Primary Site >> Colorectal Cancer
Gene >> BCL2
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Molecular mechanism of stomach carcinogenesis. PMID: 8440743 |
Ref: BCL-2 expression in human colorectal adenomas and carcinomas. PMID: 7936663 Ref: Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas. PMID: 8063611 |
Ref: Immunohistochemically detectable bcl-2 expression in colorectal carcinoma: correlation with tumour stage and patient survival. PMID: 7547253 Ref: Review article: manipulation of cell death--the development of novel strategies for the treatment of gastrointestinal disease. PMID: 7654884 Ref: bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas. PMID: 7750937 Ref: Prognostic value of bcl-2 oncoprotein expression in stage II colon carcinoma. PMID: 9815900 |
Ref: Induction of apoptosis by c-Fos protein. PMID: 8524298 Ref: Evidence of reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas. PMID: 8611422 Ref: Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance. PMID: 8625232 Ref: Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. PMID: 8625322 Ref: Increased intestinal Bak expression results in apoptosis. PMID: 8660371 Ref: Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells. PMID: 8668331 Ref: Bcl-2 expression and allelic loss of the p53 gene in gastric carcinomas. PMID: 8690754 Ref: Expression of Bcl-2 protein in hyperplastic polyps, adenomas, and carcinomas of the colon. PMID: 8691316 Ref: Early expression of bcl-2 protein in the adenoma-carcinoma sequence of colorectal neoplasia. PMID: 8691332 Ref: Bcl-2, p53, CD44, and CD44v6 isoform expression in neuroendocrine tumors of the lung. PMID: 8733762 Ref: An immunohistochemical study of the simultaneous expression of bcl-2 and p53 oncoproteins in epithelial tumors of the colon and rectum. PMID: 8757470 Ref: Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methylimidazo[4,5-f]quinoline. PMID: 8813112 Ref: Bcl-2 expression in colorectal tumors: evidence of different pathways in sporadic and ulcerative-colitis-associated carcinomas. PMID: 8909260 Ref: Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines. PMID: 8938795 Ref: Expression of bcl-2 and p53 in de novo and ex-adenoma colon carcinoma: a comparative immunohistochemical study. PMID: 8958802 Ref: Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells. PMID: 9000137 Ref: The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. PMID: 9003774 Ref: Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide. PMID: 9018084 Ref: Increased apoptosis accompanies neoplastic development in the human colorectum. PMID: 9816159 Ref: Genes mediating programmed cell death: an immunohistochemical study of bcl-2, c-myc and p53 expression in colorectal neoplasia. PMID: 16696064 |
Ref: Prognostic markers for colorectal cancer: expression of P53 and BCL2. PMID: 8995081 Ref: Bcl-2 deregulation leads to inhibition of sodium butyrate-induced apoptosis in human colorectal carcinoma cells. PMID: 9054611 Ref: Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis. PMID: 9070487 Ref: Apoptosis induced in human colorectal carcinoma by anti-Fas antibody. PMID: 9084855 Ref: Poorly differentiated colonic adenocarcinoma, medullary type: clinical, phenotypic, and molecular characteristics. PMID: 9137104 Ref: Pathological and genetic correlates of apoptosis in the progression of colorectal neoplasia. PMID: 9143411 Ref: Cell proliferation-related markers in colorectal liver metastases: correlation with patient prognosis. PMID: 9164212 Ref: Expression of bcl-2, bax, and bcl-XL proteins in azoxymethane-induced rat colonic adenocarcinomas. PMID: 9180925 Ref: Suppression of nitric oxide-induced apoptosis by N-acetyl-L-cysteine through modulation of glutathione, bcl-2, and bax protein levels. PMID: 9210957 Ref: Coexpression of Bcl-2, c-Myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma. PMID: 9221853 Ref: Improved prognosis of solid-type poorly differentiated colorectal adenocarcinoma: a clinicopathological and immunohistochemical study. PMID: 9279562 Ref: Trophoblasts express Fas ligand: a proposed mechanism for immune privilege in placenta and maternal invasion. PMID: 9294848 Ref: Apoptosis in colorectal carcinoma occurring in patients aged 45 years and under: relationship to prognosis, mitosis, and immunohistochemical demonstration of p53, c-myc and bcl-2 protein products. PMID: 9306959 Ref: Expression of Bcl-2 and p53 in the colorectal adenoma-carcinoma sequence. PMID: 9309780 Ref: The role of p53, p21WAF1/C1PI, and bcl-2 in radioresistant colorectal carcinoma. PMID: 9343326 Ref: Apoptosis induced by hyperthermia and verapamil in vitro in a human colon cancer cell line. PMID: 9354939 Ref: Mechanisms underlying apoptosis induced by combination of 5-fluorouracil and interferon-gamma. PMID: 9388485 Ref: [Expression of p53 and bcl-2 in colorectal adenomas and carcinomas]. PMID: 9674186 Ref: [Apoptosis and expression of its regulating genes in adenoma and adenocarcinoma of large intestine]. PMID: 10072852 Ref: Taxol induces apoptosis in human colon carcinoma cell lines arrested in G(2)/M phase. PMID: 21590211 |
Ref: Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. PMID: 9443418 Ref: Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factor-alpha (TNF-alpha) and/or interferon-gamma (IFN-gamma), resulting from down-modulation of Bcl-2 expression. PMID: 9472684 Ref: Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells. PMID: 9558281 Ref: Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. PMID: 9585232 Ref: [Immunohistochemical study on the progression of colorectal cancer--with respect to apoptotic index, expression of apoptosis-related gene products, and labeling index of proliferating cell nuclear antigen (PCNA)]. PMID: 9589044 Ref: Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. PMID: 9593754 Ref: A histopathological assessment of the response of rectal adenocarcinoma to combination chemo-radiotherapy: relationship to apoptotic activity, p53 and bcl-2 expression. PMID: 9630854 Ref: Apoptosis, proliferation, bax, bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal cancer. PMID: 9635706 Ref: Mutational analysis of Bax and Bcl-2 in childhood acute lymphoblastic leukaemia. PMID: 9645350 Ref: Nitrogen mustard up-regulates Bcl-2 and GSH and increases NTP and PCr in HT-29 colon cancer cells. PMID: 9652754 Ref: Immunohistochemical detection of p53 and Bcl-2 in colorectal carcinoma: no evidence for prognostic significance. PMID: 9667656 Ref: Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer. PMID: 9667660 Ref: Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis. PMID: 9671409 Ref: Absence of frameshift mutations in the bax gene in renal cell cancer (RCC) and transitional cell cancer (TCC). PMID: 9673385 Ref: Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. PMID: 9679980 Ref: Bcl-2-mediated inhibition of apoptosis prevents immunogenicity and restores tumorigenicity of spontaneously regressive tumors. PMID: 9686608 Ref: Telomerase activity significantly correlates with cell differentiation, proliferation and lymph node metastasis in colorectal carcinomas. PMID: 9750021 Ref: Induction of apoptosis in colon cancer cells by nonsteroidal anti-inflammatory drugs. PMID: 9752793 Ref: Engagement of variant CD44 confers resistance to anti-integrin antibody-mediated apoptosis in a colon carcinoma cell line. PMID: 9759519 Ref: 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins. PMID: 9792140 Ref: Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. PMID: 9823313 Ref: c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression. PMID: 9823328 Ref: Growth patterns in various macroscopic types of noninvasive intramucosal colorectal carcinoma with special reference to apoptosis and cell proliferation. PMID: 9823803 Ref: Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells. PMID: 9829751 Ref: Loss of Bcl-2 expression correlates with tumour recurrence in colorectal cancer. PMID: 9863484 Ref: Imbalance between proliferation and apoptosis in the development of colorectal carcinoma. PMID: 9870685 Ref: Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal cancer. PMID: 9881495 Ref: Expression of Bcl-XS alters cytokinetics and decreases clonogenic survival in K12 rat colon carcinoma cells. PMID: 9881700 Ref: The inhibitors of apoptosis (IAPs) and their emerging role in cancer. PMID: 9916987 Ref: Expression of genes that regulate Fas signalling and Fas-mediated apoptosis in colon carcinoma cells. PMID: 10200495 Ref: Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate. PMID: 10200499 Ref: [Cellular apoptosis, proliferation and bcl-2 Bax expression in colorectal carcinoma and their association with tumor prognosis]. PMID: 11825479 Ref: [Bcl-2 inhibits p53-induced apoptosis after genotoxic damage by inhibitors of nuclear import of p53]. PMID: 14518224 |
