Primary Site >> Colorectal Cancer
Gene >> CACNA1G
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Ref: Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors. PMID: 10493502 |
Ref: Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. PMID: 15542810 |
Ref: CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. PMID: 16407376 Ref: Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis. PMID: 16699497 Ref: Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 16820091 Ref: Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 16850502 Ref: Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma. PMID: 16931963 Ref: CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. PMID: 17065427 |
Ref: Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP. PMID: 17086168 Ref: Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype. PMID: 17239930 Ref: TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. PMID: 17270239 Ref: Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. PMID: 17339237 Ref: Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 17350669 Ref: CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. PMID: 17372756 Ref: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high. PMID: 17474983 Ref: Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. PMID: 17591929 Ref: MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. PMID: 17621591 Ref: Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 17710160 Ref: Promoter methylation status of multiple genes in uveal melanoma. PMID: 17898258 Ref: IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. PMID: 18084616 |
Ref: WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18084250 Ref: CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. PMID: 18204436 Ref: LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18366060 Ref: PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. PMID: 18516290 Ref: Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype. PMID: 18628431 Ref: CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels. PMID: 18834226 Ref: Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype. PMID: 18983468 Ref: Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PMID: 19002263 |
Ref: CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. PMID: 18832519 Ref: JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. PMID: 19107235 Ref: SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 19430421 Ref: DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. PMID: 19470733 Ref: A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. PMID: 19686742 Ref: Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. PMID: 19789368 Ref: Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. PMID: 19825961 |
Ref: Three DNA methylation epigenotypes in human colorectal cancer. PMID: 20028768 Ref: Promoter methylation of specific genes is associated with the phenotype and progression of colorectal adenocarcinomas. PMID: 20077021 Ref: PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 20200425 Ref: Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype. PMID: 20381446 Ref: Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. PMID: 21037082 |
Ref: Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. PMID: 20473920 Ref: Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. PMID: 21068132 Ref: MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. PMID: 21140203 Ref: Detection of viral DNA sequences in sporadic colorectal cancers in relation to CpG island methylation and methylator phenotype. PMID: 21625944 Ref: B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP). PMID: 21738611 |
Ref: CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer. PMID: 22001634 Ref: Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer. PMID: 22655257 |
Ref: Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer. PMID: 23034738 Ref: [Application of genome-wide genechip for screening and identifying genes related to CD133(+)CD200(+) colorectal cancer stem cells]. PMID: 24369246 |
Ref: T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells. PMID: 24362252 Ref: Comparison of CpG island methylator phenotype (CIMP) frequency in colon cancer using different probe- and gene-specific scoring alternatives on recommended multi-gene panels. PMID: 24466191 Ref: CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer. PMID: 24859205 |
Ref: The role of the CpG island methylator phenotype on survival outcome in colon cancer. PMID: 25167802 Ref: Clinicopathological and molecular characteristics of serrated lesions in Japanese elderly patients. PMID: 25632919 Ref: Nuclear maspin expression correlates with the CpG island methylator phenotype and tumor aggressiveness in colorectal cancer. PMID: 25973084 |
Ref: Evaluation of CpG Island Methylator Phenotype as a Biomarker in Colorectal Cancer Treated With Adjuvant Oxaliplatin. PMID: 26702772 |
Ref: The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases. PMID: 28469732 Ref: Transcriptome analysis of PDGFRalpha+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRalpha+ cell hyperplasia. PMID: 28806761 |
Ref: Genomic heterogeneity in primary colorectal carcinomas and their metastases: born bad or brought up a villain? PMID: 29307628 Ref: Prognostic Value of Methylator Phenotype in Stage III Colon Cancer Treated with Oxaliplatin-based Adjuvant Chemotherapy. PMID: 29921730 Ref: Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans. PMID: 29930328 |