Primary Site >> Esophagus Cancer
Gene >> CDKN2A
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Ref: Mammalian G1 cyclins. PMID: 7880531 Ref: The MTS1 gene is frequently mutated in primary human esophageal tumors. PMID: 7970734 Ref: Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. PMID: 8012957 Ref: Highly frequent homozygous deletion of the p16 gene in esophageal cancer cell lines. PMID: 8093026 |
Ref: Genomic DNA and messenger RNA expression alterations of the CDKN2B and CDKN2 genes in esophageal squamous carcinoma cell lines. PMID: 7547637 Ref: Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract. PMID: 7614482 Ref: MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines. PMID: 7845688 Ref: Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. PMID: 8595411 Ref: Multiple tumor-suppressor-1 gene and esophageal-carcinoma. PMID: 21552833 |
Ref: Low frequency of p16/CDKN2 gene mutations in esophageal carcinomas. PMID: 8621247 Ref: The molecular biology of esophageal carcinoma. PMID: 8893331 Ref: [RB gene expression in gastrointestinal tract]. PMID: 8920658 Ref: [Analysis of the p16INK4, p15INK4B genes abnormality and the amplification of cyclin D1 gene in esophageal cancer]. PMID: 8920671 Ref: [Genetic events during development of esophageal squamous cell carcinoma]. PMID: 8920674 Ref: Growth suppression of esophageal cancer cells by p16INK4 and p15INK4B in vitro. PMID: 9166536 Ref: [Loss of CDKN2 gene and amplification of cyclin D1 gene in human esophageal cancer]. PMID: 9387288 Ref: [The expression of Rb, p16 and cyclin D1 in 41 esophageal cancers]. PMID: 9388858 Ref: Expression of cyclin D1, CDK4 and p27KIP1 is associated with the p16MTS1 gene status in human esophageal carcinoma cell lines. PMID: 9414383 |
Ref: Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines. PMID: 9033652 Ref: p16 tumor suppressor gene mutations in Chinese esophageal carcinomas in Hong Kong. PMID: 9149125 Ref: Loss of heterozygosity on chromosome 9 and p16 (MTS1, CDKN2) gene mutations in esophageal cancers. PMID: 9212218 Ref: Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin D1. PMID: 9214595 Ref: Immunohistochemical studies on Waf1p21, p16, pRb and p53 in human esophageal carcinomas and neighboring epithelia from a high-risk area in northern China. PMID: 9311588 |
Ref: Effect of cyclin D1 and associated proteins on proliferation of esophageal squamous cell carcinoma. PMID: 9683778 Ref: Cell cycle-related gene abnormalities and product expression in esophageal carcinoma. PMID: 9759649 Ref: p53 and p16/CDKN2 gene mutations in esophageal tumors from a high-incidence area in South Africa. PMID: 9808520 Ref: Flavopiridol mediates cell cycle arrest and apoptosis in esophageal cancer cells. PMID: 9829756 Ref: [Deletion of MTS1/p16 gene in human esophageal carcinoma]. PMID: 10921045 |
Ref: Aberrant methylation of p16INK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China. PMID: 9934853 Ref: Clonal expansion and loss of heterozygosity at chromosomes 9p and 17p in premalignant esophageal (Barrett's) tissue. PMID: 10601379 Ref: Induction of differentiation-dependent apoptosis in human esophageal squamous cell carcinoma by adenovirus-mediated p21sdi1 gene transfer. PMID: 10632365 Ref: [Multiple tumor suppressor 1/p16 gene alterations in human esophageal squamous-cell carcinoma: clinical significance and regional difference]. PMID: 11776574 Ref: [p16 gene suppresses growth of human esophageal carcinoma cells]. PMID: 11776828 Ref: Esophageal cancer. PMID: 17023973 |
Ref: Caspase activation and changes in Bcl-2 family member protein expression associated with E2F-1-mediated apoptosis in human esophageal cancer cells. PMID: 10778992 Ref: Clinical application of malignancy potential grading as a prognostic factor of human esophageal cancers. PMID: 10819064 Ref: Early deregulation of the the p16ink4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient rats. PMID: 10969811 Ref: Adenovirus-mediated p16INK4 gene transfer significantly suppresses human breast cancer growth. PMID: 11023200 Ref: Frequent alterations in the expression of tumor suppressor genes p16INK4A and pRb in esophageal squamous cell carcinoma in the Indian population. PMID: 11079730 Ref: Clinicopathological studies of esophageal carcinoma in achalasia: analyses of carcinogenesis using histological and immunohistochemical procedures. PMID: 11268444 |
Ref: Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats. PMID: 11303587 Ref: Alterations in cyclin D1 expression in esophageal squamous cell carcinoma in the Indian population. PMID: 11315260 Ref: Esophageal squamous cell carcinomas with DNA replication errors (RER+) are associated with p16/pRb loss and wild-type p53. PMID: 11599796 |
