Primary Site >> Colorectal Cancer
Gene >> CTNNB1
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Ref: Poorly differentiated colon carcinoma cell lines deficient in alpha-catenin expression express high levels of surface E-cadherin but lack Ca(2+)-dependent cell-cell adhesion. PMID: 8081881 |
Ref: Role of the E-cadherin/alpha-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells. PMID: 7496831 Ref: The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. PMID: 7651399 Ref: Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. PMID: 7708772 Ref: Yeast artificial chromosome cloning of the beta-catenin locus on human chromosome 3p21-22. PMID: 7780664 |
Ref: Formation of focal adhesion and spreading of polarized human colon cancer cells in association with tyrosine phosphorylation of paxillin in response to phorbol ester. PMID: 8569182 Ref: Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin. PMID: 8601608 Ref: Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. PMID: 8638125 Ref: The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells. PMID: 8670282 |
Ref: A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo. PMID: 8990193 Ref: Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. PMID: 9065401 Ref: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. PMID: 9065402 Ref: Expression of E-cadherin, alpha, beta and gamma-catenin in human colorectal cancer. PMID: 9137497 Ref: Protein kinase C activation upregulates intercellular adhesion of alpha-catenin-negative human colon cancer cell variants via induction of desmosomes. PMID: 9166410 Ref: The adenomatous polyposis coli (APC) tumor suppressor. PMID: 9196022 Ref: Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. PMID: 9216695 Ref: Variations in the expression of the adenomatous polyposis coli (APC) tumor suppressor gene in human cancer cell lines of different tissue origin. PMID: 9220497 Ref: [Molecular etiology of colorectal carcinogenesis, clinical manifestations and therapy]. PMID: 9244653 Ref: Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells. PMID: 9259402 Ref: The interactions of APC, E-cadherin and beta-catenin in tumour development and progression. PMID: 9274521 Ref: Beta-catenin mutations in cell lines established from human colorectal cancers. PMID: 9294210 Ref: [APC, beta-catenin, DLG]. PMID: 9309137 Ref: Armadillo and dTCF: a marriage made in the nucleus. PMID: 9309175 Ref: Reciprocity between membranous and nuclear expression of beta-catenin in colorectal tumours. PMID: 9334837 Ref: Patterns of alpha- and beta-catenin and E-cadherin expression in colorectal adenomas and carcinomas. PMID: 9349236 Ref: Identification of four distinct pools of catenins in mammalian cells and transformation-dependent changes in catenin distributions among these pools. PMID: 9368032 Ref: Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors. PMID: 9377556 Ref: Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. PMID: 9419974 Ref: TCF/LEF factor earn their wings. PMID: 9433138 Ref: Cadherin and catenin biology represent a global mechanism for epithelial cancer progression. PMID: 9536277 Ref: [Current data on the role of APC protein in the origin of colorectal cancer]. PMID: 9536987 |
Ref: Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. PMID: 9426055 Ref: Aberrant expression and phosphorylation of beta-catenin in human colorectal cancer. PMID: 9484818 Ref: Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations. PMID: 9500465 Ref: Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription. PMID: 9501208 Ref: Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. PMID: 9501226 Ref: High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. PMID: 9515794 Ref: Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. PMID: 9515795 Ref: Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas. PMID: 9537226 Ref: A beta-catenin mutation in a sporadic colorectal tumor of the RER phenotype and absence of beta-catenin germline mutations in FAP patients. PMID: 9591632 Ref: Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. PMID: 9600336 Ref: Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. PMID: 9601641 Ref: A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer. PMID: 9602705 Ref: Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin. PMID: 9628899 Ref: Sequence-based design of a peptide probe for the APC tumor suppressor protein. PMID: 9663391 Ref: Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. PMID: 9671767 Ref: Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. PMID: 9697701 Ref: Aspirin prevents tumors in a murine model of familial adenomatous polyposis. PMID: 9706142 Ref: Beta-catenin mutation in carcinoma of the uterine endometrium. PMID: 9721853 Ref: Identification of c-MYC as a target of the APC pathway. PMID: 9727977 Ref: Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. PMID: 9734399 Ref: Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. PMID: 9734785 Ref: [Dysfunction of E-cadherin-catenin system in invasion and metastasis of colorectal cancer]. PMID: 9742518 Ref: A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity. PMID: 9762469 Ref: Predictive value of nuclear beta-catenin expression for the occurrence of distant metastases in rectal cancer. PMID: 9788389 Ref: Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. PMID: 9820866 Ref: Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas. PMID: 9823469 Ref: Hepatocyte growth factor/scatter factor induces not only scattering but also cohort migration of human colorectal-adenocarcinoma cells. PMID: 9833769 Ref: [Beta-catenin expression and its significance for metastasis in curatively operated rectum carcinoma]. PMID: 9931888 Ref: Loss of p120ctn in human colorectal cancer predicts metastasis and poor survival. PMID: 10397474 Ref: Truncating somatic mutation in exon 15 of the APC gene is a rare event in human breast carcinomas. Mutations in brief no. 179. Online. PMID: 10660330 Ref: [beta-catenin overexpression in metastasized colorectal carcinoma--an important mechanism in progression of the disease?]. PMID: 14518265 |
Ref: Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1. PMID: 9874785 Ref: Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. PMID: 10027409 Ref: Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression. PMID: 10077641 Ref: Identification of Tcf4 residues involved in high-affinity beta-catenin binding. PMID: 10080941 Ref: E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. PMID: 10085258 Ref: A common human skin tumour is caused by activating mutations in beta-catenin. PMID: 10192393 Ref: Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. PMID: 10197610 Ref: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. PMID: 10201372 Ref: Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone. PMID: 10204808 Ref: Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: implications for cell adhesion and signaling. PMID: 10211089 Ref: Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis. PMID: 10213492 Ref: Apoptosis-associated cleavage of beta-catenin in human colon cancer and rat hepatoma cells. PMID: 10224675 Ref: An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. PMID: 10228155 Ref: The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. PMID: 10318916 Ref: Dysregulation of beta-catenin is common in canine sporadic colorectal tumors. PMID: 10332831 Ref: Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. PMID: 10346819 Ref: The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling. PMID: 10347231 Ref: Excess beta-catenin promotes accumulation of transcriptionally active p53. PMID: 10357817 Ref: Intracellular distribution of beta-catenin in colorectal adenomas, carcinomas and Peutz-Jeghers polyps. PMID: 10359135 Ref: Cadherin-catenin expression in primary colorectal cancer: a survival analysis. PMID: 10362114 Ref: Establishment and characterization of 12 human colorectal-carcinoma cell lines. PMID: 10362137 Ref: Neuronal localization of the Adenomatous polyposis coli tumor suppressor protein. PMID: 10366023 Ref: Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay. PMID: 10383126 Ref: Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer. PMID: 10392898 Ref: Germline mutations are frequent in the APC gene but absent in the beta-catenin gene in familial adenomatous polyposis patients. PMID: 10398435 Ref: beta-catenin expression in primary and metastatic colorectal carcinoma. PMID: 10404062 Ref: [Familial cancer: recent advances]. PMID: 10410140 Ref: Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway. PMID: 10416591 Ref: Nuclear beta-catenin in colorectal tumors: to freeze or not to freeze? Colon Cancer Team at IMAS. PMID: 10424893 Ref: Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells. PMID: 10425198 Ref: P53 and beta catenin expression in chronic ulcerative colitis--associated polypoid dysplasia and sporadic adenomas: an immunohistochemical study. PMID: 10435567 Ref: PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin. PMID: 10462517 Ref: Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin. PMID: 10462524 Ref: CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. PMID: 10490837 Ref: Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer. PMID: 10493496 Ref: Colorectal cancer with and without microsatellite instability involves different genes. PMID: 10502323 Ref: Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer. PMID: 10507776 Ref: [The relationship between the histopathological atypia and expression of beta-catenin in colonic neoplasms resected by endoscopy; comparison with that of p53 protein]. PMID: 10513218 Ref: beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. PMID: 10514384 Ref: Identification and characterization of E-APC, a novel Drosophila homologue of the tumour suppressor APC. PMID: 10526234 Ref: Changes of E-cadherin and beta-catenin levels during induced differentiation of colorectal carcinoma cells. PMID: 10534578 Ref: Further characterization of the combining sites of Bandeiraea (Griffonia) simplicifolia lectin-I, isolectin A(4). PMID: 10536032 Ref: Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. PMID: 10545105 Ref: Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level. PMID: 10545404 Ref: PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. PMID: 10555149 Ref: Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways. PMID: 10562815 Ref: beta-catenin signaling and cancer. PMID: 10580987 Ref: Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability. PMID: 10597289 Ref: Reduction in membranous expression of beta-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric cancer. PMID: 10604738 Ref: Cross-regulation of beta-catenin-LEF/TCF and retinoid signaling pathways. PMID: 10607566 Ref: The role of the E-cadherin/catenin complex in gastrointestinal cancer. PMID: 10692769 Ref: Defects in the regulation of beta-catenin in colorectal cancer. PMID: 10709671 Ref: [Molecular carcinogenesis in ulcerative colitis-associated and sporadic colorectal carcinoma--differences and similarities]. PMID: 10714203 Ref: Sequence of molecular genetic events in colorectal tumorigenesis. PMID: 10772417 |
Ref: The Yin-Yang of TCF/beta-catenin signaling. PMID: 10549354 Ref: Butyrate regulates E-cadherin transcription, isoform expression and intracellular position in colon cancer cells. PMID: 10638989 Ref: Catenins and their associated proteins in colorectal cancer. PMID: 10668214 Ref: APC mutations are sufficient for the growth of early colorectal adenomas. PMID: 10681434 Ref: Stem cells: the intestinal stem cell as a paradigm. PMID: 10688867 Ref: Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells. PMID: 10699468 Ref: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. PMID: 10700176 Ref: Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas. PMID: 10702403 Ref: Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin. PMID: 10722668 Ref: APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits". PMID: 10737795 Ref: The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. PMID: 10738133 Ref: Rare activation of the TCF/beta-catenin pathway in ovarian cancer. PMID: 10739697 Ref: The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. PMID: 10749138 Ref: Chemoprevention of familial adenomatous polyposis development in the APC(min) mouse model by 1,4-phenylene bis(methylene)selenocyanate. PMID: 10753194 Ref: Colitis-related rat colon carcinogenesis induced by 1-hydroxy-anthraquinone and methylazoxymethanol acetate (Review). PMID: 10767359 Ref: Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. PMID: 10783313 Ref: Biology of the adenomatous polyposis coli tumor suppressor. PMID: 10784639 Ref: Nuclear translocation of beta-catenin in colorectal cancer. PMID: 10817505 Ref: Expression of prostaglandin endoperoxide H synthase-2 induced by nitric oxide in conditionally immortalized murine colonic epithelial cells. PMID: 10834941 Ref: Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane. PMID: 10836998 Ref: Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes. PMID: 10837006 Ref: gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. PMID: 10837025 Ref: Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. PMID: 10862053 Ref: APC truncation and increased beta-catenin levels in a human breast cancer cell line. PMID: 10874025 Ref: alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin*T-cell factor*DNA complex. PMID: 10896949 Ref: Structure and expression of a novel frizzled gene isolated from the developing mouse gut. PMID: 10903145 Ref: Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin. PMID: 10906131 Ref: Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis. PMID: 10910031 Ref: Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. PMID: 10910034 Ref: Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin. PMID: 10910037 Ref: Differential formation of beta-catenin/lymphoid enhancer factor-1 DNA binding complex induced by nitric oxide in mouse colonic epithelial cells differing in adenomatous polyposis coli (Apc) genotype. PMID: 10910042 Ref: The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. PMID: 10919662 Ref: Beta-catenin and adenomatous polyposis coli (APC) mutations in adenomas from hereditary non-polyposis colorectal cancer patients. PMID: 10936679 Ref: beta-Catenin, Cyclins, and More: New Insights into the Pathogenesis, Treatment, and Prevention of Colon Cancer. PMID: 10941058 Ref: Decreased expression of CD44, alpha-catenin, and deleted colon carcinoma and altered expression of beta-catenin in ulcerative colitis-associated dysplasia and carcinoma, as compared with sporadic colon neoplasms. PMID: 10951334 Ref: The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. PMID: 10951583 Ref: Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. PMID: 10953028 Ref: More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats. PMID: 10965019 Ref: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. PMID: 10972292 Ref: Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover. PMID: 10980707 Ref: The APC tumour suppressor has a nuclear export function. PMID: 10984057 Ref: Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. PMID: 10987283 Ref: Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. PMID: 11017067 Ref: Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. PMID: 11035789 Ref: Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas. PMID: 11048797 Ref: Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma. PMID: 11048799 Ref: Regulation of beta -catenin transformation by the p300 transcriptional coactivator. PMID: 11050151 Ref: Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues. PMID: 11062151 Ref: Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. PMID: 11087869 Ref: Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer. PMID: 11096342 Ref: The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease. PMID: 11099951 Ref: Increase of GKLF messenger RNA and protein expression during progression of breast cancer. PMID: 11103818 Ref: Down-regulation of monocyte chemotactic protein-3 by activated beta-catenin. PMID: 11118053 Ref: [beta-Catenin induces invasive growth by activating matrix metalloproteinases in colorectal carcinoma]. PMID: 11217438 Ref: [beta-Catenine as a genomic target of high-grade microsatellite instability in colorectal cancer]. PMID: 11217439 Ref: Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3beta activity and increases levels of both membrane-bound and Apc/axin/GSK-3beta complex-associated pools of beta-catenin. PMID: 11341469 |
