Primary Site >> Stomach Cancer

Gene >> BMP2

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Ref: BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells.
PMID: 15003517
 Ref: Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas.
PMID: 16314833
 Ref: Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.
PMID: 18498120
Ref: The Bone Morphogenesis Protein-2 (BMP-2) is associated with progression to metastatic disease in gastric cancer.
PMID: 19688119
 Ref: DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients.
PMID: 19170207
 Ref: BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.
PMID: 19835871
Ref: Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression.
PMID: 19924575
 Ref: Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.
PMID: 21551187
Ref: Metastatic function of BMP-2 in gastric cancer cells: the role of PI3K/AKT, MAPK, the NF-kappaB pathway, and MMP-9 expression.
PMID: 21570392
Ref: Bone morphogenetic protein-2 and -4 play tumor suppressive roles in human diffuse-type gastric carcinoma.
PMID: 21996676
 Ref: Effect of bone morphogenetic protein-2 on proliferation and apoptosis of gastric cancer cells.
PMID: 22359486
Ref: Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells.
PMID: 22791809
 Ref: Progastrin stimulates colonic cell proliferation via CCK2R- and beta-arrestin-dependent suppression of BMP2.
PMID: 23891976
Ref: Epigenetic effects of green tea polyphenols in cancer.
PMID: 24283885
 Ref: Bone morphogenetic protein 2 mediates epithelial-mesenchymal transition via AKT and ERK signaling pathways in gastric cancer.
PMID: 25448881
Ref: Inactivation of the phosphatidylinositol 3-kinase/Akt pathway is involved in BMP9-mediated tumor-suppressive effects in gastric cancer cells.
PMID: 25640278
Ref: C23 protein meditates bone morphogenetic protein-2-mediated EMT via up-regulation of Erk1/2 and Akt in gastric cancer.
PMID: 25698539
 Ref: Metastatic pathway-specific transcriptome analysis identifies MFSD4 as a putative tumor suppressor and biomarker for hepatic metastasis in patients with gastric cancer.
PMID: 26872374