Primary Site >> Colorectal Cancer
Gene >> CCKBR
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Ref: Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines. PMID: 3191491 |
Ref: Growth of colorectal carcinoma cells: regulation in vitro by gastrin, pentagastrin and the gastrin-receptor antagonist proglumide. PMID: 2760104 |
Ref: The effect of the gastrin receptor antagonist proglumide on survival in gastric carcinoma. PMID: 2207995 Ref: [The hormonal sensitivity of a transplantable adenocarcinoma of the large intestine]. PMID: 2226262 |
Ref: Influence of gastrin, gastrin receptor blockers, epidermal growth factor, and difluoromethylornithine on the growth and the activity of ornithine decarboxylase of colonic carcinoma cells. PMID: 1997467 |
Ref: CCK-8 and gastrin plasma levels in cholecystectomized and colorectal cancer patients. PMID: 8245672 |
Ref: Gastrin receptor gene expression in several human carcinomas. PMID: 7928627 Ref: Gastrin stimulates growth of human colon cancer cells via a receptor other than CCK-A or CCK-B. PMID: 8060296 Ref: Effects of gastrin on 3',5'-cyclic adenosine monophosphate, intracellular calcium, and phosphatidylinositol hydrolysis in human colon cancer cells. PMID: 8174118 |
Ref: Effect of endogenous hypergastrinemia on gastrin receptor expressing human colon carcinoma transplanted to athymic rats. PMID: 7557120 Ref: Gastrin sensitivity of primary human colorectal cancer: the effect of gastrin receptor antagonism. PMID: 8562170 |
Ref: Gastrin receptor antagonist CI-988 inhibits growth of human colon cancer in vivo and in vitro. PMID: 8611133 Ref: Dose dependent in vivo inhibition of human colorectal cancer (LoVo) by the gastrin receptor antagonist, CI-988. PMID: 8713686 |
Ref: Endocytosis of gastrin in cancer cells expressing gastrin/CCK-B receptor. PMID: 8995203 Ref: Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. PMID: 9287969 |
Ref: [Adjuvant intra-arterial chemotherapy with gastrin receptor antagonist after hepatic resection in colorectal cancer metastasis]. PMID: 9703835 Ref: [Gastrin-17 and G17-gly induce proliferation of LoVo cells through the CCK B/gastrin receptor]. PMID: 9762332 |
Ref: Expression of gastrin/CCK-B receptors does not lead to a mitogenic response to gastrin in two colon cell lines. PMID: 10452876 |
Ref: Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth. PMID: 10913157 Ref: Antiserum raised against an epitope of the cholecystokinin B/gastrin receptor inhibits hepatic invasion of a human colon tumor. PMID: 11059789 Ref: Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence. PMID: 11076881 Ref: Phase I/II study of G17-DT, an anti-gastrin immunogen, in advanced colorectal cancer. PMID: 11156225 |
Ref: Identification of a 70-kDa gastrin-binding protein on DLD-1 human colorectal carcinoma cells. PMID: 11551823 Ref: CCK-B/gastrin receptors in human colorectal cancer. PMID: 11589724 Ref: Molecular basis of colorectal cancer - role of gastrin and cyclooxygenase-2. PMID: 11687726 |
Ref: A misspliced form of the cholecystokinin-B/gastrin receptor in pancreatic carcinoma: role of reduced sellular U2AF35 and a suboptimal 3'-splicing site leading to retention of the fourth intron. PMID: 11830556 Ref: Frameshift mutations of human gastrin receptor gene (hGARE) in gastrointestinal cancers with microsatellite instability. PMID: 11896205 Ref: Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. PMID: 12239223 Ref: Progastrin and cyclooxygenase-2 in colorectal cancer. PMID: 12353842 |
Ref: Oncogenic ras induces gastrin/CCKB receptor gene expression in human colon cancer cell lines LoVo and Colo320HSR. PMID: 12761477 |
Ref: K-ras and B-raf gene mutations are not associated with gastrin- and CCK2-receptor mRNA expression in human colorectal tumour tissues. PMID: 14764072 Ref: Glycine-extended gastrin induces matrix metalloproteinase-1- and -3-mediated invasion of human colon cancer cells through type I collagen gel and Matrigel. PMID: 15185339 Ref: Gastrins, cholecystokinins and gastrointestinal cancer. PMID: 15238241 Ref: Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant. PMID: 15292208 Ref: The role of gastrin in colorectal carcinogenesis. PMID: 15570843 |
