proteomics screen of proteases in colorectal carcinoma. PMID: 10952024 |
Ref: Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer. PMID: 11166144 Ref: Immunohistochemical evaluation of cathepsin D expression in colorectal cancer. PMID: 11374801 Ref: MUC1 and cathepsin D expression in early colorectal carcinoma showing V type pit pattern. PMID: 11562739 Ref: Cathepsin D activity in colorectal cancer. PMID: 11780577 Ref: CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features. PMID: 11820582 Ref: Tumour budding intensity in relation to cathepsin D expression and some clinicopathological features of colorectal cancer. PMID: 11820592 |
Ref: Proteome analysis of butyrate-treated human colon cancer cells (HT-29). PMID: 11920611 Ref: Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. PMID: 12222689 Ref: Cathepsin D expression in colorectal adenocarcinomas and adenomas. PMID: 12408466 |
Ref: Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. PMID: 12615733 |
Ref: Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and function. PMID: 14767531 Ref: Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma. PMID: 15036666 Ref: Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma. PMID: 15239346 Ref: Defective acidification of intracellular organelles results in aberrant secretion of cathepsin D in cancer cells. PMID: 15258139 |
Ref: Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. PMID: 15618392 Ref: Proteomic expression analysis of colorectal cancer by two-dimensional differential gel electrophoresis. PMID: 15924290 Ref: Irreversible pan-ErbB tyrosine kinase inhibitor CI-1033 induces caspase-independent apoptosis in colorectal cancer DiFi cell line. PMID: 16151650 Ref: Cathepsin D expression in human colorectal cancer: relationship with tumour type and tissue differentiation grade. PMID: 16471040 |
Ref: New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization. PMID: 16787353 |
Ref: Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D. PMID: 17116725 Ref: Identification of differentially secreted biomarkers using LC-MS/MS in isogenic cell lines representing a progression of breast cancer. PMID: 17608509 Ref: Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer. PMID: 17657837 |
Ref: Cathepsin D and carcino-embryonic antigen in serum, urine and tissues of colon adenocarcinoma patients. PMID: 18613372 Ref: Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets. PMID: 18940803 |
Ref: Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis. PMID: 19240248 Ref: Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. PMID: 19487283 |
Ref: Differential expression proteomics of human colorectal cancer based on a syngeneic cellular model for the progression of adenoma to carcinoma. PMID: 19899082 Ref: Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-kappaB, iNOS, COX-2, TNF-alpha, and IL-6 in 1,2-dimethylhydrazine-induced rat colon carcinogenesis. PMID: 20406206 Ref: Proteomic profiling of proteins associated with lymph node metastasis in colorectal cancer. PMID: 20524204 Ref: Novel proteomic strategy reveal combined alpha1 antitrypsin and cathepsin D as biomarkers for colorectal cancer early screening. PMID: 20666480 |
Ref: The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells. PMID: 20951759 Ref: Proteomic analysis identifies translationally controlled tumor protein as a mediator of phosphatase of regenerating liver-3-promoted proliferation, migration and invasion in human colon cancer cells. PMID: 22340241 |
Ref: Cathepsin D Expression in Colorectal Cancer: From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays. PMID: 22919486 |
Ref: Hyperplex-MRM: a hybrid multiple reaction monitoring method using mTRAQ/iTRAQ labeling for multiplex absolute quantification of human colorectal cancer biomarker. PMID: 23909920 |
Ref: The expression of multiple proteins as prognostic factors in colorectal cancer: cathepsin D, p53, COX-2, epidermal growth factor receptor, C-erbB-2, and Ki-67. PMID: 24516696 Ref: Luteolin inhibits matrix metalloproteinase 9 and 2 in azoxymethane-induced colon carcinogenesis. PMID: 24532706 Ref: Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors. PMID: 24991835 |
Ref: Susceptibility to proteases of anti-Tn-antigen MLS128 binding glycoproteins expressed in human colon cancer cells. PMID: 25787909 Ref: Direct-S: a directed mass spectrometry method for biomarker verification in native serum. PMID: 25873488 |
Ref: Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells. PMID: 27064730 Ref: Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer. PMID: 27463016 |
Ref: Cigarette smoke extracts induced the colon cancer migration via regulating epithelial mesenchymal transition and metastatic genes in human colon cancer cells. PMID: 27087172 Ref: Cancer with low cathepsin D levels is susceptible to vacuolar (H(+) )-ATPase inhibition. PMID: 28317223 Ref: Identification of protein clusters predictive of tumor response in rectal cancer patients receiving neoadjuvant chemo-radiotherapy. PMID: 28423701 Ref: Capsular polysaccharide inhibits adhesion of Bifidobacterium longum 105-A to enterocyte-like Caco-2 cells and phagocytosis by macrophages. PMID: 28469711 |
Ref: Lysosomal permeabilization and endoplasmic reticulum stress mediate the apoptotic response induced after photoactivation of a lipophilic zinc(II) phthalocyanine. PMID: 30130653 |