Primary Site >> Liver Cancer
Gene >> CDK1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Vitamin K3 inhibits growth of human hepatoma HepG2 cells by decreasing activities of both p34cdc2 kinase and phosphatase. PMID: 8382492 Ref: Effects of insulin on TGF-beta 1-induced cell growth inhibition in the human hepatoma cell lines. PMID: 8401323 |
Ref: Deferoxamine arrests in vitro the proliferation of porcine hepatocyte in G1 phase of the cell cycle. PMID: 9548269 Ref: [Changes with cell cycle of N-acetylglucosaminyl transferase III, IV and V in 7721 human hepatocarcinoma cells]. PMID: 12016961 |
Ref: Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. PMID: 10657978 Ref: Expression and prognostic role of cyclin-dependent kinase 1 (cdc2) in hepatocellular carcinoma. PMID: 10895070 Ref: Hepatocellular carcinoma cell cycle: study of Long-Evans cinnamon rats. PMID: 11003614 Ref: Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. PMID: 11038236 |
Ref: Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells. PMID: 12115564 Ref: K vitamins, PTP antagonism, and cell growth arrest. PMID: 12384979 |
Ref: Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis. PMID: 12601350 Ref: Effect of resveratrol on cell cycle proteins in murine transplantable liver cancer. PMID: 14562407 |
Ref: Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. PMID: 15082532 |
Ref: Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. PMID: 16025114 |
Ref: Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery. PMID: 17102938 |
Ref: Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways. PMID: 17475221 |
Ref: 2-Methoxyestradiol inhibits hepatocellular carcinoma cell growth by inhibiting Cdc25 and inducing cell cycle arrest and apoptosis. PMID: 18246350 Ref: TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop. PMID: 18393292 Ref: RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. PMID: 18521085 Ref: Effect of TM208 on QGY-7703 xenograft tumor growth. PMID: 18525318 Ref: Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells. PMID: 18957166 |
Ref: Growth inhibition of hepatocellular carcinoma cells in vitro and in vivo by the 8-methoxy analog of WMC79. PMID: 18641988 Ref: Asparanin A induces G(2)/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. PMID: 19254688 Ref: Gonadoblastoma locus and the TSPY gene on the human Y chromosome. PMID: 19306348 Ref: Anticancer activity and mechanisms of diacetyldianhydrogalactitol on hepatoma QGY-7703 cells. PMID: 19741503 Ref: Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase. PMID: 19787227 |
Ref: Xylocydine, a novel Cdk inhibitor, is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo. PMID: 19616371 Ref: Caffeine enhances radiosensitization to orthotopic transplant LM3 hepatocellular carcinoma in vivo. PMID: 20384627 Ref: Vanadium compounds discriminate hepatoma and normal hepatic cells by differential regulation of reactive oxygen species. PMID: 20443032 Ref: Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. PMID: 20878096 Ref: Lobaplatin arrests cell cycle progression in human hepatocellular carcinoma cells. PMID: 21034513 Ref: [Role of p38MAPK in apoptosis of human paratumor cirrhosis hepatocellular cell line QSG-7701 induced by cisplatin]. PMID: 21205481 |
Ref: NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. PMID: 20948430 Ref: RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells. PMID: 21310960 Ref: Loss of transforming growth factor beta adaptor protein beta-2 spectrin leads to delayed liver regeneration in mice. PMID: 21520177 Ref: Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells. PMID: 21624128 Ref: Integrative network analysis identifies key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinoma. PMID: 21824427 Ref: GL-V9, a newly synthetic flavonoid derivative, induces mitochondrial-mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells. PMID: 21944925 Ref: [Construction and identification of adenoviral vectors expressing shRNA targeting CDK1 gene]. PMID: 21968300 |
Ref: Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. PMID: 21953552 Ref: Interaction of LHBs with C53 promotes hepatocyte mitotic entry: A novel mechanism for HBV-induced hepatocellular carcinoma. PMID: 21971960 Ref: Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways. PMID: 22213475 Ref: The activation of MEK/ERK signaling pathway by bone morphogenetic protein 4 to increase hepatocellular carcinoma cell proliferation and migration. PMID: 22241220 Ref: Resistance to paclitaxel in hepatoma cells is related to static JNK activation and prohibition into entry of mitosis. PMID: 22323130 Ref: S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers. PMID: 22407595 Ref: Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells. PMID: 22465358 Ref: [The effects of p38MAPK and HBxAg on cell proliferation and apoptosis in human hepatocarcinogenesis]. PMID: 22475145 Ref: Isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/m cell cycle arrest and apoptosis. PMID: 22623962 Ref: Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. PMID: 22841670 Ref: Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells. PMID: 22858649 |
