Primary Site >> Colorectal Cancer
Gene >> CASP3
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Ref: 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53. PMID: 9260909 Ref: Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. PMID: 9288776 |
Ref: Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells. PMID: 9558281 Ref: Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis. PMID: 9671409 Ref: The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. PMID: 9796814 Ref: A novel mutant from apoptosis-resistant colon cancer HT-29 cells showing hyper-apoptotic response to hypoxia, low glucose and cisplatin. PMID: 9914786 |
Ref: Induction of apoptosis and G2/M cell cycle arrest by DCC. PMID: 10348349 Ref: Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism. PMID: 10358077 Ref: Redistribution of activated caspase-3 to the nucleus during butyric acid-induced apoptosis. PMID: 10403841 Ref: Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. PMID: 10443335 Ref: Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic BAK and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP). PMID: 10467346 Ref: Aspirin induces cell death and caspase-dependent phosphatidylserine externalization in HT-29 human colon adenocarcinoma cells. PMID: 10496355 Ref: Ursodeoxycholic acid increases the activities of alkaline sphingomyelinase and caspase-3 in the rat colon. PMID: 10522612 Ref: Antitumor activity and induction of apoptosis by water-soluble derivatives of 7 beta-hydroxycholesterol in human colon carcinoma cell lines. PMID: 10628383 |
Ref: p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4. PMID: 10694497 Ref: Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice. PMID: 10815928 Ref: Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs. PMID: 10855553 Ref: Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. PMID: 10864208 Ref: Autocrine gastrins in colon cancer cells Up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3. PMID: 10915781 Ref: Characterization of bile salt-induced apoptosis in colon cancer cell lines. PMID: 10945641 Ref: Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4). PMID: 11077039 Ref: Apoptosis cascade proteins are regulated in vivo by high intracolonic butyrate concentration: correlation with colon cancer inhibition. PMID: 11132927 |
Ref: Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors. PMID: 11159736 Ref: The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. PMID: 11248093 Ref: 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. PMID: 11300326 Ref: Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway. PMID: 11309352 Ref: Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells. PMID: 11313933 Ref: p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. PMID: 11313989 Ref: Caspase-3 activity as a prognostic factor in colorectal carcinoma. PMID: 11351040 Ref: Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. PMID: 11396178 Ref: Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells. PMID: 11459173 Ref: Cyclooxygenase-2: a novel target for cancer chemotherapy? PMID: 11469677 Ref: Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer. PMID: 11484952 Ref: Tributyrin, an oral butyrate analogue, induces apoptosis through the activation of caspase-3. PMID: 11485828 Ref: A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells. PMID: 11507069 Ref: 4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release. PMID: 11511183 Ref: Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa. PMID: 11557285 Ref: The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax. PMID: 11574543 Ref: Glutathione-S-transferase-pi expression regulates sensitivity to glutathione-doxorubicin conjugate. PMID: 11604559 Ref: Effects of a 15% orange-pulp diet on tumorigenesis and immune response in rats with colon tumors. PMID: 11605072 Ref: E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis in colon cancer cells. PMID: 11705881 Ref: Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts. PMID: 11751522 |
Ref: Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. PMID: 11821946 Ref: Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens. PMID: 11894121 Ref: Ceramide involvement in homocamptothecin- and camptothecin-induced cytotoxicity and apoptosis in colon HT29 cells. PMID: 11894136 Ref: Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. PMID: 12005185 Ref: Increased apoptosis in infiltrating mononuclear cells of colorectal cancer: a mechanism for tumor escape. PMID: 12033956 Ref: Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line. PMID: 12060639 Ref: Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. PMID: 12097652 Ref: Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. PMID: 12208739 Ref: Role of Ca(2+) in diallyl disulfide-induced apoptotic cell death of HCT-15 cells. PMID: 12216118 Ref: Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma. PMID: 12372606 Ref: Molecular mechanisms of sulfasalazine-induced T-cell apoptosis. PMID: 12381674 Ref: Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. PMID: 12414664 Ref: Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. PMID: 12466962 Ref: Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate. PMID: 12507930 Ref: Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. PMID: 12507932 Ref: Cis 9, trans 11- and trans 10, cis 12-conjugated linoleic acid isomers induce apoptosis in cultured SW480 cells. PMID: 12553008 Ref: Incidence of apoptosis increases with age in colorectal cancer. PMID: 12559416 |
Ref: Butyrate induced Caco-2 cell apoptosis is mediated via the mitochondrial pathway. PMID: 12477768 Ref: Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-alpha or TNF-related apoptosis-inducing ligand in human cancer cell lines. PMID: 12566305 Ref: Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. PMID: 12589031 Ref: Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, induces cell cycle arrest and apoptosis in human colon cancer cells. PMID: 12604687 Ref: Opposing effects of butyrate and bile acids on apoptosis of human colon adenoma cells: differential activation of PKC and MAP kinases. PMID: 12618885 Ref: Apoptosis induction in human cancer cells by sungucine from Strychnos icaja root. PMID: 12644898 Ref: Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. PMID: 12670894 Ref: Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells. PMID: 12675269 Ref: Anti-angiogenic and apoptotic effects of metabolites of sulindac on chick embryo chorioallantoic membrane. PMID: 12713691 Ref: Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. PMID: 12819184 Ref: The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. PMID: 12819185 Ref: Dephosphorylation of p53 during cell death by N-alpha-tosyl-L-phenylalanyl chloromethyl ketone. PMID: 12821135 Ref: Sphingomyelin protects against apoptosis and hyperproliferation induced by deoxycholate: potential implications for colon cancer. PMID: 12822868 Ref: Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. PMID: 12837940 Ref: Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells. PMID: 12888913 Ref: Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells. PMID: 12898234 Ref: The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. PMID: 12902978 Ref: Regulation of caspase expression and apoptosis by adenomatous polyposis coli. PMID: 12907606 Ref: The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. PMID: 14506747 Ref: Glutamine prevents cytokine-induced apoptosis in human colonic epithelial cells. PMID: 14519785 Ref: [Effects of peroxisome proliferator-activated receptor-gamma agonist on Fas-mediated apoptosis in HT-29 cells]. PMID: 14532729 Ref: Induction of colon cancer cell death by 7-hydroxystaurosporine (UCN-01) is associated with increased p38 MAPK and decreased Bcl-xL. PMID: 14551511 Ref: Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. PMID: 14556662 Ref: Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy. PMID: 14583479 Ref: Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. PMID: 14583480 Ref: beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells. PMID: 14597880 Ref: Novel retinoic acid derivative ABPN has potent inhibitory activity on cell growth and apoptosis in cancer cells. PMID: 14601067 Ref: Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells. PMID: 14612938 |