Ref: Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells. PMID: 11157977 Ref: The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. PMID: 11158322 Ref: beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. PMID: 11181454 Ref: Altered distribution of beta-catenin, and its binding proteins E-cadherin and APC, in ulcerative colitis-related colorectal cancers. PMID: 11211307 Ref: A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics. PMID: 11221869 Ref: Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway. PMID: 11222711 Ref: Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells. PMID: 11226285 Ref: Gene expression analysis in colorectal cancer using practical DNA array filter. PMID: 11227951 Ref: Truncated DCC reduces N-cadherin/catenin expression and calcium-dependent cell adhesion in neuroblastoma cells. PMID: 11232642 Ref: Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. PMID: 11244511 Ref: Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. PMID: 11245490 Ref: Requirement of protein kinase Calpha, extracellular matrix remodeling, and cell-matrix interaction for transforming growth factorbeta-regulated expression of E-cadherin and catenins. PMID: 11267998 Ref: PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. PMID: 11274170 Ref: Sequential analysis of morphological and biological properties of beta-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis. PMID: 11280741 Ref: Stabilized beta-catenin immortalizes colonic epithelial cells. PMID: 11280772 Ref: A role for the Adenomatous Polyposis Coli protein in chromosome segregation. PMID: 11283619 Ref: Mutations in the APC tumour suppressor gene cause chromosomal instability. PMID: 11283620 Ref: Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation. PMID: 11289158 Ref: Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo. PMID: 11306465 Ref: Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation. PMID: 11309309 Ref: The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. PMID: 11313997 Ref: Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. PMID: 11326276 Ref: p73beta, a variant of p73, enhances Wnt/beta-catenin signaling in Saos-2 cells. PMID: 11327702 Ref: A possible role for the WNT-1 pathway in oral carcinogenesis. PMID: 11345525 Ref: Caspase-3 activity as a prognostic factor in colorectal carcinoma. PMID: 11351040 Ref: Changes of E-cadherin and beta-catenin in human and mouse intestinal tumours. PMID: 11352396 Ref: Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer. PMID: 11396184 Ref: Wingless-type frizzled protein receptor signaling and its putative role in human colon cancer. PMID: 11398198 Ref: Tyrosine phosphorylation translocates beta-catenin from cell-->cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function. PMID: 11401329 Ref: Suppression of occurrence and advancement of beta-catenin-accumulated crypts, possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib. PMID: 11429049 Ref: Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers. PMID: 11437404 Ref: Beta-catenin activation through mutation is rare in rectal cancer. PMID: 11454429 Ref: Clinical significance of E-cadherin-catenin complex expression in metastatic foci of colorectal carcinoma. PMID: 11455558 Ref: Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. PMID: 11470825 Ref: Suppressor of fused negatively regulates beta-catenin signaling. PMID: 11477086 Ref: The cadherin-catenin superfamily in endocrine tumors. PMID: 11478263 Ref: Expression of alpha-catenin in alpha-catenin-deficient cells increases resistance to sphingosine-induced apoptosis. PMID: 11489917 Ref: Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. PMID: 11521200 Ref: Identification of AF17 as a downstream gene of the beta-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis. PMID: 11522623 Ref: Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells. PMID: 11522655 Ref: Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. PMID: 11522744 Ref: Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. PMID: 11526241 Ref: Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney. PMID: 11526492 Ref: beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland. PMID: 11526497 Ref: Genetic alterations in the human Tcf-4 gene in Japanese patients with sporadic gastrointestinal cancers with microsatellite instability. PMID: 11528255 Ref: The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. PMID: 11532957 Ref: Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue. PMID: 11533074 Ref: Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. PMID: 11559543 Ref: Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma. PMID: 11572874 Ref: Correlation of beta-catenin and cyclin D1 expression in colon cancers. PMID: 11574779 Ref: ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A. PMID: 11585828 Ref: alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. PMID: 11590244 Ref: Mechanisms of oncogenesis in colon versus rectal cancer. PMID: 11592095 Ref: Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells. PMID: 11602670 Ref: Beta-catenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts. PMID: 11676549 Ref: The molecular basis of colorectal cancer. PMID: 11680042 Ref: Immunohistochemical distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. PMID: 11684954 Ref: Studies on human colon cancer gene APC by targeted expression in Drosophila. PMID: 11687966 Ref: Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas. PMID: 11691783 Ref: COL11A1 in FAP polyps and in sporadic colorectal tumors. PMID: 11707154 Ref: Expression and interaction of different catenins in colorectal carcinoma cells. PMID: 11712088 Ref: Tcf4 can specifically recognize beta-catenin using alternative conformations. PMID: 11713475 Ref: Inhibition of beta-catenin translocation in rodent colorectal tumors: a novel explanation for the protective effect of nonsteroidal antiinflammatory drugs in colorectal cancer. PMID: 11713928 Ref: Beta-catenin expression is altered in human colonic aberrant crypt foci. PMID: 11719432 Ref: Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin. PMID: 11719433 Ref: The expression of E-cadherin and catenins in sporadic colorectal carcinoma. PMID: 11727261 Ref: Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. PMID: 11733361 Ref: Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma. PMID: 11736900 Ref: Possible contribution of CD44 variant 6 and nuclear beta-catenin expression to the formation of budding tumor cells in patients with T1 colorectal carcinoma. PMID: 11745187 Ref: Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. PMID: 11751382 Ref: Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis. PMID: 11751493 Ref: Tissue microarray analysis of beta-catenin in colorectal cancer shows nuclear phospho-beta-catenin is associated with a better prognosis. PMID: 11751495 Ref: Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors. PMID: 11752446 Ref: E-cadherin, beta-catenin and stromelysin-3 expression in de novo carcinoma of the colorectum. PMID: 11769398 Ref: Frequent alterations of the beta-catenin and TCF-4 genes, but not of the APC gene, in colon cancers with high-frequency microsatellite instability. PMID: 11876551 Ref: [The Rudolf Virchow Prize 2001. The role of the oncoprotein beta-catenin ni the progression of colorectal cancers]. PMID: 11894405 Ref: Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers. PMID: 11939410 Ref: Nuclear localization of beta-catenin and plakoglobin in primary and metastatic human colonic carcinomas, colonic adenomas, and normal colon. PMID: 12574842 |
Ref: IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. PMID: 11734550 Ref: Reduced expression of EphrinA1 (EFNA1) inhibits three-dimensional growth of HT29 colon carcinoma cells. PMID: 11741747 Ref: Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability. PMID: 11746989 Ref: Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells. PMID: 11756231 Ref: Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet. PMID: 11756241 Ref: Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. PMID: 11756652 Ref: Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. 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PMID: 15387970 Ref: Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients. PMID: 15449173 Ref: Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. PMID: 15466189 Ref: Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. PMID: 15502862 Ref: Mutational activation of the RAS-RAF-MAPK and the Wnt pathway in small intestinal adenocarcinomas. PMID: 15513360 Ref: Expression and localization of membrane-type-1 matrix metalloproteinase, CD 44, and laminin-5gamma2 chain during colorectal carcinoma tumor progression. PMID: 15517370 Ref: Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas. PMID: 15520370 Ref: The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. PMID: 15525529 Ref: An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. PMID: 15542433 Ref: Wnt-signaling and apoptosis after neoadjuvant short-term radiotherapy for rectal cancer. PMID: 15547689 Ref: Tissue microarray analysis of cyclin D1 gene amplification and gain in colorectal carcinomas. PMID: 15557752 Ref: The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells. PMID: 15570051 Ref: Mutation of beta-catenin does not coexist with K-ras mutation in colorectal tumorigenesis. PMID: 15573917 Ref: Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. PMID: 15574752 Ref: Wnt/beta-catenin signaling pathway as a novel cancer drug target. PMID: 15578921 Ref: [The significance of beta-catenin and matrix metalloproteinase-7 expression in colorectal adenoma and carcinoma]. PMID: 15634446 |
Ref: Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. PMID: 15309432 Ref: Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma. PMID: 15389251 Ref: Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox PMID: 15459021 Ref: Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin. PMID: 15492751 Ref: Genotype phenotype correlations in Israeli colorectal cancer patients. PMID: 15523694 Ref: beta-Catenin activates the growth factor endothelin-1 in colon cancer cells. PMID: 15558022 Ref: DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells. PMID: 15563452 Ref: Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer. PMID: 15579483 Ref: The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. PMID: 15592505 Ref: The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. PMID: 15592509 Ref: The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis. PMID: 15617833 Ref: Detection of JC virus DNA sequences and expression of viral T antigen and agnoprotein in esophageal carcinoma. PMID: 15630684 Ref: Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome. PMID: 15647192 Ref: Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon. PMID: 15650110 Ref: The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells. PMID: 15665104 Ref: Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rat. PMID: 15665287 Ref: Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors. PMID: 15665292 Ref: Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. PMID: 15670774 Ref: Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. PMID: 15684064 Ref: Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon. PMID: 15712188 Ref: Wnt/beta-catenin pathway. PMID: 15713948 Ref: Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine. PMID: 15716339 Ref: L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. PMID: 15716380 Ref: Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. PMID: 15735684 Ref: Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. PMID: 15735743 Ref: Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. PMID: 15767571 Ref: Involvement of adenomatous polyposis coli in colorectal tumorigenesis. PMID: 15769611 Ref: Wnt signalling induces maturation of Paneth cells in intestinal crypts. PMID: 15778706 Ref: Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression. PMID: 15782138 Ref: Evaluation of tumor cell dissociation as a predictive marker of lymph node metastasis in submucosal invasive colorectal carcinoma. PMID: 15785891 Ref: Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families. PMID: 15788729 Ref: Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice. PMID: 15793302 Ref: Gastrin stabilises beta-catenin protein in mouse colorectal cancer cells. PMID: 15798764 Ref: The calpain system is involved in the constitutive regulation of beta-catenin signaling functions. PMID: 15817486 Ref: Synthesis of junctional proteins in metastasizing colon cancer cells. PMID: 15819418 Ref: [SFRP, a family of new colorectal tumor suppressor candidate genes]. PMID: 15828241 Ref: Analysis of Wnt/Beta catenin signalling in desmoid tumors. PMID: 15832580 Ref: Wnt signaling in lung cancer. PMID: 15837535 Ref: G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway. PMID: 15837931 Ref: The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway. PMID: 15853773 Ref: Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. PMID: 15888491 Ref: O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions. PMID: 15888787 Ref: Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. PMID: 15892897 Ref: Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer. PMID: 15899904 Ref: Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth. PMID: 15901282 Ref: Concurrent EGFr and Cox-2 expression in colorectal cancer: proliferation impact and tumour spreading. PMID: 15923435 Ref: HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. PMID: 15928669 Ref: Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line. PMID: 15930030 Ref: High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies. PMID: 15930362 Ref: Molecular and cellular effects of cis-9, trans-11-conjugated linoleic acid in enterocytes: effects on proliferation, differentiation, and gene expression. PMID: 15935729 Ref: Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta. PMID: 15940626 Ref: Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. PMID: 15940627 Ref: Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. PMID: 15942193 Ref: Comparative genomics on FGF20 orthologs. PMID: 15944804 Ref: Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. PMID: 15946992 Ref: APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers. PMID: 15951972 Ref: Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. PMID: 15965503 Ref: The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis. PMID: 15972967 Ref: EphB receptor activity suppresses colorectal cancer progression. PMID: 15973414 Ref: Identification of MYCBP as a beta-catenin/LEF-1 target using DNA microarray analysis. PMID: 15979100 Ref: A novel classification of tumour budding in colorectal cancer based on the presence of cytoplasmic pseudo-fragments around budding foci. PMID: 15982320 Ref: Effect of caffeic acid phenethyl ester on proliferation and apoptosis of colorectal cancer cells in vitro. PMID: 15996024 Ref: Global gene expression analysis in time series following N-acetyl L-cysteine induced epithelial differentiation of human normal and cancer cells in vitro. PMID: 16001974 Ref: 1alpha,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells. PMID: 16007183 Ref: The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. PMID: 16014379 Ref: Beta-catenin, cancer, and G proteins: not just for frizzleds anymore. PMID: 16014605 Ref: Loss of adenomatous polyposis coli gene function disrupts thymic development. PMID: 16025118 Ref: Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. PMID: 16027724 Ref: The role of the Wnt signalling pathway in colorectal tumorigenesis. PMID: 16042571 Ref: Relationship between the role of the adenomatous polyposis coli protein in colon cancer and its contribution to cytoskeletal regulation. PMID: 16042576 Ref: Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. PMID: 16043125 Ref: Diclofenac attenuates Wnt/beta-catenin signaling in colon cancer cells by activation of NF-kappaB. PMID: 16051228 Ref: Chemoprevention of chemically-induced mammary and colon carcinogenesis by 1alpha-hydroxyvitamin D5. PMID: 16051482 Ref: Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate. PMID: 16054165 Ref: Aberrant CpG island methylation in early-onset sporadic gastric carcinoma. PMID: 16075282 Ref: Nuclear beta-catenin expression is rare