Primary Site >> Biliary tract Cancer

Gene >> CASP8

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Ref: Cholangiocarcinomas express Fas ligand and disable the Fas receptor.
PMID: 10573518
Ref: IFN-gammaupregulates apoptosis-related molecules and enhances Fas-mediated apoptosis in human cholangiocarcinoma.
PMID: 12115528
Ref: Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin.
PMID: 19228732
Ref: Caspase-8 polymorphisms and risk of gallbladder cancer in a northern Indian population.
PMID: 20564345
Ref: Gallbladder cancer predisposition: a multigenic approach to DNA-repair, apoptotic and inflammatory pathway genes.
PMID: 21283657
Ref: Reduced CaM/FLIP binding by a single point mutation in c-FLIP(L) modulates Fas-mediated apoptosis and decreases tumorigenesis.
PMID: 21912376
Ref: Perturbation of proteasome function by bortezomib leading to ER stress-induced apoptotic cell death in cholangiocarcinoma.
PMID: 23877657
Ref: Inhibitory effects of deleted in liver cancer 1 gene on gallbladder cancer growth through induction of cell cycle arrest and apoptosis.
PMID: 24329682
Ref: UHRF1 depletion suppresses growth of gallbladder cancer cells through induction of apoptosis and cell cycle arrest.
PMID: 24756644
Ref: Ursodeoxycholyl lysophosphatidylethanolamide inhibits cholestasis- and hypoxia-induced apoptosis by upregulating antiapoptosis proteins.
PMID: 25125499
Ref: Proteasome inhibitor MG132 potentiates TRAIL-induced apoptosis in gallbladder carcinoma GBC-SD cells via DR5-dependent pathway.
PMID: 27277541