Primary Site >> Stomach Cancer
Gene >> CDKN1B
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Ref: Growth inhibitory effect of interferon-beta is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1 in a human gastric carcinoma cell line. PMID: 8993833 Ref: Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas. PMID: 9310133 |
Ref: Expression of cyclin dependent kinase inhibitor p21WAF1 alone and in combination with p27KIP1 shows prognostic value in gastric carcinoma. PMID: 9741540 |
Ref: Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: a prognostic factor independent of Ras. PMID: 9973218 Ref: Expression of cell-cycle regulators, cyclin E and p21WAF1/CIP1, potential prognostic markers for gastric cancer. PMID: 10218458 Ref: Impact of the expression of cyclin-dependent kinase inhibitor p27Kip1 and apoptosis in tumor cells on the overall survival of patients with non-early stage gastric carcinoma. PMID: 10223564 Ref: Helicobacter pylori inhibits the G1 to S transition in AGS gastric epithelial cells. PMID: 10344728 Ref: Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-beta-induced cell cycle arrest of gastric carcinoma cells. PMID: 10376964 Ref: Expression of p27/Kip1 is down-regulated in human prostate carcinoma progression. PMID: 10398122 Ref: Effect of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (vesnarinone) on the growth of gastric cancer cell lines. PMID: 10403550 Ref: Expression of p27Kip1 and cyclin D1 proteins is inversely correlated and is associated with poor clinical outcome in human gastric cancer. PMID: 10404130 Ref: Expression of p27Kip1, cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma. PMID: 10425291 Ref: Inhibition of gastric cancer by camptothecin involves apoptosis and multiple cellular pathways. PMID: 10455888 Ref: Reduced expression and altered subcellular localization of the cyclin-dependent kinase inhibitor p27(Kip1) in human colon cancer. PMID: 10559792 |
Ref: Reduced expression of the cell-cycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma. PMID: 10692028 Ref: Expression of tumor suppressor gene p16(INK4) products in primary gastric cancer. PMID: 10705239 Ref: Expressions of cell-cycle regulatory gene products in conventional gastric adenomas: possible immunohistochemical markers of malignant transformation. PMID: 10746668 Ref: Genetic and epigenetic alterations in multistep carcinogenesis of the stomach. PMID: 10779229 Ref: Induction of apoptosis in human gastric cancer by sodium butyrate. PMID: 10810354 Ref: Mutation and expression of the p27KIP1 and p57KIP2 genes in human gastric cancer. PMID: 10926119 Ref: Prognostic value of the cyclin-dependent kinase inhibitor p27Kip1 in gastric cancer. PMID: 10928108 Ref: Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1). PMID: 10948161 Ref: p27(Kip1) loss does not predict survival in patients with advanced gastric carcinoma. PMID: 11042561 Ref: Loss of p27Kip1 expression is a strong independent prognostic factor of reduced survival in N0 gastric carcinomas. PMID: 11147595 Ref: Significance of the expression of p27Kip1 in esophageal squamous cell carcinomas. PMID: 11206629 Ref: [Alterations of transforming growth factor beta 1 and p27kip1 mRNAs in gastric mucosa carcinogenesis]. PMID: 12212160 |
Ref: Genetic and epigenetic changes in stomach cancer. PMID: 11243597 Ref: Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells. PMID: 11313870 Ref: P27Kip1 expression and survival in NO gastric carcinoma. PMID: 11358008 Ref: Inhibition of proteasome function induced apoptosis in gastric cancer. PMID: 11477551 Ref: Effect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasia. PMID: 11552926 Ref: Effects of H. pylori infection of gastric epithelial cells on cell cycle control. PMID: 11578975 Ref: Combined examination of p27(Kip1), p21(Waf1/Cip1) and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma. PMID: 11903579 |
Ref: Troglitazone induces G1 arrest by p27(Kip1) induction that is mediated by inhibition of proteasome in human gastric cancer cells. PMID: 12149143 Ref: Helicobacter pylori releases a factor(s) inhibiting cell cycle progression of human gastric cell lines by affecting cyclin E/cdk2 kinase activity and Rb protein phosphorylation through enhanced p27(KIP1) protein expression. PMID: 12441136 |
Ref: p16Ink4a is overexpressed in H. pylori-associated gastritis and is correlated with increased epithelial apoptosis. PMID: 12603618 Ref: Nimesulide inhibits proliferation via induction of apoptosis and cell cycle arrest in human gastric adenocarcinoma cell line. PMID: 12717830 Ref: PPAR gamma ligand-induced apoptosis through a p53-dependent mechanism in human gastric cancer cells. PMID: 12824901 Ref: Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF. PMID: 12837699 Ref: Helicobacter pylori increases proteasome-mediated degradation of p27(kip1) in gastric epithelial cells. PMID: 12907657 Ref: [Effect of allitridi on cyclin D1 and p27(Kip1) protein expression in gastric carcinoma BGC823 cells]. PMID: 14693049 |