and its potential association with short survival in colorectal signet-ring cell carcinoma. PMID: 16082250 Ref: beta-Catenin regulates the expression of tenascin-C in human colorectal tumors. PMID: 16091738 Ref: Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expression. PMID: 16124054 Ref: Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? PMID: 16126938 Ref: Suppression of beta-catenin by antisense oligomers augments tumor response to isolated limb perfusion in a rodent model of adenomatous polyposis coli-mutant colon cancer. PMID: 16132380 Ref: Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis. PMID: 16143030 Ref: Desmoplastic fibroma of bone: an immunohistochemical study including beta-catenin expression and mutational analysis for beta-catenin. PMID: 16153468 Ref: Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene. PMID: 16158975 Ref: [Effect of NGX6 on gene expression profile of colon carcinoma cell line HT-29]. PMID: 16159426 Ref: Molecular genetic alterations and clinical features in early-onset colorectal carcinomas and their role for the recognition of hereditary cancer syndromes. PMID: 16181381 Ref: Overexpressed beta-catenin blocks nitric oxide-induced apoptosis in colonic cancer cells. PMID: 16204024 Ref: E-cadherin regulates the association between beta-catenin and actinin-4. PMID: 16204054 Ref: Bcr is a negative regulator of the Wnt signalling pathway. PMID: 16211085 Ref: Expression of E-cadherin, beta-catenin, and CD-44v6 cell adhesion molecules in primary tumors and metastases of colorectal adenocarcinoma. PMID: 16224588 Ref: Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. PMID: 16230076 Ref: Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2. PMID: 16251413 Ref: beta-Catenin, Nf-kappaB and FAS protein expression are independent events in head and neck cancer: study of their association with clinical parameters. PMID: 16253770 Ref: Oncogenic beta-catenin signaling networks in colorectal cancer. PMID: 16258275 Ref: Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer. PMID: 16273202 Ref: Identification of regions of alpha-catenin required for desmosome organization in epithelial cells. PMID: 16273278 Ref: [The features of expression of cellular adhesion molecules in primary colorectal cancer and its metastases]. PMID: 16279097 Ref: Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress. PMID: 16282376 Ref: Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors. PMID: 16288001 Ref: Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. PMID: 16288056 Ref: Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer. PMID: 16289386 Ref: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. PMID: 16293724 Ref: Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. PMID: 16356174 Ref: The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation. PMID: 16357171 Ref: [Immunohistochemical study of E-cadherin, beta-catenin and CD-44v6 expression in the cells of primary colon cancer and its metastases]. PMID: 16405020 Ref: ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. PMID: 16787331 |
Ref: Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer. PMID: 15885887 Ref: Genetic and cellular characterizations of human TCF4 with microsatellite instability in colon cancer and leukemia cell lines. PMID: 15905022 Ref: Effect of indomethacin on E-cadherin and beta-catenin expression in HT-29 colon cancer cells. PMID: 15963497 Ref: Roles and regulation of Wnt signaling and beta-catenin in prostate cancer. PMID: 16023783 Ref: Lack of enhancing effects of degraded lambda-carrageenan on the development of beta-catenin-accumulated crypts in male DBA/2J mice initiated with azoxymethane. PMID: 16046055 Ref: Nuclear factor kappaB is downregulated and correlates with p53 in the Min mouse mucosa during an accelerated tumor growth. PMID: 16049962 Ref: ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway. PMID: 16278819 Ref: Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells. PMID: 16291872 Ref: Subcellular localization of beta-catenin and APC proteins in colorectal preneoplastic and neoplastic lesions. PMID: 16298038 Ref: Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation. PMID: 16299030 Ref: Neurotensin receptor 1 gene activation by the Tcf/beta-catenin pathway is an early event in human colonic adenomas. PMID: 16299383 Ref: Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells. PMID: 16328013 Ref: Anti-proliferative effect of horehound leaf and wild cherry bark extracts on human colorectal cancer cells. PMID: 16328068 Ref: Predominant T helper type 2-inflammatory responses promote murine colon cancers. PMID: 16331625 Ref: Expression of sFRP-4 and beta-catenin in human colorectal carcinoma. PMID: 16356838 Ref: E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts. PMID: 16368435 Ref: Wnt/Frizzled signaling in hepatocellular carcinoma. PMID: 16368566 Ref: Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells. PMID: 16378739 Ref: Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis. PMID: 16407833 Ref: Prognostic value of E-cadherin, beta-catenin, MMPs (7 and 9), and TIMPs (1 and 2) in patients with colorectal carcinoma. PMID: 16425303 Ref: Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis. PMID: 16426922 Ref: Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. PMID: 16439479 Ref: Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. PMID: 16439994 Ref: Truncated APC is required for cell proliferation and DNA replication. PMID: 16450383 Ref: Combined immunohistochemistry of beta-catenin, cytokeratin 7, and cytokeratin 20 is useful in discriminating primary lung adenocarcinomas from metastatic colorectal cancer. PMID: 16451736 Ref: FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. PMID: 16465403 Ref: Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer. PMID: 16474178 Ref: Repression of HIP/RPL29 expression induces differentiation in colon cancer cells. PMID: 16475173 Ref: APC inhibits ERK pathway activation and cellular proliferation induced by RAS. PMID: 16478791 Ref: Identification of the IFITM family as a new molecular marker in human colorectal tumors. PMID: 16488993 Ref: SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. PMID: 16489032 Ref: Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. PMID: 16491118 Ref: A transcriptome anatomy of human colorectal cancers. PMID: 16504081 Ref: Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. PMID: 16507986 Ref: The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. PMID: 16510874 Ref: The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas. PMID: 16523202 Ref: Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer. PMID: 16540637 Ref: Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways. PMID: 16546990 Ref: Microsatellite instability in colorectal cancer. PMID: 16555243 Ref: Budding invasive margin and prognosis in colorectal cancer--no direct association with beta-catenin expression. PMID: 16563744 Ref: Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines. PMID: 16570344 Ref: Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. PMID: 16574648 Ref: Comparative study of T84 and T84SF human colon carcinoma cells: in vitro and in vivo ultrastructural and functional characterization of cell culture and metastasis. PMID: 16612624 Ref: Over-expressed estrogen receptor-alpha up-regulates hTNF-alpha gene expression and down-regulates beta-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells. PMID: 16628468 Ref: Mouse models of gastrointestinal tumors. PMID: 16630131 Ref: Construction of a novel DNA decoy that inhibits the oncogenic beta-catenin/T-cell factor pathway. PMID: 16648570 Ref: Prostaglandins and the colon cancer connection. PMID: 16650804 Ref: Mechanisms of disease: from stem cells to colorectal cancer. PMID: 16673006 Ref: Levels of VE-cadherin increase independently of VEGF in preoperative sera of patients with colorectal cancer. PMID: 16683386 Ref: Polysiphonia japonica extract suppresses the Wnt/beta-catenin pathway in colon cancer cells by activation of NF-kappaB. PMID: 16685408 Ref: Short hairpin RNA-expressing bacteria elicit RNA interference in mammals. PMID: 16699500 Ref: Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma. PMID: 16705313 Ref: KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand. PMID: 16707468 Ref: Regulation of transendothelial migration of colon cancer cells by E-selectin-mediated activation of p38 and ERK MAP kinases. PMID: 16715142 Ref: IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. PMID: 16717119 Ref: Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity. PMID: 16728434 Ref: Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. PMID: 16735606 Ref: Wnt pathway mutations selected by optimal beta-catenin signaling for tumorigenesis. PMID: 16764864 Ref: Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression. PMID: 16772034 Ref: Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer. PMID: 16773493 Ref: CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. PMID: 16778892 Ref: Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells. PMID: 16798748 Ref: Wnt activation and alternative promoter repression of LEF1 in colon cancer. PMID: 16809766 Ref: Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets. PMID: 16818512 Ref: Apoptotic effects of over-expressed estrogen receptor-beta on LoVo colon cancer cell is mediated by p53 signalings in a ligand-dependent manner. PMID: 16830793 Ref: High Pin1 expression is associated with tumor progression in colorectal cancer. PMID: 16847925 Ref: Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. PMID: 16857785 Ref: Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. PMID: 16878161 Ref: Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. PMID: 16885356 Ref: Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. PMID: 16906516 Ref: Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling. PMID: 16926625 Ref: Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signaling. PMID: 16928827 Ref: CD97 overexpression in tumor cells at the invasion front in colorectal cancer (CC) is independently regulated of the canonical Wnt pathway. PMID: 16929497 Ref: Inhibitory effect of caffeic acid phenethyl ester on the growth of SW480 colorectal tumor cells involves beta-catenin associated signaling pathway down-regulation. PMID: 16937493 Ref: Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells. PMID: 16968065 Ref: Automated quantitative analysis of DCC tumor suppressor protein in ovarian cancer tissue microarray shows association with beta-catenin levels and outcome in patients with epithelial ovarian cancer. PMID: 16971669 Ref: Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells. PMID: 16982769 Ref: Intracellular expression of the T-cell factor-1 RNA aptamer as an intramer. PMID: 16985077 Ref: Signal transduction cross-talk during colorectal tumorigenesis. PMID: 16998321 Ref: Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription. PMID: 17005722 Ref: Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells. PMID: 17020613 Ref: Singapore familial adenomatous polyposis (FAP) patients with classical adenomatous polyposis but undetectable APC mutations have accelerated cancer progression. PMID: 17026565 Ref: Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases. PMID: 17028196 Ref: APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. PMID: 17030180 Ref: Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway. PMID: 17030184 Ref: Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR. PMID: 17040897 Ref: E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. PMID: 17047063 Ref: Effective treatment of tumors with strong beta-catenin/T-cell factor activity by transcriptionally targeted oncolytic herpes simplex virus vector. PMID: 17047077 Ref: Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats. PMID: 17056814 Ref: Modulation of oncogenic transcription and alternative splicing by beta-catenin and an RNA aptamer in colon cancer cells. PMID: 17079480 Ref: Improved marker combination for detection of de novo genetic variation and aberrant DNA in colorectal neoplasia. PMID: 17082247 Ref: Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC. PMID: 17093505 Ref: The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer. PMID: 17101323 Ref: IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment. PMID: 17118177 Ref: Targeting the active beta-catenin pathway to treat cancer cells. PMID: 17121933 Ref: Adenovirus-mediated expression of both antisense ornithine decarboxylase and s-adenosylmethionine decarboxylase induces G1 arrest in HT-29 cells. PMID: 17129409 Ref: Colorectal cancer and genetic alterations in the Wnt pathway. PMID: 17143297 Ref: Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection. PMID: 17145847 Ref: Effects of gastrin 17 on beta-catenin/Tcf-4 pathway in Colo320WT colon cancer cells. PMID: 17167838 Ref: Prognostic significance of beta-catenin in colorectal cancer with liver metastasis. PMID: 17168211 Ref: Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice. PMID: 17347588 Ref: Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay. PMID: 17652946 |
Ref: Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide at the invasive front of colon cancers. PMID: 16809422 Ref: Phenotypic heterogeneity in hereditary non-polyposis colorectal cancer: identical germline mutations associated with variable tumour morphology and immunohistochemical expression. PMID: 16901974 Ref: A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth. PMID: 16953230 Ref: Thymosin beta4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase. PMID: 17072345 Ref: BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. PMID: 17113272 Ref: An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. PMID: 17121828 Ref: Wnt/FZD signaling and colorectal cancer morphogenesis. PMID: 17127310 Ref: Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. PMID: 17128412 Ref: Up-regulation of a BCL9-related beta-catenin-binding protein, B9L, in different stages of sporadic colorectal adenoma. PMID: 17129358 Ref: Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. PMID: 17131344 Ref: The role of cyclooxygenase-2 and prostaglandins in colon cancer. PMID: 17164142 Ref: Wnt signaling as a therapeutic target for cancer. PMID: 17172707 Ref: Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. PMID: 17183061 Ref: Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner. PMID: 17189293 Ref: Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. PMID: 17192415 Ref: Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer. PMID: 17203186 Ref: Requirement of Pygopus 2 in breast cancer. PMID: 17203217 Ref: L1 expression as a marker for poor prognosis, tumor progression, and short survival in patients with colorectal cancer. PMID: 17211730 Ref: Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines. PMID: 17219422 Ref: Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. PMID: 17227893 Ref: Frequent mutation of Apc gene in rat colon tumors and mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis. PMID: 17234750 Ref: Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. PMID: 17234755 Ref: Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. PMID: 17241872 Ref: Phenotypes of invasion in sporadic colorectal carcinomas related to aberrations of the adenomatous polyposis coli (APC ) gene. PMID: 17257127 Ref: Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. PMID: 17258725 Ref: Transcriptionally targeted nonviral gene transfer using a beta-catenin/TCF-dependent promoter in a series of different human low passage colon cancer cells. PMID: 17274670 Ref: Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. PMID: 17278192 Ref: Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer. PMID: 17283120 Ref: beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1. PMID: 17291450 Ref: Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis. PMID: 17297457 Ref: Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. PMID: 17297461 Ref: Wnt/beta-catenin signaling in cancer stemness and malignant behavior. PMID: 17306971 Ref: Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. PMID: 17317856 Ref: Gardner fibroma: a clinicopathologic and immunohistochemical analysis of 45 patients with 57 fibromas. PMID: 17325483 Ref: Establishment and characterization of a novel human colorectal cancer cell line (CLY) metastasizing spontaneously to the liver in nude