Ref: Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production. PMID: 15655524 Ref: [Expressions of cyclooxygenase-2 and cholecystokinin-B receptor mRNA in human colonic cancer and their significances]. PMID: 15694043 Ref: [Effect of gastrin on invasiveness of human colon cancer cells]. PMID: 15949418 Ref: Valine-286 residue in the third intracellular loop of the cholecystokinin 2 receptor exerts a pivotal role in cholecystokinin 2 receptor mediated intracellular signal transduction in human colon cancer cells. PMID: 15951156 Ref: [A study of gastrin-focal adhesion kinase signal pathway in human colon cancer cells]. PMID: 16008856 Ref: Gastrointestinal hormone receptors in primary human colorectal carcinomas. PMID: 16051276 Ref: Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo. PMID: 16143134 Ref: Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin. PMID: 16150104 |
Ref: Gastrin enhances the angiogenic potential of endothelial cells via modulation of heparin-binding epidermal-like growth factor. PMID: 16585174 Ref: Enhanced expression of cholecystokinin-2 receptor promotes the progression of colon cancer through activation of focal adhesion kinase. PMID: 16998832 Ref: Effects of gastrin 17 on beta-catenin/Tcf-4 pathway in Colo320WT colon cancer cells. PMID: 17167838 |
Ref: G17DT: an antigastrin immunogen for the treatment of gastrointestinal malignancy. PMID: 17309331 Ref: [The role of p38 MAPK in gastrin-induced u-PA expression in human colon cancer cells]. PMID: 17575684 Ref: An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells. PMID: 17604853 Ref: [Molecular mechanism of gastrin increasing colon cancer cells' invasion]. PMID: 17825155 Ref: [Effects of hFRNK on E-cadherin/beta-catenin in colon cancer cells in vitro]. PMID: 17892129 Ref: The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro. PMID: 17936921 |
Ref: The apoptosis-inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-kappa B inhibition. PMID: 17704804 Ref: Targeting of a CCK(2) receptor splice variant with (111)In-labelled cholecystokinin-8 (CCK8) and (111)In-labelled minigastrin. PMID: 17934729 Ref: Designing antibodies for the inhibition of gastrin activity in tumoral cell lines. PMID: 18224686 |
Ref: Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. PMID: 19652364 |
Ref: CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells. PMID: 19697327 Ref: Altered expression of MiR-148a and MiR-152 in gastrointestinal cancers and its clinical significance. PMID: 20422307 Ref: Gastrin stimulates the VEGF-A promotor in a human colon cancer cell line. PMID: 20600355 Ref: Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor. PMID: 20932834 |
Ref: p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. PMID: 21224360 |
Ref: MicroRNA-148b suppresses cell growth by targeting cholecystokinin-2 receptor in colorectal cancer. PMID: 22020560 |
Ref: Progastrin stimulates colonic cell proliferation via CCK2R- and beta-arrestin-dependent suppression of BMP2. PMID: 23891976 Ref: Gastrin promotes intestinal polyposis through cholecystokinin-B receptor-mediated proliferative signaling and fostering tumor microenvironment. PMID: 24101389 |
Ref: The gastrin/cholecystokinin-B receptor on prostate cells--a novel target for bifunctional prostate cancer imaging. PMID: 24211650 |
Ref: Retro-inverso forms of gastrin5-12 are as biologically active as glycine-extended gastrin in vitro but not in vivo. PMID: 26471904 |
Ref: Expression of cholecystokinin receptors in colon cancer and the clinical correlation in Taiwan. PMID: 26508021 Ref: Novel, isoform-selective, cholecystokinin A receptor antagonist inhibits colon and pancreatic cancers in preclinical models through novel mechanism of action. PMID: 26820391 Ref: Assessment of cholecystokinin 2 receptor (CCK2R) in neoplastic tissue. PMID: 26910279 |
Ref: The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis. PMID: 28380450 |
Ref: Targeting of the cholecystokinin-2 receptor with the minigastrin analog (177)Lu-DOTA-PP-F11N: does the use of protease inhibitors further improve in vivo distribution? PMID: 30002107 |