Ref: Changes of angiogenesis and tumor cell apoptosis during colorectal carcinogenesis. PMID: 9918211 Ref: Bcl-2 protein expression and gut neurohormonal polypeptide/amine production in colorectal carcinomas and tumor-neighboring mucosa, which closely correlate to the occurrence of tumor. PMID: 9987648 Ref: An aggressive desmoid tumor in a patient with familial adenomatous polyposis: immunohistochemical findings. PMID: 10022664 Ref: Prognostic significance of Bcl-2, Bcl-xL/S, Bax and Bak expressions in colorectal carcinomas. PMID: 10023006 Ref: Usefulness of p53 protein, Bcl-2 protein and Ki-67 as predictors of chemosensitivity of malignant tumors. PMID: 10203614 Ref: K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma. PMID: 10216477 Ref: The role of bcl-2 in the progression of the colorectal adenoma-carcinoma sequence. PMID: 10216484 Ref: Induction of apoptosis and G2/M cell cycle arrest by DCC. PMID: 10348349 Ref: An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. PMID: 10359525 Ref: Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity. PMID: 10360653 Ref: Apoptosis in relation to proliferating cell nuclear antigen and Dukes' stage in colorectal adenocarcinoma. PMID: 10375593 Ref: Expression of p53, p21/waf, bcl-2, bax, Rb and Ki67 proteins in colorectal adenocarcinomas. PMID: 10382939 Ref: Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro. PMID: 10394957 Ref: p21WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations. PMID: 10398083 Ref: Redistribution of activated caspase-3 to the nucleus during butyric acid-induced apoptosis. PMID: 10403841 Ref: Villous tumor of the colon and rectum with special reference to roles of p53 and bcl-2 in adenoma-carcinoma sequence. PMID: 10417679 Ref: [Pathogenesis of malignant melanoma. Molecular biology aspect]. PMID: 10427507 Ref: Apoptotic and mitotic indices predict survival rates in lymph node-negative colon carcinomas. PMID: 10430084 Ref: The immunohistochemical expression of BCL-2 oncoprotein in colorectal adenocarcinoma. PMID: 10452254 Ref: Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices. PMID: 10470163 Ref: Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. PMID: 10473109 Ref: Comparison of p53 and bcl-2 expression in initial, synchronous, and metachronous colorectal adenomas. PMID: 10483743 Ref: Protein-kinase-C iso-enzymes support DNA synthesis and cell survival in colorectal-tumor cells. PMID: 10521802 Ref: Combined role of tumor angiogenesis, bcl-2, and p53 expression in the prognosis of patients with colorectal carcinoma. PMID: 10526268 Ref: bcl-2 protein expression is associated with better prognosis in colorectal cancer. PMID: 10564391 Ref: Evaluation of multiple bio-pathological factors in colorectal adenocarcinomas: independent prognostic role of p53 and bcl-2. PMID: 10567896 Ref: A case of adenocarcinoma of the small intestine in a Japanese patient with Crohn disease: a report with immunohistochemical and oncogenic analyses. PMID: 10582770 Ref: Correlation of bcl-2 oncoprotein immunohistochemical expression with proliferation index and histopathologic parameters in colorectal neoplasia. PMID: 10607921 Ref: B-cell leukemia protein-2 and peptide YY chemotherapy resistance in colon cancer. PMID: 10612539 Ref: Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa. PMID: 10632348 Ref: Oncoprotein coexpression in human aberrant crypt foci and minute polypoid lesions of the large bowel. PMID: 10652634 Ref: Prognostic evaluation of metallothionein expression in human colorectal neoplasms. PMID: 10711249 Ref: [Are there differences between ex adenoma and de novo colorectal carcinomas?]. PMID: 10714204 Ref: Association of increased radiocurability of murine carcinomas with low constitutive expression of p21(WAF1/CIP1) protein. PMID: 10760438 Ref: Technology evaluation: G-3139. PMID: 11713806 Ref: [Chemotherapeutic failure in micrometastasis in peripheral blood of patients with colorectal carcinomas]. PMID: 11829878 Ref: [Roles of bifidobacterium on prevention of experimental colorectal carcinoma and induction of apoptosis]. PMID: 11864503 Ref: [Significance of apoptosis status and apoptosis-associated antigen expression in human colorectal adenocarcinoma sequence]. PMID: 12212055 |
Ref: Role of tumor cell apoptosis in tumor antigen migration to the draining lymph nodes. PMID: 10657650 Ref: Molecular pathology of cyclooxygenase-2 in neoplasia. PMID: 10678579 Ref: Dietary regulation and localization of apoptosis cascade proteins in the colonic crypt. PMID: 10679813 Ref: p53 and Bcl-2 as significant predictors of recurrence and survival in rectal cancer. PMID: 10708936 Ref: Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. PMID: 10728709 Ref: New directions in the treatment of colorectal cancer: a look to the future. PMID: 10738119 Ref: Evidence for post-transcriptional down-regulation of the apoptosis-related gene bcl-2 in human colorectal cancer. PMID: 10767713 Ref: Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas. PMID: 10782880 Ref: Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed. PMID: 10785598 Ref: Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy. PMID: 10786699 Ref: Molecular prognostic factors in rectal cancer treated by radiation and surgery. PMID: 10789738 Ref: Telomerase activity in colorectal cancer and its relationship to bcl-2 expression. PMID: 10797335 Ref: Development of resistance to glutathione depletion-induced cell death in CC531 colon carcinoma cells: association with increased expression of bcl-2. PMID: 10799652 Ref: p53 and APC mutations are detectable in the plasma and serum of patients with colorectal cancer (CRC) or adenomas. PMID: 10818595 Ref: Association of a duodenal follicular lymphoma and hereditary nonpolyposis colorectal cancer. PMID: 10824932 Ref: Application of the enrichment approach to identify putative markers of response to 5-fluorouracil therapy in advanced colorectal carcinomas. PMID: 10853033 Ref: Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict. PMID: 10911913 Ref: Involvement of lipid peroxidation, oncogene expression and induction of apoptosis in the antitumorous activity of ferric-sorbitol-citrate. PMID: 10941536 Ref: Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers. PMID: 10944610 Ref: Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine. PMID: 10951589 Ref: Bcl-2 expression in colorectal tumours. Correlation with p53, mdm-2, Rb proteins and proliferation indices. PMID: 10963109 Ref: Bcl-X(L) antisense sensitizes human colon cancer cell line to 5-fluorouracil. PMID: 10965024 Ref: Immunohistochemical expression of bcl-2 and p53 oncoproteins: correlation with Ki67 proliferation index and prognostic histopathologic parameters in colorectal neoplasia. PMID: 10981868 Ref: Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution. PMID: 10984511 Ref: Apoptosis in rectal cancer: prognostic significance in comparison with clinical histopathologic, and immunohistochemical variables. PMID: 11005488 Ref: Bcl-2 expression is associated with improved prognosis in patients with distal colorectal adenocarcinomas. PMID: 11008204 Ref: Heterodimerization of Bcl-2 and Bcl-X(L) with Bax and Bad in colorectal cancer. PMID: 11041112 Ref: Multiple factors other than p53 influence colon cancer sensitivity to paclitaxel. PMID: 11052631 Ref: Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis. PMID: 11056003 Ref: Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. PMID: 11078056 Ref: Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. PMID: 11090257 Ref: Cytotoxic effect of gossypol on colon carcinoma cells. PMID: 11105982 Ref: Bax induction activates apoptotic cascade via mitochondrial cytochrome c release and Bax overexpression enhances apoptosis induced by chemotherapeutic agents in DLD-1 colon cancer cells. PMID: 11123425 Ref: Apoptosis cascade proteins are regulated in vivo by high intracolonic butyrate concentration: correlation with colon cancer inhibition. PMID: 11132927 Ref: Colorectal carcinomas with high microsatellite instability: defining a distinct immunologic and molecular entity with respect to prognostic markers. PMID: 11150376 Ref: Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines. PMID: 11205258 Ref: Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates. PMID: 11417748 Ref: Change of apoptotic status in the human colorectal adenoma-carcinoma sequences and its correlation with carcinogenesis and prognosis. PMID: 11775833 Ref: Chemoprevention of tea on colorectal cancer induced by dimethylhydrazine in Wistar rats. PMID: 11819677 Ref: [Biomarkers in the studies on chemoprevention of colorectal cancer]. PMID: 12725091 Ref: Expression of p27(Kip1) and bcl-2, cigarette smoking, and colorectal cancer risk. PMID: 23889224 |