mice. PMID: 17342324 Ref: Down-regulation of PGE2 by physiologic levels of celecoxib is not sufficient to induce apoptosis or inhibit cell proliferation in human colon carcinoma cell lines. PMID: 17342386 Ref: Adjuvant immunochemotherapy with protein-bound polysaccharide K for colon cancer in relation to oncogenic beta-catenin activation. PMID: 17347903 Ref: Alternative splicing and nonsense-mediated mRNA decay in the regulation of a new adenomatous polyposis coli transcript. PMID: 17360132 Ref: Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells. PMID: 17360646 Ref: Loss of membranous Ep-CAM in budding colorectal carcinoma cells. PMID: 17361206 Ref: Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells. PMID: 17363564 Ref: Myc deletion rescues Apc deficiency in the small intestine. PMID: 17377531 Ref: Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3beta-axin complex: role of packing hydrophobic residues. PMID: 17380482 Ref: Elucidating the interactions between the adhesive and transcriptional functions of beta-catenin in normal and cancerous cells. PMID: 17382967 Ref: Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing. PMID: 17383426 Ref: The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells. PMID: 17395983 Ref: Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. PMID: 17407603 Ref: CBP/p300 are bimodal regulators of Wnt signaling. PMID: 17410209 Ref: Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer. PMID: 17415713 Ref: The functional genetic variant Arg324Gly of frizzled-related protein is associated with colorectal cancer risk. PMID: 17420170 Ref: Distinguishing prostatic from colorectal adenocarcinoma on biopsy samples: the role of morphology and immunohistochemistry. PMID: 17425391 Ref: Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Kruppel-like factor 5. PMID: 17430902 Ref: Increased pontin expression in human colorectal cancer tissue. PMID: 17442372 Ref: Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: a tissue microarray-based analysis. PMID: 17448021 Ref: The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. PMID: 17449905 Ref: [Stem cell theory of colorectal cancer and its connection with molecular-biological data]. PMID: 17452307 Ref: No difference in the occurrence of mismatch repair defects and APC and CTNNB1 genes mutation in a multi-racial colorectal carcinoma patient cohort. PMID: 17454753 Ref: Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. PMID: 17463182 Ref: Signet ring cell differentiation in mucinous colorectal carcinoma. PMID: 17471475 Ref: Role of c-Myc in Apc mutant intestinal phenotype: case closed or time for a new beginning? PMID: 17482129 Ref: Human scribble accumulates in colorectal neoplasia in association with an altered distribution of beta-catenin. PMID: 17509663 Ref: Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/beta-catenin pathway and progression of early lesions in the rat. PMID: 17510081 Ref: Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and beta-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. PMID: 17510083 Ref: Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. PMID: 17510365 Ref: Artesunate attenuates the growth of human colorectal carcinoma and inhibits hyperactive Wnt/beta-catenin pathway. PMID: 17520675 Ref: Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. PMID: 17534895 Ref: Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. PMID: 17555873 Ref: Regulation of E-cadherin and beta-catenin by Ca2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function. PMID: 17557293 Ref: The 15-lipoxygenase-1 expression may enhance the sensitivity to non-steroidal anti-inflammatory drug-induced apoptosis in colorectal cancers from patients who are treated with the compounds. PMID: 17559385 Ref: Analysis of pathway activity in primary tumors and NCI60 cell lines using gene expression profiling data. PMID: 17572360 Ref: Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia. PMID: 17572842 Ref: Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC. PMID: 17588722 Ref: Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain. PMID: 17611409 Ref: Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. PMID: 17615082 Ref: Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer. PMID: 17631641 Ref: Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARgamma and APC/beta-catenin pathways. PMID: 17632092 Ref: Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling. PMID: 17634137 Ref: Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells. PMID: 17635998 Ref: Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. PMID: 17638895 Ref: Green tea selectively targets initial stages of intestinal carcinogenesis in the AOM-ApcMin mouse model. PMID: 17638923 Ref: Adiposity-related protection of intestinal tumorigenesis: interaction with dietary calcium. PMID: 17640161 Ref: Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients. PMID: 17641414 Ref: Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. PMID: 17671182 Ref: Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli. PMID: 17673467 Ref: Value of staining intensity in the interpretation of immunohistochemistry for tumor markers in colorectal cancer. PMID: 17674041 Ref: Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. PMID: 17675336 Ref: Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. PMID: 17681179 Ref: Galectin-3 expression in colorectal cancer: relation to invasion and metastasis. PMID: 17695516 Ref: GSK-3 inhibitors induce chromosome instability. PMID: 17697341 Ref: Involvement of RNA helicases p68 and p72 in colon cancer. PMID: 17699760 Ref: Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. PMID: 17699774 Ref: Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 17710160 Ref: WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer. PMID: 17761539 Ref: E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription. PMID: 17785436 Ref: Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. PMID: 17785439 Ref: Strain-specific homeostatic responses during early stages of Azoxymethane-induced colon tumorigenesis in mice. PMID: 17786315 Ref: A proteomics analysis of cell signaling alterations in colorectal cancer. PMID: 17848589 Ref: beta-Catenin signaling in biological control and cancer. PMID: 17854061 Ref: Colorectal adenocarcinoma involving the prostate: report of 9 cases. PMID: 17868775 Ref: Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type. PMID: 17873890 Ref: Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. PMID: 17875709 Ref: Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. PMID: 17875931 Ref: Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene. PMID: 17881494 Ref: [Effects of hFRNK on E-cadherin/beta-catenin in colon cancer cells in vitro]. PMID: 17892129 Ref: APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. PMID: 17893240 Ref: EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. PMID: 17906625 Ref: Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways. PMID: 17908962 Ref: beta-catenin regulates multiple steps of RNA metabolism as revealed by the RNA aptamer in colon cancer cells. PMID: 17909039 Ref: SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis. PMID: 17909068 Ref: Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors. PMID: 17920061 Ref: [Expression and significance of APC, beta-catenin, C-myc, and Cyclin D1 proteins in colorectal carcinoma]. PMID: 17927853 Ref: [Mechanism of Wnt signaling pathway regulation by a truncated mutant of Axin2 in colorectal cancer]. PMID: 17927870 Ref: Modulation of beta-catenin-mediated TCF-signalling in prostate cancer cell lines by wild-type and mutant p53. PMID: 17929268 Ref: Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. PMID: 17942902 Ref: Dietary modulation of colon cancer risk. PMID: 17951506 Ref: Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin. PMID: 17954973 Ref: Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex. PMID: 17983804 Ref: Alpha-catenin is essential in intestinal adenoma formation. PMID: 17989230 Ref: Putative tumor suppressor EDD interacts with and up-regulates APC. PMID: 18076571 Ref: Mast cells are an essential hematopoietic component for polyp development. PMID: 18077429 Ref: ShRNA-mediated gene silencing of beta-catenin inhibits growth of human colon cancer cells. PMID: 18161931 Ref: Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/+ mice due to decreases in c-Myc expression. PMID: 18171987 Ref: [Effects of NGX6 on the transcriptional activation of beta-catenin/TCF/LEF in Wnt/beta-catenin signal pathway]. PMID: 18182714 Ref: n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved. PMID: 18220742 Ref: Epithelial-mesenchymal and mesenchymal-epithelial transitions during cancer progression. PMID: 18314592 Ref: The significance of beta-catenin, E-cadherin, and P-cadherin expressions in neoplastic progression of colorectal mucosa: an immunohistochemical study. PMID: 18330089 Ref: Gene expression profiling in familial adenomatous polyposis adenomas and desmoid disease. PMID: 19725988 |
Ref: Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. PMID: 17599042 Ref: Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. PMID: 17620308 Ref: Eukaryotic initiation factor 6 selectively regulates Wnt signaling and beta-catenin protein synthesis. PMID: 17667944 Ref: Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines. PMID: 17681772 Ref: A role for iron in Wnt signalling. PMID: 17700530 Ref: Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells. PMID: 17828298 Ref: Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. PMID: 17893236 Ref: Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. PMID: 17993259 Ref: Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARdelta/PGE2 and elevation of PGE3. PMID: 18024478 Ref: Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. PMID: 18058799 Ref: Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas. PMID: 18084253 Ref: Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor. PMID: 18097612 Ref: Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. PMID: 18160396 Ref: PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo. PMID: 18161004 Ref: Functional characterization of the novel APC N1026S variant associated with attenuated familial adenomatous polyposis. PMID: 18166348 Ref: WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer. PMID: 18172252 Ref: Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression. PMID: 18172264 Ref: Wnt signaling inside the nucleus. PMID: 18177486 Ref: Histopathologic determinants of regional lymph node metastasis in early colorectal cancer. PMID: 18181096 Ref: Metachronous cancer development in patients with sporadic colorectal adenomas-multivariate risk model with independent and combined value of hTERT and survivin. PMID: 18189140 Ref: The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis. PMID: 18196581 Ref: A direct protein-protein interaction is involved in the suppression of beta-catenin transcription by retinoid X receptor alpha in colorectal cancer cells. PMID: 18196974 Ref: Differential Notch and TGFbeta signaling in primary colorectal tumors and their corresponding metastases. PMID: 18219106 Ref: Prostatic adenocarcinoma in colorectal biopsy: clinical and pathologic features. PMID: 18234278 Ref: Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps. PMID: 18239078 Ref: DEAD-box RNA helicase p68 is not required for nuclear translocation of beta-catenin in colon cancer cells. PMID: 18239468 Ref: Expression of the cell-cell adhesion molecule beta-catenin in colorectal carcinomas and their metastases. PMID: 18254773 Ref: Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis. PMID: 18260092 Ref: Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. PMID: 18268006 Ref: Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. PMID: 18281465 Ref: Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. PMID: 18281498 Ref: Differential Wnt pathway gene expression and E-cadherin truncation in sporadic colorectal cancers with and without microsatellite instability. PMID: 18281531 Ref: Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. PMID: 18283038 Ref: Sulindac suppresses beta-catenin expression in human cancer cells. PMID: 18291362 Ref: E-cadherin and beta-catenin mRNA levels throughout colon cancer progression. PMID: 18316097 Ref: Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. PMID: 18326857 Ref: Wnt signaling and cancer development: therapeutic implication. PMID: 18348648 Ref: The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression. PMID: 18350253 Ref: Crosstalk between tumor cells and microenvironment via Wnt pathway in colorectal cancer dissemination. PMID: 18350618 Ref: Indole-3-carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines. PMID: 18358454 Ref: Altered distribution of beta-catenin and prognostic roles in colorectal carcinogenesis. PMID: 18365911 Ref: Transforming growth factor beta suppresses beta-catenin/Wnt signaling and stimulates an adhesion response in human colon carcinoma cells in a Smad4/DPC4 independent manner. PMID: 18367323 Ref: Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence. PMID: 18370954 Ref: Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. PMID: 18384130 Ref: Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours. PMID: 18387968 Ref: Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway. PMID: 18391483 Ref: Disturbed expression of E-cadherin, beta-catenin and tight junction proteins in colon carcinoma is unrelated to growth pattern and genetic polymorphisms. PMID: 18397460 Ref: MUC1 and colorectal cancer pathophysiology considerations. PMID: 18407586 Ref: DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. PMID: 18408752 Ref: Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model. PMID: 18413814 Ref: The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PMID: 18414679 Ref: Regulation of Wnt signaling by the nuclear pore complex. PMID: 18439914 Ref: Retinol Increases beta-catenin-RXRalpha binding leading to the increased proteasomal degradation of beta-catenin and RXRalpha. PMID: 18444141 Ref: Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherin. PMID: 18448095 Ref: Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis. PMID: 18451151 Ref: Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism. PMID: 18451518 Ref: Intestinal tumor progression is promoted by decreased apoptosis and dysregulated Wnt signaling in Ceacam1-/- mice. PMID: 18454175 Ref: Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. PMID: 18455124 Ref: Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. PMID: 18461655 Ref: Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. PMID: 18465804 Ref: Snail promotes Wnt target gene expression and interacts with beta-catenin. PMID: 18469861 Ref: PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway. PMID: 18473178 Ref: The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus. PMID: 18474248 Ref: Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. PMID: 18483247 Ref: Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1. PMID: 18487207 Ref: Hyperinduction of Wnt activity: a new paradigm for the treatment of colorectal cancer? PMID: 18488710 Ref: An oncogenic hub: beta-catenin as a molecular target for cancer therapeutics. PMID: 18491056 Ref: Large-scale N-terminal deletions but not point mutations stabilize beta-catenin in small bowel carcinomas, suggesting divergent molecular pathways of small and large intestinal carcinogenesis. PMID: 18491352 Ref: Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: implications for colon cancer prevention. PMID: 18504708 Ref: Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness. PMID: 18506144 Ref: PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. PMID: 18516290 Ref: Targeted suppression of beta-catenin blocks intestinal adenoma formation in APC Min mice. PMID: 18521697 Ref: Lycopene inhibits growth of human colon cancer cells via suppression of the Akt signaling pathway. PMID: 18537129 Ref: DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. PMID: 18538736 Ref: Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. PMID: 18550571 Ref: Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors. PMID: 18550572 Ref: Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription. PMID: 18591935 Ref: Frizzled-7 as a potential therapeutic target in colorectal cancer. PMID: 18592008 Ref: Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling. PMID: 