Primary Site >> Colorectal Cancer
Gene >> CDH1
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Ref: Colon carcinoma cells blocked in polarization exhibit increased expression of carcinoembryonic antigen. PMID: 8241027 |
Ref: Soluble fragments of e-cadherin cell-adhesion molecule increase in urinary-excretion of cancer-patients, potentially indicating its shedding from epithelial tumor-cells. PMID: 21559679 |
Ref: Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. PMID: 7757285 |
Ref: Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells. PMID: 10051639 Ref: Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. PMID: 10072428 |
Ref: The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea. PMID: 10896919 |
Ref: Germline mutation analysis of the transforming growth factor beta receptor type II (TGFBR2) and E-cadherin (CDH1) genes in early onset and familial colorectal cancer. PMID: 11158177 Ref: Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer. PMID: 11171827 Ref: A germline E-cadherin mutation in a family with gastric and colon cancer. PMID: 11562785 Ref: Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. PMID: 11729114 Ref: DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. PMID: 11751682 |
Ref: Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer. PMID: 11896626 Ref: Epigenetic control of the E-cadherin gene (CDH1) by CpG methylation in colectomy samples of patients with ulcerative colitis. PMID: 12203775 |
Ref: Geno- and pheno-typic characterization in ten patients with double-primary gastric and colorectal adenocarcinomas. PMID: 15083323 Ref: Germline mutational analysis of CDH1 and pathologic features in familial cancer syndrome with diffuse gastric cancer/breast cancer proband in a Chinese family. PMID: 15135482 Ref: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. PMID: 15476557 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 |
Ref: E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations. PMID: 16203744 |
Ref: Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. PMID: 16369045 Ref: CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. PMID: 16708352 Ref: The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas. PMID: 16804902 |
Ref: Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. PMID: 17221870 Ref: Establishment and characterization of a novel human colorectal cancer cell line (CLY) metastasizing spontaneously to the liver in nude mice. PMID: 17342324 Ref: Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development. PMID: 17890272 |
Ref: Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes. PMID: 17960397 Ref: The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis. PMID: 18196581 Ref: Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis. PMID: 18535175 Ref: Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. PMID: 19011631 Ref: RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. PMID: 19015318 |
Ref: AXIN2 and CDH1 polymorphisms, tooth agenesis, and oral clefts. PMID: 18683894 Ref: Promoter hypermethylation of tumor-related genes in peritoneal lavage and the prognosis of patients with colorectal cancer. PMID: 19384904 Ref: Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. PMID: 19417139 Ref: The CDH1-160C>A polymorphism is a risk factor for colorectal cancer. PMID: 19569232 Ref: E-cadherin and metalloproteinase-1 and -7 polymorphisms in colorectal cancer. PMID: 19634113 Ref: SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue. PMID: 19802011 Ref: [Hereditary non-polyposis colorectal cancer associated with hereditary gastric cancer. A case report.]. PMID: 19858019 Ref: Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer. PMID: 19861116 Ref: CDH1 promoter polymorphism (-347G-->GA) is a possible prognostic factor in sporadic colorectal cancer. PMID: 19908344 Ref: Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. PMID: 19915572 |
Ref: Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. PMID: 19795419 Ref: Epithelial-to-mesenchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells. PMID: 20406951 Ref: SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. PMID: 20543868 Ref: [Hypermethylation of the CDH1, SEPT9, HLTF and ALX4 genes and their diagnostic significance in colorectal cancer]. PMID: 20552891 Ref: Hypermethylation of RARbeta2 correlates with high COX-2 expression and poor prognosis in patients with colorectal carcinoma. PMID: 20571967 Ref: Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. PMID: 20572039 Ref: Genetic testing and prevention of hereditary cancer at the MMCI--over 10 years of experience. PMID: 21348412 |
Ref: Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. PMID: 21241068 Ref: A novel case of rhabdoid colon carcinoma associated with a positive CpG island methylator phenotype and BRAF mutation. PMID: 21315413 Ref: High frequency of genes' promoter methylation, but lack of BRAF V600E mutation among Iranian colorectal cancer patients. PMID: 21455633 Ref: Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variation and unexpected candidate target genes. PMID: 21531788 Ref: [Effects of CDH1 gene promoter methylation on expression of E-cadherin and beta-catenin and its clinicopathological significance in colon carcinoma]. PMID: 21792768 Ref: DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis. PMID: 22132162 |
Ref: E-cadherin (CDH1) gene promoter polymorphism and the risk of colorectal cancer : a meta-analysis. PMID: 21997289 Ref: Integrated analysis of whole genome exon array and array-comparative genomic hybridization in gastric and colorectal cancer cells. PMID: 22034905 Ref: A systematic review of the indications for genetic testing and prophylactic gastrectomy among patients with hereditary diffuse gastric cancer. PMID: 22160243 Ref: Germline promoter hypermethylation of tumor suppressor genes in gastric cancer. PMID: 22228973 Ref: SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation. PMID: 22286765 Ref: Analysis of cell adhesion during early stages of colon cancer based on an extended multi-valued logic approach. PMID: 22298312 Ref: The E-cadherin (CDH1) -C160A polymorphism and colorectal cancer susceptibility: a meta-analysis. PMID: 22339265 Ref: Characterization of gene-environment interactions for colorectal cancer susceptibility loci. PMID: 22367214 Ref: Enrichment of colorectal cancer stem cells through epithelial-mesenchymal transition via CDH1 knockdown. PMID: 22684815 Ref: Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions. PMID: 22788692 Ref: MiR-214 targets beta-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma. PMID: 22962603 Ref: Down-regulation of CDH1 is associated with expression of SNAI1 in colorectal adenomas. PMID: 23029563 |