Ref: Molecular characterization of colorectal neoplasia in translational research. PMID: 11151060 Ref: Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements. PMID: 11156956 Ref: Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors. PMID: 11159736 Ref: Cancer cells surviving hypoxia obtain hypoxia resistance and maintain anti-apoptotic potential under reoxygenation. PMID: 11169954 Ref: Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells. PMID: 11169965 Ref: Determinants of prognosis and response to therapy in colorectal cancer. PMID: 11177741 Ref: Modulation of protein kinase C in antitumor treatment. PMID: 11190577 Ref: Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer. PMID: 11237386 Ref: Aspirin effects on endometrial cancer cell growth. PMID: 11239649 Ref: Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. PMID: 11245478 Ref: Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins. PMID: 11259472 Ref: Molecular markers and prediction of response to chemoradiation in rectal cancer. PMID: 11295069 Ref: Correlation of immunohistochemical p53 labeling index with inhibition rate in chemosensitivity test in gastric and colon cancer. PMID: 11299739 Ref: Bax protein expression in colorectal cancer: association with p53, bcl-2 and patterns of relapse. PMID: 11299743 Ref: 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. PMID: 11300326 Ref: Sodium nitroprusside enhances TRAIL-induced apoptosis via a mitochondria-dependent pathway in human colorectal carcinoma CX-1 cells. PMID: 11313891 Ref: A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function. PMID: 11313999 Ref: Molecular markers are predictors of recurrence and survival in patients with Dukes B and Dukes C colorectal adenocarcinoma. PMID: 11330579 Ref: Expression of Bcl-2 and c-ErbB-2 in colorectal neoplasia. PMID: 11349216 Ref: Immunohistochemical detection of the anti-apoptosis protein, survivin, predicts survival after curative resection of stage II colorectal carcinomas. PMID: 11352303 Ref: Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation. PMID: 11355956 Ref: Expression of survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis. PMID: 11391581 Ref: p53, BCL-2, and Ki-67 expression according to tumor response after concurrent chemoradiotherapy for advanced rectal cancer. PMID: 11407516 Ref: Cyclooxygenase-2: a novel target for cancer chemotherapy? PMID: 11469677 Ref: Cryptophycins: a novel class of potent antimitotic antitumor depsipeptides. PMID: 11472266 Ref: Apoptosis as an independent prognostic indicator in squamous cell carcinoma of the esophagus. PMID: 11472561 Ref: Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29. PMID: 11478840 Ref: Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer. PMID: 11484952 Ref: Combined blockade of protein kinase A and bcl-2 by antisense strategy induces apoptosis and inhibits tumor growth and angiogenesis. PMID: 11489837 Ref: Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization. PMID: 11494135 Ref: The comparison of immunohistochemical proliferation and apoptosis markers in rectal carcinoma treated surgically or by preoperative radio-chemotherapy. PMID: 11505681 Ref: 4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release. PMID: 11511183 Ref: The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. PMID: 11513873 Ref: Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer. PMID: 11515678 Ref: Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival. PMID: 11523051 Ref: Apoptosis induction by sennoside laxatives in man; escape from a protective mechanism during chronic sennoside use? PMID: 11523059 Ref: Genasense (Genta Inc). PMID: 11566020 Ref: Mechanisms of oncogenesis in colon versus rectal cancer. PMID: 11592095 Ref: Molecular basis of colorectal cancer - role of gastrin and cyclooxygenase-2. PMID: 11687726 Ref: Short-chain fatty acids inhibit invasive human colon cancer by modulating uPA, TIMP-1, TIMP-2, mutant p53, Bcl-2, Bax, p21 and PCNA protein expression in an in vitro cell culture model. PMID: 11694645 Ref: E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis in colon cancer cells. PMID: 11705881 Ref: Methylation of CpG sites in exon 2 of the bcl-2 gene occurs in colorectal carcinoma. PMID: 11724359 Ref: Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells. PMID: 11746819 Ref: Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis. PMID: 11751493 Ref: Interleukin-15 expression is associated with malignant potential in colon cancer cells. PMID: 11752902 Ref: bcl-2/bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with rectal cancer. PMID: 11759059 Ref: Non-steroidal anti-inflammatory drugs induce apoptosis in head and neck cancer cell lines. PMID: 11813903 Ref: Activation of c-MYC and c-MYB proto-oncogenes is associated with decreased apoptosis in tumor colon progression. PMID: 11848471 |
Ref: Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by beta-carotene through down-regulation of cyclin A and Bcl-2 family proteins. PMID: 11756218 Ref: Molecular staging of colorectal cancer in African-American and Caucasian patients using phenotypic expression of p53, Bcl-2, MUC-1 AND p27(kip-1). PMID: 11802199 Ref: Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria. PMID: 11840168 Ref: Immunohistochemical expression of P53 and oncogenes in ulcerative colitis-associated colorectal carcinoma. PMID: 11865380 Ref: Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer. PMID: 11872273 Ref: Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. PMID: 11875499 Ref: Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. PMID: 11875713 Ref: Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases. PMID: 11896073 Ref: Stromal extracellular matrix reduces chemotherapy-induced apoptosis in colon cancer cell lines. PMID: 11918083 Ref: Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status. PMID: 11920608 Ref: Apoptosis and its correlation with proliferative activity in rectal cancer. PMID: 11920781 Ref: Resistance to apoptosis is increased during metastatic dissemination of colon cancer. PMID: 11964082 Ref: Distinct intracellular signaling in tumor necrosis factor-related apoptosis-inducing ligand- and CD95 ligand-mediated apoptosis. PMID: 11980895 Ref: Effect of non-steroidal anti-inflammatory drugs on colon carcinoma Caco-2 cell responsiveness to topoisomerase inhibitor drugs. PMID: 11986787 Ref: Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. PMID: 12005185 Ref: Increased apoptosis in infiltrating mononuclear cells of colorectal cancer: a mechanism for tumor escape. PMID: 12033956 Ref: High apoptotic activity and low epithelial cell proliferation with underexpression of p21(WAF1/CIP1) and p27Kip1 of mucinous carcinomas of the colorectum: comparison with well-differentiated type. PMID: 12047142 Ref: Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis. PMID: 12082630 Ref: Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. PMID: 12097652 Ref: Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression. PMID: 12149448 Ref: Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. PMID: 12151395 Ref: Comparative study of various biological parameters, including expression of survivin, between primary and metastatic human colonic adenocarcinomas. PMID: 12168867 Ref: Increased apoptosis in metastatic human colonic adenocarcinomas. PMID: 12170764 Ref: Hypoxia upregulates Bcl-2 expression and suppresses interferon-gamma induced antiangiogenic activity in human tumor derived endothelial cells. PMID: 12173346 Ref: Primary colorectal carcinomas and their intrapulmonary metastases: clinical, glyco-, immuno- and lectin histochemical, nuclear and syntactic structure analysis with emphasis on correlation with period of occurrence of metastases and survival. PMID: 12193204 Ref: Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice. PMID: 12207005 Ref: Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. PMID: 12208739 Ref: Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line. PMID: 12215894 Ref: High survivin expression is associated with reduced apoptosis in rectal cancer and may predict disease-free survival after preoperative radiochemotherapy and surgical resection. PMID: 12240548 