Primary Site >> Colorectal Cancer
Gene >> BCL9
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Identification and in vivo role of the Armadillo-Legless interaction. PMID: 15294866 Ref: Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. PMID: 15574752 |
Ref: FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. PMID: 16465403 Ref: Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells. PMID: 17020613 |
Ref: BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. PMID: 17113272 Ref: Up-regulation of a BCL9-related beta-catenin-binding protein, B9L, in different stages of sporadic colorectal adenoma. PMID: 17129358 |
Ref: The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells. PMID: 18627596 |
Ref: BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells. PMID: 19738061 |
Ref: BCL9-2 promotes early stages of intestinal tumor progression. PMID: 21703997 |
Ref: An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid. PMID: 22353711 Ref: Targeted disruption of the BCL9/beta-catenin complex inhibits oncogenic Wnt signaling. PMID: 22914623 |
Ref: LATS2 suppresses oncogenic Wnt signaling by disrupting beta-catenin/BCL9 interaction. PMID: 24360964 |
Ref: LEF1 and B9L shield beta-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. PMID: 24419084 Ref: Crosstalk between microRNA30a/b/c/d/e-5p and the canonical Wnt pathway: implications for multiple myeloma therapy. PMID: 25228654 Ref: Mixed adenoneuroendocrine carcinoma of the colon: molecular pathogenesis and treatment. PMID: 25275049 |
Ref: Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. PMID: 26384318 Ref: [beta-Catenin: Structure, Function and Role in Malignant Transformation of Epithelial Cells]. PMID: 26710532 Ref: Tuning WNT-beta-catenin signaling via BCL9 proteins for targeting colorectal cancer cells. PMID: 26844253 Ref: BCL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer. PMID: 26844272 |
Ref: The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway. PMID: 27338550 Ref: The role of Pygo2 for Wnt/ss-catenin signaling activity during intestinal tumor initiation and progression. PMID: 27811361 |
Ref: HIF-1alpha activates hypoxia-induced BCL-9 expression in human colorectal cancer cells. PMID: 27121066 Ref: Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1. PMID: 28539123 |
Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 |