Primary Site >> Biliary tract Cancer

Gene >> BCL2L1

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Ref: Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line.
PMID: 9328309
 Ref: Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas.
PMID: 12120204
 Ref: Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells.
PMID: 12235080
 Ref: Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation.
PMID: 15057907
Ref: Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.
PMID: 15150106
 Ref: Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis.
PMID: 16024633
 Ref: Treatment of biliary tract cancer with NVP-AEW541: mechanisms of action and resistance.
PMID: 20066734
Ref: Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells.
PMID: 20480521
 Ref: The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid.
PMID: 20473610
Ref: Overexpression of LAPTM4B-35 attenuates epirubucin-induced apoptosis of gallbladder carcinoma GBC-SD cells.
PMID: 21429547
 Ref: Icariin potentiates the antitumor activity of gemcitabine in gallbladder cancer by suppressing NF-kappaB.
PMID: 23274410
 Ref: Mycoepoxydiene induces apoptosis and inhibits TPA-induced invasion in human cholangiocarcinoma cells via blocking NF-kappaB pathway.
PMID: 24486723
Ref: FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling.
PMID: 25344679
 Ref: The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine.
PMID: 26870236
Ref: Nrf2 inhibition sensitizes cholangiocarcinoma cells to cytotoxic and antiproliferative activities of chemotherapeutic agents.
PMID: 27015836
Ref: FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression.
PMID: 27127878