Ref: Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome. PMID: 11815963 Ref: [Quantitive detection of multi-gene expressions and DNA content in the precancerous cells of esophageal carcinoma]. PMID: 11977632 Ref: [Molecular alterations in esophageal cancer]. PMID: 12094695 Ref: Adenovirus-mediated p14ARF gene transfer cooperates with Ad5CMV-p53 to induce apoptosis in human cancer cells. PMID: 12162819 Ref: Cell cycle-regulated factors in esophageal cancer. PMID: 12220423 Ref: The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas. PMID: 12234996 Ref: The role of tumor suppressor genes in esophageal cancer. PMID: 12592219 |
Ref: A cancer-prone case with a background of methylation of p16 tumor suppressor gene. PMID: 12631606 Ref: Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. PMID: 14633667 Ref: Expression properties of recombinant pEgr-P16 plasmid in esophageal squamous cell carcinoma induced by ionizing irradiation. PMID: 14669305 |
Ref: Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice. PMID: 14734483 Ref: Molecular biology of esophageal cancer. PMID: 15138356 Ref: Prognostic factors in esophageal cancer. PMID: 15143904 Ref: Detection of lymph node micrometastases by gene promoter hypermethylation in samples obtained by endosonography- guided fine-needle aspiration biopsy. PMID: 15240535 Ref: In situ analysis of p16/INK4 promoter hypermethylation in esophageal carcinoma and gastric carcinoma. PMID: 15612883 |
Ref: CGMIM: automated text-mining of Online Mendelian Inheritance in Man (OMIM) to identify genetically-associated cancers and candidate genes. PMID: 15796777 Ref: [Expression of retinoic acid receptor-beta mRNA and p16, p53, Ki67 proteins in esophageal carcinoma and its precursor lesions]. PMID: 15946564 Ref: Polymorphism of p16 INK4A and cyclin D1 in adenocarcinomas of the upper gastrointestinal tract. PMID: 16163549 Ref: Aberrant p16 methylation, a possible epigenetic risk factor in familial esophageal squamous cell carcinoma. PMID: 16227635 Ref: The molecular biology of esophageal adenocarcinoma. PMID: 16299787 |
Ref: ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells. PMID: 16380648 Ref: Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells. PMID: 16434257 Ref: Id-1 promotes proliferation of p53-deficient esophageal cancer cells. PMID: 16506209 Ref: Nicotine induces the fragile histidine triad methylation in human esophageal squamous epithelial cells. PMID: 16570269 Ref: Promoter methylation and response to chemotherapy and radiation in esophageal cancer. PMID: 16678495 Ref: Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagus. PMID: 16899597 Ref: [Plasma methylation-specific polymerase chain reaction as a diagnostic tool for esophageal cancer patients]. PMID: 17212085 Ref: Biomarkers in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma. PMID: 17576439 |
Ref: Papillomavirus type 16 E6/E7 and human telomerase reverse transcriptase in esophageal cell immortalization and early transformation. PMID: 16488074 Ref: Multistage carcinogenesis in Barrett's esophagus. PMID: 16713672 Ref: Circulating tumor cells and aberrant methylation as tumor markers in patients with esophageal cancer. PMID: 17348438 Ref: Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. PMID: 17405999 Ref: Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. PMID: 17650224 |
Ref: Genomic profiling of 766 cancer-related genes in archived esophageal normal and carcinoma tissues. PMID: 18241037 Ref: Hypermethylation of p16 gene promoter correlates with loss of p16 expression that results in poorer prognosis in esophageal squamous cell carcinomas. PMID: 18269647 Ref: Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays. PMID: 18519675 Ref: Aberrant methylation of p16, DLEC1, BLU and E-cadherin gene promoters in nasopharyngeal carcinoma biopsies from Tunisian patients. PMID: 18751390 Ref: [p53, p16 E COX-2 expression in esophageal squamous cell carcinoma and histopathological association]. PMID: 19148359 |
Ref: Aberrant promoter CpG island hypermethylation of the adenomatosis polyposis coli gene can serve as a good prognostic factor by affecting lymph node metastasis in squamous cell carcinoma of the esophagus. PMID: 18847451 Ref: Gene mutations in esophageal mucosa of chagas disease patients. PMID: 19414370 Ref: Aberrant promoter methylation and reduced expression of p16 gene in esophageal squamous cell carcinoma from Kashmir valley: a high-risk area. PMID: 19513816 Ref: Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice. PMID: 19627616 |
Ref: Genetic alterations in a telomerase-immortalized human esophageal epithelial cell line: implications for carcinogenesis. PMID: 20092939 Ref: Chromosomal imbalances are uncommon in chagasic megaesophagus. PMID: 20163722 Ref: p16INK4a hypermethylation and p53, p16 and MDM2 protein expression in esophageal squamous cell carcinoma. PMID: 20388212 Ref: Associations of risk factors obesity and occupational airborne exposures with CDKN2A/p16 aberrant DNA methylation in esophageal cancer patients. PMID: 20459442 Ref: Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma. PMID: 20549141 Ref: Expression of Bmi-1 gene in esophageal carcinoma cell EC9706 and its effect on cell cycle, apoptosis and migration. PMID: 20591222 Ref: [Effects of RNAi-silenced id1 gene on the biology behavior of esophageal cancer cell lines Eca-109]. PMID: 20629303 Ref: [Pathology and pathobiology of the oesophageal carcinoma]. PMID: 20954310 |