Ref: Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. PMID: 12244568 Ref: Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer. PMID: 12269390 Ref: Protein expression of NF-kappaB in human colorectal adenocarcinoma. PMID: 12373289 Ref: Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa). PMID: 12374696 Ref: Molecular mechanisms of sulfasalazine-induced T-cell apoptosis. PMID: 12381674 Ref: Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells. PMID: 12384529 Ref: Requirement of BAX for efficient adenovirus-induced apoptosis. PMID: 12388688 Ref: Defining characteristics of Types I and II apoptotic cells in response to TRAIL. PMID: 12407450 Ref: Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. PMID: 12414664 Ref: Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. PMID: 12417302 Ref: Therapeutics targeting signal transduction for patients with colorectal carcinoma. PMID: 12421735 Ref: The effects of acetylsalicylic acid on proliferation, apoptosis, and invasion of cyclooxygenase-2 negative colon cancer cells. PMID: 12423325 Ref: Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis. PMID: 12473598 Ref: Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate. PMID: 12507930 Ref: Correlation between colorectal cancer Bcl-2 expression and tumour clinicopathological variables. PMID: 12533967 Ref: Cis 9, trans 11- and trans 10, cis 12-conjugated linoleic acid isomers induce apoptosis in cultured SW480 cells. PMID: 12553008 Ref: Incidence of apoptosis increases with age in colorectal cancer. PMID: 12559416 Ref: The expression of the apoptosis-suppressive gene bcl-2 in the tissue of colon carcinoma. PMID: 12658808 |
Ref: Apoptosis induced by cryo-injury in human colorectal cancer cells is associated with mitochondrial dysfunction. PMID: 12471619 Ref: The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. PMID: 12482325 Ref: c-myc down-regulation induces apoptosis in human cancer cell lines exposed to RPR-115135 (C31H29NO4), a non-peptidomimetic farnesyltransferase inhibitor. PMID: 12490573 Ref: Inhibition of alcohol-associated colonic hyperregeneration by alpha-tocopherol in the rat. PMID: 12544013 Ref: The role of various Bcl-2 domains in the anti-proliferative effect and modulation of cellular glutathione levels: a prominent role for the BH4 domain. PMID: 12558659 Ref: Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. PMID: 12589031 Ref: Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2. PMID: 12604350 Ref: Restored T-cell activation mechanisms in human tumour-infiltrating lymphocytes from melanomas and colorectal carcinomas after exposure to interleukin-2. PMID: 12610520 Ref: Antisense protein kinase A RIalpha acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy. PMID: 12631623 Ref: Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. PMID: 12660816 Ref: Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. PMID: 12670866 Ref: Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. PMID: 12670894 Ref: Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells. PMID: 12675269 Ref: The mitochondrial apoptosis-inducing factor plays a role in E2F-1-induced apoptosis in human colon cancer cells. PMID: 12679318 Ref: Tumour 'budding' and its relationship to p53 and Bcl-2 expression in colorectal cancer. PMID: 12680162 Ref: Differential, stage-dependent expression of Hsp70, Hsp110 and Bcl-2 in colorectal cancer. PMID: 12753152 Ref: Apoptotic index and bcl-2 expression as prognostic factors in colorectal carcinoma. PMID: 12759543 Ref: Cigarette smoke exposure increases ulcerative colitis-associated colonic adenoma formation in mice. PMID: 12807736 Ref: Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. PMID: 12818369 Ref: Increased expression of RelA/nuclear factor-kappa B protein correlates with colorectal tumorigenesis. PMID: 12837981 Ref: 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis. PMID: 12842827 Ref: Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C. PMID: 12844481 Ref: Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. PMID: 12851702 Ref: Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough? PMID: 12853343 Ref: Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells. PMID: 12888913 Ref: Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells. PMID: 12898234 Ref: Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK. PMID: 12898509 Ref: [Synergistic effect of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and doxorubicin on human colon cancer SW480 cells]. PMID: 12917026 Ref: Fish oil enhances targeted apoptosis during colon tumor initiation in part by downregulating Bcl-2. PMID: 12925303 Ref: Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. PMID: 12941843 Ref: Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease. PMID: 12950415 Ref: Passage from normal mucosa to adenoma and colon cancer: alteration of normal sCD30 mechanisms regulating TH1/TH2 cell functions. PMID: 14503949 Ref: The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. PMID: 14506747 Ref: The early response of p53-dependent proteins during radiotherapy in human rectal carcinoma and in adjacent normal tissue. PMID: 14532965 Ref: Bcl-2 expression is a prognostic factor in the subgroups of patients with colorectal cancer. PMID: 14532988 Ref: Frameshift mutations in the bax gene are not involved in development of ovarian endometrioid carcinoma. PMID: 14559989 Ref: 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway. PMID: 14566836 Ref: beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells. PMID: 14597880 Ref: Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells. PMID: 14612938 Ref: Potential role of bcl-2 and ki-67 expression and apoptosis in colorectal carcinoma: a clinicopathologic study. PMID: 14627346 Ref: Induction of apoptosis by p53, bax, bcl-2, and p21 expressed in colorectal cancer. PMID: 14663636 Ref: Bcl-2 overexpression does not prevent but retards adriamycin toxicity in CC531 colon carcinoma cells. PMID: 14671432 Ref: Interferon-gamma-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the inhibitor of apoptosis survivin. PMID: 14695155 Ref: Prognostic significance and correlation with survival of bcl-2 and TGF-beta RII in colon cancer. PMID: 14714614 Ref: [Studies on cancer chemoprevention by tea pigments]. PMID: 14963910 Ref: Bio-pathological factors of prognostic value in colorectal adenocarcinomas. PMID: 16767924 |
Ref: Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. PMID: 14578157 Ref: The chemopreventive agent sulindac attenuates expression of the antiapoptotic protein survivin in colorectal carcinoma cells. PMID: 14610217 Ref: Clinical and molecular biologic characteristics of early-onset versus late-onset colorectal carcinoma in Filipinos. PMID: 14708047 Ref: Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. PMID: 14712090 Ref: Inhibition of cell survival and invasive potential of colorectal carcinoma cells by the tyrosine kinase inhibitor STI571. PMID: 14726674 Ref: Low extracellular pH augments TRAIL-induced apoptotic death through the mitochondria-mediated caspase signal transduction pathway. PMID: 14729063 Ref: Transcriptional regulation of TNF family receptors and Bcl-2 family by chemotherapeutic agents in murine CT26 cells. PMID: 14743399 Ref: Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. PMID: 14760102 Ref: Deleted in oral cancer-1 expression upregulates proapoptosis elements in microsatellite-unstable human colorectal cancer. PMID: 14761923 Ref: Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect. PMID: 14985457 Ref: Diosgenin-3-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway. PMID: 15008458 Ref: Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. PMID: 15024076 Ref: Inactivating mutations of proapoptotic Bad gene in human colon cancers. PMID: 15033904 Ref: Role of caspase activation in butyrate-induced terminal differentiation of HT29 colon carcinoma cells. PMID: 15047183 Ref: Inverse PCR-based RFLP scanning identifies low-level mutation signatures in colon cells and tumors. PMID: 15059910 Ref: Dietary conjugated linoleic acid increases the mRNA ratio of Bax/Bcl-2 in the colonic mucosa of rats. PMID: 15068816 Ref: Prognostic value of proliferation, apoptosis, defective DNA mismatch repair, and p53 overexpression in patients with resected Dukes' B2 or C colon cancer: a North Central Cancer Treatment Group Study. PMID: 15117979 Ref: Correlation of p53 and bcl-2 expression with vascular endothelial growth factor (VEGF), microvessel density (MVD) and clinico-pathological features in colon cancer. PMID: 15142682 Ref: Molecular prognostic factors in