18593907 Ref: Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma. PMID: 18609711 Ref: The ubiquitin-proteasome system in colorectal cancer. PMID: 18619533 Ref: Genetic alterations in colorectal cancers with demethylation of insulin-like growth factor II. PMID: 18619647 Ref: A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. PMID: 18621708 Ref: The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells. PMID: 18627596 Ref: Nuclear beta-catenin expression at the invasive front and in the vessels predicts liver metastasis in colorectal carcinoma. PMID: 18630466 Ref: Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. PMID: 18632633 Ref: E-cadherin, beta-catenin adhesion complex and relation to matrilysin expression in pT3 rectosigmoid cancers. PMID: 18674869 Ref: OPG is regulated by beta-catenin and mediates resistance to TRAIL-induced apoptosis in colon cancer. PMID: 18676739 Ref: The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. PMID: 18679426 Ref: Dark Aberrant Crypt Foci with activated Wnt pathway are related to tumorigenesis in the colon of AOM-treated rat. PMID: 18681964 Ref: A new formula for predicting liver metastasis in patients with colorectal cancer: immunohistochemical analysis of a large series of 439 surgically resected cases. PMID: 18728370 Ref: Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID: 18756595 Ref: Up-regulation of alpha-catenin is associated with increased lymph node involvement in colorectal cancer. PMID: 18756598 Ref: Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways. PMID: 18758483 Ref: Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. PMID: 18765800 Ref: Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. PMID: 18768809 Ref: HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. PMID: 18769117 Ref: RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. PMID: 18772112 Ref: Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells. PMID: 18774639 Ref: Importance of Wnt signaling in the tumor stroma microenvironment. PMID: 18781892 Ref: Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and Snail. PMID: 18790788 Ref: Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. PMID: 18791199 Ref: Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. PMID: 18794809 Ref: CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. PMID: 18794900 Ref: Modulation of intestinal environment by prebiotic germinated barley foodstuff prevents chemo-induced colonic carcinogenesis in rats. PMID: 18813820 Ref: Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. PMID: 18819930 Ref: Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. PMID: 18826597 Ref: A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. PMID: 18852287 Ref: Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers. PMID: 18932285 Ref: Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor. PMID: 18940664 Ref: Positive KL-6 mucin expression combined with decreased membranous beta-catenin expression indicates worse prognosis in colorectal carcinoma. PMID: 18949395 Ref: Voluntary exercise inhibits intestinal tumorigenesis in Apc(Min/+) mice and azoxymethane/dextran sulfate sodium-treated mice. PMID: 18976499 Ref: KLF4 regulation in intestinal epithelial cell maturation. PMID: 18977346 Ref: Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells. PMID: 18983819 Ref: Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors. PMID: 18992165 Ref: Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer. PMID: 18992635 Ref: Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. PMID: 19000900 Ref: New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. PMID: 19001663 Ref: Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PMID: 19002263 Ref: Period 2 mutation accelerates ApcMin/+ tumorigenesis. PMID: 19010825 Ref: RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. PMID: 19015318 Ref: Analysis of SOX9 expression in colorectal cancer. PMID: 19019766 Ref: Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes. PMID: 19035286 Ref: Inhibition of peroxisome proliferator-activated receptor gamma promotes tumorigenesis through activation of the beta-catenin / T cell factor (TCF) pathway in the mouse intestine. PMID: 19075513 Ref: Prognostic and therapeutic implications of Apc mutations in colorectal cancer. PMID: 19110823 Ref: (-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db mice. PMID: 19138973 Ref: Identification of mucin depleted foci in the human colon. PMID: 19139006 Ref: Mechanical factors activate beta-catenin-dependent oncogene expression in APC mouse colon. PMID: 19404440 Ref: Clinical significance of levels of molecular biological markers in zones of invasive front-line of colorectal cancer. PMID: 19526105 Ref: Sex modulates intestinal transformation by the tumor-suppressor GCC. PMID: 20443837 |
Ref: Src transformation of colonic epithelial cells: enhanced anchorage-independent growth in an Apc(+/min) background. PMID: 18613032 Ref: KITENIN recruits Dishevelled/PKC delta to form a functional complex and controls the migration and invasiveness of colorectal cancer cells. PMID: 18653728 Ref: Mutational analysis of WTX gene in Wnt/ beta-catenin pathway in gastric, colorectal, and hepatocellular carcinomas. PMID: 18720004 Ref: Calcium, calcium-sensing receptor and colon cancer. PMID: 18725175 Ref: Regulation of beta-catenin and connexin-43 expression: targets for sphingolipids in colon cancer prevention. PMID: 18837472 Ref: Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours. PMID: 18854359 Ref: p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors. 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Ref: DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis. PMID: 25648220 Ref: Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression. PMID: 25915847 Ref: Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells. PMID: 26014148 Ref: Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis. PMID: 26071132 Ref: Serrated tubulovillous adenoma of the large intestine. PMID: 26212352 Ref: E-cadherin increasing multidrug resistance protein 1 via hypoxia-inducible factor-1alpha contributes to multicellular resistance in colorectal cancer. PMID: 26219897 Ref: Tankyrase Inhibition Blocks Wnt/beta-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer. PMID: 26224873 Ref: High Ki67 expression is an independent good prognostic marker in colorectal cancer. PMID: 26281861 Ref: RNA binding protein RBM3 increases beta-catenin signaling to increase stem cell characteristics in colorectal cancer cells. PMID: 26331352 Ref: Frequent activation of the beta-catenin gene in sporadic colorectal carcinomas: A mutational & expression analysis. PMID: 26373808 Ref: TMPyP4-regulated cell proliferation and apoptosis through the Wnt/beta-catenin signaling pathway in SW480 cells. PMID: 26382555 Ref: Prognostic significance of leucine-rich-repeat-containing G-protein-coupled receptor 5, an intestinal stem cell marker, in gastric carcinomas. PMID: 26386561 Ref: Targeting the Wnt signaling pathway in colorectal cancer. PMID: 26439805 Ref: JRK is a positive regulator of beta-catenin transcriptional activity commonly overexpressed in colon, breast and ovarian cancer. PMID: 26455321 Ref: Positive regulation of beta-catenin-PROX1 signaling axis by DBC1 in colon cancer progression. PMID: 26477307 Ref: Prognostic Utility of Molecular Factors by Age at Diagnosis of Colorectal Cancer. PMID: 26490308 Ref: FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3beta/beta- catenin signaling cascade via FGFR4 activation. PMID: 26498355 Ref: hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer. PMID: 26607374 Ref: OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors. PMID: 26619963 Ref: A Small-Molecule Antagonist of the beta-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis. PMID: 26645562 Ref: A High-Content Imaging Screen for Cellular Regulators of beta-Catenin Protein Abundance. PMID: 26656867 Ref: All Trans-Retinoic Acid Mediates MED28/HMG Box-Containing Protein 1 (HBP1)/beta-Catenin Signaling in Human Colorectal Cancer Cells. PMID: 26660958 Ref: PDLIM1 Stabilizes the E-Cadherin/beta-Catenin Complex to Prevent Epithelial-Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells. PMID: 26701804 Ref: Effects of CD73 on human colorectal cancer cell growth in vivo and in vitro. PMID: 26708311 Ref: beta-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG. PMID: 26713600 Ref: Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy. PMID: 26717967 Ref: Differential membranous E-cadherin expression, cell proliferation and O-GlcNAcylation between primary and metastatic nodal lesion in colorectal cancer. PMID: 26724145 Ref: Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by gamma-secretase inhibition. PMID: 26746659 Ref: Adenomatous polyposis coli genotype-dependent toll-like receptor 4 activity in colon cancer. PMID: 26760960 Ref: Mucins and Wnt/beta-catenin signaling in gastrointestinal cancers: an unholy nexus. PMID: 26762229 Ref: Expression and clinical significance of SALL4 and beta-catenin in colorectal cancer. PMID: 26779651 Ref: An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis. PMID: 26785732 Ref: Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases. PMID: 26797410 Ref: Adenomatous polyposis coli (APC) regulates miR17-92 cluster through beta-catenin pathway in colorectal cancer. PMID: 26804172 Ref: SATB1 expression is correlated with beta-catenin associated epithelial-mesenchymal transition in colorectal cancer. PMID: 26810818 Ref: Identification of quinazoline compounds as novel potent inhibitors of Wnt/beta-catenin signaling in colorectal cancer cells. PMID: 26820295 Ref: Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway. PMID: 26820603 Ref: MicroRNA-224 sustains Wnt/beta-catenin signaling and promotes aggressive phenotype of colorectal cancer. PMID: 26822534 Ref: Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment. PMID: 26840292 Ref: Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach. PMID: 26844701 Ref: Potential Dual Role of Activating Transcription Factor 3 in Colorectal Cancer. PMID: 26851004 Ref: Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling. PMID: 26862734 Ref: Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K. PMID: 26863299 Ref: Regulation of functional KCNQ1OT1 lncRNA by beta-catenin. PMID: 26868975 Ref: Acquired resistance to HSP90 inhibitor 17-AAG and increased metastatic potential are associated with MUC1 expression in colon carcinoma cells. PMID: 26872308 Ref: Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells. PMID: 26883103 Ref: DDX3 promotes tumor invasion in colorectal cancer via the CK1epsilon/Dvl2 axis. PMID: 26892600 Ref: LGALS3 and AXIN1 gene variants playing role in the Wnt/ beta-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer. PMID: 26894286 Ref: Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development. PMID: 26908355 Ref: Copy number variants associated with 18p11.32, DCC and the promoter 1B region of APC in colorectal polyposis patients. PMID: 26909336 Ref: Molecular characterization of colorectal cancer patients and concomitant patient-derived tumor cell establishment. PMID: 26909603 Ref: Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/beta-catenin signaling. PMID: 26910283 Ref: Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-beta-catenin axis. PMID: 26910375 Ref: PS341 inhibits hepatocellular and colorectal cancer cells through the FOXO3/CTNNB1 signaling pathway. PMID: 26915315 Ref: Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of beta-Catenin Degradation-Competent Axin Puncta. PMID: 26930278 Ref: Antitumor effects of calgranulin B internalized in human colon cancer cells. PMID: 26933915 Ref: Target beta-catenin/CD44/Nanog axis in colon cancer cells by certain N'-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides. PMID: 26944615 Ref: A Crosstalk Between K ras (Kirsten Rat Sarcoma Viral Oncogene Homologue) and Adherence Molecular Complex Leads to Disassociation of Cells-A Possible Contribution Towards Metastasis in Colorectal Cancer. PMID: 26945839 Ref: CTNNB1-mutant colorectal carcinomas with immediate invasive growth: a model of interval cancers in Lynch syndrome. PMID: 26960970 Ref: Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells. PMID: 26981430 Ref: Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. PMID: 26983878 Ref: Role of cancer stem cells in racial disparity in colorectal cancer. PMID: 26990997 Ref: Whole-exome sequencing of duodenal adenocarcinoma identifies recurrent Wnt/beta-catenin signaling pathway mutations. PMID: 26998897 Ref: DDX3 enhances oncogenic KRASinduced tumor invasion in colorectal cancer via the betacatenin/ZEB1 axis. PMID: 27007150 Ref: LIG4 mediates Wnt signalling-induced radioresistance. PMID: 27009971 Ref: Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis. PMID: 27013588 Ref: HDAC1 controls CIP2A transcription in human colorectal cancer cells. PMID: 27029072 Ref: Overexpression of long non-coding RNA-CTD903 inhibits colorectal cancer invasion and migration by repressing Wnt/beta-catenin signaling and predicts favorable prognosis. PMID: 27035092 Ref: Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer. PMID: 27035413 Ref: Epigenetic silencing of miR-490-3p promotes development of an aggressive colorectal cancer phenotype through activation of the Wnt/beta-catenin signaling pathway. PMID: 27037061 Ref: The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking beta-Catenin/TCF Regulated Transcription. PMID: 27047543 Ref: Wnt9A Induction Linked to Suppression of Human Colorectal Cancer Cell Proliferation. PMID: 27049382 Ref: Visfatin is involved in promotion of colorectal carcinoma malignancy through an inducing EMT mechanism. PMID: 27058759 Ref: Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells. PMID: 27068260 Ref: Tolfenamic acid downregulates beta-catenin in colon cancer. PMID: 27089389 Ref: Cytotoxic activity of aeroplysinin-1 against colon cancer cells by promoting beta-catenin degradation. PMID: 27120392 Ref: Apigenin suppresses colorectal cancer cell proliferation, migration and invasion via inhibition of the Wnt/beta-catenin signaling pathway. PMID: 27123066 Ref: Syndecan-1, Epithelial-Mesenchymal Transition Markers (E-cadherin/beta-catenin) and Neoangiogenesis-related Proteins (PCAM-1 and Endoglin) in Colorectal Cancer. PMID: 27127133 Ref: CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition. PMID: 27149649 Ref: Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer. PMID: 27150059 Ref: Complex Behavior of ALDH1A1 and IGFBP1 in Liver Metastasis from a Colorectal Cancer. PMID: 27152521 Ref: RSPO2 enriches LGR5(+) spheroid colon cancer stem cells and promotes its metastasis by epithelial-mesenchymal transition. PMID: 27158331 Ref: Determination of the Role of CBP- and p300-Mediated Wnt Signaling on Colonic Cells. PMID: 27177606 Ref: Targeted delivery of small interfering RNA to colon cancer cells using chitosan and PEGylated chitosan nanoparticles. PMID: 27178938 Ref: The Wnt Target Gene L1 in Colon Cancer Invasion and Metastasis. PMID: 27187476 Ref: Knockdown of linc-UFC1 suppresses proliferation and induces apoptosis of colorectal cancer. PMID: 27195675 Ref: The Discovery and Characterization of K-756, a Novel Wnt/beta-Catenin Pathway Inhibitor Targeting Tankyrase. PMID: 27196752 Ref: The UVB1 Vitamin D analogue inhibits colorectal carcinoma progression. PMID: 27208626 Ref: miR-375 inhibits the invasion and metastasis of colorectal cancer via targeting SP1 and regulating EMT-associated genes. PMID: 27222350 Ref: An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer. PMID: 27226778 Ref: Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). PMID: 27234654 Ref: Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer. PMID: 27245242 Ref: Refining Pathways: A Model Comparison Approach. PMID: 27248690 Ref: Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells. PMID: 27255403 Ref: AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis by Modulating Wnt/beta-Catenin Signaling. PMID: 27262173 Ref: Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer. PMID: 27302477 Ref: Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/beta-catenin signaling. PMID: 27302922 Ref: Expression of mu-protocadherin is negatively regulated by the activation of the beta-catenin signaling pathway in normal and cancer colorectal