Ref: 2'-benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive oxygen species. PMID: 14660655 Ref: Heparin/heparan sulfate interacting protein plays a role in apoptosis induced by anticancer drugs. PMID: 14729579 Ref: Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol. PMID: 14871845 Ref: Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin. PMID: 14971901 Ref: Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis. PMID: 15010835 Ref: Apoptosis induced by oxaliplatin in human colon cancer HCT15 cell line. PMID: 15015600 Ref: Overexpression of caspase-3 in hepatocellular carcinomas. PMID: 15098015 Ref: LIGHT sensitizes IFN-gamma-mediated apoptosis of HT-29 human carcinoma cells through both death receptor and mitochondria pathways. PMID: 15115612 Ref: Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms. PMID: 15120327 Ref: CD44 negatively regulates apoptosis in murine colonic epithelium via the mitochondrial pathway. PMID: 15126101 Ref: Somatic mutations of CASP3 gene in human cancers. PMID: 15127291 Ref: Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. PMID: 15139523 Ref: IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines. PMID: 15144569 Ref: Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species production. PMID: 15163544 Ref: Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats. PMID: 15192017 Ref: Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. PMID: 15205359 Ref: CD44 promotes resistance to apoptosis in human colon cancer cells. PMID: 15215046 Ref: Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis. PMID: 15219941 Ref: NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs. PMID: 15240129 Ref: Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. PMID: 15289867 Ref: Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. PMID: 15298963 Ref: Astilbic acid induced COLO 205 cell apoptosis by regulating Bcl-2 and Bax expression and activating caspase-3. PMID: 15301745 Ref: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. PMID: 15322075 Ref: Identification of cell surface and secreted proteins essential for tumor cell survival using a genetic suppressor element screen. PMID: 15361835 Ref: Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKBR3 cells with: cis -platin, Tamoxifen, Melphalan, Betulinic acid, L-PDMP, L-PPMP, and GD3 ganglioside. PMID: 15454695 Ref: Cytotoxic effect of different camptothecin formulations on human colon carcinoma in vitro. PMID: 15457131 Ref: Fluorouracil induces apoptosis and surface molecule modulation of peripheral blood leukocytes. PMID: 15485462 Ref: Low-dose radiation hypersensitivity is associated with p53-dependent apoptosis. PMID: 15498930 Ref: The HIV protease inhibitor ritonavir synergizes with butyrate for induction of apoptotic cell death and mediates expression of heme oxygenase-1 in DLD-1 colon carcinoma cells. PMID: 15504750 Ref: Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells. PMID: 15545975 Ref: Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. PMID: 15570007 Ref: Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. PMID: 15623604 Ref: Coptidis rhizoma induces apoptosis in human colorectal cancer cells SNU-C4. PMID: 15673193 Ref: Atiprimod is an inhibitor of cancer cell proliferation and angiogenesis. PMID: 15844657 |
Ref: Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor. PMID: 15365741 Ref: Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. PMID: 15494216 Ref: Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells. PMID: 15546879 Ref: Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells. PMID: 15550935 Ref: Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. PMID: 15618392 Ref: Citri Reticulatae Viride Pericarpium extract induced apoptosis in SNU-C4, human colon cancer cells. PMID: 15707758 Ref: EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. PMID: 15711178 Ref: CF101, an agonist to the A3 adenosine receptor, enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model. PMID: 15720820 Ref: The APC tumor suppressor promotes transcription-independent apoptosis in vitro. PMID: 15755874 Ref: Induction of apoptosis in human colon cancer HCT116 cells treated with an extract of the plant product, Chios mastic gum. PMID: 15796160 Ref: HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. PMID: 15846298 Ref: Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis. PMID: 15867384 Ref: Kahalalide F induces necrosis-like cell death that involves depletion of ErbB3 and inhibition of Akt signaling. PMID: 15908515 Ref: Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. PMID: 15946692 Ref: 17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines. PMID: 15993848 Ref: Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independen PMID: 16010439 Ref: Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitis. PMID: 16049281 Ref: Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino. PMID: 16055336 Ref: Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells. PMID: 16080519 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4. PMID: 16094708 Ref: Sulindac metabolites inhibit epidermal growth factor receptor activation and expression. PMID: 16138927 Ref: Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors. PMID: 16139803 Ref: Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo. PMID: 16143134 Ref: Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells. PMID: 16143316 Ref: Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL). PMID: 16153452 Ref: Sabarubicin- (MEN 10755) and paclitaxel show different kinetics in nuclear factor-kappaB (NF-kB) activation: effect of parthenolide on their cytotoxicity. PMID: 16158953 Ref: Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo. PMID: 16158974 Ref: Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. PMID: 16243822 Ref: Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. PMID: 16308138 Ref: Caspase-3 activation and induction of PARP cleavage by cyclic dipeptide cyclo(Phe-Pro) in HT-29 cells. PMID: 16309216 Ref: [Study on the apoptosis and its mechanism of lovo human colorectal cancer cells induced by SFPS]. PMID: 16363126 Ref: Irinotecan/5-fluorouracil combination induces alterations in mitochondrial membrane potential and caspases on colon cancer cell lines. PMID: 16491956 |
Ref: Inhibition of DLX4 promotes apoptosis in choriocarcinoma cell lines. PMID: 15975650 Ref: Molecular signaling cascade in DNA bisintercalator, echinomycin-induced apoptosis of HT-29 cells: evidence of the apoptotic process via activation of the cytochrome c-ERK-caspase-3 pathway. PMID: 16214385 Ref: Apoptotic effect of red wine polyphenols on human colon cancer SNU-C4 cells. PMID: 16243419 Ref: Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers. PMID: 16337741 Ref: Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents. PMID: 16343908 Ref: Alpha-chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation. PMID: 16387404 Ref: Diclofenac, a non-steroidal anti-inflammatory drug, suppresses apoptosis induced by endoplasmic reticulum stresses by inhibiting caspase signaling. PMID: 16388830 Ref: Characterization of four clones derived from human adenocarcinoma cell line, HT29, and analysis of their response to sodium butyrate. PMID: 16391813 Ref: Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines. PMID: 16417629 Ref: The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. PMID: 16426830 Ref: Crude extract of garlic induced caspase-3 gene expression leading to apoptosis in human colon cancer cells. PMID: 16433033 Ref: Mechanisms of cardiotoxin lll-induced apoptosis in human colorectal cancer colo205 cells. PMID: 16487259 Ref: c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-beta-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. PMID: 16505115 Ref: N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system. PMID: 16530191 Ref: Induction of apoptosis by hexaminolevulinate-mediated photodynamic therapy in human colon carcinoma cell line 320DM. PMID: 16566715 Ref: Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. PMID: 16596197 Ref: Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol. PMID: 16617056 Ref: Over-expressed estrogen receptor-alpha up-regulates hTNF-alpha gene expression and down-regulates beta-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells. PMID: 