locally irresectable rectal cancer treated preoperatively by chemo-radiotherapy. PMID: 15154650 Ref: Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation. PMID: 15205314 Ref: Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis. PMID: 15219941 Ref: Expression of vascular endothelial growth factor and receptor flk-1 in colon cancer liver metastases. PMID: 15235888 Ref: Bcl2 expression and its correlation with neuroendocrine differentiation in colon carcinomas. PMID: 15237588 Ref: p53 dependence and apoptosis in response to FP treatment with p53-transfected colon cancer cell lines by use of thin layer collagen gel. PMID: 15254702 Ref: Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. PMID: 15259066 Ref: Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. PMID: 15298963 Ref: Immunohistochemical patterns in rectal cancer: application of tissue microarray with prognostic correlations. PMID: 15300804 Ref: Detection of BCL2-IGH rearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma. PMID: 15300917 Ref: Astilbic acid induced COLO 205 cell apoptosis by regulating Bcl-2 and Bax expression and activating caspase-3. PMID: 15301745 Ref: Nutritional-pharmacological combinations--a novel approach to reducing colon cancer incidence. PMID: 15309441 Ref: Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat. PMID: 15312680 Ref: Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway. PMID: 15314290 Ref: Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. PMID: 15353307 Ref: Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. PMID: 15375533 Ref: Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: special reference to tumor proliferation and apoptosis. PMID: 15375710 Ref: Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis. PMID: 15377997 Ref: Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. PMID: 15453709 Ref: Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. PMID: 15480430 Ref: Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue. PMID: 15484295 Ref: Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. PMID: 15488634 Ref: Colonic crypt changes during adenoma development in familial adenomatous polyposis: immunohistochemical evidence for expansion of the crypt base cell population. PMID: 15509520 Ref: Microsatellite status and cell cycle associated markers in rectal cancer patients undergoing a combined regimen of 5-FU and CPT-11 chemotherapy and radiotherapy. PMID: 15510606 Ref: [The occurrence and significance of apoptosis in tumors]. PMID: 15520871 Ref: Dietary corn oil promotes colon cancer by inhibiting mitochondria-dependent apoptosis in azoxymethane-treated rats. PMID: 15522837 Ref: Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome. PMID: 15525823 Ref: Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells. PMID: 15533593 Ref: Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. PMID: 15535974 Ref: Conjugated docosahexaenoic acid is a potent inducer of cell cycle arrest and apoptosis and inhibits growth of colo 201 human colon cancer cells. PMID: 15572300 Ref: Evaluation of prognosis for malignant rectal gastrointestinal stromal tumor by clinical parameters and immunohistochemical staining. PMID: 15622586 Ref: Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. PMID: 15623604 Ref: Thymidylate synthase expression, p53, bcl-2, Ki-67 and p27 in colorectal cancer: relationships with tumor recurrence and survival. PMID: 15627889 Ref: Apoptosis inducing effects of 6-methoxydihydrosanguinarine in HT29 colon carcinoma cells. PMID: 15646800 Ref: Serum levels of bcl-2 in patients with colorectal cancer. PMID: 15655644 Ref: Coptidis rhizoma induces apoptosis in human colorectal cancer cells SNU-C4. PMID: 15673193 Ref: Role of P53 and Bcl-2 in advanced rectal carcinomas treated with adjuvant therapy. PMID: 15675468 |
Ref: Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil. PMID: 15365767 Ref: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. PMID: 15547111 Ref: Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells. PMID: 15560738 Ref: Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. PMID: 15592498 Ref: Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. PMID: 15596295 Ref: Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. PMID: 15661804 Ref: Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. PMID: 15671246 Ref: Citri Reticulatae Viride Pericarpium extract induced apoptosis in SNU-C4, human colon cancer cells. PMID: 15707758 Ref: Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. PMID: 15741050 Ref: Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability. PMID: 15743744 Ref: Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells. PMID: 15751275 Ref: The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. PMID: 15767553 Ref: Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors. PMID: 15824729 Ref: Role of intracellular glutathione in cell sensitivity to the apoptosis induced by tumor necrosis factor {alpha}-related apoptosis-inducing ligand/anticancer drug combinations. PMID: 15837763 Ref: Changes in Mcl-1 expression in rectal cancer in relation to neo-adjuvant radiotherapy. PMID: 15847193 Ref: Prognostic evaluation of CD44 expression in correlation with bcl-2 and p53 in colorectal cancer. PMID: 15871560 Ref: Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma. PMID: 15891997 Ref: Immunohistochemistry of p53, Bcl-2, and Ki-67 as predictors of chemosensitivity. PMID: 15901938 Ref: Mechanisms of mitochondrial apoptosis induced by peripheral benzodiazepine receptor ligands in human colorectal cancer cells. PMID: 15907803 Ref: Flavone initiates a hierarchical activation of the caspase-cascade in colon cancer cells. PMID: 15909122 Ref: Possible role of REG Ialpha protein in ulcerative colitis and colitic cancer. PMID: 15914572 Ref: Molecular markers that predict response to colon cancer therapy. PMID: 15934813 Ref: Expression of cell survival/death genes: Bcl-2 and Bax at the rate of colon cancer prognosis. PMID: 15955446 Ref: Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. PMID: 15961301 Ref: Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway. PMID: 15995977 Ref: Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis. PMID: 16012947 Ref: Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: a tissue microarray study of 460 patients. PMID: 16029489 Ref: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. PMID: 16052481 Ref: A predictive model of rectal tumor response to preoperative radiotherapy using classification and regression tree methods. PMID: 16061859 Ref: Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers. PMID: 16061861 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: Effects of genistein on the polyamine metabolism and cell growth in DLD-1 human colon cancer cells. PMID: 16091008 Ref: Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4. PMID: 16094708 Ref: Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines. PMID: 16103097 Ref: CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy. PMID: 16115938 Ref: Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells. PMID: 16127422 Ref: Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells. PMID: 16143316 Ref: Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo. PMID: 16158974 Ref: Juvenile polyposis coli: a facultative precancerosis with some similarities to ulcerative colitis? PMID: 16164047 Ref: Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. PMID: 16192633 Ref: Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. PMID: 16199534 Ref: Venous invasion and down-regulation of p21(WAF1/CIP1) are associated with metastasis in colorectal carcinomas. PMID: 16201087 Ref: Photodynamic therapy-induced death of HCT 116 cells: Apoptosis with or without Bax expression. PMID: 16215676 Ref: Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. PMID: 16227396 Ref: WMC-79, a potent agent against colon cancers, induces apoptosis through a p53-dependent pathway. PMID: 16227412 Ref: [Expression of bcl-2 gene in spleen deficiency syndrome in colorectal carcinoma and the regulatory effect of Jianpikangfu decoction]. PMID: 16234105 Ref: Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms. PMID: 16243795 Ref: [Testosterone production by tumor tissue in partial androgen deficiency in aged men (PADAM)]. PMID: 16281838 Ref: Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer. PMID: 16289386 Ref: p53, Bcl-2 and C-Myc expressions in colorectal carcinoma associated with schistosomiasis in Egypt. PMID: 16308474 Ref: [Effects of genistein on proliferation and apoptosis in HT-29 cells]. PMID: 16329599 Ref: Survivin expression in colorectal adenocarcinoma using tissue microarray. PMID: 16353082 Ref: Prognostic significance of bcl-2 and p53 expression in colorectal carcinoma. PMID: 16358373 Ref: TRAIL (TNF-related apoptosis-inducing ligand) induces necrosis-like cell death in tumor cells at acidic extracellular pH. PMID: 16387703 Ref: The significance of tumor markers for proliferation and apoptosis in predicting survival in colorectal cancer. PMID: 16400510 Ref: Immunohistochemical expression of bcl-2 in Dukes' stage B and C colorectal carcinoma patients: correlation with p53 and ki-67 in evaluating prognostic significance. PMID: 16477877 Ref: Molecular characterization of established human colon carcinoma cell lines (HCT-8) made resistant to 5-fluorouracil by different selection schedules. PMID: 16925115 Ref: Recurrence and survival predictive value of phenotypic expression of Bcl-2 varies with tumor stage of colorectal adenocarcinoma. PMID: 17192048 |