enterocytes. PMID: 27310872 Ref: Inhibitory effects of Hedyotis diffusa Willd. on colorectal cancer stem cells. PMID: 27313710 Ref: Knockdown of beta-catenin by siRNA influences proliferation, apoptosis and invasion of the colon cancer cell line SW480. PMID: 27313713 Ref: Correlation of GOLPH3 Gene with Wnt Signaling Pathway in Human Colon Cancer Cells. PMID: 27313783 Ref: S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction. PMID: 27331819 Ref: TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3. PMID: 27333864 Ref: The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway. PMID: 27338550 Ref: Protocadherin 17 functions as a tumor suppressor suppressing Wnt/beta-catenin signaling and cell metastasis and is frequently methylated in breast cancer. PMID: 27351130 Ref: Direct Pharmacological Inhibition of beta-Catenin by RNA Interference in Tumors of Diverse Origin. PMID: 27390343 Ref: beta-Catenin activation in fundic gland polyps, gastric cancer and colonic polyps in families afflicted by 'gastric adenocarcinoma and proximal polyposis of the stomach' (GAPPS). PMID: 27406052 Ref: Physical Activity and Cancer Outcomes: A Precision Medicine Approach. PMID: 27407093 Ref: High expression of WISP1 in colon cancer is associated with apoptosis, invasion and poor prognosis. PMID: 27409174 Ref: Histone deacetylase inhibitors regulate P-gp expression in colorectal cancer via transcriptional activation and mRNA stabilization. PMID: 27409663 Ref: Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and beta-catenin signaling pathways. PMID: 27422337 Ref: ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration. PMID: 27440078 Ref: SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate. PMID: 27451147 Ref: Walnut Phenolic Extract and Its Bioactive Compounds Suppress Colon Cancer Cell Growth by Regulating Colon Cancer Stemness. PMID: 27455311 Ref: A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/beta-catenin signalling pathway. PMID: 27462437 Ref: The destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma. PMID: 27462886 Ref: Loss of ZFP36 expression in colorectal cancer correlates to wnt/ ss-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of ZEB1, SOX9 and MACC1. PMID: 27463018 Ref: A Rare Colon Cancer with Ossification: Pathogenetic Analysis of Bone Formation. PMID: 27466305 Ref: The Effect of (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-Olide (LS-1) from Lobophyyum sp. on the Apoptosis Induction of SNU-C5 Human Colorectal Cancer Cells. PMID: 27469141 Ref: Simultaneous destabilization of beta-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer. PMID: 27470214 Ref: Anticancer Activity of Buttermilk Against SW480 Colon Cancer Cells is Associated with Caspase-Independent Cell Death and Attenuation of Wnt, Akt, and ERK Signaling. PMID: 27472445 Ref: Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity. PMID: 27482906 Ref: Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening. PMID: 27490956 Ref: Chronic exposure to endosulfan induces inflammation in murine colon via beta-catenin expression and IL-6 production. PMID: 27494533 Ref: Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells. PMID: 27494849 Ref: Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells. PMID: 27517620 Ref: RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells. PMID: 27520449 Ref: G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/beta-catenin pathway. PMID: 27525719 Ref: Wnt signalling is a bi-directional vulnerability of cancer cells. PMID: 27531891 Ref: beta-Catenin accumulation and S33F mutation of CTNNB1 gene in colorectal cancer in Saudi Arabia. PMID: 27543871 Ref: Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis. PMID: 27563825 Ref: NHERF1/EBP50 Suppresses Wnt-beta-Catenin Pathway-Driven Intestinal Neoplasia. PMID: 27566107 Ref: The omega-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of beta-catenin complex, inhibiting COX-2 through repressing NF-kappaB, and inducing 15-prostaglandin dehydrogenase. PMID: 27566583 Ref: Enhancement of Pathologist's Routine Practice: Reuse of DNA Extracted from Immunostained Formalin-fixed Paraffin-embedded (FFPE) Slides in Downstream Molecular Analysis of Cancer. PMID: 27566658 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer. PMID: 27578919 Ref: Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials. PMID: 27598201 Ref: GSK-3beta-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63. PMID: 27599658 Ref: Targeting H19 by lentivirus-mediated RNA interference increases A549 cell migration and invasion. PMID: 27607135 Ref: Comparative profiling between primary colorectal carcinomas and metastases identifies heterogeneity on drug resistance. PMID: 27613840 Ref: Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ss-catenin. PMID: 27619912 Ref: Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer. PMID: 27622014 Ref: CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3beta signaling pathway. PMID: 27634891 Ref: c-Cbl mediates the degradation of tumorigenic nuclear beta-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. PMID: 27661103 Ref: TRAP1 regulates stemness through Wnt/beta-catenin pathway in human colorectal carcinoma. PMID: 27662365 Ref: TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways. PMID: 27669982 Ref: Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans. PMID: 27688749 Ref: Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells. PMID: 27698922 Ref: Wnt-beta-catenin signaling regulates ABCC3 (MRP3) transporter expression in colorectal cancer. PMID: 27709738 Ref: LDB1 overexpression is a negative prognostic factor in colorectal cancer. PMID: 27713177 Ref: Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer. PMID: 27750216 Ref: Transcription Factor ZBP-89 Drives a Feedforward Loop of beta-Catenin Expression in Colorectal Cancer. PMID: 27758879 Ref: beta-catenin interaction with NHERF1 and RASSF1A methylation in metastatic colorectal cancer patients. PMID: 27765918 Ref: microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells. PMID: 27769860 Ref: LMO2 attenuates tumor growth by targeting the Wnt signaling pathway in breast and colorectal cancer. PMID: 27779255 Ref: ASBEL-TCF3 complex is required for the tumorigenicity of colorectal cancer cells. PMID: 27791078 Ref: beta-Catenin Expression Regulates Cell Migration of Human Colonic Adenocarcinoma Cells Through Gelsolin. PMID: 27798885 Ref: KRAS Mutant Status, p16 and beta-catenin Expression May Predict Local Recurrence in Patients Who Underwent Transanal Endoscopic Microsurgery (TEMS) for Stage I Rectal Cancer. PMID: 27798894 Ref: The role of Pygo2 for Wnt/ss-catenin signaling activity during intestinal tumor initiation and progression. PMID: 27811361 Ref: KY1022, a small molecule destabilizing Ras via targeting the Wnt/beta-catenin pathway, inhibits development of metastatic colorectal cancer. PMID: 27835580 Ref: Gankyrin sustains PI3K/GSK-3beta/beta-catenin signal activation and promotes colorectal cancer aggressiveness and progression. PMID: 27835604 Ref: Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of beta-Catenin Signaling. PMID: 27851986 Ref: Wnt/beta Catenin-Mediated Signaling Commonly Altered in Colorectal Cancer. PMID: 27865466 Ref: [Expression of CD10 in tumor-associated fibroblast of cancerized or recurrent colorectal adenomas]. PMID: 27868405 Ref: Loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of colorectal cancer. PMID: 27880730 Ref: Bile acid: a potential inducer of colon cancer stem cells. PMID: 27908290 Ref: Nuclear expression and/or reduced membranous expression of beta-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis. PMID: 27930552 Ref: Retraction: G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/beta-catenin pathway. PMID: 28008183 Ref: The effect of a germline mutation in the APC gene on beta-catenin in human embryonic stem cells. PMID: 28010732 Ref: [Expression of CD10 in cancer-associated fibroblasts and its effect on initiation and progression of colorectal carcinoma]. PMID: 28056302 Ref: Comparison of Anticancer Effects of Carbamazepine and Valproic Acid. PMID: 28184324 Ref: Protein Markers Associated with an ALDH Sub-Population in Colorectal Cancer. PMID: 28503055 Ref: Wnt Signaling in Normal and Malignant Stem Cells. PMID: 28503404 Ref: [Experiment on Jianpi Qingre Huoxue Decoction Drug Serum Regulates SW480 Cell Proliferation,Apoptosis,Cycle and the Expression of beta-Catenin by Altering PI3K/Akt Signal Pathway]. PMID: 30204364 |
Ref: Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma. PMID: 26475632 Ref: RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. PMID: 27329244 Ref: Differential expression of LEF1/TCFs family members in colonic carcinogenesis. PMID: 27433921 Ref: RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis. PMID: 27511199 Ref: Vitamin D receptor is a novel transcriptional regulator for Axin1. PMID: 27601169 Ref: The high expression of long non-coding RNA PANDAR indicates a poor prognosis for colorectal cancer and promotes metastasis by EMT pathway. PMID: 27629879 Ref: FERMT1 mediates epithelial-mesenchymal transition to promote colon cancer metastasis via modulation of beta-catenin transcriptional activity. PMID: 27641329 Ref: From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells. PMID: 27664423 Ref: Expanding the genotype-phenotype spectrum in hereditary colorectal cancer by gene panel testing. PMID: 27696107 Ref: Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced beta-Catenin Signaling in Endothelial Cells. PMID: 27712599 Ref: Empty Spiracles Homeobox 2 (EMX2) Inhibits the Invasion and Tumorigenesis in Colorectal Cancer Cells. PMID: 27712600 Ref: Identification of High-Risk Aberrant Crypt Foci and Mucin-Depleted Foci in the Human Colon With Study of Colon Cancer Stem Cell Markers. PMID: 27789195 Ref: Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. PMID: 27793841 Ref: Genetic disruption of tubulin acetyltransferase, alphaTAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/beta-catenin signaling. PMID: 27836544 Ref: Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression. PMID: 27859949 Ref: TrpC5 regulates differentiation through the Ca2+/Wnt5a signalling pathway in colorectal cancer. PMID: 27895148 Ref: Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/beta-catenin signaling pathways in hepatocellular and colorectal carcinoma cells. PMID: 27901475 Ref: Oncogenic retinoic acid receptor alpha promotes human colorectal cancer growth through simultaneously regulating p21 transcription and GSK3beta/beta-catenin signaling. PMID: 27932034 Ref: Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and beta-Catenin Signaling. PMID: 27983919 Ref: Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets. PMID: 27997180 Ref: Unlocking Aspirin's Chemopreventive Activity: Role of Irreversibly Inhibiting Platelet Cyclooxygenase-1. PMID: 27998883 Ref: Clinical relevance of colorectal cancer molecular subtypes. PMID: 28010901 Ref: Loss of FOXN3 in colon cancer activates beta-catenin/TCF signaling and promotes the growth and migration of cancer cells. PMID: 28039460 Ref: Taspine derivative 12k suppressed A549 cell migration through the Wnt/beta-catenin and EphrinB2 signaling pathway. PMID: 28049091 Ref: VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. PMID: 28051067 Ref: Knockdown of Tripartite Motif-Containing Protein 37 (TRIM37) Inhibits the Proliferation and Tumorigenesis in Colorectal Cancer Cells. PMID: 28081740 Ref: The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/beta-catenin signaling. PMID: 28086904 Ref: M2-like macrophages induce colon cancer cell invasion via matrix metalloproteinases. PMID: 28098359 Ref: Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis. PMID: 28104986 Ref: Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and beta-Catenin Degradation. PMID: 28107521 Ref: Mitochondrial uncoupler exerts a synthetic lethal effect against beta-catenin mutant tumor cells. PMID: 28107588 Ref: Identification of FERM domain-containing protein 5 as a novel target of beta-catenin/TCF7L2 complex. PMID: 28117551 Ref: YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. PMID: 28130546 Ref: The lncRNA H19 Promotes Cell Proliferation by Competitively Binding to miR-200a and Derepressing beta-Catenin Expression in Colorectal Cancer. PMID: 28164117 Ref: Research of the relationship between beta-catenin and c-myc-mediated Wnt pathway and laterally spreading tumors occurrence. PMID: 28165564 Ref: APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer. PMID: 28179481 Ref: Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. PMID: 28183047 Ref: Forkhead Box Protein J1 (FOXJ1) is Overexpressed in Colorectal Cancer and Promotes Nuclear Translocation of beta-Catenin in SW620 Cells. PMID: 28209947 Ref: USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. PMID: 28216017 Ref: Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. PMID: 28218467 Ref: Tissue transglutaminase induces Epithelial-Mesenchymal-Transition and the acquisition of stem cell like characteristics in colorectal cancer cells. PMID: 28223538 Ref: CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells. PMID: 28229932 Ref: Conventional colon adenomas harbor various disturbances in microsatellite stability and contain micro-serrated foci with microsatellite instability. PMID: 28234922 Ref: Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways. PMID: 28241877 Ref: Construction of a multiplex mutation hot spot PCR panel: the first step towards colorectal cancer genotyping on the GS Junior platform. PMID: 28243320 Ref: Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits the Proliferation, Migration, and Invasion in Colorectal Cancer Cells. PMID: 28244854 Ref: USP39 promotes colorectal cancer growth and metastasis through the Wnt/beta-catenin pathway. PMID: 28259917 Ref: Fatty acid composition and anticancer activity in colon carcinoma cell lines of Prunus dulcis seed oil. PMID: 28262033 Ref: Dietary glycemic and insulin scores and colorectal cancer survival by tumor molecular biomarkers. PMID: 28268248 Ref: A kinetic model to study the regulation of beta-catenin, APC, and Axin in the human colonic crypt. PMID: 28271271 Ref: Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. PMID: 28275297 Ref: Correlations between TBL1XR1 and recurrence of colorectal cancer. PMID: 28295012 Ref: Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer. PMID: 28298922 Ref: The impact of body mass index and nuclear beta-catenin on survival in locally advanced rectal cancer treated with preoperative radiochemotherapy. PMID: 28335081 Ref: Apigenin-induced lysosomal degradation of beta-catenin in Wnt/beta-catenin signaling. PMID: 28337019 Ref: p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration. PMID: 28339031 Ref: Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3beta/beta-catenin pathways. PMID: 28356111 Ref: Effect of antitumor drugs in low concentrationson the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro. PMID: 28361849 Ref: Dickkopf-Related Protein 2 is Epigenetically Inactivated and Suppresses Colorectal Cancer Growth and Tumor Metastasis by Antagonizing Wnt/beta-Catenin Signaling. PMID: 28365691 Ref: Possible role of nuclear beta-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancer. PMID: 28370249 Ref: Targeting Tankyrase to Fight WNT-dependent Tumours. PMID: 28371398 Ref: ME-143 Is Superior to Genistein in Suppression of WNT Signaling in Colon Cancer Cells. PMID: 28373425 Ref: Bidirectional KCNQ1:beta-catenin interaction drives colorectal cancer cell differentiation. PMID: 28373572 Ref: A lignan induces lysosomal dependent degradation of FoxM1 protein to suppress beta-catenin nuclear translocation. PMID: 28378765 Ref: Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells. PMID: 28390310 Ref: SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of beta-catenin. PMID: 28390865 Ref: Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer. PMID: 28410235 Ref: Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia. PMID: 28414304 Ref: Reciprocal control of lncRNA-BCAT1 and beta-catenin pathway reveals lncRNA-BCAT1 long non-coding RNA acts as a tumor suppressor in colorectal cancer. PMID: 28416735 Ref: [A change in the expression of membrane-associated proteins and cytoplasmic actin isoforms in the progression of human colon tumors]. PMID: 28418353 Ref: The addition of celecoxib