16628468 Ref: Outgrowth of human liver metastases after resection of the primary colorectal tumor: a shift in the balance between apoptosis and proliferation. PMID: 16642475 Ref: Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line. PMID: 16697099 Ref: Fas-associated phosphatase-1 promotes Fas-mediated apoptosis in human colon cancer cells: novel function of FAP-1. PMID: 16706817 Ref: Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. PMID: 16715131 Ref: TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas. PMID: 16857810 Ref: Antiangiogenic effect of sulindac sulfide could be secondary to induction of apoptosis and cell cycle arrest. PMID: 16886631 Ref: Cytotoxic activity of violacein in human colon cancer cells. PMID: 16889929 Ref: Requirement for pre-existing of p21 to prevent doxorubicin-induced apoptosis through inhibition of caspase-3 activation. PMID: 16909308 Ref: PPARgamma is a key target of butyrate-induced caspase-3 activation in the colorectal cancer cell line Caco-2. PMID: 16927016 Ref: EMAP-II-dependent lymphocyte killing is associated with hypoxia in colorectal cancer. PMID: 16929248 Ref: Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. PMID: 16936720 Ref: The anti-tumor effect of Euchema serra agglutinin on colon cancer cells in vitro and in vivo. PMID: 16940804 Ref: Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas. PMID: 16948818 Ref: Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells. PMID: 16988125 Ref: Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria. PMID: 16998592 Ref: Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel, flavopiridol, and 5-fluorouracil. PMID: 17007746 Ref: Intestinal overexpression of ZNF148 suppresses ApcMin/+ neoplasia. PMID: 17019648 Ref: (2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. PMID: 17083937 Ref: p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. PMID: 17145870 Ref: 3 Beta-hydroxyolean-12-en-27-oic acid: a cytotoxic, apoptosis-inducing natural drug against COLO-205 cancer cells. PMID: 17193218 Ref: Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway? PMID: 17202837 |
Ref: Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53. PMID: 17056233 Ref: Comparison of the rapid pro-apoptotic effect of trans-beta-nitrostyrenes with delayed apoptosis induced by the standard agent 5-fluorouracil in colon cancer cells. PMID: 17136318 Ref: Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells. PMID: 17237286 Ref: Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells. PMID: 17250644 Ref: Biphasic effect of falcarinol on caco-2 cell proliferation, DNA damage, and apoptosis. PMID: 17263451 Ref: Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines. PMID: 17273769 Ref: Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. PMID: 17283163 Ref: Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression. PMID: 17292358 Ref: TNF potentiates anticancer activity of bortezomib (Velcade) through reduced expression of proteasome subunits and dysregulation of unfolded protein response. PMID: 17373661 Ref: Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects. PMID: 17382202 Ref: Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review). PMID: 17390089 Ref: Isolation of fatty acids with anticancer activity from Protaetia brevitarsis larva. PMID: 17424944 Ref: 4- [3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induced fas expression and activated caspase-3 and -8 in a DLD-1 colon cancer cell line. PMID: 17436592 Ref: Celecoxib attenuates 5-fluorouracil-induced apoptosis in HCT-15 and HT-29 human colon cancer cells. PMID: 17461495 Ref: 2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation. PMID: 17510524 Ref: Quantitative imaging of apoptosis commitment in colorectal tumor cells. PMID: 17511782 Ref: 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. PMID: 17513605 Ref: Activation of peroxisome proliferator-activated receptor gamma inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer. PMID: 17532820 Ref: Activation of p38 mitogen-activated protein kinase by celecoxib oppositely regulates survivin and gamma-H2AX in human colorectal cancer cells. PMID: 17540426 Ref: Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. PMID: 17597109 Ref: Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. PMID: 17609769 Ref: A novel in vitro model of lymphatic metastasis from colorectal cancer. PMID: 17640671 Ref: Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis. PMID: 17645780 Ref: Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. PMID: 17656449 Ref: Caspase-3 activity predicts local recurrence in rectal cancer. PMID: 17908973 Ref: [Effects of blocking phospholipase C-gamma1 signaling pathway on proliferation and apoptosis of human colorectal cancer cell line LoVo]. PMID: 17927852 Ref: Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. PMID: 17938270 Ref: Apicularen A induces cell death through Fas ligand up-regulation and microtubule disruption by tubulin down-regulation in HM7 human colon cancer cells. PMID: 17975164 Ref: Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumours. PMID: 18027258 |
Ref: Effect of hyperthermia and chemotherapeutic agents on TRAIL-induced cell death in human colon cancer cells. PMID: 17520700 Ref: MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release. PMID: 17653087 Ref: Caspase-3 activity, response to chemotherapy and clinical outcome in patients with colon cancer. PMID: 17805550 Ref: Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon. PMID: 17823781 Ref: Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4. PMID: 17897817 Ref: In vitro cytotoxic potential of Polyalthia longifolia on human cancer cell lines and induction of apoptosis through mitochondrial-dependent pathway in HL-60 cells. PMID: 17935706 Ref: Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins. PMID: 17936584 Ref: Differential sensitivity of human colon cancer cell lines to the nucleoside analogs ARC and DRB. PMID: 17999411 Ref: SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release. PMID: 18172320 Ref: Dietary heme injures surface epithelium resulting in hyperproliferation, inhibition of apoptosis and crypt hyperplasia in rat colon. PMID: 18174249 Ref: Ceramide induces release of mitochondrial proapoptotic proteins in caspase-dependent and -independent manner in HT-29 cells. PMID: 18176793 Ref: A novel role for villin in intestinal epithelial cell survival and homeostasis. PMID: 18198174 Ref: Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB. PMID: 18241858 Ref: Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer. 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PMID: 25543053 Ref: Discovery of PAT-1102, a novel, potent and orally active histone deacetylase inhibitor with antitumor activity in cancer mouse models. PMID: 25550555 Ref: Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-kappaB pathway. PMID: 25555669 Ref: DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by Ruta graveolens in human colon cancer cells. PMID: 25576270 Ref: Stachyose-induced apoptosis of Caco-2 cells via the caspase-dependent mitochondrial pathway. PMID: 25578308 Ref: Activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cells. PMID: 25603347 Ref: The Tomato Glycoalkaloid alpha-Tomatine Induces Caspase-Independent Cell Death in Mouse Colon Cancer CT-26 Cells and Transplanted Tumors in Mice. PMID: 25614934 Ref: Induction of apoptosis in HCT-116 colon cancer cells by polysaccharide of Larimichthys crocea swim bladder. PMID: 25624917 Ref: Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer. PMID: 25644785 Ref: Hydroquinone analog 4-[(Tetrahydro-2H-pyran-2yl) oxy] phenol induces C26 colon cancer cell apoptosis and inhibits tumor growth in vivo. PMID: 25651526 Ref: Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway. PMID: 25652758 Ref: Violacein anticancer activity is enhanced under hypoxia. PMID: 25652759 Ref: Effect of fermented wheat germ extract with lactobacillus plantarum dy-1 on HT-29 cell proliferation and apoptosis. PMID: 25658135 Ref: CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo. PMID: 25663456 Ref: Design, synthesis and in vitro antiproliferative activity of novel isatin-quinazoline hybrids. PMID: 25664631 Ref: Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. PMID: 25684945 Ref: Tumor