Ref: Hypoxia, angiogenesis and apoptosis markers in locally advanced rectal cancer. PMID: 16052307 Ref: Induction of apoptosis by puerarin in colon cancer HT-29 cells. PMID: 16055262 Ref: Apoptotic effect of red wine polyphenols on human colon cancer SNU-C4 cells. PMID: 16243419 Ref: Antitumor activity and downregulation of pro-angiogenic molecules in human prostate cancer cells by a novel thiazolidione compound. PMID: 16302260 Ref: A phase I, pharmacokinetic and biologic correlative study of oblimersen sodium (Genasense, G3139) and irinotecan in patients with metastatic colorectal cancer. PMID: 16322117 Ref: Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy. PMID: 16324817 Ref: Angiogenesis and p53 at the invading tumor edge: prognostic markers for colorectal cancer beyond stage. PMID: 16325858 Ref: Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells. PMID: 16337836 Ref: in vitro synergistic antitumor activity of a combination of 5-fluorouracil and irinotecan in human colon cancer. PMID: 16391804 Ref: Cyclooxygenase-2 knockdown by RNA interference in colon cancer. PMID: 16391811 Ref: Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. PMID: 16401477 Ref: Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. PMID: 16401637 Ref: Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL. PMID: 16407826 Ref: Decrease in c-Myc activity enhances cancer cell sensitivity to vinblastine. PMID: 16428936 Ref: Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. PMID: 16434969 Ref: Mechanisms of cardiotoxin lll-induced apoptosis in human colorectal cancer colo205 cells. PMID: 16487259 Ref: Profiling markers of prognosis in colorectal cancer. PMID: 16489072 Ref: Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. PMID: 16500682 Ref: Pioglitazone, a synthetic ligand for PPARgamma, induces apoptosis in RB-deficient human colorectal cancer cells. PMID: 16520894 Ref: Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells. PMID: 16563722 Ref: Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members. PMID: 16574665 Ref: Dietary trans-10, cis-12 and cis-9,trans-11 conjugated linoleic acids induce apoptosis in the colonic mucosa of rats treated with 1,2-dimethylhydrazine. PMID: 16579724 Ref: Relationship between somatostatin receptor subtype expression and clinicopathology, Ki-67, Bcl-2 and p53 in colorectal cancer. PMID: 16610049 Ref: Effects of cyclooxygenase-2 inhibition on serum and tumor gastrins and expression of apoptosis-related proteins in colorectal cancer. PMID: 16615003 Ref: hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. PMID: 16619047 Ref: [Impact of STAT6 signaling pathway blockade on apoptosis of human colon cancer cells]. PMID: 16620708 Ref: Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line. PMID: 16697099 Ref: Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway. PMID: 16697692 Ref: Fas-associated phosphatase-1 promotes Fas-mediated apoptosis in human colon cancer cells: novel function of FAP-1. PMID: 16706817 Ref: Scoring of p53, VEGF, Bcl-2 and APAF-1 immunohistochemistry and interobserver reliability in colorectal cancer. PMID: 16741523 Ref: [Ursolic acid induces apoptosis in colon cancer HT-29 cells]. PMID: 16750011 Ref: Nutrient and antioxidant modulation of apoptosis in gastric and colon cancer cells. PMID: 16760645 Ref: Apoptosis of human colon carcinoma HT-29 cells induced by ceramide. PMID: 16773715 Ref: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. PMID: 16799551 Ref: Differential expression of Bcl-2, Bcl-XL and p53 in colorectal cancer. PMID: 16824061 Ref: Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells. PMID: 16827117 Ref: Influence of the c-erb B-2, nm23, bcl-2 and p53 protein markers on colorectal cancer. PMID: 16830272 Ref: Anticancer effects of amooranin in human colon carcinoma cell line in vitro and in nude mice xenografts. PMID: 16894569 Ref: 5-aminosalicylic acid enhances anchorage-independent colorectal cancer cell death. PMID: 16914308 Ref: Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells. PMID: 16964520 Ref: Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria. PMID: 16998592 Ref: Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. PMID: 17007015 Ref: Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines. PMID: 17012835 Ref: Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells. PMID: 17016662 Ref: Correlation of microsatellite status, proliferation, apoptotic and selected immunohistochemical markers in colorectal carcinoma studied with tissue microarray. PMID: 17019973 Ref: [Effect of ceramide on apoptosis of human colon cancer HT-29 cells]. PMID: 17086696 Ref: Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: correlation to activated K-ras oncogene. PMID: 17089045 Ref: Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery. PMID: 17102938 Ref: Colon cancer and gene alterations: their immunological implications and suggestions for prognostic indices and improvements in biotherapy. PMID: 17105421 Ref: Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. PMID: 17106246 Ref: Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. PMID: 17121918 Ref: Effect of ligand troglitazone on peroxisome proliferator-activated receptor gamma expression and cellular growth in human colon cancer cells. PMID: 17143939 Ref: 3 Beta-hydroxyolean-12-en-27-oic acid: a cytotoxic, apoptosis-inducing natural drug against COLO-205 cancer cells. PMID: 17193218 Ref: Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3. PMID: 17201150 Ref: Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. PMID: 17201158 Ref: Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway? PMID: 17202837 Ref: [Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium]. PMID: 17216011 Ref: Immunohistochemical expression of bcl-2 in UICC stage I and III colorectal carcinoma patients: correlation with c-erbB-2, p53, ki-67, CD44, laminin and collagen IV in evaluating prognostic significance. PMID: 17219742 Ref: p53 and p27 as predictors of clinical outcome for rectal-cancer patients receiving neoadjuvant therapy. PMID: 17360176 Ref: Down-regulation of FHIT inhibits apoptosis of colorectal cancer: mechanism and clinical implication. PMID: 17382535 Ref: Bcl-2 expression in rectal cancer. PMID: 17406756 |
Ref: Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia. PMID: 16713222 Ref: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. PMID: 17030349 Ref: Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53. PMID: 17056233 Ref: In vivo evaluation of the role of DNp73alpha protein in regulating the p53-dependent apoptotic pathway after treatment with cytotoxic drugs. PMID: 17096333 Ref: Exercise associated genes in rat colon mucosa: upregulation of ornithin decarboxylase-1. PMID: 17111318 Ref: Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7beta-hydroxysitosterol and 7beta-hydroxycholesterol triggered apoptosis in human colon cancer cells. PMID: 17136497 Ref: Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach. PMID: 17145638 Ref: Identification of an HLA-A*0201 restricted Bcl2-derived epitope expressed on tumors. PMID: 17182178 Ref: Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. PMID: 17182797 Ref: Gender-specific modulation of markers for premalignancy by nutritional soy and calcium in the mouse colon. PMID: 17182828 Ref: Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status. PMID: 17192871 Ref: Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells. PMID: 17201910 Ref: Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. PMID: 17218778 Ref: Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine. PMID: 17222494 Ref: