Primary Site >> Colorectal Cancer

Gene >> CNR2

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Ref: Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes.
PMID: 15034673
 Ref: The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.
PMID: 17583570
 Ref: Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines.
PMID: 18938775
Ref: Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells.
PMID: 19047095
 Ref: The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.
PMID: 20514410
 Ref: [Anandamide inhibits the growth of colorectal cancer cells through CB1 and lipid rafts].
PMID: 21575494
Ref: Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent.
PMID: 22110202
 Ref: Cannabinoid receptor CB2 modulates axon guidance.
PMID: 23951024
 Ref: Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.
PMID: 24373545
Ref: Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.
PMID: 25269802
 Ref: Cannabinoids receptor type 2, CB2, expression correlates with human colon cancer progression and predicts patient survival.
PMID: 25859556
Ref: Endocannabinoid and ceramide levels are altered in patients with colorectal cancer.
PMID: 25975960
 Ref: CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3beta signaling pathway.
PMID: 27634891
 Ref: Power of screening tests for colorectal cancer enhanced by high levels of M2-PK in addition to FOBT.
PMID: 28155016
Ref: Fatty acid amide hydrolase (FAAH) inhibitor PF-3845 reduces viability, migration and invasiveness of human colon adenocarcinoma Colo-205 cell line: an in vitro study.
PMID: 28850633