Primary Site >> Colorectal Cancer

Gene >> CD59

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Ref: Expression of CD59, a complement regulator protein and a second ligand of the CD2 molecule, and CD46 in normal and neoplastic colorectal epithelium.
PMID: 7692919
 Ref: Distribution of complement regulatory proteins, decay-accelerating factor, CD59/homologous restriction factor 20 and membrane cofactor protein in human colorectal adenoma and cancer.
PMID: 7532345
 Ref: Down-regulation of CD59 (protectin) expression on human colorectal adenocarcinoma cell lines by levamisole.
PMID: 7481554
 Ref: Human carcinomas variably express the complement inhibitory proteins CD46 (membrane cofactor protein), CD55 (decay-accelerating factor), and CD59 (protectin).
PMID: 8686736
 Ref: The complement regulatory proteins CD46 and CD59, but not CD55, are highly expressed by glandular epithelium of human breast and colorectal tumour tissues.
PMID: 9808413
 Ref: Expression and regulation by interferon-gamma of the membrane-bound complement regulators CD46 (MCP), CD55 (DAF) and CD59 in gastrointestinal tumours.
PMID: 10211099
 Ref: Glycophosphatidylinositol-anchored protein deficiency as a marker of mutator phenotypes in cancer.
PMID: 11212264
Ref: Immunization against tumor cell surface complement-regulatory proteins.
PMID: 11757799
Ref: Expression of 17-1A antigen and complement resistance factors CD55 and CD59 on liver metastasis in colorectal cancer.
PMID: 12086907
 Ref: Membrane-bound complement regulatory proteins inhibit complement activation by an immunotherapeutic mAb in a syngeneic rat colorectal cancer model.
PMID: 12909127
 Ref: Loss of CD55 is associated with aggressive breast tumors.
PMID: 15102687
 Ref: Expression of the membrane complement regulatory protein CD59 (protectin) is associated with reduced survival in colorectal cancer patients.
PMID: 16151805
Ref: Dexamethasone modifies the susceptibility to serum cytotoxicity and increases the metastatic efficiency of a colon carcinoma cell line.
PMID: 16380115
 Ref: Cell-surface density of complement restriction factors (CD46, CD55, and CD59): oral squamous cell carcinoma versus other solid tumors.
PMID: 17234541
 Ref: CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy?
PMID: 19380765
 Ref: Cytometric profiling of CD133+ cells in human colon carcinoma cell lines identifies a common core phenotype and cell type-specific mosaics.
PMID: 23709346
 Ref: CD55 limits sensitivity to complement-dependent cytolysis triggered by heterologous expression of alpha-gal xenoantigen in colon tumor cells.
PMID: 24763553
Ref: Systematic immunohistochemical analysis of the expression of CD46, CD55, and CD59 in colon cancer.
PMID: 24978917
 Ref: Silencing of CD59 enhanced the sensitivity of HT29 cells to 5-Fluorouracil and Oxaliplatin.
PMID: 25444672
 Ref: Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116.
PMID: 28036279