improves the antitumor effect of cetuximab in colorectal cancer: role of EGFR-RAS-FOXM1-beta- catenin signaling axis. PMID: 28423516 Ref: Invasive Fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade. PMID: 28423670 Ref: The regulation of beta-catenin activity and function in cancer: therapeutic opportunities. PMID: 28430641 Ref: Oncogenic beta-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. PMID: 28442534 Ref: DNA methylation assay for colorectal carcinoma. PMID: 28443202 Ref: TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells. PMID: 28450117 Ref: Interleukin-37 mediates the antitumor activity in colon cancer through beta-catenin suppression. PMID: 28467774 Ref: The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells. PMID: 28467911 Ref: The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/beta-Catenin Signaling Pathway. PMID: 28472810 Ref: Discovery of small molecule inhibitors of the Wnt/beta-catenin signaling pathway by targeting beta-catenin/Tcf4 interactions. PMID: 28474989 Ref: Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cells. PMID: 28522946 Ref: Hyper activation of beta-catenin signalling induced by IKKepsilon inhibition thwarts colorectal cancer cell proliferation. PMID: 28523736 Ref: Assessing the clinical utility of Wnt pathway markers in colorectal cancer. PMID: 28534366 Ref: Molecular Basis of Alcohol-Related Gastric and Colon Cancer. PMID: 28538665 Ref: Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/beta-catenin/Slug pathway. PMID: 28542126 Ref: Fas signaling induces stemness properties in colorectal cancer by regulation of Bmi1. PMID: 28543447 Ref: MicroRNA-200b is downregulated in colon cancer budding cells. PMID: 28552992 Ref: Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression. PMID: 28553956 Ref: Mesenchymal-Epithelial Transition and Circulating Tumor Cells in Small Cell Lung Cancer. PMID: 28560677 Ref: Origin of Somatic Mutations in beta-Catenin versus Adenomatous Polyposis Coli in Colon Cancer: Random Mutagenesis in Animal Models versus Nonrandom Mutagenesis in Humans. PMID: 28578586 Ref: Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells. PMID: 28587064 Ref: PCDH18 is frequently inactivated by promoter methylation in colorectal cancer. PMID: 28588296 Ref: Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer. PMID: 28600477 Ref: Tanshinone IIA inhibits beta-catenin/VEGF-mediated angiogenesis by targeting TGF-beta1 in normoxic and HIF-1alpha in hypoxic microenvironments in human colorectal cancer. PMID: 28602978 Ref: mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer. PMID: 28615517 Ref: [Expression of regulatory factor R-spondin family in Wnt signaling pathway in colorectal cancer and its clinical significance]. PMID: 28626093 Ref: Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner. PMID: 28630428 Ref: Upregulation of miR-199a/b contributes to cisplatin resistance via Wnt/beta-catenin-ABCG2 signaling pathway in ALDHA1(+) colorectal cancer stem cells. PMID: 28639895 Ref: Meta-analysis of miRNA expression profiles for prostate cancer recurrence following radical prostatectomy. PMID: 28651018 Ref: Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. PMID: 28659575 Ref: Silencing of long non-coding RNA CCAT2 depressed malignancy of oral squamous cell carcinoma via Wnt/beta-catenin pathway. PMID: 28671055 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Expression of epithelial-mesenchymal transition and cancer stem cell markers in colorectal adenocarcinoma: Clinicopathological significance. PMID: 28677737 Ref: Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/beta-catenin signaling pathways in human colon cancer cells. PMID: 28688953 Ref: Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development. PMID: 28704539 Ref: Blocking endothelin-1-receptor/beta-catenin circuit sensitizes to chemotherapy in colorectal cancer. PMID: 28708138 Ref: Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PMID: 28708826 Ref: Portulaca oleracea extract can inhibit nodule formation of colon cancer stem cells by regulating gene expression of the Notch signal transduction pathway. PMID: 28714363 Ref: Molecular genetics and targeted therapy of WNT-related human diseases (Review). PMID: 28731148 Ref: Aldose reductase inhibitor, fidarestat prevents high-fat diet-induced intestinal polyps in ApcMin/+ mice. PMID: 28786349 Ref: R-spondin 2 promotes proliferation and migration via the Wnt/beta-catenin pathway in human hepatocellular carcinoma. PMID: 28789406 Ref: The interaction between the Wnt/beta-catenin signaling cascade and PKG activation in cancer. PMID: 28808213 Ref: Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/beta-catenin Signaling. PMID: 28811361 Ref: Knockdown of IRE1alpha inhibits colonic tumorigenesis through decreasing beta-catenin and IRE1alpha targeting suppresses colon cancer cells. PMID: 28825721 Ref: Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. PMID: 28829046 Ref: Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. PMID: 28829588 Ref: Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study. PMID: 28856682 Ref: Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells. PMID: 28859077 Ref: Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells. PMID: 28862656 Ref: Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells. PMID: 28870200 Ref: The Effect of Pyrroloquinoline Quinone on the Expression of WISP1 in Traumatic Brain Injury. PMID: 28883836 Ref: The Role of Pontin and Reptin in Cellular Physiology and Cancer Etiology. PMID: 28884116 Ref: SATB2/beta-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer. PMID: 28887549 Ref: Cytotoxic activities of Telectadium dongnaiense and its constituents by inhibition of the Wnt/beta-catenin signaling pathway. PMID: 28899495 Ref: Regulation of Wnt/beta-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding. PMID: 28910490 Ref: MicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor. PMID: 28932920 Ref: Polyyne-Enriched Extract from Oplopanax elatus Significantly Ameliorates the Progression of Colon Carcinogenesis in Apc(Min/+) Mice. PMID: 28937627 Ref: Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/beta-Catenin and PI3K/Akt Signaling. PMID: 28939743 Ref: NOTCH1 activates the Wnt/beta-catenin signaling pathway in colon cancer. PMID: 28947978 Ref: A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer. PMID: 28962550 Ref: Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PMID: 28968471 Ref: miR-223 promotes colon cancer by directly targeting p120 catenin. PMID: 28969027 Ref: SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/beta-Catenin complex. PMID: 28970068 Ref: miR-214 activates TP53 but suppresses the expression of RELA, CTNNB1, and STAT3 in human cervical and colorectal cancer cells. PMID: 29023799 Ref: GSK-3beta inhibitor 6-bromo-indirubin-3'-oxime promotes both adhesive activity and drug resistance in colorectal cancer cells. PMID: 29039496 Ref: Colorectal carcinoma tumour budding and podia formation in the xenograft microenvironment. PMID: 29040282 Ref: TGFbeta induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/beta-catenin signaling. PMID: 29050273 Ref: Different effection of p.1125Val>Ala and rs11954856 in APC on Wnt signaling pathway. PMID: 29050326 Ref: Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression. PMID: 29066742 Ref: Interleukin-35 expression is associated with colon cancer progression. PMID: 29069729 Ref: Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300. PMID: 29069825 Ref: A structured group exercise program for patients with metastatic cancer receiving chemotherapy and CTNNB1 (beta-catenin) as a biomarker of exercise efficacy. PMID: 29075139 Ref: Scutellaria barbata D. Don inhibits colorectal cancer growth via suppression of Wnt/beta-catenin signaling pathway. PMID: 29080197 Ref: Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer. PMID: 29108267 Ref: RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations. PMID: 29127379 Ref: Long noncoding RNA HNF1A-AS1 indicates a poor prognosis of colorectal cancer and promotes carcinogenesis via activation of the Wnt/beta-catenin signaling pathway. PMID: 29145164 Ref: Beta-catenin and p53 expression in topographic compartments of colorectal cancer and its prognostic value following surgery. PMID: 29146051 Ref: The effect of miR-224 down-regulation on SW80 cell proliferation and apoptosis and weakening of ADM drug resistance. PMID: 29164556 Ref: miR-590-3p promotes colon cancer cell proliferation via Wnt/beta-catenin signaling pathway by inhibiting WIF1 and DKK1. PMID: 29164578 Ref: Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/beta-catenin signaling in colorectal cancer cells. PMID: 29183322 Ref: Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/beta-Catenin Pathways via miR-130a. PMID: 29225578 Ref: The effect of flubendazole on adhesion and migration in SW480 and SW620 colon cancer cells. PMID: 29237383 Ref: Distinctive DNA mismatch repair and APC rare variants in African Americans with colorectal neoplasia. PMID: 29245953 Ref: Decreased expression of interferon-induced protein 2 (IFIT2) by Wnt/beta-catenin signaling confers anti-apoptotic properties to colorectal cancer cells. PMID: 29245969 Ref: Commensal-infected macrophages induce dedifferentiation and reprogramming of epithelial cells during colorectal carcinogenesis. PMID: 29254234 Ref: Long non-coding RNA LINC00261 sensitizes human colon cancer cells to cisplatin therapy. PMID: 29267503 Ref: High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling. PMID: 29269789 Ref: LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics. PMID: 29312635 Ref: Up-regulation of lncRNA SNHG1 indicates poor prognosis and promotes cell proliferation and metastasis of colorectal cancer by activation of the Wnt/beta-catenin signaling pathway. PMID: 29340086 Ref: Long non-coding RNA lncTCF7 activates the Wnt/beta-catenin pathway to promote metastasis and invasion in colorectal cancer. PMID: 29344178 Ref: Significance of intratissue estrogen concentration coupled with estrogen receptors levels in colorectal cancer prognosis. PMID: 29383180 Ref: Dishevelled1-3 contribute to multidrug resistance in colorectal cancer via activating Wnt/beta-catenin signaling. PMID: 29383202 Ref: microRNA-335 inhibits colorectal cancer HCT116 cells growth and epithelial-mesenchymal transition (EMT) process by targeting Twist1. PMID: 29441907 Ref: Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology. PMID: 29552640 |
Ref: Introduction of hsa-miR-103a and hsa-miR-1827 and hsa-miR-137 as new regulators of Wnt signaling pathway and their relation to colorectal carcinoma. PMID: 28817181 Ref: microRNA-145 downregulates SIP1-expression but differentially regulates proliferation, migration, invasion and Wnt signaling in SW480 and SW620 cells. PMID: 28833449 Ref: Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells. PMID: 28887754 Ref: Tumor-suppressive miR-145 co-repressed by TCF4-beta-catenin and PRC2 complexes forms double-negative regulation loops with its negative regulators in colorectal cancer. PMID: 28921929 Ref: Early genetic aberrations in patients with sporadic colorectal cancer. PMID: 28926134 Ref: 'MCC' protein interacts with E-cadherin and beta-catenin strengthening cell-cell adhesion of HCT116 colon cancer cells. PMID: 29035389 Ref: The human PKP2/plakophilin-2 gene is induced by Wnt/beta-catenin in normal and colon cancer-associated fibroblasts. PMID: 29044515 Ref: The effects of Curcumin on HCT-116 cells proliferation and apoptosis via the miR-491/PEG10 pathway. PMID: 29058812 Ref: Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human gammadeltaT cells against colon cancer. PMID: 29104081 Ref: Overexpression of lamin B1 induces mitotic catastrophe in colon cancer LoVo cells and is associated with worse clinical outcomes. PMID: 29115590 Ref: Ca(2+)/nuclear factor of activated T cells signaling is enriched in early-onset rectal tumors devoid of canonical Wnt activation. PMID: 29124284 Ref: Excluding Lynch syndrome in a female patient with metachronous DNA mismatch repair deficient colon- and ovarian cancer. PMID: 29124495 Ref: A look into centrosome abnormalities in colon cancer cells, how they arise and how they might be targeted therapeutically. PMID: 29128368 Ref: Silencing of CEMIP suppresses Wnt/beta-catenin/Snail signaling transduction and inhibits EMT program of colorectal cancer cells. PMID: 29173982 Ref: Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes. PMID: 29180604 Ref: DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment. PMID: 29199082 Ref: Mutational Mechanisms That Activate Wnt Signaling and Predict Outcomes in Colorectal Cancer Patients. PMID: 29212857 Ref: Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX-2 involvement. PMID: 29215713 Ref: TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting beta-CATENIN and AKT Signaling in Colorectal Cancer. PMID: 29222171 Ref: Activation of KLF4 expression by small activating RNA promotes migration and invasion in colorectal epithelial cells. PMID: 29274293 Ref: Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1. PMID: 29274585 Ref: beta-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models. PMID: 29282298 Ref: Emodin inhibits colon cancer cell invasion and migration by suppressing epithelialmesenchymal transition via the Wnt/beta-catenin pathway. PMID: 29301594 Ref: MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer. PMID: 29304823 Ref: Long noncoding RNA CASC9.5 promotes the proliferation and metastasis of lung adenocarcinoma. PMID: 29311567 Ref: Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer. PMID: 29316426 Ref: Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells. PMID: 29316729 Ref: Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting. PMID: 29318445 Ref: The gain-of-function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/beta-catenin signaling pathway. PMID: 29323748 Ref: Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix. PMID: 29327707 Ref: A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer. PMID: 29329541 Ref: Beta-catenin cleavage enhances transcriptional activation. PMID: 29330435 Ref: Identification of a noncanonical function for ribose-5-phosphate isomerase A promotes colorectal cancer formation by stabilizing and activating beta-catenin via a novel C-terminal domain. PMID: 29337987 Ref: NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis. PMID: 29343851 Ref: LIMK/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance. PMID: 29352327 Ref: CCRK is a novel signalling hub exploitable in cancer immunotherapy. PMID: 29360538 Ref: MiRNA-155 promotes the invasion of colorectal cancer SW-480 cells through regulating the Wnt/beta-catenin. PMID: 29364476 Ref: Long non-coding RNA DLEU7-AS1 promotes the occurrence and development of colorectal cancer via Wnt/beta-catenin pathway. PMID: 29364477 Ref: RNF6 Promotes Colorectal Cancer by Activating the Wnt/beta-Catenin Pathway via Ubiquitination of TLE3. PMID: 29374067 Ref: Transglutaminase 2 Regulates Self-renewal and Stem Cell Marker of Human Colorectal Cancer Stem Cells. PMID: 29374703 Ref: Thyroid Hormone Promotes beta-Catenin Activation and Cell Proliferation in Colorectal Cancer. PMID: 29380230 Ref: XPNPEP3 is a novel transcriptional target of canonical Wnt/beta-catenin signaling. PMID: 29383790 Ref: Protein Kinase C-zeta stimulates colorectal cancer cell carcinogenesis via PKC-zeta/Rac1/Pak1/beta-Catenin signaling cascade. PMID: 29408512 Ref: Three molecular pathways model colorectal carcinogenesis in Lynch syndrome. PMID: 29424427 Ref: RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1. PMID: 29426364 Ref: Ectopic expression of miR-147 inhibits stem cell marker and epithelial-mesenchymal transition (EMT)-related protein expression in colon cancer cells. PMID: 29426374 Ref: DKK2 imparts tumor immunity evasion through beta-catenin-independent suppression of cytotoxic immune-cell activation. PMID: 29431745 Ref: Anti-inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer. PMID: 29434827 Ref: beta-catenin, leucine-rich repeat-containing G protein-coupled receptor 5 and GATA-binding factor 6 are associated with the normal mucosa-adenoma-adenocarcinoma sequence of colorectal tumorigenesis. PMID: 29434936 Ref: Long non-coding RNA CCAT2 promotes epithelial-mesenchymal transition involving Wnt/beta-catenin pathway in epithelial ovarian carcinoma