NF-kappaB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL-60 cells. PMID: 17226769 Ref: Berry phenolic extracts modulate the expression of p21(WAF1) and Bax but not Bcl-2 in HT-29 colon cancer cells. PMID: 17243699 Ref: Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells. PMID: 17250644 Ref: Short hairpin RNAs targeting Bcl-xL modulate senescence and apoptosis following SN-38 and irinotecan exposure in a colon cancer model. PMID: 17273826 Ref: Early apoptosis and cell death induced by ATX-S10Na (II)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells. PMID: 17278191 Ref: Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. PMID: 17278192 Ref: Recombinant human erythropoietin alpha modulates the effects of radiotherapy on colorectal cancer microvessels. PMID: 17299396 Ref: Genetic markers predictive of response to induction chemoradiotherapy for locally advanced rectal cancers. PMID: 17310874 Ref: What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor? PMID: 17323428 Ref: Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer. PMID: 17332927 Ref: Down-regulation of PGE2 by physiologic levels of celecoxib is not sufficient to induce apoptosis or inhibit cell proliferation in human colon carcinoma cell lines. PMID: 17342386 Ref: Decreased fragile histidine triad expression in colorectal cancer and its association with apoptosis inhibition. PMID: 17373735 Ref: [Fragile histidine triad protein expression and correlation with apoptosis in rectal carcinoma]. PMID: 17380463 Ref: Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines. PMID: 17389773 Ref: Gene profile analysis of colorectal cancer cell lines by cDNA macroarray. PMID: 17390045 Ref: Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX. PMID: 17426704 Ref: Sulindac treatment in hereditary non-polyposis colorectal cancer. PMID: 17434727 Ref: 4- [3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induced fas expression and activated caspase-3 and -8 in a DLD-1 colon cancer cell line. PMID: 17436592 Ref: p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells. PMID: 17440101 Ref: Expression of anti-apoptotic factors modulates Apo2L/TRAIL resistance in colon carcinoma cells. PMID: 17440816 Ref: Rosiglitazone enhances fluorouracil-induced apoptosis of HT-29 cells by activating peroxisome proliferator-activated receptor gamma. PMID: 17461445 Ref: NF-kappaB and apoptosis in colorectal tumourigenesis. PMID: 17461988 Ref: Signet ring cell differentiation in mucinous colorectal carcinoma. PMID: 17471475 Ref: Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer. PMID: 17472962 Ref: 18F-FDG PET scanning correlates with tissue markers of poor prognosis and predicts mortality for patients after liver resection for colorectal metastases. PMID: 17475966 Ref: Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer. PMID: 17487413 Ref: The growth-inhibitory effects of tomatoes digested in vitro in colon adenocarcinoma cells occur through down regulation of cyclin D1, Bcl-2 and Bcl-xL. PMID: 17490506 Ref: Modulation of tumor radiation response with G3139, a bcl-2 antisense oligonucleotide. PMID: 17492397 Ref: 2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation. PMID: 17510524 Ref: 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. PMID: 17513605 Ref: Nanosecond pulsed electric fields induce apoptosis in p53-wildtype and p53-null HCT116 colon carcinoma cells. PMID: 17520193 Ref: Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad. PMID: 17544220 Ref: Beclin 1 gene inhibits tumor growth in colon cancer cell lines. PMID: 17595761 Ref: Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. PMID: 17603079 Ref: Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. PMID: 17609769 Ref: [Expression of survivin in colorectal adenoma and adenocarcinoma]. PMID: 17633470 Ref: Bone morphogenetic protein-4 inhibits heat-induced apoptosis by modulating MAPK pathways in human colon cancer HCT116 cells. PMID: 17640799 Ref: The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal carcinomas. PMID: 17641794 Ref: Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis. PMID: 17645780 Ref: Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. PMID: 17652460 Ref: Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. PMID: 17673978 Ref: Change in expression of apoptosis genes after hyperthermia, chemotherapy and radiotherapy in human colon cancer transplanted into nude mice. PMID: 17708613 Ref: Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells. PMID: 17721042 Ref: Effect of betulinic acid on anticancer drug-resistant colon cancer cells. PMID: 17845510 Ref: Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. PMID: 17855695 Ref: P21WAF1/CIP1 expression in colorectal carcinomas is related to Kras mutations and prognosis. PMID: 17873613 Ref: Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. PMID: 17938270 Ref: Can the clinical outcome in stage II colon carcinomas be predicted by determination of molecular marker expression? PMID: 17974527 Ref: Role of insulin-like growth factor binding protein-4 in prevention of colon cancer. PMID: 17988381 Ref: Evaluation of apoptosis in nasal and buccal cells of septic patients. PMID: 18019433 Ref: Anti-proliferate and pro-apoptotic effects of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyranone through inactivation of NF-kappaB in human colon cancer cells. PMID: 18087815 Ref: Induction of apoptosis in HT-29 colon cancer cells by phloretin. PMID: 18158826 Ref: Predicting 5-year survival of colorectal carcinoma patients using data mining methods. PMID: 18694007 Ref: Clinico-Pathological and Prognostic Significance of p53, Bcl-2 and Her-2/neu Protein Markers in Colorectal Cancer Using Tissue Microarray. PMID: 18839030 Ref: Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients. PMID: 19090149 Ref: Comparison of predicted probabilities of proportional hazards regression and linear discriminant analysis methods using a colorectal cancer molecular biomarker database. PMID: 19455238 Ref: Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer. PMID: 24557667 |
Ref: Potential role of apoptosis and apoptotic regulatory proteins in colorectal neoplasia: correlations with clinico-pathological parameters and survival. PMID: 17562177 Ref: Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4. PMID: 17897817 Ref: Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins. PMID: 17936584 Ref: 1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. PMID: 17957723 Ref: WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers. PMID: 18035333 Ref: p53 Nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior. PMID: 18071066 Ref: Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29). PMID: 18084318 Ref: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. PMID: 18097482 Ref: BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. PMID: 18098337 Ref: Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. PMID: 18160396 Ref: Combined analysis of VEGF and EGFR predicts complete tumour response in rectal cancer treated with preoperative radiotherapy. PMID: 18182986 Ref: Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts. PMID: 18189352 Ref: Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB. PMID: 18241858 Ref: Effects of recombinant MAP30 on cell proliferation and apoptosis of human colorectal carcinoma LoVo cells. PMID: 18246454 Ref: Acquired and innate resistance to the cancer-specific apoptosis-inducing cytokine, mda-7/IL-24: not insurmountable therapeutic problems. PMID: 18277093 Ref: Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2. PMID: 18292181 Ref: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. PMID: 18320073 Ref: Modulation of key signal transduction molecules by a novel peptide combination effective for the treatment of gastrointestinal carcinomas. PMID: 18322652 Ref: CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. PMID: 18325984 Ref: Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity. PMID: 18339878 Ref: Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. PMID: 18357373 Ref: The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. PMID: 18357397 Ref: Growth associated proteins in tumor cells and stroma related to disease progression of colon cancer accounting for tumor tissue PGE2 content. PMID: 18360718 Ref: Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells. PMID: 18377873 Ref: Signaling and regulatory mechanisms of integrin alphavbeta6 on the apoptosis of colon cancer cells. PMID: 18381232 Ref: Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. PMID: 18381954 Ref: 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. PMID: 