Primary Site >> Colorectal Cancer

Gene >> CSNK1A1

  • 2006
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  • 2018
Ref: Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines.
PMID: 16708370
 Ref: Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha.
PMID: 20890287
Ref: Independent interactions of phosphorylated beta-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions.
PMID: 21152425
 Ref: CKIalpha ablation highlights a critical role for p53 in invasiveness control.
PMID: 21331045
 Ref: Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer.
PMID: 23739040
Ref: A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.
PMID: 23890787
Ref: Modeling the effect of APC truncation on destruction complex function in colorectal cancer cells.
PMID: 24086117
 Ref: Calotropin: a cardenolide from calotropis gigantea that inhibits Wnt signaling by increasing casein kinase 1alpha in colon cancer cells.
PMID: 24644251
Ref: The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of beta-catenin through mechanisms involving FRAT1 and PAK4.
PMID: 24829151
 Ref: Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1alpha by Chemical Proteomics.
PMID: 27031502
Ref: Casein kinase 1 is recruited to nuclear speckles by FAM83H and SON.
PMID: 27681590
 Ref: Differential abundance of CK1alpha provides selectivity for pharmacological CK1alpha activators to target WNT-dependent tumors.
PMID: 28655862
 Ref: CK1alpha overexpression correlates with poor survival in colorectal cancer.
PMID: 29409464