suppression by resistant maltodextrin, Fibersol-2. PMID: 25692338 Ref: Macrophage and colon tumor cells as targets for a binuclear silver(I) N-heterocyclic carbene complex, an anti-inflammatory and apoptosis mediator. PMID: 25699476 Ref: Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways. PMID: 25738796 Ref: Apoptotic effect of novel Schiff based CdCl(2)(C(1)(4)H(2)(1)N(3)O(2)) complex is mediated via activation of the mitochondrial pathway in colon cancer cells. PMID: 25764970 Ref: The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression. PMID: 25767680 Ref: Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. PMID: 25787076 Ref: HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion. PMID: 25800793 Ref: Benzo[b]tryptanthrin inhibits MDR1, topoisomerase activity, and reverses adriamycin resistance in breast cancer cells. PMID: 25809558 Ref: Adenosine induces apoptosis through TNFR1/RIPK1/P38 axis in colon cancer cells. PMID: 25817730 Ref: Esculetin induces death of human colon cancer cells via the reactive oxygen species-mediated mitochondrial apoptosis pathway. PMID: 25818986 Ref: Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro. PMID: 25832431 Ref: Poly-gamma-glutamic acid induces apoptosis via reduction of COX-2 expression in TPA-induced HT-29 human colorectal cancer cells. PMID: 25854428 Ref: Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer. PMID: 25870767 Ref: Biocompatible iota-carrageenan-gamma-maghemite nanocomposite for biomedical applications - synthesis, characterization and in vitro anticancer efficacy. PMID: 25890231 Ref: Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis. PMID: 25906152 Ref: [Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells]. PMID: 25907934 Ref: Cyclopentadienyl-ruthenium(II) and iron(II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agents. PMID: 25923600 Ref: Early diagnostic value of Bcl-3 localization in colorectal cancer. PMID: 25929479 Ref: Mushroom Extracts Induce Human Colon Cancer Cell (COLO-205) Death by Triggering the Mitochondrial Apoptosis Pathway and Go/G1-Phase Cell Cycle Arrest. PMID: 25959910 Ref: Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer. PMID: 25986235 Ref: Anticancer and anti-inflammatory activities of some dietary cucurbits. PMID: 26011982 Ref: Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation. PMID: 26026836 Ref: Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells. PMID: 26043756 Ref: Functional characterization of the nitrogen permease regulator-like-2 candidate tumor suppressor gene in colorectal cancer cell lines. PMID: 26044952 Ref: gamma-Tocotrienol and 6-Gingerol in Combination Synergistically Induce Cytotoxicity and Apoptosis in HT-29 and SW837 Human Colorectal Cancer Cells. PMID: 26046324 Ref: Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects. PMID: 26054686 Ref: Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer. PMID: 26074733 Ref: Water extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/beta-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced colon c PMID: 26122204 Ref: Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. PMID: 26132569 Ref: Parthenolide induces apoptosis in colitis-associated colon cancer, inhibiting NF-kappaB signaling. PMID: 26137027 Ref: Pleiocarpa pycnantha leaves and its triterpenes induce apoptotic cell death in Caco-2 cells in vitro. PMID: 26169589 Ref: Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. PMID: 26204233 Ref: CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186. PMID: 26231038 Ref: Ponicidin suppresses HT29 cell growth via the induction of G1 cell cycle arrest and apoptosis. PMID: 26239027 Ref: Targeted inhibition of p38MAPK-enhanced autophagy in SW620 cells resistant to photodynamic therapy-induced apoptosis. PMID: 26254783 Ref: Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest. PMID: 26287184 Ref: Synthesis of Tolmetin Hydrazide-Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells. PMID: 26287512 Ref: Colchicine induces apoptosis in HT29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways. PMID: 26299305 Ref: Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. PMID: 26310874 Ref: Synthesis and biological evaluation of spiro[cyclopropane-1,3'-indolin]-2'-ones as potential anticancer agents. PMID: 26330077 Ref: Coated chitosan nanoparticles encapsulating caspase 3 activator for effective treatment of colorectral cancer. PMID: 26334865 Ref: Novel self-micellizing anticancer lipid nanoparticles induce cell death of colorectal cancer cells. PMID: 26342325 Ref: Prognostic value of Caspase-3 expression in cancers of digestive tract: a meta-analysis and systematic review. PMID: 26379814 Ref: Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography. PMID: 26396545 Ref: Inhibition of migration and induction of apoptosis in LoVo human colon cancer cells by polysaccharides from Ganoderma lucidum. PMID: 26397202 Ref: Colon cancer chemopreventive effects of baicalein, an active enteric microbiome metabolite from baicalin. PMID: 26398706 Ref: Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine. PMID: 26400108 Ref: Fermented So-Cheong-Ryong-Tang (FCY) induces apoptosis via the activation of caspases and the regulation of MAPK signaling pathways in cancer cells. PMID: 26403976 Ref: Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo. PMID: 26408414 Ref: Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis. PMID: 26457107 Ref: Down-Regulating Receptor Interacting Protein Kinase 1 (RIP1) Promotes Oxaliplatin-Induced Tca8113 Cell Apoptosis. PMID: 26460489 Ref: Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells. PMID: 26463716 Ref: Anti-cancer effects of 2-oxoquinoline derivatives on the HCT116 and LoVo human colon cancer cell lines. PMID: 26498992 Ref: Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway. PMID: 26503559 Ref: Effect of dapagliflozin on colon cancer cell [Rapid Communication]. PMID: 26522271 Ref: Polyunsaturated fatty acids trigger apoptosis of colon cancer cells through a mitochondrial pathway. PMID: 26528354 Ref: p-Methoxycinnamic acid, an active phenylpropanoid induces mitochondrial mediated apoptosis in HCT-116 human colon adenocarcinoma cell line. PMID: 26546748 Ref: Novel beta-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway. PMID: 26555243 Ref: Antitumor Activities and Apoptosis-regulated Mechanisms of Fermented Wheat Germ Extract in the Transplantation Tumor Model of Human HT-29 Cells in Nude Mice. PMID: 26582094 Ref: Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-kappaB Transcription Factors and the Induction of Cytoprotective Genes. PMID: 26625825 Ref: Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. PMID: 26678268 Ref: Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways. PMID: 26770191 Ref: Functional mechanism of the enhancement of 5-fluorouracil sensitivity by TUSC4 in colon cancer cells. PMID: 26788191 Ref: Mechanism of Action of the Novel Nickel(II) Complex in Simultaneous Reactivation of the Apoptotic Signaling Networks Against Human Colon Cancer Cells. PMID: 26858642 Ref: Epieriocalyxin A Induces Cell Apoptosis Through JNK and ERK1/2 Signaling Pathways in Colon Cancer Cells. PMID: 27352353 |