Ref: Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models. PMID: 23543898 Ref: Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. PMID: 23737956 Ref: AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer. PMID: 23752226 Ref: Comparison of primarily diet-modifiable intestinal factors, connexin 43 and E-cadherin with TP53 and TGFB1 in colorectal cancer. PMID: 23803369 Ref: [Expression of molecular markers detected by immunohistochemistry and risk of lymph node metastasis in stage T1 and T2 colorecrectal cancers]. PMID: 23985256 Ref: Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. PMID: 24129635 Ref: The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. PMID: 24163370 Ref: beta-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths. PMID: 24268141 |
Ref: Modulation of N-glycosylation by mesalamine facilitates membranous E-cadherin expression in colon epithelial cells. PMID: 24184502 Ref: MicroRNA-147 induces a mesenchymal-to-epithelial transition (MET) and reverses EGFR inhibitor resistance. PMID: 24454732 Ref: PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice. PMID: 24530606 Ref: Role of CDH1 promoter methylation in colorectal carcinogenesis: a meta-analysis. PMID: 24684676 Ref: Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. PMID: 24691442 Ref: Shared and independent colorectal cancer risk alleles in TGFbeta-related genes in African and European Americans. PMID: 24753543 Ref: Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. PMID: 24760019 Ref: Roles of E-cadherin (CDH1) genetic variations in cancer risk: a meta-analysis. PMID: 24870781 Ref: Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) alterations to colorectal cancer susceptibility: a case-control study. PMID: 25146682 Ref: Epithelial-mesenchymal transition and somatic alteration in colorectal cancer with and without peritoneal carcinomatosis. PMID: 25157365 Ref: [Detection of CDH1 gene methylation of suspension cells in abdominal lavage fluid from colorectal cancer patients and its clinical significance]. PMID: 25421776 Ref: TIMP-1 expression in human colorectal cancer is associated with SMAD3 gene expression levels: a pilot study. PMID: 25532000 Ref: JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines. PMID: 25542019 |
Ref: SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. PMID: 25277775 Ref: Inhibitory effects of proton beam irradiation on integrin expression and signaling pathway in human colon carcinoma HT29 cells. PMID: 25845382 Ref: Analyses of 7,635 Patients with Colorectal Cancer Using Independent Training and Validation Cohorts Show That rs9929218 in CDH1 Is a Prognostic Marker of Survival. PMID: 25873087 Ref: Expression and promoter methylation status of hMLH1, MGMT, APC, and CDH1 genes in patients with colon adenocarcinoma. PMID: 25908636 Ref: Prognostic implications of adhesion molecule expression in colorectal cancer. PMID: 26097606 Ref: Expression Level of Genes Coding for Cell Adhesion Molecules of Cadherin Group in Colorectal Cancer Patients. PMID: 26167814 Ref: Colorectal cancer DNA methylation patterns from patients in Manaus, Brazil. PMID: 26363785 Ref: CDH1 POLYMORPHISMS AND LOW EXPRESSION OF E-CADHERIN AND beta-CATENIN IN COLORECTAL CANCER PATIENTS. PMID: 26511186 |
Ref: Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein. PMID: 25823022 Ref: NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing. PMID: 27121310 Ref: CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility. PMID: 27259261 Ref: The Effect of Analogues of 1alpha,25-Dihydroxyvitamin D(2) on the Regrowth and Gene Expression of Human Colon Cancer Cells Refractory to 5-Fluorouracil. PMID: 27314328 Ref: [New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "a la carte" treatment?]. PMID: 27345450 Ref: Downregulated long non-coding RNA CLMAT3 promotes the proliferation of colorectal cancer cells by targeting regulators of the cell cycle pathway. PMID: 27391344 Ref: 5-Azacytidine suppresses EC9706 cell proliferation and metastasis by upregulating the expression of SOX17 and CDH1. PMID: 27513557 Ref: Enhancement of Pathologist's Routine Practice: Reuse of DNA Extracted from Immunostained Formalin-fixed Paraffin-embedded (FFPE) Slides in Downstream Molecular Analysis of Cancer. PMID: 27566658 Ref: microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells. PMID: 27769860 |
Ref: MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. PMID: 28193514 Ref: Colitic Cancer Develops Through Mutational Alteration Distinct from that in Sporadic Colorectal Cancer: A Comparative Analysis of Mutational Rates at Each Step. PMID: 28871001 Ref: SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells. PMID: 29155818 Ref: [Current status of hereditary gastrointestinal neoplasms]. PMID: 29178089 Ref: Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort. PMID: 29212164 Ref: Association between the Epithelial Cadherin - 160C/A Polymorphism and Colorectal Cancer Risk: Evidence from a Meta-Analysis. PMID: 29283329 |
Ref: microRNA-145 downregulates SIP1-expression but differentially regulates proliferation, migration, invasion and Wnt signaling in SW480 and SW620 cells. PMID: 28833449 Ref: The silent healer: miR-205-5p up-regulation inhibits epithelial to mesenchymal transition in colon cancer cells by indirectly up-regulating E-cadherin expression. PMID: 29352232 Ref: miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer. PMID: 29374066 Ref: The impact of polyunsaturated fatty acids on DNA methylation and expression of DNMTs in human colorectal cancer cells. PMID: 29477476 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: FOXD4 induces tumor progression in colorectal cancer by regulation of the SNAI3/CDH1 axis. PMID: 30252597 Ref: Colorectal cancer susceptibility loci and influence on survival. PMID: 30350386 |