Primary Site >> Colorectal Cancer
Gene >> CTSB
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Ref: Granulocyte collagenase and cathepsin B in patients with cancer of digestive organs. PMID: 6098511 Ref: Proteases in human tumors. PMID: 6240998 |
Ref: Changes in serum cathepsin B-like activity in patients with colorectal cancer. PMID: 3982561 |
Ref: Clinical experience with the testing of serum proteinase activity by cathepsin B-like sensitive amino acid derivatives of 7-amino-4-methylcoumarine. PMID: 3122064 |
Ref: Immunohistochemical and biochemical study of a cathepsin B-like proteinase in human colonic cancers. PMID: 3180094 |
Ref: Cysteine protease activities and tumor development in human colorectal carcinoma. PMID: 2544258 Ref: Immunodetection of cathepsins B and L present in and secreted from human pre-malignant and malignant colorectal tumour cell lines. PMID: 2647640 |
Ref: [Protease activities in gastric and colon cancer tissues]. PMID: 2232301 |
Ref: Cysteine endopeptidase activity levels in normal human tissues, colorectal adenomas and carcinomas. PMID: 1917131 Ref: Stage-specific increases in cathepsin B messenger RNA content in human colorectal carcinoma. PMID: 1997157 |
Ref: Biosynthesis and endocytosis of lysosomal enzymes in human colon carcinoma SW 1116 cells: impaired internalization of plasma membrane-associated cation-independent mannose 6-phosphate receptor. PMID: 1326252 Ref: Cystatin C and cathepsin B in human colon carcinoma: expression by cell lines and matrix degradation. PMID: 1399147 Ref: An inactive cathepsin B-like enzyme and cysteine proteinase inhibitors in colon cancer ascites. PMID: 1528307 |
Ref: Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival. PMID: 7519824 Ref: The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator. PMID: 7911458 Ref: Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples. PMID: 7992833 Ref: Cathepsin B and other proteases in human colorectal carcinoma. PMID: 8053486 Ref: Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase. PMID: 8204657 Ref: Cathepsin-d activity levels in colorectal-cancer - correlation with cathepsin-B and cathepsin-L and other biological and clinical-parameters. PMID: 21559606 Ref: Serum cathepsin-B levels and urinary-excretion of cathepsin-B in the patients with colorectal-cancer - possible indicators for tumor malignancy. PMID: 21566905 |
Ref: The urokinase/urokinase-receptor system and cancer invasion. PMID: 7549068 Ref: Tissue cathepsins as tumor markers. PMID: 7664480 |
Ref: Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D. PMID: 8759615 Ref: Cathepsin B: multiple enzyme forms from a single gene and their relation to cancer. PMID: 8797000 Ref: Human colon carcinoma cells synthesize and secrete alpha 1-proteinase inhibitor. PMID: 8828821 Ref: Relationship between morphological diversity and AgNORs or cathepsin B expression in colorectal cancers. PMID: 8887029 Ref: Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm. PMID: 8985466 Ref: Cathepsin B in the growth of colorectal cancer: increased activity of cathepsin B in human colorectal cancer. PMID: 8985467 |
Ref: Oncogenic c-Ki-ras but not oncogenic c-Ha-ras up-regulates CEA expression and disrupts basolateral polarity in colon epithelial cells. PMID: 9346938 Ref: Elevations in cathepsin B protein content and enzyme activity occur independently of glycosylation during colorectal tumor progression. PMID: 9360997 |
Ref: Evaluation of the 5' spliced form of human cathepsin B mRNA in colorectal mucosa and tumors. PMID: 9458288 Ref: Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B. PMID: 9514097 Ref: Cysteine proteinases in cancer progression and their clinical relevance for prognosis. PMID: 9524063 Ref: Prognostic values of cathepsin B and carcinoembryonic antigen in sera of patients with colorectal cancer. PMID: 9626470 Ref: Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas. PMID: 9699522 Ref: Cathepsin B and tumor-associated laminin expression in the progression of colorectal adenoma to carcinoma. PMID: 9720496 Ref: Serum proteolytic activities and antiproteases in human colorectal carcinoma. PMID: 9732103 |
Ref: Expression of cathepsin B and cystatin C in human colorectal cancer. PMID: 10374777 Ref: [The role of cathepsins and the plasminogen activator/inhibitor system in colorectal cancer]. PMID: 10489782 Ref: The role of cysteine and serine proteases in colorectal carcinoma. PMID: 10506696 |
Ref: Proteases in gastrointestinal neoplastic diseases. PMID: 10675722 Ref: Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas. PMID: 10755408 Ref: Cysteine proteinases and their inhibitors in extracellular fluids: markers for diagnosis and prognosis in cancer. PMID: 10763147 Ref: Signal amplification in immunohistochemistry at the light microscopic level using biotinylated tyramide and nanogold-silver staining. PMID: 10858270 Ref: A functional proteomics screen of proteases in colorectal carcinoma. PMID: 10952024 Ref: Comparative localization of cathepsin B protein and activity in colorectal cancer. PMID: 10990495 |
Ref: Cathepsin B/cystatin C complex levels in sera from patients with lung and colorectal cancer. PMID: 11517934 |
