Primary Site >> Colorectal Cancer

Gene >> CIITA

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Ref: Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells.
PMID: 16210330
Ref: Epithelial human leukocyte antigen-DR expression predicts reduced recurrence rates and prolonged survival in rectal cancer patients.
PMID: 18281539
Ref: Polymorphism in MHC class II transactivator gene is not associated with susceptibility to colorectal cancer in Swedish patients.
PMID: 18630461
Ref: MHC Class II alleles in ulcerative colitis-associated colorectal cancer.
PMID: 19251712
Ref: Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes.
PMID: 20013806
Ref: Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers.
PMID: 21804607
Ref: Exosomes from CIITA-transfected CT26 cells enhance anti- tumor effects.
PMID: 23621273
Ref: Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer.
PMID: 25445815
Ref: Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells.
PMID: 27509880
Ref: High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer.
PMID: 29308317