Primary Site >> Stomach Cancer
Gene >> CHEK1
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Ref: Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability. PMID: 11691784 |
Ref: Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance. PMID: 16103057 |
Ref: Administration sequence-dependent antitumor effects of paclitaxel and 5-fluorouracil in the human gastric cancer cell line MKN45. PMID: 16075279 |
Ref: Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide. PMID: 20401435 Ref: [Expression of checkpoint kinase 1 and polo-like kinase 1 and its clinicopathological significance in benign and malignant lesions of the stomach]. PMID: 21051833 |
Ref: Pteridium aquilinum and its ptaquiloside toxin induce DNA damage response in gastric epithelial cells, a link with gastric carcinogenesis. PMID: 22143989 Ref: Xanthatin induces G2/M cell cycle arrest and apoptosis in human gastric carcinoma MKN-45 cells. PMID: 22532019 |
Ref: Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line. PMID: 23568717 |
Ref: Chk1, but not Chk2, is responsible for G2/M phase arrest induced by diallyl disulfide in human gastric cancer BGC823 cells. PMID: 24650757 Ref: Diallyl disulfide selectively causes checkpoint kinase-1 mediated G2/M arrest in human MGC803 gastric cancer cell line. PMID: 25176258 |
Ref: Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner. PMID: 25334010 |
Ref: CHK1 expression in Gastric Cancer is modulated by p53 and RB1/E2F1: implications in chemo/radiotherapy response. PMID: 26867682 Ref: [Jaridonin, a new diterpenoid from Isodon rubescens, induces cell cycle arrest in gastric cancer cells through activating ataxia telangiectasia mutated kinase]. PMID: 27087371 |
Ref: DNA damage repair and survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy. PMID: 28233295 Ref: Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. PMID: 28401005 Ref: MAEL contributes to gastric cancer progression by promoting ILKAP degradation. PMID: 29371914 |
Ref: Chk1 activation attenuates sensitivity of lapatinib in HER2-positive gastric cancer. PMID: 29271513 Ref: Expression of DNA damage response proteins in gastric cancer: Comprehensive protein profiling and histological analysis. PMID: 29328366 Ref: RNF138 confers cisplatin resistance in gastric cancer cells via activating Chk1 signaling pathway. PMID: 30260263 |