Primary Site >> Colorectal Cancer
Gene >> BRCA2
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Ref: Prophylactic Oophorectomy: Reducing the U.S. Death Rate from Epithelial Ovarian Cancer. A Continuing Debate. PMID: 10388011 |
Ref: The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. PMID: 9145676 Ref: The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds. PMID: 9407954 Ref: Cancer genetics in the new era of molecular biology. PMID: 9616736 |
Ref: Inherited susceptibility to breast and ovarian cancer. PMID: 9484622 Ref: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. PMID: 9622070 Ref: The genetics of hereditary common cancers. PMID: 9690990 Ref: Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes. PMID: 9708796 Ref: Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. PMID: 9839517 Ref: Hereditary Factors in Gynecologic Cancer. PMID: 10388122 |
Ref: Causes and consequences of microsatellite instability in endometrial carcinoma. PMID: 9927063 Ref: [Hereditary neoplastic diseases (genetic predisposition and cancer syndromes)]. PMID: 10204401 Ref: Prognostic implications of cancer susceptibility genes: any news? PMID: 10337719 Ref: Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. PMID: 10362364 Ref: Colorectal cancer in hereditary breast cancer kindreds. PMID: 10458128 Ref: A novel sensitive method to detect frameshift mutations in exonic repeat sequences of cancer-related genes. PMID: 10545425 Ref: The candidate tumour suppressor gene, ING1, is retained in colorectal carcinomas. PMID: 10615239 |
Ref: The effect of mismatch repair deficiency on tumourigenesis; microsatellite instability affecting genes containing short repeated sequences. PMID: 10601558 Ref: Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma. PMID: 10709098 Ref: Incidence of BRCA1 and BRCA2 mutations in Ashkenazi colorectal cancer patients: preliminary study. PMID: 10769725 Ref: Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. PMID: 10773412 Ref: Identification of Rad51 alteration in patients with bilateral breast cancer. PMID: 10807537 Ref: BRCA1 and BRCA2 gene mutations: decision-making dilemmas concerning testing and management. PMID: 10841315 Ref: Health, life and disability insurance and hereditary risk for breast or colorectal cancer. PMID: 10859009 Ref: BRCA1 germline mutations in women with uterine serous papillary carcinoma. PMID: 10862837 Ref: Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells. PMID: 11103814 |
Ref: Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. PMID: 11179017 Ref: The frequency of the predominant Jewish mutations in BRCA1 and BRCA2 in unselected Ashkenazi colorectal cancer patients. PMID: 11207040 Ref: The rate of the 6174delT founder Jewish mutation in BRCA2 in patients with non-colonic gastrointestinal tract tumours in Israel. PMID: 11207041 Ref: Localization of human BRCA1 and BRCA2 in non-inherited colorectal carcinomas and matched normal mucosas. PMID: 11497291 Ref: Risk of breast and ovarian cancer in women with strong family histories. PMID: 11499690 Ref: Characterization of anti-BRCA2 antibodies in cell lines by Western blot analysis. PMID: 11605067 Ref: Cancer risks in women with 2 breast or ovarian cancers: clues to genetic cancer susceptibility. PMID: 11745474 Ref: MRNA expression of genes altered by 5-azacytidine treatment in cancer cell lines is associated with clinicopathological parameters of human cancers. PMID: 11768609 |
Ref: An endonuclease/ligase based mutation scanning method especially suited for analysis of neoplastic tissue. PMID: 11896624 Ref: Mutation analysis of the CHK2 gene in breast carcinoma and other cancers. PMID: 12052256 Ref: Hereditary risk of women's cancers. PMID: 12475549 Ref: [Recommendations for the management of women with an increased genetic risk of gynaecological cancer]. PMID: 12518519 |
Ref: A high-throughput nonisotopic protein truncation test. PMID: 12524552 Ref: Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. PMID: 12837831 Ref: Does the occurrence of certain rare cancers indicate an inherited cancer susceptibility? PMID: 14574163 |
Ref: BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer. PMID: 14709734 Ref: Frequency of BRCA1 and BRCA2 mutations in unselected Ashkenazi Jewish patients with colorectal cancer. PMID: 14709740 Ref: Germline truncating mutations in both MSH2 and BRCA2 in a single kindred. PMID: 14735197 Ref: BRCA germline mutations in Jewish women with uterine serous papillary carcinoma. PMID: 14766242 Ref: Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. PMID: 15162061 Ref: No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. PMID: 15217503 Ref: Re: BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer. PMID: 15292392 Ref: Bias in intervention studies that enroll patients from high-risk clinics. PMID: 15316055 Ref: Evaluation of psychosocial effects of pre-symptomatic testing for breast/ovarian and colon cancer pre-disposing genes: a 12-month follow-up. PMID: 15340261 Ref: [Genetic predisposition and ovarian cancer]. PMID: 15630879 Ref: Inheritance of cancer. PMID: 20704938 |