Ref: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. PMID: 26152521 Ref: TRAIL-Induced Caspase Activation Is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways. PMID: 26212606 Ref: A novel quinazolinone chalcone derivative induces mitochondrial dependent apoptosis and inhibits PI3K/Akt/mTOR signaling pathway in human colon cancer HCT-116 cells. PMID: 26615871 Ref: Endogenous conversion of omega-6 to omega-3 polyunsaturated fatty acids in fat-1 mice attenuated intestinal polyposis by either inhibiting COX-2/beta-catenin signaling or activating 15-PGDH/IL-18. PMID: 26650508 Ref: A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells. PMID: 26673746 Ref: Ocoxin(R) oral solution slows down tumor growth in an experimental model of colorectal cancer metastasis to the liver in Balb/c mice. PMID: 26676882 Ref: Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells. PMID: 26702744 Ref: Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway. PMID: 26714930 Ref: Pristimerin demonstrates anticancer potential in colorectal cancer cells by inducing G1 phase arrest and apoptosis and suppressing various pro-survival signaling proteins. PMID: 26718323 Ref: Study on the inhibition of hyperthermic CO(2) pneumoperitoneum on the proliferation and migration of colon cancer cells and its mechanism. PMID: 26718327 Ref: MiR-331-3p inhibits proliferation and promotes apoptosis by targeting HER2 through the PI3K/Akt and ERK1/2 pathways in colorectal cancer. PMID: 26718987 Ref: Interdependence of DNA mismatch repair proteins MLH1 and MSH2 in apoptosis in human colorectal carcinoma cell lines. PMID: 26728996 Ref: Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by gamma-secretase inhibition. PMID: 26746659 Ref: Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents. PMID: 26750401 Ref: The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth. PMID: 26774105 Ref: Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line. PMID: 26774143 Ref: Long non-coding RNA AK027294 involves in the process of proliferation, migration, and apoptosis of colorectal cancer cells. PMID: 26820130 Ref: Synergistic anti-tumor activity and mechanisms of total glycosides from Cimicifuga dahurica in combination with cisplatin. PMID: 26825081 Ref: Early Prediction of Tumor Response to Treatment: Preclinical Validation of 99mTc-Duramycin. PMID: 26837335 Ref: Anti-proliferative and Apoptotic Effects of Basella rubra (L.) Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in Rats. PMID: 26838257 Ref: Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach. PMID: 26844701 Ref: Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro. PMID: 26848703 Ref: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PMID: 26859847 Ref: Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-kappaB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways. PMID: 26870201 Ref: Low toxic and high soluble camptothecin derivative 2-47 effectively induces apoptosis of tumor cells in vitro. PMID: 26879138 Ref: miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3. PMID: 26895377 Ref: The effect of celecoxib and its combination with imatinib on human HT-29 colorectal cancer cells: Involvement of COX-2, Caspase-3, VEGF and NF-kappaB genes expression. PMID: 26950454 Ref: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. PMID: 27004568 Ref: Bakuchiol sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins. PMID: 27033605 Ref: Polyphenol stabilized colloidal gold nanoparticles from Abutilon indicum leaf extract induce apoptosis in HT-29 colon cancer cells. PMID: 27038915 Ref: The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest. PMID: 27044842 Ref: Effective Targeting Survivin, Caspase-3 and MicroRNA-16-1 Expression by Methyl-3-pentyl-6-methoxyprodigiosene Triggers Apoptosis in Colorectal Cancer Stem-Like Cells. PMID: 27055667 Ref: CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis. PMID: 27058823 Ref: Hyperoside and rutin of Nelumbo nucifera induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells. PMID: 27073499 Ref: Induction of ROS Overload by Alantolactone Prompts Oxidative DNA Damage and Apoptosis in Colorectal Cancer Cells. PMID: 27089328 Ref: The Herbal Medicine Utrica Dioica Inhibits Proliferation of Colorectal Cancer Cell Line by Inducing Apoptosis and Arrest at the G2/M Phase. PMID: 27090648 Ref: Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells. PMID: 27098859 Ref: 5-Hydroxy-7-Methoxyflavone Triggers Mitochondrial-Associated Cell Death via Reactive Oxygen Species Signaling in Human Colon Carcinoma Cells. PMID: 27116119 Ref: 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane potentiates in vitro and in vivo antitumor effects of irinotecan on human colorectal cancer cells. PMID: 27123150 Ref: Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment. PMID: 27166181 Ref: Knockdown of linc-UFC1 suppresses proliferation and induces apoptosis of colorectal cancer. PMID: 27195675 Ref: HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells. PMID: 27220399 Ref: Apoptotic effect of eugenol envolves G2/M phase abrogation accompanied by mitochondrial damage and clastogenic effect on cancer cell in vitro. PMID: 27235711 Ref: Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. PMID: 27271587 Ref: Combination treatment with flavonoid morin and telomerase inhibitor MST312 reduces cancer stem cell traits by targeting STAT3 and telomerase. PMID: 27279256 Ref: Apoptosis inducing capacity of Holothuria arenicola in CT26 colon carcinoma cells in vitro and in vivo. PMID: 27279978 Ref: PAR2-dependent activation of GSK3beta regulates the survival of colon stem/progenitor cells. PMID: 27313176 Ref: Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation. PMID: 27314273 Ref: Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation. PMID: 27372405 Ref: Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cells. PMID: 27378626 Ref: Dragon (RGMb) induces oxaliplatin resistance in colon cancer cells. PMID: 27384995 Ref: Engineering of caveolae-specific self-micellizing anticancer lipid nanoparticles to enhance the chemotherapeutic efficacy of oxaliplatin in colorectal cancer cells. PMID: 27395829 Ref: Myenteric plexuses atrophy in the vicinity of colorectal cancer tissue is not caused by apoptosis or necrosis. PMID: 27439439 Ref: Indole-3-carbinol induces tumor cell death: function follows form. PMID: 27451867 Ref: Depletion of UBA protein 2-like protein inhibits growth and induces apoptosis of human colorectal carcinoma cells. PMID: 27456362 Ref: Treatment of undifferentiated colorectal cancer cells with fish-oil derived docosahexaenoic acid triggers caspase-3 activation and apoptosis. PMID: 27461654 Ref: Clausenidin induces caspase-dependent apoptosis in colon cancer. PMID: 27473055 Ref: Role of gamma-glutamyl cyclotransferase as a therapeutic target for colorectal cancer based on the lentivirus-mediated system. PMID: 27500968 Ref: miR-6734 Up-Regulates p21 Gene Expression and Induces Cell Cycle Arrest and Apoptosis in Colon Cancer Cells. PMID: 27509128 Ref: Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells. PMID: 27509880 Ref: ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2. PMID: 27559856 Ref: Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures. PMID: 27573437 Ref: Apoptotic pathways and stemness in the colorectal epithelium and lamina propria mucosae during the human embryogenesis and carcinogenesis. PMID: 27612611 Ref: Dimethoxy Curcumin Induces Apoptosis by Suppressing Survivin and Inhibits Invasion by Enhancing E-Cadherin in Colon Cancer Cells. PMID: 27614381 Ref: Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. PMID: 27622714 Ref: BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells. PMID: 27628414 Ref: Colonic Lamina Propria Inflammatory Cells from Patients with IBD Induce the Nuclear Factor-E2 Related Factor-2 Thereby Leading to Greater Proteasome Activity and Apoptosis Protection in Human Colonocytes. PMID: 27661668 Ref: Stereoisomers of Astaxanthin Inhibit Human Colon Cancer Cell Growth by Inducing G2/M Cell Cycle Arrest and Apoptosis. PMID: 27726394 Ref: Inducing G2/M Cell Cycle Arrest and Apoptosis through Generation Reactive Oxygen Species (ROS)-Mediated Mitochondria Pathway in HT-29 Cells by Dentatin (DEN) and Dentatin Incorporated in Hydroxypropyl-beta-Cyclodextrin (DEN-HPbetaCD). PMID: 27763535 Ref: Evaluation of a furochromone from the halophyte Corydalis heterocarpa for cytotoxic activity against human gastric cancer (AGS) cells. PMID: 27808331 Ref: Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model. PMID: 27825113 Ref: MicroRNA-455-3p Inhibits Tumor Cell Proliferation and Induces Apoptosis in HCT116 Human Colon Cancer Cells. PMID: 27861461 Ref: Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing. PMID: 27863397 Ref: Knockdown of KLK11 inhibits cell proliferation and increases oxaliplatin sensitivity in human colorectal cancer. PMID: 27882085 Ref: The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition. PMID: 27902462 Ref: Genistein Induces Apoptosis and Inhibits Proliferation of HT29 Colon Cancer Cells. PMID: 27942504 Ref: (125)I Seeds Radiation Induces Paraptosis-Like Cell Death via PI3K/AKT Signaling Pathway in HCT116 Cells. PMID: 28078301 Ref: Naphthazarin suppresses cell proliferation and induces apoptosis in human colorectal cancer cells via the B-cell lymphoma 2/B-cell associated X protein signaling pathway. PMID: 28101239 Ref: Microbiota Composition, HSP70 and Caspase-3 Expression as Marker for Colorectal Cancer Patients in Aceh, Indonesia. PMID: 28143990 Ref: Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae Miltiorrhizae) induced apoptosis in nine human cancer cell lines. PMID: 28459519 Ref: Water extract of Galla Rhois with steaming process enhances apoptotic cell death in human colon cancer cells. PMID: 28462130 Ref: Anticancer Properties of Chrysin on Colon Cancer Cells, In vitro and In vivo with Modulation of Caspase-3, -9, Bax and Sall4. PMID: 28959334 Ref: Effect of ethanol extract of HPRS, a Traditional Chinese Medicine formula, on HCT116 cell Line. PMID: 29949709 |
