Primary Site >> Stomach Cancer
Gene >> CDX2
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Ref: Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines. PMID: 10942535 |
Ref: Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. PMID: 11790453 Ref: Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. PMID: 11875002 Ref: CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: Prognostic implications. PMID: 12239615 Ref: CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. PMID: 12404231 |
Ref: Oncocytic adenocarcinoma of the rectum with diffuse intra-luminal microcalcifications: the first reported case. PMID: 12955503 |
Ref: Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells. PMID: 14615935 Ref: PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas. PMID: 14960508 Ref: Immunohistochemical characterization of signet-ring cell carcinomas of the stomach, breast, and colon. PMID: 15198362 Ref: Runx3-/- gastric epithelial cells differentiate into intestinal type cells. PMID: 15358215 Ref: Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. PMID: 15520178 |
Ref: Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. PMID: 15498792 Ref: Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma. PMID: 15591501 Ref: Expression of homeodomain protein CDX2 in gallbladder carcinomas. PMID: 15645288 Ref: CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach. PMID: 15732140 Ref: Utility of immunohistochemistry in distinguishing primary adenocarcinomas from metastatic breast carcinomas in the gastrointestinal tract. PMID: 15737028 Ref: Aberrant expression of the gastric mucin MUC6 in human pulmonary adenocarcinoma xenografts. PMID: 15753982 Ref: Interferon gamma induction of gastric mucous neck cell hypertrophy. PMID: 15765119 Ref: Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. PMID: 15825076 Ref: Co-expression of CDX2 and MUC2 in gastric carcinomas: correlations with clinico-pathological parameters and prognosis. PMID: 15929165 Ref: Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice. PMID: 15970710 Ref: Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer. PMID: 16044349 Ref: Microsatellite instability is linked to loss of hMLH1 expression in advanced gastric cancers: lack of a relationship with the histological type and phenotype. PMID: 16086119 Ref: Tumor induction by azoxymethane (AOM) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in F344 rat gastric mucosa featuring intestinal metaplasia caused by X-irradiation. PMID: 16110765 Ref: [Cdx2 and gastric carcinoma]. PMID: 16124704 Ref: Expression of Cdx2 and hepatocyte antigen in gastric carcinoma: correlation with histologic type and implications for prognosis. PMID: 16144916 Ref: Colonic and small-intestinal phenotypes in gastric cancers: relationships with clinicopathological findings. PMID: 16185290 Ref: OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells. PMID: 16278805 |
Ref: CDX2 does not suppress tumorigenicity in the human gastric cancer cell line MKN45. PMID: 16331267 Ref: [Expression of intestine-specific transcription factor CDX2 in different subtypes of intestinal metaplasia and gastric carcinoma]. PMID: 16480583 Ref: CDX2 expression is increased in gastric cancers with less invasiveness and intestinal mucin phenotype. PMID: 16803685 Ref: Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer exhibits sonic hedgehog loss and aberrant CDX2 expression. PMID: 17209848 |
Ref: Expression of the caudal-type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma. PMID: 17295772 Ref: CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. PMID: 17906616 Ref: Homeoprotein Cdx2 and nuclear PTEN expression profiles are related to gastric cancer prognosis. PMID: 18184409 |