Ref: [DNA-analysis in hereditary cancer: the importance of a reliable family history]. PMID: 15688834 Ref: Coinheritance of BRCA1 and BRCA2 mutations with Fanconi anemia and Bloom syndrome mutations in Ashkenazi Jewish population: possible role in risk modification for cancer development. PMID: 15726604 Ref: Hereditary breast cancer syndromes in a Turkish population. Results of molecular germline analysis. PMID: 15993273 Ref: Effect of NS398 on metastasis-associated gene expression in a human colon cancer cell line. PMID: 16038031 Ref: Quantitative analysis of BRCA1, BRCA2 and Hmsh2 mRNA expression in colorectal Lieberkuhnien adenocarcinomas and matched normal mucosa: relationship with cellular proliferation. PMID: 16158938 Ref: [Hereditary predispositions to gynaecological cancers]. PMID: 16256400 Ref: Organization and running of the first comprehensive hereditary cancer clinic in India. PMID: 20223043 |
Ref: Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. PMID: 16533773 Ref: Implication of the BRCA2 and putative "BRCA3" genes in Dukes' stage C, replication error-negative colon cancer. PMID: 16614877 Ref: [Hereditary ovarian cancer]. PMID: 16768054 Ref: Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies. PMID: 16825437 |
Ref: Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas. PMID: 17143621 Ref: Cancer risks in carriers of the BRCA1/2 Ashkenazi founder mutations. PMID: 17307836 Ref: Morphological features of TMPRSS2-ERG gene fusion prostate cancer. PMID: 17385188 Ref: Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players. PMID: 17613548 Ref: A diagnostic dilemma following risk-reducing surgery for BRCA1 mutation - a case report of primary papillary serous carcinoma presenting as sigmoid cancer. PMID: 17850658 Ref: Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. PMID: 17950381 |
Ref: Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. PMID: 18313025 Ref: Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes. PMID: 18481196 Ref: Inherited cancer predisposition syndromes in Greece. PMID: 18505076 Ref: Counseling for male BRCA mutation carriers: a review. PMID: 18657973 Ref: 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin- 1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. PMID: 18800822 |
Ref: BRCA2 alteration is important in clear cell carcinoma of the ovary. PMID: 19656163 Ref: Germline variants of the promyelocytic leukemia tumor suppressor gene in patients with familial cancer. PMID: 19728758 |
Ref: Impact of gene patents and licensing practices on access to genetic testing for inherited susceptibility to cancer: comparing breast and ovarian cancers with colon cancers. PMID: 20393305 Ref: Common genetic variants and cancer risk in Mendelian cancer syndromes. PMID: 20399636 Ref: Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. PMID: 20423983 Ref: Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model. PMID: 20454511 Ref: Genetic profiles distinguish different types of hereditary ovarian cancer. PMID: 20811668 Ref: The rate of the predominant Jewish mutations in the BRCA1, BRCA2, MSH2 and MSH6 genes in unselected Jewish endometrial cancer patients. PMID: 20850175 Ref: Screening for common copy-number variants in cancer genes. PMID: 21156252 Ref: Genetic testing and prevention of hereditary cancer at the MMCI--over 10 years of experience. PMID: 21348412 |
Ref: German national case collection for familial pancreatic cancer (FaPaCa): ten years experience. PMID: 21207249 Ref: Drug therapy for hereditary cancers. PMID: 21819606 Ref: Ileal metastasis of breast cancer in a patient with a BRCA2 gene mutation: report of a case. PMID: 21969203 Ref: Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. PMID: 22977515 |
Ref: DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome. PMID: 21974800 Ref: Intraductal papillary mucinous neoplasm of the pancreas: associated cancers, family history, genetic predisposition? PMID: 21975290 Ref: Using tumour pathology to identify people at high genetic risk of breast and colorectal cancers. PMID: 22198256 Ref: Germline DNA copy number variation in familial and early-onset breast cancer. PMID: 22314128 Ref: Epigenetic markers of early tumor development. PMID: 22359284 Ref: Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer. PMID: 22875147 Ref: Germline truncating-mutations in BRCA1 and MSH6 in a patient with early onset endometrial cancer. PMID: 23164213 |
Ref: Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924. PMID: 23100467 Ref: Differential BCCIP gene expression in primary human ovarian cancer, renal cell carcinoma and colorectal cancer tissues. PMID: 24101097 Ref: Translating genomics in cancer care. PMID: 24225968 Ref: [Multiple primary malignancies in BRCA1 mutation carriers--two clinical cases]. PMID: 24273914 |
