Primary Site >> Colorectal Cancer
Gene >> CDK6
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Ref: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). PMID: 10207115 Ref: Differential cyclin-dependent kinase expression and activation in human colon cancer. PMID: 10216486 |
Ref: Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein. PMID: 11032757 Ref: A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1. PMID: 11089522 |
Ref: Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines. PMID: 11481417 |
Ref: [Stat3 signal transduction pathway orchestrates G1 to S cell cycle transition in colon cancer cells]. PMID: 12920809 |
Ref: Expression patterns of cell cycle and apoptosis-related genes in a multidrug-resistant human colon carcinoma cell line. PMID: 15180185 Ref: Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells. PMID: 15202011 Ref: Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. PMID: 15542782 Ref: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. PMID: 15604277 |
Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 |
Ref: Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. PMID: 16434969 |
Ref: Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells. PMID: 18948598 |
Ref: Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors. PMID: 18931700 Ref: MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. PMID: 19441017 |
Ref: miR-129 regulates cell proliferation by downregulating Cdk6 expression. PMID: 20404570 |
Ref: G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer. PMID: 20979106 Ref: Impact of cell-proliferation-associated gene expression on 2-deoxy-2-[(18)f]fluoro-D-glucose (FDG) kinetics as measured by dynamic positron emission tomography (dPET) in colorectal tumors. PMID: 21153447 Ref: EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators. PMID: 21653642 |
Ref: The chemopreventive agent ursodeoxycholic acid inhibits proliferation of colon carcinoma cells by suppressing c-Myc expression. PMID: 22395148 Ref: Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21. PMID: 22464014 Ref: Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family. PMID: 22983985 Ref: Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer. PMID: 23010077 |
Ref: In situ validation of an intestinal stem cell signature in colorectal cancer. PMID: 22637696 Ref: The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. PMID: 23308284 Ref: microRNA-16 represses colorectal cancer cell growth in vitro by regulating the p53/survivin signaling pathway. PMID: 23380758 Ref: Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PMID: 23637631 Ref: Sporadic colorectal cancer development shows rejuvenescence regarding epithelial proliferation and apoptosis. PMID: 24098334 |
Ref: Reg4-induced mitogenesis involves Akt-GSK3beta-beta-Catenin-TCF-4 signaling in human colorectal cancer. PMID: 24151146 Ref: microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma. PMID: 24647829 Ref: PD-0332991 induces G1 arrest of colorectal carcinoma cells through inhibition of the cyclin-dependent kinase-6 and retinoblastoma protein axis. PMID: 24765199 Ref: DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis. PMID: 24825593 Ref: Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway. PMID: 24932287 Ref: Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. PMID: 25051885 Ref: Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy. PMID: 25162504 Ref: CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest. PMID: 25351403 Ref: Cooperation of DLC1 and CDK6 affects breast cancer clinical outcome. PMID: 25425654 |
Ref: Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins. PMID: 24292678 Ref: MicroRNA-29b is a Novel Prognostic Marker in Colorectal Cancer. PMID: 25472644 Ref: Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer. PMID: 26074733 Ref: Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks. PMID: 26295583 Ref: Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis. PMID: 26457107 Ref: MicroRNA-219-5p functions as a tumor suppressor partially by targeting platelet-derived growth factor receptor alpha in colorectal cancer. PMID: 26458304 Ref: microRNA-26a and -584 inhibit the colorectal cancer progression through inhibition of the binding of hnRNP A1-CDK6 mRNA. PMID: 26494299 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 |
Ref: Pristimerin demonstrates anticancer potential in colorectal cancer cells by inducing G1 phase arrest and apoptosis and suppressing various pro-survival signaling proteins. PMID: 26718323 Ref: Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer. PMID: 26783196 Ref: Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors. PMID: 27217383 Ref: MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6. PMID: 27559432 Ref: MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression. PMID: 27568568 Ref: Stereoisomers of Astaxanthin Inhibit Human Colon Cancer Cell Growth by Inducing G2/M Cell Cycle Arrest and Apoptosis. PMID: 27726394 Ref: High expression of CREPT promotes tumor growth and is correlated with poor prognosis in colorectal cancer. PMID: 27773816 Ref: c-Myc is regulated by HIF-2alpha in chronic hypoxia and influences sensitivity to 5-FU in colon cancer. PMID: 27793037 |
Ref: CBX3 promotes colon cancer cell proliferation by CDK6 kinase-independent function during cell cycle. PMID: 28193906 Ref: The Novel Long Noncoding RNA TUSC7 Inhibits Proliferation by Sponging MiR-211 in Colorectal Cancer. PMID: 28214867 Ref: LncRNA SNHG12 promotes cell growth and inhibits cell apoptosis in colorectal cancer cells. PMID: 28225893 Ref: Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels. PMID: 28283655 Ref: RSK activation via ERK modulates human colon cancer cells response to PTHrP. PMID: 28385776 Ref: FOXQ1 promotes cancer metastasis by PI3K/AKT signaling regulation in colorectal carcinoma. PMID: 28559972 Ref: ICT1 predicts a poor survival and correlated with cell proliferation in diffuse large B-cell lymphoma. PMID: 28629825 Ref: Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth. PMID: 28708871 Ref: miR-6883 Family miRNAs Target CDK4/6 to Induce G1 Phase Cell-Cycle Arrest in Colon Cancer Cells. PMID: 29061672 Ref: Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells. PMID: 29137335 Ref: Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b. PMID: 29207676 |
Ref: Down-regulation of miRNA-320c promotes tumor growth and metastasis and predicts poor prognosis in human glioma. PMID: 29438779 Ref: Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer. PMID: 29760449 Ref: C-glycosyl flavone from Urginea indica inhibits proliferation & angiogenesis & induces apoptosis via cyclin-dependent kinase 6 in human breast, hepatic & colon cancer cell lines. PMID: 29806604 Ref: Anti-inflammation and Anti-Cancer Activity of Ethanol Extract of Antarctic Freshwater Microalga, Micractinium sp. PMID: 30008606 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 |