Ref: siRNA-Mediated Silencing of HMGA2 Induces Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma. PMID: 27629422 Ref: Anacyclus Pyrethrum Extract Exerts Anticancer Activities on the Human Colorectal Cancer Cell Line (HCT) by Targeting Apoptosis, Metastasis and Cell Cycle Arrest. PMID: 27796737 Ref: Design and validation of an orally administrated active L. fermentum-L. acidophilus probiotic formulation using colorectal cancer Apc (Min/+) mouse model. PMID: 27837314 Ref: Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis. PMID: 27861153 Ref: Casticin induced apoptotic cell death and altered associated gene expression in human colon cancer colo 205 cells. PMID: 27862857 Ref: (99m)Tc-Duramycin SPECT Imaging of Early Tumor Response to Targeted Therapy: A Comparison with (18)F-FDG PET. PMID: 27879368 Ref: A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice. PMID: 27888812 Ref: In-silico and in-vitro anti-cancer potential of a curcumin analogue (1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-dione. PMID: 27889234 Ref: Methyl jasmonate induces the apoptosis of human colorectal cancer cells via downregulation of EZH2 expression by microRNA101. PMID: 28000868 Ref: Thioridazine elicits potent antitumor effects in colorectal cancer stem cells. PMID: 28000884 Ref: [Overexpression of N-myc downstream regulated gene 2 (NDRG2) inhibits proliferation, migration and promotes apoptosis in SW480 rectal cancer cells]. PMID: 28031114 Ref: Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. PMID: 28035355 Ref: Evaluation of [(18)F]CP18 as a Substrate-Based Apoptosis Imaging Agent for the Assessment of Early Treatment Response in Oncology. PMID: 28050749 Ref: Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells. PMID: 28103302 Ref: Knockdown of TCTN1 Strongly Decreases Growth of Human Colon Cancer Cells. PMID: 28123172 Ref: miR-433 reduces cell viability and promotes cell apoptosis by regulating MACC1 in colorectal cancer. PMID: 28123526 Ref: Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis. PMID: 28169543 Ref: Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF. PMID: 28182330 Ref: Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. PMID: 28183047 Ref: Macrophage migration inhibitory factor siRNA inhibits hepatic metastases of colorectal cancer cells. PMID: 28199208 Ref: LncRNA SNHG12 promotes cell growth and inhibits cell apoptosis in colorectal cancer cells. PMID: 28225893 Ref: Antitumor and Immunomodulatory Effect of Gastrodia elata on Colon Cancer In Vitro and In Vivo. PMID: 28231745 Ref: Antitumor Activities and Apoptosis-regulated Mechanisms of Fermented Barley Extract in the Transplantation Tumor Model of Human HT-29 Cells in Nude Mice. PMID: 28245895 Ref: Imatinib and its combination with 2,5-dimethyl-celecoxibinduces apoptosis of human HT-29 colorectal cancer cells. PMID: 28255316 Ref: AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells. PMID: 28296564 Ref: ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29. PMID: 28306533 Ref: The evaluation of the anti-cancer activity of ixazomib on Caco2 colon solid tumor cells, comparison with bortezomib. PMID: 28327055 Ref: LRG1 promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation. PMID: 28376129 Ref: [Inhibitory effect of apatinib on HCT-116 cells and its mechanism]. PMID: 28377354 Ref: Effects of Hylomecon vernalis ethanol extracts on cell cycle and apoptosis of colon cancer cells. PMID: 28393197 Ref: Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells. PMID: 28412728 Ref: Reduced NOV expression correlates with disease progression in colorectal cancer and is associated with survival, invasion and chemoresistance of cancer cells. PMID: 28412738 Ref: Phototoxic action of a zinc(II) phthalocyanine encapsulated into poloxamine polymeric micelles in 2D and 3D colon carcinoma cell cultures. PMID: 28432944 Ref: Anticancer activity of Nelumbo nucifera stamen extract in human colon cancer HCT-116 cells in vitro. PMID: 28454279 Ref: Kanglaite sensitizes colorectal cancer cells to Taxol via NF-kappaBeta inhibition and connexin 43 upregulation. PMID: 28455529 Ref: CO-Induced apoptotic death of colorectal cancer cells by a luminescent photoCORM grafted on biocompatible carboxymethyl chitosan. PMID: 28466932 Ref: Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line. PMID: 28472978 Ref: Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS-12, induces apoptosis pathways in human colorectal cancer cell lines. PMID: 28477945 Ref: Cytotoxic Metabolites from Callyspongia siphonella Display Antiproliferative Activity by Inducing Apoptosis in HCT-116 Cells. PMID: 28479724 Ref: The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line. PMID: 28487731 Ref: [Knock-down of cadherin 17 inhibits proliferation and promote apoptosis in noscapine-resistant human SW480 colon cancer cells]. PMID: 28502297 Ref: Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC). PMID: 28506198 Ref: Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cells. PMID: 28522946 Ref: A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53. PMID: 28526414 Ref: AKT is indispensable for coordinating Par-4/JNK cross talk in p21 downmodulation during ER stress. PMID: 28530706 Ref: The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations. PMID: 28560697 Ref: Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line. PMID: 28586741 Ref: PCDH18 is frequently inactivated by promoter methylation in colorectal cancer. PMID: 28588296 Ref: The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway. PMID: 28597038 Ref: Ocoxin oral solution((R)) as a complement to irinotecan chemotherapy in the metastatic progression of colorectal cancer to the liver. PMID: 28599406 Ref: Novel proapoptotic agent SM-1 enhances the inhibitory effect of 5-fluorouracil on colorectal cancer cells in vitro and in vivo. PMID: 28599477 Ref: Apoptosis and Caspase 3 Pathway Role on Anti-Proliferative Effects of Scrophulariaoxy Sepala Methanolic Extract on Caco-2 Cells. PMID: 28628925 Ref: ICT1 predicts a poor survival and correlated with cell proliferation in diffuse large B-cell lymphoma. PMID: 28629825 Ref: Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and mitochondrial apoptosis. PMID: 28675857 Ref: Synthesis and cytotoxic activities of novel 4-methoxy-substituted and 5-methyl-substituted (3'S,4'S)-(-)-cis-khellactone derivatives that induce apoptosis via the intrinsic pathway. PMID: 28694689 Ref: Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells. PMID: 28706417 Ref: Inhibition of IL-6/STAT3 signaling in human cancer cells using Evista. PMID: 28711499 Ref: Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway. PMID: 28713983 Ref: PSMB8 as a Candidate Marker of Responsiveness to Preoperative Radiation Therapy in Rectal Cancer Patients. PMID: 28721901 Ref: Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species. PMID: 28781645 Ref: Treatment mechanism of matrine in combination with irinotecan for colon cancer. PMID: 28781667 Ref: Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells. PMID: 28789442 Ref: Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells. PMID: 28791416 Ref: Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies. PMID: 28802125 Ref: Acyl-CoA Synthetase 5 Promotes the Growth and Invasion of Colorectal Cancer Cells. PMID: 28808653 Ref: Naja Naja Oxiana Venom Fraction Selectively Induces ROS-Mediated Apoptosis in Human Colorectal Tumor Cells by Directly Targeting Mitochondria PMID: 28843256 Ref: Knockdown of tripartite motif-59 inhibits the malignant processes in human colorectal cancer cells. PMID: 28849218 