Ref: [Prognostic significance and clinic utility of serum and immunohistochemical cathepsin B levels in colorectal cancer]. PMID: 14585038 Ref: Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis. PMID: 14649059 Ref: Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells. PMID: 14965444 |
Ref: EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer. PMID: 14871799 Ref: Overexpression of cathepsin B correlates with angiogenesis in colon adenocarcinoma. PMID: 15004658 Ref: Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma. PMID: 15036666 Ref: Expression of Cathepsin B and L antigen and activity is associated with early colorectal cancer progression. PMID: 15196548 Ref: [The construction of yeast two-hybrid method in the protein-interactions and its significance in hepatic metastasis of colorectal carcinoma]. PMID: 15329257 Ref: Activity of cathepsin B and D in colorectal cancer: relationships with tumour budding. PMID: 15517887 |
Ref: Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. PMID: 15618392 Ref: Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. PMID: 15769846 Ref: Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture--regulation of cathepsin B expression and invasiveness. PMID: 15896466 Ref: Evaluation of serum cathepsin B and D in relation to clinicopathological staging of colorectal cancer. PMID: 16015694 Ref: [Expression of cathepsin B and its clinical importance in colorectal cancer]. PMID: 16299652 |
Ref: Total and lipid-bound plasma sialic acid as diagnostic markers in colorectal cancer patients: correlation with cathepsin B expression in progression to Dukes stage. PMID: 16528972 Ref: MMP-9 and cathepsin B expression in tumor budding as an indicator of a more aggressive phenotype of colorectal cancer (CRC). PMID: 16619576 |
Ref: The expression of low density lipoprotein receptor-related protein in colorectal carcinoma. PMID: 17203175 Ref: Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells. PMID: 17431792 Ref: Colonic adenocarcinomas: near-infrared microcatheter imaging of smart probes for early detection--study in mice. PMID: 17507718 |
Ref: Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. PMID: 18494941 Ref: Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer. PMID: 18616803 |
Ref: Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms. PMID: 19208367 Ref: Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis. PMID: 19240248 |
Ref: Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis. PMID: 19943316 Ref: Protease-activatable organometal-Peptide bioconjugates with enhanced cytotoxicity on cancer cells. PMID: 20586419 Ref: Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia. PMID: 20833970 |
Ref: In vitro degradation and antitumor activity of oxime bond-linked daunorubicin-GnRH-III bioconjugates and DNA-binding properties of daunorubicin-amino acid metabolites. PMID: 20953647 Ref: Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53. PMID: 21557998 Ref: Control of active B and L cathepsins in tissues of colorectal cancer using cystatins isolated from chicken egg proteins: in vitro studies. PMID: 22252763 Ref: Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B. PMID: 24900316 |
Ref: Effects of symptomatic and asymptomatic isolates of Blastocystis hominis on colorectal cancer cell line, HCT116. PMID: 22278727 Ref: Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PMID: 22574158 |
Ref: Cystatin SN neutralizes the inhibitory effect of cystatin C on cathepsin B activity. PMID: 24357805 Ref: In vivo imaging of tissue-remodeling activity involving infiltration of macrophages by a systemically administered protease-activatable probe in colon cancer tissues. PMID: 24466365 |
Ref: [Impact of chemotherapies on immunosuppression and discovery of new therapeutic targets]. PMID: 24899072 Ref: Cyclopalladated and cycloplatinated benzophenone imines: antitumor, antibacterial and antioxidant activities, DNA interaction and cathepsin B inhibition. PMID: 25063911 Ref: Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation. PMID: 25375375 |
Ref: Neutral and ionic platinum compounds containing a cyclometallated chiral primary amine: synthesis, antitumor activity, DNA interaction and topoisomerase I-cathepsin B inhibition. PMID: 26140359 Ref: Targeting Cathepsin B for Cancer Therapies. PMID: 26623174 |
Ref: Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis. PMID: 25808857 Ref: Dietary cholesterol promotes AOM-induced colorectal cancer through activating the NLRP3 inflammasome. PMID: 26921636 Ref: [Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer]. PMID: 28070042 |
Ref: Synergistic induction of apoptosis by salinomycin and gefitinib through lysosomal and mitochondrial dependent pathway overcomes gefitinib resistance in colorectal cancer. PMID: 26461472 Ref: Daughter Cells and Erythroid Cells Budding from PGCCs and Their Clinicopathological Significances in Colorectal Cancer. PMID: 28261349 Ref: Cathepsin B expression in colorectal cancer in a Middle East population: Potential value as a tumor biomarker for late disease stages. PMID: 28440429 |
Ref: Qualitative evaluation of mobile cancer apps with particular attention to the target group, content, and advertising. PMID: 29052039 Ref: Synthesis, characterization and biological activity of new cyclometallated platinum(iv) complexes containing a para-tolyl ligand. PMID: 29922789 |