Primary Site >> Biliary tract Cancer

Gene >> CDKN1B

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Ref: p27(Kip1) expression in normal epithelia, precancerous lesions, and carcinomas of the gallbladder: association with cancer progression and prognosis.
PMID: 10796881
Ref: Cyclin D1 overexpression is a critical event in gallbladder carcinogenesis and independently predicts decreased survival for patients with gallbladder carcinoma.
PMID: 11106243
 Ref: Involvement of p38 mitogen-activated protein kinase signaling in transformed growth of a cholangiocarcinoma cell line.
PMID: 11124819
Ref: The role of p27kip1 protein expression on the biological behavior of intrahepatic cholangiocarcinoma.
PMID: 11343239
 Ref: Deregulation of G1/S transition is a common event in carcinoma of the ampulla of vater.
PMID: 12239913
 Ref: Low p27Kip1 expression is an independent prognostic factor in gallbladder carcinoma.
PMID: 12680166
Ref: Inhibition of cholangiocarcinoma growth by tannic acid.
PMID: 12717390
 Ref: Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest.
PMID: 14973068
Ref: Adenovirus expressing mutant p27kip1 enhanced apoptosis against cholangiocarcinoma than adenovirus-p27kip1 wild type.
PMID: 15011833
Ref: Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers.
PMID: 15596046
 Ref: [Effect of adenovirus-mediated mutant exogenous P27kip1 gene expression on the chemosensitivities of cholangiocarcinoma cell line].
PMID: 17217824
 Ref: Skp2 is an independent prognosticator of gallbladder carcinoma among p27(Kip1)-interacting cell cycle regulators: an immunohistochemical study of 62 cases by tissue microarray.
PMID: 17384652
Ref: Expression of p21 and p27 in gallbladder cancer.
PMID: 17457432
Ref: Expression of p21(Wafl/Cip1), p57(Kip2) and HER2/neu in patients with gallbladder cancer.
PMID: 17595796
 Ref: Immunohistochemically detected expression of p27(Kip1) and Skp2 predicts survival in patients with intrahepatic cholangiocarcinomas.
PMID: 19034576
Ref: ZD1839 (IRESSA) stabilizes p27Kip1 and enhances radiosensitivity in cholangiocarcinoma cell lines.
PMID: 19414361
Ref: Overexpression of adenovirus-mediated p27kip1 lacking the Jab1-binding region enhances cytotoxicity and inhibits xenografted human cholangiocarcinoma growth.
PMID: 19528460
 Ref: Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells.
PMID: 21331764
 Ref: Enhancer of zeste homolog 2 (EZH2) promotes progression of cholangiocarcinoma cells by regulating cell cycle and apoptosis.
PMID: 23887863
 Ref: Epidermal growth factor upregulates Skp2/Cks1 and p27(kip1) in human extrahepatic cholangiocarcinoma cells.
PMID: 24574749
 Ref: CRM-1 knockdown inhibits extrahepatic cholangiocarcinoma tumor growth by blocking the nuclear export of p27Kip1.
PMID: 27279267