Ref: Functional polymorphisms associated with disease-free survival in resected carcinoma of the esophagus. PMID: 20922573 Ref: Human papillomavirus is detectable in Barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance. PMID: 21169053 |
Ref: Clear cell variant of squamous cell carcinoma originating in the esophagus: report of a case with immunohistochemical and oncogenetic analyses. PMID: 22243784 Ref: Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma. PMID: 22450065 Ref: Distinct involvement of 9p21-24 and 13q14.1-14.3 chromosomal regions in raw betel-nut induced esophageal cancers in the state of Meghalaya, India. PMID: 22938432 Ref: Expression of p14(ARF), p15(INK4b), p16(INK4a) and skp2 increases during esophageal squamous cell cancer progression. PMID: 22970012 |
Ref: Primary high-grade neuroendocrine carcinoma of the esophagus: a clinicopathologic and immunohistochemical study of 42 resection cases. PMID: 23426118 Ref: Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. PMID: 23525077 Ref: The role of cellular senescence in the gastrointestinal mucosa. PMID: 23710306 Ref: A systematic review of hypermethylation of p16 gene in esophageal cancer. PMID: 24240582 |
Ref: p14ARF repression induced by promoter methylation associated with metastasis in esophageal squamous cell carcinoma. PMID: 22973996 Ref: Prediction of response to endoscopic therapy of Barrett's dysplasia by using genetic biomarkers. PMID: 25085335 Ref: Integrative post-genome-wide association analysis of CDKN2A and TP53 SNPs and risk of esophageal adenocarcinoma. PMID: 25280564 |
Ref: Anti-p16 autoantibodies may be a useful biomarker for early diagnosis of esophageal cancer. PMID: 24811068 Ref: p16 hypermethylation: a biomarker for increased esophageal cancer susceptibility in high incidence region of North East India. PMID: 25361631 Ref: Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers. PMID: 25826681 |
Ref: Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis. PMID: 26785143 Ref: Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. PMID: 26873401 Ref: Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing. PMID: 26900290 Ref: Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression. PMID: 26936624 Ref: Radiosensitization of esophageal carcinoma cells by the silencing of BMI-1. PMID: 27108688 Ref: The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. PMID: 27110300 Ref: Hesa-A Effects on Cell Cycle Signaling in Esophageal Carcinoma Cell Line. PMID: 27957293 |
Ref: Accumulated promoter methylation as a potential biomarker for esophageal cancer. PMID: 27893424 Ref: Comprehensive characterization of genes associated with the TP53 signal transduction pathway in various tumors. PMID: 28258440 Ref: Genetic Alterations in Esophageal Tissues From Squamous Dysplasia to Carcinoma. PMID: 28365443 Ref: p16 gene silencing along with p53 single-nucleotide polymorphism and risk of esophageal cancer in Northeast India. PMID: 28459370 Ref: The Relation of HPV Infection and Expression of p53 and p16 Proteins in Esophageal Squamous Cells Carcinoma. PMID: 28529620 Ref: CDKN2A methylation in esophageal cancer: a meta-analysis. PMID: 28637022 Ref: Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene. PMID: 28693288 Ref: Multiregional sequencing reveals genomic alterations and clonal dynamics in primary malignant melanoma of the esophagus. PMID: 28972077 Ref: Predictive biomarkers for response of esophageal cancer to chemo(radio)therapy: A systematic review and meta-analysis. PMID: 29113666 |
Ref: Phase I study of single-agent ribociclib in Japanese patients with advanced solid tumors. PMID: 29059492 Ref: Retention Esophagitis as a Significant Clinical Predictor of Progression to Esophageal Cancer in Achalasia. PMID: 29506341 Ref: LncRNA SNHG7 promotes the proliferation of esophageal cancer cells and inhibits its apoptosis. PMID: 29771415 Ref: Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update. PMID: 29776635 Ref: Primary Esophageal Mixed Sarcomatoid and Small Cell Neuroendocrine Carcinoma With Brain Metastasis: A Challenging Diagnosis on Biopsy. PMID: 30009659 Ref: Relationship between the Methylation of Folic Acid Metabolism-Related Genes and the Incidence and Prognosis of Esophageal Cancer among Ethnic Kazakhs. PMID: 30123355 Ref: Distinct esophageal adenocarcinoma molecular subtype has subtype-specific gene expression and mutation patterns. PMID: 30355311 |