Primary Site >> Colorectal Cancer
Gene >> CDKN2B
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. PMID: 7553622 |
Ref: Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. PMID: 8631003 Ref: The molecular biology of esophageal carcinoma. PMID: 8893331 |
Ref: Establishment and characterization of 12 human colorectal-carcinoma cell lines. PMID: 10362137 |
Ref: Involvement of p21(Waf1/Cip1) and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate. PMID: 10607727 Ref: [Mechanism of resistance to growth inhibition by transforming growth factor-beta 1 (TGF-beta 1) in primary lung cancer and new molecular targets in therapy]. PMID: 10945024 |
Ref: Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors. PMID: 11536370 Ref: Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. PMID: 11584062 |
Ref: Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. PMID: 14715079 Ref: Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features. PMID: 14719065 Ref: Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. PMID: 15386372 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 |
Ref: Progressive methylation during the serrated neoplasia pathway of the colorectum. PMID: 15389252 Ref: Genotype phenotype correlations in Israeli colorectal cancer patients. PMID: 15523694 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: Loss of heterozygosity on chromosome 10p14-p15 in colorectal carcinoma. PMID: 16127298 |
Ref: Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. PMID: 16369045 Ref: Influence of methylated p15 and p16 genes on clinicopathological features in colorectal cancer. PMID: 16872319 |
Ref: Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium. PMID: 17365822 Ref: ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. PMID: 17513607 Ref: Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. PMID: 17597109 Ref: Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor. PMID: 17784872 Ref: High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. PMID: 17997817 Ref: Promoter hypermethylation of tumor-related genes in sporadic colorectal cancer in young patients. PMID: 18365548 |
Ref: Growth associated proteins in tumor cells and stroma related to disease progression of colon cancer accounting for tumor tissue PGE2 content. PMID: 18360718 Ref: Epigenetic events in normal colonic mucosa surrounding colorectal cancer lesions. PMID: 18938072 Ref: [Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]. PMID: 19140325 |
Ref: TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. PMID: 19208363 Ref: Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. PMID: 19690970 |
Ref: New insights into susceptibility to glioma. PMID: 20212223 Ref: Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. PMID: 20572039 Ref: cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells. PMID: 20957031 Ref: IGFBP-rP1, a potential molecule associated with colon cancer differentiation. PMID: 20977730 Ref: Epigenetic control of estrogen receptor expression and tumor suppressor genes is modulated by bioactive food compounds. PMID: 21088384 |
Ref: Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. PMID: 21523318 |
Ref: Distinct genetic and epigenetic signatures of colorectal cancers according to ethnic origin. PMID: 22028395 Ref: Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(beta-D-ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells. PMID: 22409771 Ref: Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer. PMID: 23010077 |
Ref: The oxysterol receptors LXRalpha and LXRbeta suppress proliferation in the colon. PMID: 22610535 Ref: microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis. PMID: 23208495 Ref: beta-Asarone induces senescence in colorectal cancer cells by inducing lamin B1 expression. PMID: 23357361 Ref: Common genetic variants in the 9p21 region and their associations with multiple tumours. PMID: 23361049 Ref: Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. PMID: 23434653 Ref: Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells. PMID: 23438367 Ref: ERRalpha metabolic nuclear receptor controls growth of colon cancer cells. PMID: 23720198 |
Ref: Demethylation effect of the antineoplaston AS2-1 on genes in colon cancer cells. PMID: 24213840 Ref: [Proliferative and invasive effects of inhibitors of kinase 4(P15(ink4b) and P16(ink4a)/CDKN2) gene activation on RKO human colorectal cancer cells]. PMID: 24519046 Ref: A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. PMID: 24623306 Ref: Loss of p15INK(4)b expression in colorectal cancer is linked to ethnic origin. PMID: 24716938 Ref: Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. PMID: 25051885 Ref: Regulatory roles of microRNA-708 and microRNA-31 in proliferation, apoptosis and invasion of colorectal cancer cells. PMID: 25202407 |
Ref: Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis. PMID: 25663692 Ref: Ontogenic expression profiles and oxaliplatin regulation of leptin expression in mice dorsal root ganglion. PMID: 26302162 Ref: Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells. PMID: 26341689 |
Ref: The Prognostic Significance of Histone Lysine Demethylase JMJD3/KDM6B in Colorectal Cancer. PMID: 26416711 Ref: Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis. PMID: 26637668 Ref: ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture. PMID: 26708220 Ref: Association of well-characterized lung cancer lncRNA polymorphisms with lung cancer susceptibility and platinum-based chemotherapy response. PMID: 26729200 Ref: [Roles of glucose-regulated protein 78 in proliferation and migration of human colorectal carcinoma cell line RKO]. PMID: 27256049 |
Ref: Long noncoding RNA BLACAT1 indicates a poor prognosis of colorectal cancer and affects cell proliferation by epigenetically silencing of p15. PMID: 28277544 Ref: CDKL1 promotes tumor proliferation and invasion in colorectal cancer. PMID: 28352193 Ref: High expression of long non-coding RNA ZEB1-AS1 promotes colorectal cancer cell proliferation partially by suppressing p15 expression. PMID: 28618933 Ref: PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity. PMID: 28729699 Ref: Upregulation of MicroRNA 18b Contributes to the Development of Colorectal Cancer by Inhibiting CDKN2B. PMID: 28784723 Ref: Screening of exon methylation biomarkers for colorectal cancer via LC-MS/MS strategy. PMID: 28940471 |
Ref: The 9p21 locus as a potential therapeutic target and prognostic marker in colorectal cancer. PMID: 29629612 Ref: The TGFbeta-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs. PMID: 29986714 Ref: Prognostic value of long noncoding RNAs in gastric cancer: a meta-analysis. PMID: 30147339 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 Ref: The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p. PMID: 30266084 |