Ref: Co-delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition. PMID: 28852020 Ref: GRP78 Regulates Apoptosis, Cell Survival and Proliferation in 5-Fluorouracil-resistant SNUC5 Colon Cancer Cells. PMID: 28870916 Ref: [Role of PpIX-based photodynamic therapy in promoting the damage and apoptosis of colorectal cancer cell and its mechanisms]. PMID: 28872077 Ref: In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells. PMID: 28880032 Ref: The Effect of Pyrroloquinoline Quinone on the Expression of WISP1 in Traumatic Brain Injury. PMID: 28883836 Ref: Smad4 re-expression increases the sensitivity to parthenolide in colorectal cancer. PMID: 28902368 Ref: In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells. PMID: 28923355 Ref: Catalpol promotes cellular apoptosis in human HCT116 colorectal cancer cells via microRNA-200 and the downregulation of PI3K-Akt signaling pathway. PMID: 28927141 Ref: Inhibitory Effects of Culinary Herbs and Spices on the Growth of HCA-7 Colorectal Cancer Cells and Their COX-2 Expression. PMID: 28934138 Ref: PPA1 regulates tumor malignant potential and clinical outcome of colon adenocarcinoma through JNK pathways. PMID: 28938583 Ref: Sulforaphane induces p53deficient SW480 cell apoptosis via the ROSMAPK signaling pathway. PMID: 28944886 Ref: Resveratrol Regulates Colorectal Cancer Cell Invasion by Modulation of Focal Adhesion Molecules. PMID: 28953264 Ref: Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect. PMID: 28955240 Ref: Identification of 7-(4'-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells. PMID: 28963527 Ref: Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PMID: 28968471 Ref: Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway. PMID: 28972559 Ref: Human colorectal cancer cells induce vascular smooth muscle cell apoptosis in an exocrine manner. PMID: 28977925 Ref: Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells. PMID: 29036264 Ref: Upregulation of Yes-associated protein and transcriptional co-activator with PDZ-binding motif influences the behavior of LOVO human colon adenocarcinoma cells. PMID: 29042987 Ref: Inhibitory effect of hyperoside isolated from Zanthoxylum bungeanum leaves on SW620 human colorectal cancer cells via induction of the p53 signaling pathway and apoptosis. PMID: 29067453 Ref: Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines. PMID: 29078261 Ref: [Effect of resveratrol in regulating proliferation and apoptosis of rectal cancer cells via up-regulating PTEN]. PMID: 29082697 Ref: Grape seed proanthocyanidins induce mitochondrial pathway-mediated apoptosis in human colorectal carcinoma cells. PMID: 29113217 Ref: Genistein induces apoptosis of colon cancer cells by reversal of epithelial-to-mesenchymal via a Notch1/NF-kappaB/slug/E-cadherin pathway. PMID: 29202800 Ref: Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum. PMID: 29204990 Ref: Long non-coding RNA LINC00959 predicts colorectal cancer patient prognosis and inhibits tumor progression. PMID: 29228592 Ref: In vivo and in vitro induction of the apoptotic effects of oxysophoridine on colorectal cancer cells via the Bcl-2/Bax/caspase-3 signaling pathway. PMID: 29344242 Ref: Xylopine Induces Oxidative Stress and Causes G2/M Phase Arrest, Triggering Caspase-Mediated Apoptosis by p53-Independent Pathway in HCT116 Cells. PMID: 29362667 Ref: Serum miR-129 functions as a biomarker for colorectal cancer by targeting estrogen receptor (ER) beta. PMID: 29441863 Ref: Zoledronic Acid Regulates Autophagy and Induces Apoptosis in Colon Cancer Cell Line CT26. PMID: 29457036 Ref: Establishment of optimal regulatory network of colorectal cancer based on p42.3 protein. PMID: 29551923 |
Ref: Thymol Elicits HCT-116 Colorectal Carcinoma Cell Death Through Induction of Oxidative Stress. PMID: 28356011 Ref: Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway. PMID: 28822989 Ref: Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway. PMID: 28965196 Ref: Down-regulation of LncRNA CCAT1 enhances radiosensitivity via regulating miR-148b in breast cancer. PMID: 29024383 Ref: Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-alpha-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells. PMID: 29115534 Ref: Does Mutated K-RAS Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention? PMID: 29118162 Ref: Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer. PMID: 29233910 Ref: Musa paradisiaca inflorescence induces human colon cancer cell death by modulating cascades of transcriptional events. PMID: 29243757 Ref: Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122. PMID: 29253766 Ref: Down-regulation of FN1 inhibits colorectal carcinogenesis by suppressing proliferation, migration, and invasion. PMID: 29274284 Ref: Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest, and Antimigratory Effects in SW480 Colorectal Cancer Cells. PMID: 29276946 Ref: Modulated electro-hyperthermia induced loco-regional and systemic tumor destruction in colorectal cancer allografts. PMID: 29290768 Ref: Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line. PMID: 29308053 Ref: Caspase-3/MAPK pathways as main regulators of the apoptotic effect of the phyto-mediated synthesized silver nanoparticle from dried stem of Eleutherococcus senticosus in human cancer cells. PMID: 29331758 Ref: Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines. PMID: 29337231 Ref: Synergistic role of Caspase-8 and Caspase-3 expressions: Prognostic and predictive biomarkers in colorectal cancer. PMID: 29355114 Ref: Inhibition of autophagy potentiates the apoptosis-inducing effects of photodynamic therapy on human colon cancer cells. PMID: 29355734 Ref: Eupatorin and Salvigenin Potentiate Doxorubicin-Induced Apoptosis and Cell Cycle Arrest in HT-29 and SW948 Human Colon Cancer Cells PMID: 29373904 Ref: Acetaminophen and Metamizole Induce Apoptosis in HT 29 and SW 480 Colon Carcinoma Cell Lines In Vitro. PMID: 29374698 Ref: Bone marrow-derived mesenchymal stromal cells promote colorectal cancer cell death under low-dose irradiation. PMID: 29384527 Ref: Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway. PMID: 29393371 Ref: Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells. PMID: 29414823 Ref: Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells. PMID: 29423046 Ref: Chemoprevention by Probiotics During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats. PMID: 29427224 Ref: A novel small molecular STAT3 inhibitor, 5Br-6b, induces apoptosis and inhibits migration in colorectal cancer cells. PMID: 29438179 Ref: Glycolysis is essential for chemoresistance induced by transient receptor potential channel C5 in colorectal cancer. PMID: 29463225 Ref: Polyphenols-rich extract from Pleurotus eryngii with growth inhibitory of HCT116 colon cancer cells and anti-inflammatory function in RAW264.7 cells. PMID: 29465116 Ref: Dihydroartemisinin inhibits colon cancer cell viability by inducing apoptosis through up-regulation of PPARgamma expression. PMID: 29472793 Ref: Apoptosis as a Prognostic Factor in Colorectal Carcinoma: Comparison of TUNEL Method and Immunohistochemical Expression of Caspase-3. PMID: 29489504 Ref: Polymeric micelles for potentiated antiulcer and anticancer activities of naringin. PMID: 29497294 Ref: Chlorogenic Acid and Its Microbial Metabolites Exert Anti-Proliferative Effects, S-Phase Cell-Cycle Arrest and Apoptosis in Human Colon Cancer Caco-2 Cells. PMID: 29510500 Ref: Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells. PMID: 29524226 Ref: Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K/AKT/mTOR/p70S6K signaling pathway. PMID: 29541215 Ref: Interferon-gamma induces autophagy-associated apoptosis through induction of cPLA2-dependent mitochondrial ROS generation in colorectal cancer cells. PMID: 29551681 Ref: beta-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy. PMID: 29551770 Ref: Deciphering the molecular mechanism and apoptosis underlying the in-vitro and in-vivo chemotherapeutic efficacy of vanadium luteolin complex in colon cancer. PMID: 29574863 Ref: The silencing of replication protein A1 induced cell apoptosis via regulating Caspase 3. PMID: 29601890 Ref: Anticancer effect of fermented Insampaedok-san in human colon cancer cells: a pilot study. PMID: 29611024 