Ref: Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. PMID: 23117090 Ref: Smh-3 induces G(2)/M arrest and apoptosis through calciummediated endoplasmic reticulum stress and mitochondrial signaling in human hepatocellular carcinoma Hep3B cells. PMID: 23233035 Ref: Biological features of core networks that result from a high-fat diet in hepatic and pulmonary tissues in mammary tumour-bearing, obesity-resistant mice. PMID: 23234678 Ref: Effects of sulfated polysaccharide from Masson pine (Pinus massoniana) pollen on the proliferation and cell cycle of HepG2 cells. PMID: 23270833 Ref: Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction. PMID: 23562365 Ref: Zoledronic acid inhibits growth of hepatocellular carcinoma cells in vitro and in vivo. PMID: 23595382 Ref: The role of CDK1 in apoptin-induced apoptosis in hepatocellular carcinoma cells. PMID: 23619525 Ref: [Study on inhibitory effect of triterpenoid saponin from Ardisia japonica TSP02 on proliferation and metastasis of human hepatocellular carcinoma cells and its mechanism]. PMID: 23717968 Ref: 4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway. PMID: 23733185 Ref: Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance. PMID: 23939380 Ref: Dihydromyricetin suppresses the proliferation of hepatocellular carcinoma cells by inducing G2/M arrest through the Chk1/Chk2/Cdc25C pathway. PMID: 24002546 Ref: Identification of biomarkers for hepatocellular carcinoma using network-based bioinformatics methods. PMID: 24083576 |
Ref: Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint. PMID: 24238094 Ref: Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. PMID: 24802190 Ref: Inhibitory effects of alpha-pinene on hepatoma carcinoma cell proliferation. PMID: 24815485 Ref: PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinoma. PMID: 24824184 Ref: Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. PMID: 24954031 Ref: Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling. PMID: 24980220 |
Ref: Induction of S phase arrest and apoptosis by ethyl acetate extract from Tetrastigma hemsleyanum in human hepatoma HepG2 cells. PMID: 25596082 Ref: Identifying hub genes and dysregulated pathways in hepatocellular carcinoma. PMID: 25753876 Ref: Anti-tumor effect of alpha-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest. PMID: 25837931 Ref: Accelerated hepatocellular carcinoma development in CUL4B transgenic mice. PMID: 25945838 Ref: miR-582-5p inhibits proliferation of hepatocellular carcinoma by targeting CDK1 and AKT3. PMID: 26002580 Ref: c-Myc plays a key role in TADs-induced apoptosis and cell cycle arrest in human hepatocellular carcinoma cells. PMID: 26045987 Ref: Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model. PMID: 26313006 Ref: Targeted inhibition of mitochondrial Hsp90 induces mitochondrial elongation in Hep3B hepatocellular carcinoma cells undergoing apoptosis by increasing the ROS level. PMID: 26351876 Ref: Molecular mechanisms underlying anticancer effects of myricetin. PMID: 26455550 Ref: Quantitative Proteomics Reveals That the Inhibition of Na(+)/K(+)-ATPase Activity Affects S-Phase Progression Leading to a Chromosome Segregation Disorder by Attenuating the Aurora A Function in Hepatocellular Carcinoma Cells. PMID: 26491887 Ref: Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis. PMID: 26536659 Ref: The tumor-suppressor gene LZTS1 suppresses hepatocellular carcinoma proliferation by impairing PI3K/Akt pathway. PMID: 26653561 Ref: Anti-cancer Activity of Osmanthus matsumuranus Extract by Inducing G2/M Arrest and Apoptosis in Human Hepatocellular Carcinoma Hep G2 Cells. PMID: 26734586 Ref: [Oleanolic acid induces G(2)/M phase arrest and apoptosis in human hepatocellular carcinoma Bel-7402 cells]. PMID: 27245040 |
Ref: JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells. PMID: 26621097 Ref: Systematic Analysis of Sex-Linked Molecular Alterations and Therapies in Cancer. PMID: 26755347 Ref: The Antitumor Effect of DYC-279 on Human Hepatocellular Carcinoma HepG2 Cells. PMID: 26849623 Ref: Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress. PMID: 26975930 Ref: Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis. PMID: 27052251 Ref: A novel cell cycle blocker extracted from Stellera chamaejasme L. inhibits the proliferation of hepatocarcinoma cells. PMID: 27109908 Ref: Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference. PMID: 27220462 Ref: EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway. PMID: 27244890 Ref: (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression. PMID: 27287718 Ref: A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells. PMID: 27525972 Ref: A Novel Tetraenoic Fatty Acid Isolated from Amaranthus spinosus Inhibits Proliferation and Induces Apoptosis of Human Liver Cancer Cells. PMID: 27669220 Ref: Inhibitory effects of Silibinin combined with doxorubicin in hepatocellular carcinoma; an in vivo study. PMID: 27685914 Ref: Sonic hedgehog signaling pathway mediates development of hepatocellular carcinoma. PMID: 27744627 Ref: Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition. PMID: 27909289 |