Ref: Mucosal colonization of gastric endocrine tumors mimicking mixed neoplasms. PMID: 18080138 Ref: Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma. PMID: 18251778 Ref: Genetic alterations of the Cdx2 gene in gastric cancer. PMID: 18254783 Ref: A clinicopathological study on the expression of cadherin-17 and caudal-related homeobox transcription factor (CDX2) in human gastric carcinoma. PMID: 18353622 Ref: Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration. PMID: 18400571 Ref: Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. PMID: 18498120 Ref: Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma. PMID: 18580680 Ref: Polymeric immunoglobulin receptor-negative tumors represent a more aggressive type of adenocarcinomas of distal esophagus and gastroesophageal junction. PMID: 18684029 Ref: [Caudal-related homeobox 2 gene expression and its effects on human gastric carcinoma cell line]. PMID: 19035222 Ref: [Expression of guanylyl cyclase-c and caudal type homeobox transcription factor 2 in human gastric cancer and precursor lesions]. PMID: 19159573 |
Ref: Phosphatase activity of nuclear PTEN is required for CDX2-mediated intestinal differentiation of gastric carcinoma. PMID: 18996641 Ref: DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients. PMID: 19170207 Ref: Expression of osteopontin and CDX2: indications of phenotypes and prognosis in advanced gastric cancer. PMID: 19212618 Ref: Expression profile of REG family proteins REG Ialpha and REG IV in advanced gastric cancer: comparison with mucin phenotype and prognostic markers. PMID: 19329938 Ref: [Case of a sigmoid colon cancer with metachronous metastases of the stomach and the abdominal wall]. PMID: 19420869 Ref: A distinctive novel epitheliomesenchymal biphasic tumor of the stomach in young adults ("gastroblastoma"): a series of 3 cases. PMID: 19718790 Ref: CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer. PMID: 19724852 Ref: Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomach. PMID: 19725873 |
Ref: CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance. PMID: 19820687 Ref: Overexpression of Cdx2 inhibits progression of gastric cancer in vitro. PMID: 20043087 Ref: Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation. PMID: 20199401 Ref: Gastrointestinal stromal tumor and gastric adenocarcinoma collision tumors. PMID: 20381123 Ref: Monocyte chemoattractant protein-1 is generated via TGF-beta by myofibroblasts in gastric intestinal metaplasia and carcinoma without H. pylori infection. PMID: 20557309 Ref: Intestinal metaplasia -the effect of Acid on the gastric mucosa and gastric carcinogenesis-. PMID: 22272022 |
Ref: MiR-9 downregulates CDX2 expression in gastric cancer cells. PMID: 21225631 Ref: Loss of Runx3 is a key event in inducing precancerous state of the stomach. PMID: 21277301 Ref: Transcriptional factor typing with SOX2, HNF4aP1, and CDX2 closely relates to tumor invasion and Epstein-Barr virus status in gastric cancer. PMID: 21487519 Ref: The relationship among PDX1, CDX2, and mucin profiles in gastric carcinomas; correlations with clinicopathologic parameters. PMID: 21909647 Ref: Molecular pathology of gastric cancer: research and practice. PMID: 22005013 Ref: Molecular pathology of gastric carcinoma. PMID: 22104201 Ref: Predictability of Gastric Intestinal Metaplasia by Mottled Patchy Erythema Seen on Endoscopy. PMID: 27957016 |
Ref: Identification of cancer stem cells in vincristine preconditioned SGC7901 gastric cancer cell line. PMID: 21913215 Ref: Relationship between alpha-methylacyl-coenzyme A racemase expression and mucin phenotype in gastric cancer. PMID: 22078291 Ref: Aberrant expression of intelectin-1 in gastric cancer: its relationship with clinicopathological features and prognosis. PMID: 22083213 Ref: Association between environmental factors and CDX2 expression in gastric cancer patients. PMID: 22157086 Ref: The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7-/20+ phenotype is more specific than CDX2 antibody. PMID: 22268990 Ref: Cytokeratin expression profiling in gastric carcinoma: clinicopathologic significance and comparison with tumor-associated molecules. PMID: 22286119 