Primary Site >> Colorectal Cancer

Gene >> CASP6

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Ref: Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate.
PMID: 12507930
 Ref: Regulation of caspase-6 and FLIP by the AMPK family member ARK5.
PMID: 15273717
 Ref: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.
PMID: 15547111
Ref: Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling.
PMID: 15592498
 Ref: Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
PMID: 16518869
Ref: Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
PMID: 16948818
 Ref: Proteomic analysis reveals differences in protein expression in spheroid versus monolayer cultures of low-passage colon carcinoma cells.
PMID: 17918984
 Ref: Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.
PMID: 18497562
 Ref: Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation.
PMID: 19661313
 Ref: Spontaneous and 5-fluorouracil-induced centrosome amplification lowers the threshold to resveratrol-evoked apoptosis in colon cancer cells.
PMID: 19616374
 Ref: Aloe emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells.
PMID: 22343391
Ref: Prognostic Impact of Polymorphisms in the CASPASE Genes on Survival of Patients with Colorectal Cancer.
PMID: 22500158
 Ref: Plant-derived mAbs have effective anti-cancer activities by increasing ganglioside expression in colon cancers.
PMID: 24078119
 Ref: Unbiased proteomic and transcript analyses reveal that stathmin-1 silencing inhibits colorectal cancer metastasis and sensitizes to 5-fluorouracil treatment.
PMID: 25063586
Ref: Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
PMID: 25470254
 Ref: Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine.
PMID: 26400108
 Ref: Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line.
PMID: 26774143
 Ref: Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling.
PMID: 28179995
Ref: Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
PMID: 28241839