Ref: Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study. PMID: 24292448 Ref: Mismatch repair deficiency in ovarian cancer -- molecular characteristics and clinical implications. PMID: 24333356 Ref: [Hereditary predisposition to cancers of the digestive tract, breast, gynecological and gonadal: focus on the Peutz-Jeghers]. PMID: 25036236 Ref: Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells. PMID: 25043256 Ref: A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells. PMID: 25091037 Ref: Risk-benefit assessment of the combined oral contraceptive pill in women with a family history of female cancer. PMID: 25146351 Ref: Exome-wide somatic microsatellite variation is altered in cells with DNA repair deficiencies. PMID: 25402475 Ref: [Genotyping of BRCA1, BRCA2 and CHEK2 germline mutations in Russian breast cancer patients using diagnostic biochips]. PMID: 25850293 |
Ref: BRCA2 gene: a candidate for clinical testing in familial colorectal cancer type X. PMID: 24814045 Ref: The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage. PMID: 24912782 Ref: Tumor genome analysis includes germline genome: are we ready for surprises? PMID: 25123297 Ref: BRCA1 and BRCA2 mutations and the risk for colorectal cancer. PMID: 25195694 Ref: Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions. PMID: 25238946 Ref: Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition. PMID: 25388513 Ref: Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer. PMID: 25479140 Ref: Tailoring heated intraperitoneal mitomycin C for peritoneal metastases originating from colorectal carcinoma: a translational approach to improve survival. PMID: 25668003 Ref: Treatment with the PARP inhibitor, niraparib, sensitizes colorectal cancer cell lines to irinotecan regardless of MSI/MSS status. PMID: 25685067 Ref: RNA Interference Using c-Myc-Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models. PMID: 25695957 Ref: A 12-year experience at a tertiary hospital on patients with multiple primary malignant neoplasms. PMID: 25778335 Ref: Psychosocial Impact of Lynch Syndrome on Affected Individuals and Families. PMID: 25786861 Ref: 5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair. PMID: 25909291 Ref: BRCA1 5382insC founder mutation has not a significative recurrent presence in Northeastern Romanian cancer patients. PMID: 26193202 Ref: Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. PMID: 26678268 |
Ref: ROBO1 deletion as a novel germline alteration in breast and colorectal cancer patients. PMID: 26427657 Ref: A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer. PMID: 26637267 Ref: Improving performance of multigene panels for genomic analysis of cancer predisposition. PMID: 26845104 Ref: Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications. PMID: 26984550 Ref: The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer. PMID: 27165003 Ref: B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu. PMID: 27175567 Ref: Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. PMID: 27197191 Ref: Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study. PMID: 27197284 Ref: Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil. PMID: 27223485 Ref: Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia. PMID: 27246457 Ref: Undefined familial colorectal cancer and the role of pleiotropism in cancer susceptibility genes. PMID: 27356891 Ref: Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2- and CDKN1A-interacting protein (BCCIP) in cells. PMID: 27535137 Ref: Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset epithelial ovarian cancer. PMID: 27602174 Ref: Expression pattern of BCCIP in hepatocellular carcinoma is correlated with poor prognosis and enhanced cell proliferation. PMID: 27832471 Ref: Familial prostate cancer. PMID: 27899188 |
Ref: Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer. PMID: 27978560 Ref: Prostate Cancer in a Patient with a Family History of BRCA Mutation: a Case Report and Literature Review. PMID: 28049253 Ref: High-risk epithelial ovarian cancer patients for hereditary ovarian cancer. PMID: 28188963 Ref: Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP. PMID: 28386336 Ref: Multigene Panel Testing Provides a New Perspective on Lynch Syndrome. PMID: 28514183 Ref: BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations. PMID: 28591715 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Preclinical rationale for combination of crizotinib with mitomycin C for the treatment of advanced colorectal cancer. PMID: 28886275 Ref: Expanding the spectrum of germline variants in cancer. PMID: 28975465 Ref: Familial Colorectal Cancer Type X (FCCTX) and the correlation with various genes-A systematic review. PMID: 29096939 |
Ref: BRCA1 and BRCA2 expression patterns and prognostic significance in digestive system cancers. PMID: 29126833 Ref: A mutational comparison of adult and adolescent and young adult (AYA) colon cancer. PMID: 29194591 Ref: Evaluating the role of public health in implementation of genomics-related recommendations: a case study of hereditary cancers using the CDC Science Impact Framework. PMID: 29907802 Ref: BCCIP binds to and activates its promoter in a YY1-dependent fashion in HCT116 cells. PMID: 29932276 Ref: Impact of Patient Age on Molecular Alterations of Left-Sided Colorectal Tumors. PMID: 30018131 Ref: Rare loss of function variants in candidate genes and risk of colorectal cancer. PMID: 30267214 Ref: BRCA1 and BRCA2 Gene Mutations and Colorectal Cancer Risk: Systematic Review and Meta-analysis. PMID: 30380096 |