Ref: Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype: reduction during tumor progression and favorable prognosis. PMID: 22411957 Ref: Gastric composite tumor of alpha fetoprotein-producing carcinoma/hepatoid adenocarcinoma and endocrine carcinoma with reference to cellular phenotypes. PMID: 22482081 Ref: siRNA targeting of Cdx2 inhibits growth of human gastric cancer MGC-803 cells. PMID: 22563170 Ref: Keratin 17 expression correlates with tumor progression and poor prognosis in gastric adenocarcinoma. PMID: 22695933 Ref: Expression and significance of homeodomain protein Cdx2 in gastric carcinoma and precancerous lesions. PMID: 22783055 Ref: Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells. PMID: 22791809 Ref: Bile acid promotes intestinal metaplasia and gastric carcinogenesis. PMID: 23010643 Ref: Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer. PMID: 23133598 Ref: Prognostic significance of Cdx2 immunohistochemical expression in gastric cancer: a meta-analysis of published literatures. PMID: 23181722 |
Ref: A clinical-biological risk stratification model for resected gastric cancer: prognostic impact of Her2, Fhit, and APC expression status. PMID: 23131390 Ref: The contribution of cell phenotype to the behavior of gastric cancer. PMID: 23329390 Ref: Reactivation of the homeotic tumor suppressor gene CDX2 by 5-aza-2'-deoxycytidine-induced demethylation inhibits cell proliferation and induces caspase-independent apoptosis in gastric cancer cells. PMID: 23408490 Ref: PTEN expression and suppression of proliferation are associated with Cdx2 overexpression in gastric cancer cells. PMID: 23546539 Ref: Premalignant conditions of gastric cancer. PMID: 23560829 Ref: Dysregulation of CDX1, CDX2 and SOX2 in patients with gastric cancer also affects the non-malignant mucosa. PMID: 23613102 Ref: Reversal of multidrug resistance in gastric cancer cells by CDX2 downregulation. PMID: 23864778 Ref: [Morphological observation of human gastric cancer cell SGC-7901 clones and identification of gastric cancer stem cells]. PMID: 23879994 Ref: TTF-1 and napsin A do not differentiate metastatic lung adenocarcinomas from primary esophageal adenocarcinomas: proposal of a novel staining panel. PMID: 23899066 Ref: Effects of the hippo signaling pathway in human gastric cancer. PMID: 24175801 Ref: Epigenetic effects of green tea polyphenols in cancer. PMID: 24283885 |
Ref: Reduced expression of alphaGlcNAc in Barrett's oesophagus adjacent to Barrett's adenocarcinoma--a possible biomarker to predict the malignant potential of Barrett's oesophagus. PMID: 24117499 Ref: An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. PMID: 24317510 Ref: New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer. PMID: 24744585 Ref: Gastric cancer patients less than 50 years of age exhibit significant downregulation of E-cadherin and CDX2 compared to older reference populations. PMID: 24797991 Ref: Modified-chitosan/siRNA nanoparticles downregulate cellular CDX2 expression and cross the gastric mucus barrier. PMID: 24925340 Ref: CDX2 can be regulated through the signalling pathways activated by IL-6 in gastric cells. PMID: 24953186 Ref: Cyclooxygenase 2 in gastric carcinoma is expressed in doublecortin- and CaM kinase-like-1-positive tuft cells. PMID: 25228975 Ref: Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome. PMID: 25300947 |