Ref: Romidepsin induces G2/M phase arrest via Erk/cdc25C/cdc2/cyclinB pathway and apoptosis induction through JNK/c-Jun/caspase3 pathway in hepatocellular carcinoma cells. PMID: 28012958 Ref: Korean Byungkyul - Citrus platymamma Hort.et Tanaka flavonoids induces cell cycle arrest and apoptosis, regulating MMP protein expression in Hep3B hepatocellular carcinoma cells. PMID: 28035361 Ref: Promotion of HepG2 cell apoptosis by flower of Allium atroviolaceum and the mechanism of action. PMID: 28187719 Ref: In vitro Antiproliferative and Apoptosis Inducing Effect of Allium atroviolaceum Bulb Extract on Breast, Cervical, and Liver Cancer Cells. PMID: 28197098 Ref: Synthesis and biological evaluation of novel pyrazolic chalcone derivatives as novel hepatocellular carcinoma therapeutics. PMID: 28219046 Ref: Aberrant expression of cell cycle and material metabolism related genes contributes to hepatocellular carcinoma occurrence. PMID: 28238542 Ref: Design, Synthesis and Evaluation of Naphthalimide Derivatives as Potential Anticancer Agents for Hepatocellular Carcinoma. PMID: 28241441 Ref: Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation. PMID: 28256105 Ref: Prognostic Biomarker Identification Through Integrating the Gene Signatures of Hepatocellular Carcinoma Properties. PMID: 28434945 Ref: E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma. PMID: 28607595 Ref: Bioinformatics analysis of key genes and pathways for hepatocellular carcinoma transformed from cirrhosis. PMID: 28640074 Ref: Gene expression profiling, pathway analysis and subtype classification reveal molecular heterogeneity in hepatocellular carcinoma and suggest subtype specific therapeutic targets. PMID: 29025594 Ref: Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance. PMID: 29130100 Ref: MiR-3613-3p affects cell proliferation and cell cycle in hepatocellular carcinoma. PMID: 29190974 |
Ref: UBAP2L silencing inhibits cell proliferation and G2/M phase transition in breast cancer. PMID: 29196913 Ref: A novel harmine derivative, N-(4-(hydroxycarbamoyl)benzyl)-1-(4- methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide (HBC), as histone deacetylase inhibitor: in vitro antiproliferation, apoptosis induction, cell cycle arrest, and antimetastatic effects. PMID: 29428472 Ref: Karyopherin subunit-alpha 2 expression accelerates cell cycle progression by upregulating CCNB2 and CDK1 in hepatocellular carcinoma. PMID: 29435009 Ref: Overexpression of Zwint predicts poor prognosis and promotes the proliferation of hepatocellular carcinoma by regulating cell-cycle-related proteins. PMID: 29440916 Ref: CDCA5 regulates proliferation in hepatocellular carcinoma and has potential as a negative prognostic marker. PMID: 29503564 Ref: Design, synthesis and biological evaluation of novel 1,3,4-trisubstituted pyrazole derivatives as potential chemotherapeutic agents for hepatocellular carcinoma. PMID: 29567429 Ref: Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. PMID: 29606879 Ref: Key signaling pathways, genes and transcription factors associated with hepatocellular carcinoma. PMID: 29658607 Ref: Identification and functional analysis of a core gene module associated with hepatitis C virus-induced human hepatocellular carcinoma progression. PMID: 29725417 Ref: Expression of the Long Intergenic Non-Protein Coding RNA 665 (LINC00665) Gene and the Cell Cycle in Hepatocellular Carcinoma Using The Cancer Genome Atlas, the Gene Expression Omnibus, and Quantitative Real-Time Polymerase Chain Reaction. PMID: 29728556 Ref: Screening and function analysis of hub genes and pathways in hepatocellular carcinoma via bioinformatics approaches. PMID: 29843214 Ref: Tetrandrine Enhances Radiosensitization in Human Hepatocellular Carcinoma Cell Lines. PMID: 29979637 Ref: Microarray gene expression profiling in colorectal (HCT116) and hepatocellular (HepG2) carcinoma cell lines treated with Melicope ptelefolia leaf extract reveals transcriptome profiles exhibiting anticancer activity. PMID: 30042885 Ref: Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest. PMID: 30055311 Ref: Blocking CDK1/PDK1/beta-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma. PMID: 30083256 Ref: Metformin induces miR-378 to downregulate the CDK1, leading to suppression of cell proliferation in hepatocellular carcinoma. PMID: 30104887 Ref: Antioxidant and anticancer activities of Trigonella foenum-graecum, Cassia acutifolia and Rhazya stricta. PMID: 30134897 Ref: Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality. PMID: 30190546 Ref: Knockdown of Ubiquitin Associated Protein 2-Like (UBAP2L) Inhibits Growth and Metastasis of Hepatocellular Carcinoma. PMID: 30291221 Ref: Exportin-T Promotes Tumor Proliferation and Invasion in Hepatocellular Carcinoma. PMID: 30334580 Ref: Bioinformatics identification of crucial genes and pathways associated with hepatocellular carcinoma. PMID: 30341252 Ref: Upregulation of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in Tumor Tissues Predicted Worse Overall Survival and Disease-Free Survival in Hepatocellular Carcinoma Patients. PMID: 30363964 Ref: Evodiamine Induces Apoptosis in SMMC-7721 and HepG2 Cells by Suppressing NOD1 Signal Pathway. PMID: 30384473 |