cells. PMID: 29435081 Ref: Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals. PMID: 29436668 Ref: Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer. PMID: 29438985 Ref: Bone Marrow Cell Therapy on 1,2-Dimethylhydrazine (DMH)-Induced Colon Cancer in Rats. PMID: 29439258 Ref: Interaction of the Wnt/beta-catenin and RAS-ERK pathways involving co-stabilization of both beta-catenin and RAS plays important roles in the colorectal tumorigenesis. PMID: 29449169 Ref: Atrial Natriuretic Peptide Acts as a Neuroprotective Agent in in Vitro Models of Parkinson's Disease via Up-regulation of the Wnt/beta-Catenin Pathway. PMID: 29449807 Ref: beta-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells. PMID: 29453334 Ref: miRNA-185 serves as a prognostic factor and suppresses migration and invasion through Wnt1 in colon cancer. PMID: 29454608 Ref: Molecular dynamics of interaction of Sesamin and related compounds with the cancer marker beta-catenin: an in silico study. PMID: 29455637 Ref: Sp5 negatively regulates the proliferation of HCT116 cells by upregulating the transcription of p27. PMID: 29456745 Ref: Abrus agglutinin stimulates BMP-2-dependent differentiation through autophagic degradation of beta-catenin in colon cancer stem cells. PMID: 29457276 Ref: Modulation of the colon cancer cell phenotype by pro-inflammatory macrophages: A preclinical model of surgery-associated inflammation and tumor recurrence. PMID: 29462209 Ref: Loss of CDX2 gene expression is associated with DNA repair proteins and is a crucial member of the Wnt signaling pathway in liver metastasis of colorectal cancer. PMID: 29467879 Ref: Microenvironment dependent gene expression signatures in reprogrammed human colon normal and cancer cell lines. PMID: 29482503 Ref: Nigericin Exerts Anticancer Effects on Human Colorectal Cancer Cells by Inhibiting Wnt/beta-catenin Signaling Pathway. PMID: 29483216 Ref: A silyl andrographolide analogue suppresses Wnt/beta-catenin signaling pathway in colon cancer. PMID: 29501763 Ref: Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells. PMID: 29507187 Ref: Genetic Biopsy for Prediction of Surveillance Intervals after Endoscopic Resection of Colonic Polyps: Results of the GENESIS Study. PMID: 29511559 Ref: Wnt/catenin beta1/microRNA 183 predicts recurrence and prognosis of patients with colorectal cancer. PMID: 29541213 Ref: Colon cancers carrying BRAF V600E and beta-catenin T41A activating mutations are resistant to numerous common anticancer drugs. PMID: 29541216 Ref: The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression. PMID: 29551399 Ref: beta-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy. PMID: 29551770 Ref: Colon cancer-induced interleukin-35 inhibits beta-catenin-mediated pro-oncogenic activity. PMID: 29552287 Ref: Cytotoxic activity of the twigs of Cinnamomum cassia through the suppression of cell proliferation and the induction of apoptosis in human colorectal cancer cells. PMID: 29554905 Ref: CREPT facilitates colorectal cancer growth through inducing Wnt/beta-catenin pathway by enhancing p300-mediated beta-catenin acetylation. PMID: 29563608 Ref: Extracted metabolite from Streptomyces Levis ABRIINW111 altered the gene expression in colon cancer. PMID: 29564063 Ref: Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells. PMID: 29568348 Ref: Retraction notice to "SRI36160 is a specific inhibitor of Wnt/ PMID: 29579438 Ref: Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells. PMID: 29587241 Ref: Wnt/beta-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells. PMID: 29594332 Ref: Ethanolic Extract of Traditional Chinese Medicine (TCM) Gamboge Inhibits Colon Cancer via the Wnt/Beta-Catenin Signaling Pathway in an Orthotopic Mouse Model. PMID: 29599307 Ref: Inhibition of DNMT suppresses the stemness of colorectal cancer cells through down-regulating Wnt signaling pathway. PMID: 29601907 Ref: A Positive Feed-Forward Loop between LncRNA-CYTOR and Wnt/beta-Catenin Signaling Promotes Metastasis of Colon Cancer. PMID: 29606502 Ref: Effects of secreted frizzled-related protein 1 on proliferation, migration, invasion, and apoptosis of colorectal cancer cells. PMID: 29610564 Ref: Long noncoding RNA BC200 regulates cell growth and invasion in colon cancer. PMID: 29625226 Ref: Revisiting colorectal cancer animal model - An improved metastatic model for distal rectosigmoid colon carcinoma. PMID: 29628185 Ref: Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116. PMID: 29637602 Ref: Ube2s stabilizes beta-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development. PMID: 29674637 Ref: Long non-coding RNA XIST sponges miR-34a to promotes colon cancer progression via Wnt/beta-catenin signaling pathway. PMID: 29679755 Ref: LncRNA HOTAIR is a Prognostic Biomarker for the Proliferation and Chemoresistance of Colorectal Cancer via MiR-203a-3p-Mediated Wnt/ss-Catenin Signaling Pathway. PMID: 29680837 Ref: Inhibitory effects of aesculetin on the proliferation of colon cancer cells by the Wnt/beta-catenin signaling pathway. PMID: 29725434 Ref: Immunohistochemical and genetic characteristics of a colorectal mucin-rich variant of traditional serrated adenoma. PMID: 29729192 Ref: Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/beta-Catenin Signaling. PMID: 29730655 Ref: Tetrandrine suppresses adhesion, migration and invasion of human colon cancer SW620 cells via inhibition of nuclear factor-kappaB, matrix metalloproteinase-2 and matrix metalloproteinase-9 signaling pathways. PMID: 29731901 Ref: Macrophages induce "budding" in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions. PMID: 29731961 Ref: Over-activation of AKT signaling leading to 5-Fluorouracil resistance in SNU-C5/5-FU cells. PMID: 29731993 Ref: Beta-elemene increases chemosensitivity to 5-fluorouracil through down-regulating microRNA-191 expression in colorectal carcinoma cells. PMID: 29737579 Ref: [A beta-catenin/IQGAP1 regulatory feedback loop and its effects on the proliferation of colon cancer cells]. PMID: 29745605 Ref: Multiproteomic and Transcriptomic Analysis of Oncogenic beta-Catenin Molecular Networks. PMID: 29747501 Ref: Long non-coding RNA SNHG1 predicts a poor prognosis and promotes colon cancer tumorigenesis. PMID: 29749530 Ref: LncRNA H19/miR-29b-3p/PGRN Axis Promoted Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Acting on Wnt Signaling. PMID: 29754471 Ref: Molecular Background of Colorectal Tumors From Patients With Lynch Syndrome Associated With Germline Variants in PMS2. PMID: 29758216 Ref: Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer. PMID: 29760449 Ref: The anti-cancer activity of an andrographolide analogue functions through a GSK-3beta-independent Wnt/beta-catenin signaling pathway in colorectal cancer cells. PMID: 29784906 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: YAP-dependent ubiquitination and degradation of beta-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer. PMID: 29789528 Ref: KLF4 Mediates the Effect of 5-ASA on the beta-Catenin Pathway in Colon Cancer Cells. PMID: 29794245 Ref: Tumor Necrosis Factor Ligand-Related Molecule 1A Regulates the Occurrence of Colitis-Associated Colorectal Cancer. PMID: 29796912 Ref: Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing Wnt/beta-catenin signaling. PMID: 29802196 Ref: Adenovirus-mediated overexpression FADD induces a significant antitumor effect on human colorectal cancer cells both in vitro and in vivo. PMID: 29808797 Ref: The NK1 receptor antagonist NKP608 inhibits proliferation of human colorectal cancer cells via Wnt signaling pathway. PMID: 29843798 Ref: Vicenin-2 inhibits Wnt/beta-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line. PMID: 29849451 Ref: Interaction between Wnt/beta-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of beta-catenin and RAS by targeting the Wnt/beta-catenin pathway. PMID: 29872723 Ref: Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis. PMID: 29875662 Ref: Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of beta-catenin signaling. PMID: 29884842 Ref: beta-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer. PMID: 29895971 Ref: P1 promoter-driven HNF4alpha isoforms are specifically repressed by beta-catenin signaling in colorectal cancer cells. PMID: 29898915 Ref: PSMD4 is a novel therapeutic target in chemoresistant colorectal cancer activated by cytoplasmic localization of Nrf2. PMID: 29899863 Ref: Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. PMID: 29909986 Ref: The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids. PMID: 29915160 Ref: beta-Catenin gene promoter hypermethylation by reactive oxygen species correlates with the migratory and invasive potentials of colon cancer cells. PMID: 29923144 Ref: [Antimicrobial peptide LL-37 in macrophages promotes colorectal cancer growth]. PMID: 29936765 Ref: Zerumbone inhibits epithelial-mesenchymal transition and cancer stem cells properties by inhibiting the beta-catenin pathway through miR-200c. PMID: 29943808 Ref: Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations. PMID: 29945573 Ref: MiR-195 suppresses colon cancer proliferation and metastasis by targeting WNT3A. PMID: 29948330 Ref: URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion. PMID: 29955600 Ref: The stress response gene ATF3 is a direct target of the Wnt/beta-catenin pathway and inhibits the invasion and migration of HCT116 human colorectal cancer cells. PMID: 29966001 Ref: Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting beta-catenin nuclear translocation. PMID: 29970879 Ref: Raddeanin A inhibits growth and induces apoptosis in human colorectal cancer through downregulating the Wnt/beta-catenin and NF-kappaB signaling pathway. PMID: 29972765 Ref: Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells. PMID: 29981429 Ref: beta-catenin regulates IRF3-mediated innate immune signalling in colorectal cancer. PMID: 30004146 Ref: Inhibitory effect of icariin on osteosarcoma cell proliferation via the Wnt/beta-catenin signaling pathway. PMID: 30008817 Ref: Inhibitory effect of selenomethionine on carcinogenesis in the model of human colorectal cancer in vitro and its link to the Wnt/beta-catenin pathway. PMID: 30016378 Ref: Wnt3a/beta-Catenin Signaling Conditions Differentiation of Partially Exhausted T-effector Cells in Human Cancers. PMID: 30018041 Ref: c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/beta-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation. PMID: 30029779 Ref: Deep sequencing and pathway-focused analysis revealed multigene oncodriver signatures predicting survival outcomes in advanced colorectal cancer. PMID: 30032163 Ref: Expression Profile of LGR5 and Its Prognostic Significance in Colorectal Cancer Progression. PMID: 30036518 Ref: LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells. PMID: 30038898 Ref: CYP24A1 Inhibition Facilitates the Antiproliferative Effect of 1,25(OH)2D3 Through Downregulation of the WNT/beta-Catenin Pathway and Methylation-Mediated Regulation of CYP24A1 in Colorectal Cancer Cells. PMID: 30052060 Ref: Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells. PMID: 30065304 Ref: Inositol hexaphosphate limits the migration and the invasiveness of colorectal carcinoma cells in vitro. PMID: 30066850 Ref: MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/beta-catenin signaling. PMID: 30068336 Ref: DBC1 regulates Wnt/beta-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer. PMID: 30082743 Ref: Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19. PMID: 30083271 Ref: Correction to: beta-Catenin gene promoter hypermethylation by reactive oxygen species correlates with the migratory and invasive potentials of colon cancer cells. PMID: 30088261 Ref: FLYWCH1, a Novel Suppressor of Nuclear beta-Catenin, Regulates Migration and Morphology in Colorectal Cancer. PMID: 30097457 Ref: Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts. PMID: 30098400 Ref: Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells. PMID: 30111797 Ref: MiRNA-206 suppresses PGE2-induced colorectal cancer cell proliferation, migration, and invasion by targetting TM4SF1. PMID: 30135139 Ref: ELF3 is an antagonist of oncogenic-signalling-induced expression of EMT-TF ZEB1. PMID: 30148686 Ref: Opposite functions of GSN and OAS2 on colorectal cancer metastasis, mediating perineural and lymphovascular invasion, respectively. PMID: 30148861 Ref: Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/beta-Catenin Signaling in Colon Cancer Cells. PMID: 30150508 Ref: DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis. PMID: 30158634 Ref: CircRNA_100290 promotes colorectal cancer progression through miR-516b-induced downregulation of FZD4 expression and Wnt/beta-catenin signaling. PMID: 30173892 Ref: An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissues. PMID: 30177831 Ref: The lncRNA NEAT1 activates Wnt/beta-catenin signaling and promotes colorectal cancer progression via interacting with DDX5. PMID: 30185232 Ref: CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases. PMID: 30185549 Ref: beta-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC. PMID: 30186819 Ref: Cell Motility Facilitated by Mono(2-ethylhexyl) Phthalate via Activation of the AKT-beta-Catenin-IL-8 Axis in Colorectal Cancer. PMID: 30188700 Ref: Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases. PMID: 30202242 Ref: Gland Attenuation, a Novel Morphological Feature of Colorectal Cancer: Evidence for an Epithelial-Mesenchymal Transition. PMID: 30208682 Ref: Upregulation of C/EBPalpha contributes to colorectal cancer growth, metastasis and indicates poor survival outcome. PMID: 30210916 Ref: Long non-coding RNA-CCAT2 promotes the occurrence of non-small cell lung cancer by regulating the Wnt/beta-catenin signaling pathway. PMID: 30214594 Ref: SCC-S2 Facilitates Tumor Proliferation and Invasion via Activating Wnt Signaling and Depressing Hippo Signaling in Colorectal Cancer Cells and Predicts Poor Prognosis of Patients. PMID: 30216108 Ref: Proliferative and Invasive Colorectal Tumors in Pet Dogs Provide Unique Insights into Human Colorectal Cancer. PMID: 30223484 Ref: Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/beta-Catenin Signaling Pathway. PMID: 30231258 Ref: RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model. PMID: 30238564 Ref: PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/beta-catenin signaling pathway. PMID: 30243096 Ref: Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/beta-Catenin Pathway. PMID: 30257507 Ref: Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/beta-Catenin Signaling. PMID: 30257989 Ref: Identification of DK419, a potent inhibitor of Wnt/beta-catenin signaling and colorectal cancer growth. PMID: 30274939 Ref: FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3beta-related pathways. PMID: 30275459 Ref: Loss of expression of mu-protocadherin and protocadherin-24 in sporadic and hereditary non polyposis colorectal cancers (HNPCC). PMID: 30296522 Ref: DNA-methylation-mediated silencing of miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/beta-catenin signal pathways. PMID: 30305607 Ref: Microcystin-LR promotes migration via the cooperation between microRNA-221/PTEN and STAT3 signal pathway in colon cancer cell line DLD-1. PMID: 30312888 Ref: Evaluation of a novel liquid biopsy-based ColoScape assay for mutational analysis of colorectal neoplasia and triage of FIT+ patients: a pilot study. PMID: 30315134 Ref: Sulforaphane inhibits growth and blocks Wnt/beta-catenin signaling of colorectal cancer cells. PMID: 30338040 Ref: MiR-30-5p suppresses cell chemoresistance and stemness in colorectal cancer through USP22/Wnt/beta-catenin signaling axis. PMID: 30338942 Ref: Clinical, Histologic, and Immunophenotypic Features of Serrated Polyps in Patients With Inflammatory Bowel Disease. PMID: 30344807 Ref: NUP153 overexpression suppresses the proliferation of colorectal cancer by negatively regulating Wnt/beta-catenin signaling pathway and predicts good prognosis. PMID: 30347601 Ref: TRIB3 Interacts with Beta-catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. PMID: 30365932 Ref: Taxifolin, a natural flavonoid interacts with cell cycle regulators causes cell cycle arrest and causes tumor regression by activating Wnt/ beta -catenin signaling pathway. PMID: 30367624 Ref: TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/beta-catenin signalling. PMID: 30374053 |