Primary Site >> Liver Cancer
Gene >> CCL2
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Ref: Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma. PMID: 12679798 |
Ref: Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization. PMID: 16052523 Ref: Molecular fingerprinting and autocrine growth regulation of endothelial cells in a murine model of hepatocellular carcinoma. PMID: 16397233 |
Ref: Lack of association of some chemokine system polymorphisms with the risks of death and hepatocellular carcinoma occurrence in patients with alcoholic cirrhosis: a prospective study. PMID: 17413295 |
Ref: Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis. PMID: 18205260 Ref: Optimal amount of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy against hepatocellular carcinoma by M1 macrophage activation. PMID: 19016769 |
Ref: Amphotericin B up-regulates angiogenic genes in hepatocellular carcinoma cell lines. PMID: 19260954 Ref: Identifying apoptosis-evasion proteins/pathways in human hepatoma cells via induction of cellular hormesis by UV irradiation. PMID: 19545154 Ref: Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis. PMID: 19706805 |
Ref: Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells. PMID: 19642141 Ref: Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients. PMID: 19720422 Ref: Pharmacologic concentrations of ascorbic acid cause diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines. PMID: 19932582 Ref: Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. PMID: 20525221 Ref: Pharmacologic concentrations of melatonin have diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines. PMID: 20970952 Ref: Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice. PMID: 21157824 |
Ref: Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNFalpha-signaling due to oxidative cellular stress in rats. PMID: 21295105 Ref: Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2. PMID: 21499310 Ref: Recombinant VP1, an Akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of CCL2 production. PMID: 21826248 |
Ref: Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma. PMID: 21930732 Ref: Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer. PMID: 22267597 Ref: Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells. PMID: 22681909 Ref: The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma. PMID: 22719066 Ref: Cancer-associated fibroblasts up-regulate CCL2, CCL26, IL6 and LOXL2 genes related to promotion of cancer progression in hepatocellular carcinoma cells. PMID: 22739041 Ref: High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells. PMID: 23089469 Ref: An immunosuppressive subtype of neutrophils identified in patients with hepatocellular carcinoma. PMID: 23170048 |
Ref: Recruitment of a myeloid cell subset (CD11b/Gr1 mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis. PMID: 23081697 Ref: Hepatocellular carcinoma cells cause different responses in expressions of cancer-promoting genes in different cancer-associated fibroblasts. PMID: 23684136 Ref: p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. PMID: 24043758 |
Ref: Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression. PMID: 24005989 Ref: Transcriptome profiling of malignant transformed rat hepatic stem-like cells by aflatoxin B1. PMID: 24299315 Ref: CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis. PMID: 24561613 Ref: Roles for chemokines in liver disease. PMID: 25066692 Ref: Tumor induced hepatic myeloid derived suppressor cells can cause moderate liver damage. PMID: 25401795 |
Ref: p53 suppresses CCL2-induced subcutaneous tumor xenograft. PMID: 25492482 Ref: Interleukin-8 Induces Expression of FOXC1 to Promote Transactivation of CXCR1 and CCL2 in Hepatocellular Carcinoma Cell Lines and Formation of Metastases in Mice. PMID: 26065367 Ref: Knockdown of SOX18 inhibits the proliferation, migration and invasion of hepatocellular carcinoma cells. PMID: 26151573 Ref: CD34(+) Liver Cancer Stem Cells Were Formed by Fusion of Hepatobiliary Stem/Progenitor Cells with Hematopoietic Precursor-Derived Myeloid Intermediates. PMID: 26192559 Ref: Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma. PMID: 26270232 |
Ref: Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible? PMID: 26761430 Ref: Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib. PMID: 26924089 Ref: FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling. PMID: 27216177 Ref: Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-beta pathways. PMID: 27216982 Ref: DJ-1 deficiency attenuates expansion of liver progenitor cells through modulating the inflammatory and fibrogenic niches. PMID: 27277679 Ref: A Novel Small Molecule Activator of Nuclear Receptor SHP Inhibits HCC Cell Migration via Suppressing Ccl2. PMID: 27486225 Ref: Sorafenib Inhibits Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Inhibition of Macrophage Infiltration. PMID: 27744426 Ref: Impact of myeloid-derived suppressor cell on Kupffer cells from mouse livers with hepatocellular carcinoma. PMID: 27999748 |
Ref: Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma. PMID: 26452628 Ref: Sorafenib with ASC-J9((R)) synergistically suppresses the HCC progression via altering the pSTAT3-CCL2/Bcl2 signals. PMID: 27668844 Ref: Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. PMID: 27980102 Ref: Genes directly regulated by NF-kappaB in human hepatocellular carcinoma HepG2. PMID: 28579529 Ref: Peri-tumor associated fibroblasts promote intrahepatic metastasis of hepatocellular carcinoma by recruiting cancer stem cells. PMID: 28716525 Ref: A Natural CCR2 Antagonist Relieves Tumor-associated Macrophage-mediated Immunosuppression to Produce a Therapeutic Effect for Liver Cancer. PMID: 28754304 Ref: IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness. PMID: 29113298 Ref: EphA2 signaling is impacted by carcinoembryonic antigen cell adhesion molecule 1-L expression in colorectal cancer liver metastasis in a cell context-dependent manner. PMID: 29262644 Ref: Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice. PMID: 29273476 |
Ref: Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma. PMID: 28866620 Ref: CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway. PMID: 29115520 Ref: Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B4. PMID: 29378914 Ref: Long non-coding RNA HOTAIR up-regulates chemokine (C-C motif) ligand 2 and promotes proliferation of macrophages and myeloid-derived suppressor cells in hepatocellular carcinoma cell lines. PMID: 29387231 Ref: Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma. PMID: 29556041 Ref: Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis. PMID: 30097285 |