Ref: Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45. PMID: 14605879 Ref: Five-lipoxygenase-activating protein inhibitor MK-886 induces apoptosis in gastric cancer through upregulation of p27kip1 and bax. PMID: 14675240 Ref: [Correlation of Skp2 and P27kip1 protein expression and clinicopathological features of prostate cancer]. PMID: 14960249 Ref: P27kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori. PMID: 15138205 Ref: Evaluation of protein products of cell cycle regulating genes in gastric cancer. PMID: 15638378 |
Ref: COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. PMID: 15645119 Ref: p27kip1 expression is inversely related to the grade of gastric MALT lymphoma. PMID: 15722571 Ref: The prognostic significance of p53, p27 kip1, p21 waf1, HER-2/neu, and Ki67 proteins expression in gastric cancer: a clinicopathological and immunohistochemical study of 121 Arab patients. PMID: 16121348 Ref: p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice. PMID: 16285954 Ref: Effect of p27(KIP1) on cell cycle and apoptosis in gastric cancer cells. PMID: 16437650 |
Ref: Comparative immunoproteomics of identification and characterization of virulence factors from Helicobacter pylori related to gastric cancer. PMID: 16769709 Ref: Inhibition of cell cycle progression via p27Kip1 upregulation and apoptosis induction by an ethanol extract of Rhus verniciflua Stokes in AGS gastric cancer cells. PMID: 16786174 |
Ref: Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16(INK4A), p27(KIP1), p21(WAF1), Ki-67 expression patterns in gastric cancer. PMID: 16998811 Ref: Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. PMID: 17376510 Ref: Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells. PMID: 17389617 Ref: Prognostic significance of p21WAF1/CIP1, p27Kip1, p53 and E-cadherin expression in gastric cancer. PMID: 17483253 Ref: Prognostic implications of cyclin B1, p34cdc2, p27(Kip1) and p53 expression in gastric cancer. PMID: 17722244 |
Ref: Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. PMID: 18097546 Ref: Inhibition of the PI3K-Akt/PKB survival pathway enhanced an ethanol extract of Rhus verniciflua Stokes-induced apoptosis via a mitochondrial pathway in AGS gastric cancer cell lines. PMID: 18378393 Ref: Immunohistochemical expression of cell-cycle proteins in gastric precancerous lesions. PMID: 18397488 Ref: Mammalian target of rapamycin pathway inhibition enhances the effects of 5-aza-dC on suppressing cell proliferation in human gastric cancer cell lines. PMID: 18622747 Ref: The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines. PMID: 18774637 Ref: Extensive alteration in the expression profiles of TGFB pathway signaling components and TP53 is observed along the gastric dysplasia-carcinoma sequence. PMID: 18830930 Ref: Activated Akt as an indicator of prognosis in gastric cancer. PMID: 18841391 Ref: MG-132 inhibits telomerase activity, induces apoptosis and G(1) arrest associated with upregulated p27kip1 expression and downregulated survivin expression in gastric carcinoma cells. PMID: 19093261 |
Ref: Anticancer effect of celecoxib via COX-2 dependent and independent mechanisms in human gastric cancers cells. PMID: 18923901 Ref: CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma. PMID: 19081179 Ref: Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer. PMID: 19153141 Ref: FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27 kip1. PMID: 19235838 Ref: Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3. PMID: 19350572 Ref: RhoA regulates G1-S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors. PMID: 19372585 Ref: Endocrine dysfunction in p27Kip1 deficient mice and susceptibility to Wnt-1 driven breast cancer. PMID: 19380520 Ref: Arginine deiminase originating from Lactococcus lactis ssp. lactis American Type Culture Collection (ATCC) 7962 induces G1-phase cell-cycle arrest and apoptosis in SNU-1 stomach adenocarcinoma cells. PMID: 19624867 Ref: Upregulated p27kip1 can downregulate survivin expression and inhibit telomerase activity in gastric carcinoma cells. PMID: 19832036 Ref: Macrophage migration inhibitory factor regulates proliferation of gastric cancer cells via the PI3K/Akt pathway. PMID: 19938192 Ref: [Effect of weikangning on growth and cell cycle regulators of gastric cancer cell]. PMID: 20329612 |
Ref: The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells. PMID: 19850045 Ref: Anticancer bioactive peptide suppresses human gastric cancer growth through modulation of apoptosis and the cell cycle. PMID: 19956858 Ref: p27KIP1 expression in gastric cancer: differential pathways in the histological subtypes associated with Helicobacter pylori infection. PMID: 20059402 Ref: Evaluation of cell cycle protein expression in gastric cancer: cyclin B1 expression and its prognostic implication. PMID: 20334896 Ref: Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells. PMID: 20522955 Ref: Gastric adenocarcinoma and Helicobacter pylori: correlation with p53 mutation and p27 immunoexpression. PMID: 20541486 Ref: Absence of CIP1/KIP1 hypermethylation in gastric cancer patients from Northern Brazil. PMID: 20668328 |