Ref: Differentiation reprogramming in gastric intestinal metaplasia and dysplasia: role of SOX2 and CDX2. PMID: 25196071 Ref: Overexpression of CDX2 in gastric cancer cells promotes the development of multidrug resistance. PMID: 25628941 Ref: Gastric-type expression signature in serrated pathway-associated colorectal tumors. PMID: 25704805 Ref: Overexpression of caudal type homeobox transcription factor 2 inhibits the growth of the MGC-803 human gastric cancer cell line in vivo. PMID: 25738600 Ref: CDX2 inhibits invasion and migration of gastric cancer cells by phosphatase and tensin homologue deleted from chromosome 10/Akt signaling pathway. PMID: 25881601 Ref: Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype. PMID: 26033320 Ref: Olfactomedin-related proteins 4 (OLFM4) expression is involved in early gastric carcinogenesis and of prognostic significance in advanced gastric cancer. PMID: 26070873 Ref: UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation. PMID: 26147747 Ref: Nuclear transcription factor CDX2 inhibits gastric cancercell growth and reverses epithelialtomesenchymal transition in vitro and in vivo. PMID: 26238762 Ref: NKX6.3 controls gastric differentiation and tumorigenesis. PMID: 26314965 Ref: Reactivation of CDX2 in Gastric Cancer as Mark for Gene Silencing Memory. PMID: 26379313 Ref: Pyloric gland adenoma: a histologic, immunohistochemical and molecular genetic study of 23 cases. PMID: 26421956 |
Ref: Inactivation of NKX6.3 in the stomach leads to abnormal expression of CDX2 and SOX2 required for gastric-to-intestinal transdifferentiation. PMID: 26743476 Ref: Leptin receptor signaling is required for high-fat diet-induced atrophic gastritis in mice. PMID: 26839577 Ref: Epigenetic changes of CDX2 in gastric adenocarcinoma. PMID: 27139434 Ref: CDX2 as a prognostic marker in gastric cancer. PMID: 27382937 Ref: Unusual focal keratin expression in plexiform angiomyxoid myofibroblastic tumor: A case report and review of the literature. PMID: 27428222 Ref: Impact of homeobox genes in gastrointestinal cancer. PMID: 27729732 Ref: A case report of chylous ascites after gastric bypass for morbid obesity. PMID: 27846453 |
Ref: Re-evaluation of Phenotypic Expression in Differentiated-type Early Adenocarcinoma of the Stomach. PMID: 28088838 Ref: Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection. PMID: 29021452 Ref: Helicobacter PyloriAssociation with Expression of CDX2 in Intestinal Metaplasia. PMID: 29132476 Ref: Immunohistochemical expression of CDX2, CK7, HER2 and HER4 in periampullary adenocarcinoma : implications for clinicopathology and patient outcomes. PMID: 29364095 Ref: CDX2 expression can predict response to neoadjuvant therapy in gastric carcinoma. PMID: 29556617 Ref: Long-term survival in a patient with advanced gastric cancer and metachronous right-sided colon cancer. PMID: 29556659 |
Ref: An extremely rare case of Epstein-Barr virus-associated gastric carcinoma with differentiation to neuroendocrine carcinoma. PMID: 29244230 Ref: Histologic and immunohistochemical differences between hereditary and sporadic diffuse gastric carcinoma. PMID: 29307626 Ref: Differentiating breast carcinoma with signet ring features from gastrointestinal signet ring carcinoma: assessment of immunohistochemical markers. PMID: 29317235 Ref: Morphologic and Immunohistochemical Appraisal of Primary Gastric Carcinomas. PMID: 29438113 Ref: [Value of immunocytochemistry in differential diagnosis of gastric adenocarcinoma, reactive mesothelial cells and malignant epithelial mesothelioma in metastatic effusion fluid]. PMID: 29534357 Ref: Diagnostic Algorithmic Proposal Based on Comprehensive Immunohistochemical Evaluation of 297 Invasive Endocervical Adenocarcinomas. PMID: 29851704 Ref: Pyloric Gland Adenoma (PGA) of the Gallbladder: A Unique and Distinct Tumor from PGAs of the Stomach, Duodenum, and Pancreas. PMID: 29975247 Ref: Purified sulforaphane from broccoli (Brassica oleracea var. italica) leads to alterations of CDX1 and CDX2 expression and changes in miR-9 and miR-326 levels in human gastric cancer cells. PMID: 30096452 Ref: Establishment and Characterization of gc-006-03, a Novel Human Signet Ring Cell Gastric Cancer Cell Line Derived from Metastatic Ascites. PMID: 30271482 Ref: Transduced caudal-type homeobox (CDX) 2/CDX1 can induce growth inhibition on CDX-deficient gastric cancer by rapid intestinal differentiation. PMID: 30289576 Ref: Pathologic differential diagnosis of metastatic carcinoma in the liver. PMID: 30300991 |