Ref: Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells. PMID: 29619114 Ref: Effect of HOXA6 on the proliferation, apoptosis, migration and invasion of colorectal cancer cells. PMID: 29620285 Ref: Shikonin Prevents Early Phase Inflammation Associated with Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer and Induces Apoptosis in Human Colon Cancer Cells. PMID: 29642242 Ref: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. PMID: 29645049 Ref: Macranthoidin B Modulates Key Metabolic Pathways to Enhance ROS Generation and Induce Cytotoxicity and Apoptosis in Colorectal Cancer. PMID: 29689551 Ref: Baicalein induces the apoptosis of HCT116 human colon cancer cells via the upregulation of DEPP/Gadd45a and activation of MAPKs. PMID: 29749481 Ref: Downregulation of RPN2 induces apoptosis and inhibits migration and invasion in colon carcinoma. PMID: 29749494 Ref: The HDAC6 inhibitor ACY1215 enhances the anticancer activity of oxaliplatin in colorectal cancer cells. PMID: 29749542 Ref: Resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide induces G2/M cell cycle arrest through the activation of p53-p21(CIP1/WAF1) in human colorectal HCT116 cells. PMID: 29754265 Ref: Wasabi 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human colorectal cancer cells through p53-independent mitochondrial dysfunction pathway. PMID: 29756671 Ref: Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol. PMID: 29771951 Ref: [Adiponectin inhibits proliferation and induces apoptosis in colorectal cancer HCT116 cells]. PMID: 29773108 Ref: Mitotic and apoptotic activity in colorectal neoplasia. PMID: 29776402 Ref: 1,2,3,4,6-Penta-O-galloyl-beta-d-glucose suppresses colon cancer through induction of tumor suppressor. PMID: 29778287 Ref: Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK. PMID: 29783958 Ref: In Vitro and In Vivo Evaluation of Antitumor Activity of Ligustrum robustum, A Chinese Herbal Tea. PMID: 29790063 Ref: Expression Level of Caspase Genes in Colorectal Cancer PMID: 29801534 Ref: Proteomics Study Reveals That Docosahexaenoic and Arachidonic Acids Exert Different In Vitro Anticancer Activities in Colorectal Cancer Cells. PMID: 29804451 Ref: Upregulation of let-7f-5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro-apoptotic proteins. PMID: 29805607 Ref: shRNAinduced knockdown of the SPERT gene inhibits proliferation and promotes apoptosis of human colorectal cancer RKO cells. PMID: 29845259 Ref: Vicenin-2 inhibits Wnt/beta-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line. PMID: 29849451 Ref: N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models. PMID: 29850457 Ref: Dioscorea bulbifera induced apoptosis through inhibition of ERK 1/2 and activation of JNK signaling pathways in HCT116 human colorectal carcinoma cells. PMID: 29860114 Ref: Blue light-emitting diodes induce autophagy in colon cancer cells by Opsin 3. PMID: 29863164 Ref: Reactive oxygen species-mediated phosphorylation of p38 signaling is critically involved in apoptotic effect of Tanshinone I in colon cancer cells. PMID: 29876988 Ref: NUDCD1 promotes metastasis through inducing EMT and inhibiting apoptosis in colorectal cancer. PMID: 29888104 Ref: Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway. PMID: 29892198 Ref: A452, an HDAC6-selective inhibitor, synergistically enhances the anticancer activity of chemotherapeutic agents in colorectal cancer cells. PMID: 29917295 Ref: Ellagitannins from Pomegranate Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Rats while Enhancing Its Chemotoxicity against HT-29 Colorectal Cancer Cells through Intrinsic Apoptosis Induction. PMID: 29920075 Ref: Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine PMID: 29938466 Ref: Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies. PMID: 29944015 Ref: Wnt6 contributes tumorigenesis and development of colon cancer via its effects on cell proliferation, apoptosis, cell-cycle and migration. PMID: 29963191 Ref: Neuropilin 1 (NRP1) is a novel tumor marker in hepatocellular carcinoma. PMID: 29966621 Ref: Anti-inflammatory and anticancer effects of p-methoxycinnamic acid, an active phenylpropanoid, against 1,2-dimethylhydrazine-induced rat colon carcinogenesis. PMID: 29980883 Ref: Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway. PMID: 29982425 Ref: Resveratrol Chemosensitizes TNF-beta-Induced Survival of 5-FU-Treated Colorectal Cancer Cells. PMID: 30002278 Ref: Inhibitory effect of icariin on osteosarcoma cell proliferation via the Wnt/beta-catenin signaling pathway. PMID: 30008817 Ref: Identification of long non-coding RNA CCAT1 as an oncogene in nasopharyngeal carcinoma. PMID: 30013670 Ref: miR200b3p inhibits proliferation and induces apoptosis in colorectal cancer by targeting Wnt1. PMID: 30015876 Ref: Bisphenol A suppresses proliferation and induces apoptosis in colonic epithelial cells through mitochondrial and MAPK/AKT pathways. PMID: 30036487 Ref: Design, Synthesis and Antiproliferative Activities of Oxidative Stress Inducers Based on 2-Styryl-3,5-dihydro-4H-imidazol-4-one Scaffold. PMID: 30047515 Ref: Thermal Co-reduction engineered silver nanoparticles induce oxidative cell damage in human colon cancer cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis. PMID: 30056045 Ref: Upregulation of PDL1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300mediated NFkappaB signaling. PMID: 30066852 Ref: Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities. PMID: 30088538 Ref: Design, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents. PMID: 30099687 Ref: Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes. PMID: 30111296 Ref: MicroRNA-423-5p inhibits colon cancer growth by promoting caspase-dependent apoptosis. PMID: 30116373 Ref: Silencing long non-coding RNA, differentiation antagonizing non-protein coding RNA promotes apoptosis and inhibits tumor growth in colon cancer. PMID: 30127873 Ref: Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-3beta signaling pathway. PMID: 30142548 Ref: Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA-21-mediated activation of phosphatase and tensin homolog. PMID: 30186399 Ref: Terpenes from essential oils and hydrolate of Teucrium alopecurus triggered apoptotic events dependent on caspases activation and PARP cleavage in human colon cancer cells through decreased protein expressions. PMID: 30190788 Ref: Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer. PMID: 30191976 Ref: Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels. PMID: 30195524 Ref: Sorbus commixta water extract induces apoptotic cell death via a ROS-dependent pathway. PMID: 30197667 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 Ref: Matricellular protein periostin promotes colitis-associated colon tumorigenesis in mice. PMID: 30204842 Ref: Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells. PMID: 30211553 Ref: Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer. PMID: 30219719 Ref: Silencing of cadherin-17 enhances apoptosis and inhibits autophagy in colorectal cancer cells. PMID: 30227326 Ref: Glycyrrhizic acid suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats: Alleviation of inflammatory, proliferation, angiogenic, and apoptotic markers. PMID: 30255981 Ref: PTBP1 promotes tumorigenesis by regulating apoptosis and cell cycle in colon cancer. PMID: 30309622 Ref: Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line. PMID: 30314650 Ref: Puerarin 6''-O-xyloside possesses significant antitumor activities on colon cancer through inducing apoptosis. PMID: 30344709 Ref: Effects and mechanism of STAT3 silencing on the growth and apoptosis of colorectal cancer cells. PMID: 30344711 Ref: CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NFkappaB and/or caspase-3/7 signaling pathway. PMID: 30344756 Ref: Bio-Effects of TiO2 Nanoparticles on Human Colorectal Cancer and Umbilical Vein Endothelial Cell Lines PMID: 30361551 Ref: Galla Rhois water extract inhibits lung metastasis by inducing AMPKmediated apoptosis and suppressing metastatic properties of colorectal cancer cells. PMID: 30365120 Ref: Synergetic Inhibition of Human Colorectal Cancer Cells by Combining Polyyne-Enriched Fraction from Oplopanax elatus and Irinotecan. PMID: 30372160 Ref: The long noncoding RNA TPTE2P1 promotes the viability of colorectal cancer cells. PMID: 30382596 |