Ref: Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27(Kip1). PMID: 19912438 Ref: Cetuximab enhances the activities of irinotecan on gastric cancer cell lines through downregulating the EGFR pathway upregulated by irinotecan. PMID: 21286718 Ref: Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells. PMID: 21312237 Ref: P27(Kip1), regulated by glycogen synthase kinase-3beta, results in HMBA-induced differentiation of human gastric cancer cells. PMID: 21439087 Ref: Sox17 regulates proliferation and cell cycle during gastric cancer progression. PMID: 21514720 Ref: Pivotal role of epithelial cell adhesion molecule in the survival of lung cancer cells. PMID: 21535318 |
Ref: MiR-196a is upregulated in gastric cancer and promotes cell proliferation by downregulating p27(kip1). PMID: 22343731 Ref: p27(kip1) upregulated by hnRNPC1/2 antagonizes CagA (a virulence factor of Helicobacter pylori)-mediated pathogenesis. PMID: 22404445 Ref: miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1. PMID: 22450659 Ref: Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. PMID: 22634261 Ref: A-62176, a potent topoisomerase inhibitor, inhibits the expression of human epidermal growth factor receptor 2. PMID: 22732416 Ref: ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI(3)K and MAPK signaling pathways in gastric cancer. PMID: 22799764 Ref: 7-difluoromethoxyl-5,4'-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1. PMID: 22969238 |
Ref: Connexin32 inhibits gastric carcinogenesis through cell cycle arrest and altered expression of p21Cip1 and p27Kip1. PMID: 23351380 Ref: FoxM1 is overexpressed in Helicobacter pylori-induced gastric carcinogenesis and is negatively regulated by miR-370. PMID: 23576572 Ref: Upregulation of miR-370 contributes to the progression of gastric carcinoma via suppression of FOXO1. PMID: 23721824 Ref: MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2. PMID: 23794145 Ref: Expression of p27Kip1 protein in gastric carcinoma. PMID: 23858559 Ref: Urushiol Induces Apoptosis via a p53-dependent Pathway in Human Gastric Cancer Cells. PMID: 25337543 |
Ref: Artemisinin inhibits gastric cancer cell proliferation through upregulation of p53. PMID: 24078446 Ref: Prolyl oligopeptidase inhibition-induced growth arrest of human gastric cancer cells. PMID: 24269815 Ref: Her3 is associated with poor survival of gastric adenocarcinoma: Her3 promotes proliferation, survival and migration of human gastric cancer mediated by PI3K/AKT signaling pathway. PMID: 24623015 Ref: Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress. PMID: 24971481 Ref: 14-3-3epsilon functions as an oncogene in SGC7901 gastric cancer cells through involvement of cyclin E and p27kip1. PMID: 25310086 |
Ref: Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells. PMID: 25609923 Ref: Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and N PMID: 25767376 Ref: MHY-449, a novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, mediates oxidative stress-induced apoptosis in AGS human gastric cancer cells. PMID: 25998412 |
Ref: Overexpressed CISD2 has prognostic value in human gastric cancer and promotes gastric cancer cell proliferation and tumorigenesis via AKT signaling pathway. PMID: 26565812 Ref: Sustained ERK activation-mediated proliferation inhibition of farrerol on human gastric carcinoma cell line by G0/G1-phase cell-cycle arrest. PMID: 26656929 Ref: GNA13 as a prognostic factor and mediator of gastric cancer progression. PMID: 26735177 Ref: MiR-320a inhibits gastric carcinoma by targeting activity in the FoxM1-P27KIP1 axis. PMID: 27086911 Ref: CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells. PMID: 27099442 Ref: [Correlation between cyclin-dependent kinase inhibitor p27kip1 and trastuzumab-resistance in gastric cancer]. PMID: 27269920 Ref: Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1. PMID: 27323780 Ref: Ablation of human telomerase reverse transcriptase (hTERT) induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism. PMID: 27494887 Ref: Inhibiting the role of Skp2 suppresses cell proliferation and tumorigenesis of human gastric cancer cells via the upregulation of p27kip1. PMID: 27572672 Ref: Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers. PMID: 27781065 Ref: MicroRNA-200c is involved in proliferation of gastric cancer by directly repressing p27(Kip1). PMID: 28955960 |
Ref: The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro. PMID: 28070831 Ref: Proteomic analysis of cell cycle arrest and differentiation induction caused by ATPR, a derivative of all-trans retinoic acid, in human gastric cancer SGC-7901 cells. PMID: 28164444 Ref: Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901. PMID: 28498440 Ref: Mutational analysis of driver genes with tumor suppressive and oncogenic roles in gastric cancer. PMID: 28729958 |
Ref: Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma. PMID: 29468062 Ref: Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. PMID: 29853970 Ref: Berberine: A potential adjunct for the treatment of gastrointestinal cancers? PMID: 30125974 Ref: A functional genetic variant in GAS5 lncRNA (rs145204276) modulates p27(Kip1) expression and confers risk for gastric cancer. PMID: 30269656 Ref: Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 (Kip1) axis. PMID: 30336780 Ref: A BAP31 intrabody induces gastric cancer cell death by inhibiting p27(kip1) proteasome degradation. PMID: 30338855 |