18384088 Ref: Targeting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or small interfering RNA. PMID: 18413748 Ref: P53 and bcl-2 in colorectal cancer arising in patients under 40 years of age: distribution and prognostic relevance. PMID: 18424032 Ref: The bisphosphonate zoledronic acid inhibits the growth of HCT-116 colon carcinoma cells and induces tumor cell apoptosis. PMID: 18437576 Ref: Benzoylurea derivatives as a novel class of antimitotic agents: synthesis, anticancer activity, and structure-activity relationships. PMID: 18457382 Ref: [Expression change of apoptosis-associated genes after hyperthermia, chemotherapy and radiotherapy in human colon cancer-transplanted nude mice]. PMID: 18478475 Ref: Bcl-B expression in human epithelial and nonepithelial malignancies. PMID: 18483366 Ref: Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. PMID: 18494941 Ref: Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). PMID: 18507053 Ref: Potential role of bcl-2 expression and apoptotic body index in colorectal cancer. PMID: 18507083 Ref: Ki-67, p53 and bcl-2 analysis in colonic versus rectal adenocarcinoma. PMID: 18516322 Ref: Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. PMID: 18521906 Ref: Vanadium and 1, 25 (OH)2 vitamin D3 combination in inhibitions of 1,2, dimethylhydrazine-induced rat colon carcinogenesis. PMID: 18539154 Ref: A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma. PMID: 18560353 Ref: Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone. PMID: 18593931 Ref: Proapoptotic Bad and Bid protein expression predict survival in stages II and III colon cancers. PMID: 18593990 Ref: Enhancement of sodium butyrate-induced cell death by hyperthermia in HCT 116 human colorectal cancer cells. PMID: 18630528 Ref: Evaluation of the potential anti-cancer activity of the antidepressant sertraline in human colon cancer cell lines and in colorectal cancer-xenografted mice. PMID: 18636148 Ref: Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480. PMID: 18636671 Ref: Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress. PMID: 18663430 Ref: Preoperative radiochemotherapy is successful also in patients with locally advanced rectal cancer who have intrinsically high apoptotic tumours. PMID: 18664561 Ref: Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent. PMID: 18665601 Ref: Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells. PMID: 18695877 Ref: Synergism of CPT-11 and Apo2L/TRAIL against two differentially sensitive human colon tumor xenografts. PMID: 18714167 Ref: Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. PMID: 18716166 Ref: Anti colon cancer components from Lebanese sage (Salvia libanotica) essential oil: Mechanistic basis. PMID: 18787402 Ref: [Role of high mobility group box 1 in adriamycin-induced apoptosis in leukemia K562 cells]. PMID: 18799030 Ref: c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs. PMID: 18802399 Ref: Molecular mechanism of protection against chemically and gamma-radiation induced apoptosis in human colon cancer cells. PMID: 18812638 Ref: Quantitative expression analysis and prognostic significance of the novel apoptosis-related gene BCL2L12 in colon cancer. PMID: 18844453 Ref: Transcriptional profiling of mRNA expression in the mouse distal colon. PMID: 18848557 Ref: Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism. PMID: 18852136 Ref: Antitumor bioactivity of adenovirus-mediated p27mt in colorectal cancer cell line SW480. PMID: 18855981 Ref: Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. PMID: 18922894 Ref: Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. PMID: 18949393 Ref: Induction of apoptosis in HT-29 colon cancer cells by crude saponin from Platycodi Radix. PMID: 18955103 Ref: Bcl-2 expression significantly correlates with thymidylate synthase expression in colorectal cancer patients. PMID: 18985814 Ref: NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells. PMID: 19003586 Ref: Statistical strategies to improve the efficiency of molecular studies of colorectal cancer prognosis. PMID: 19018265 Ref: Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737. PMID: 19088028 Ref: [Tumor proliferation and apoptosis after preoperative hepatic and regional arterial infusion chemotherapy in prevention of liver metastasis after colorectal cancer surgery]. PMID: 19094597 Ref: Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. PMID: 19568915 |
Ref: Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway. PMID: 18790561 Ref: Immunosensitization with a Bcl-2 small molecule inhibitor. PMID: 18807035 Ref: Regulation of beta-catenin and connexin-43 expression: targets for sphingolipids in colon cancer prevention. PMID: 18837472 Ref: Tumour cell survival signalling by the ERK1/2 pathway. PMID: 18846109 Ref: New time-dependent approach to analyse the prognostic significance of immunohistochemical biomarkers in colon cancer and diffuse large B-cell lymphoma. PMID: 18977805 Ref: Loss of Bcl-2 expression in colon cancer: a prognostic factor for recurrence in stage II colon cancer. PMID: 19027288 Ref: Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways. PMID: 19038304 Ref: Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4alpha. PMID: 19048623 Ref: In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF. PMID: 19105980 Ref: Growth inhibition and induction of apoptosis of colon cancer cell lines by applying marine phospholipid. PMID: 19116882 Ref: Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancer. PMID: 19119184 Ref: Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells. PMID: 19121919 Ref: The Bcl-w promoter is activated by beta-catenin/TCF4 in human colorectal carcinoma cells. PMID: 19124064 Ref: Sodium butyrate sensitizes human colon adenocarcinoma COLO 205 cells to both intrinsic and TNF-alpha-dependent extrinsic apoptosis. PMID: 19130237 Ref: Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. PMID: 19148542 Ref: HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins. PMID: 19179333 Ref: Docosahexaenoic acid induces dose dependent cell death in an early undifferentiated subtype of acute myeloid leukemia cell line. PMID: 19197149 Ref: Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. PMID: 19232820 Ref: The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis. PMID: 19240372 Ref: Effects of vitamin D and calcium supplementation on markers of apoptosis in normal colon mucosa: a randomized, double-blind, placebo-controlled clinical trial. PMID: 19258546 Ref: Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin. PMID: 19264955 Ref: Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells. PMID: 19266600 Ref: Combining radiotherapy with APO010 in cancer treatment. PMID: 19276268 Ref: Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells. PMID: 19290007 Ref: The potential role of Bcl-2 expression, apoptosis and cell proliferation (Ki-67 expression) in cases of gastric carcinoma and correlation with classic prognostic factors and patient outcome. PMID: 19331225 Ref: Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. PMID: 19341726 Ref: Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells. PMID: 19367670 Ref: Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. PMID: 19380879 Ref: Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. PMID: 19423215 Ref: A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. PMID: 19426686 Ref: Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells. PMID: 19439215 Ref: Mechanisms of thiosulfinates from Allium tuberosum L.-induced apoptosis in HT-29 human colon cancer cells. PMID: 19446247 Ref: Factors influencing histological response after neoadjuvant chemoradiation therapy for rectal carcinoma. PMID: 19446404 Ref: Comparative analysis of prognostic significance of molecular markers of apoptosis with clinical stage and tumor differentiation in patients with colorectal cancer: a single institute experience. PMID: 19453036 Ref: Beta-sitosterol inhibits cell growth and induces apoptosis in SGC-7901 human stomach cancer cells. PMID: 19456133 Ref: Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells. PMID: 19477064 Ref: Biomarkers for response to neoadjuvant chemoradiation for rectal cancer. PMID: 19480968 Ref: Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. PMID: 19483104 Ref: High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction. PMID: 19491899 Ref: Anti-proliferative effects of Lethariella zahlbruckneri extracts in human HT-29 human colon cancer cells. PMID: 19501127 Ref: Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate. PMID: 19507186 Ref: Antibodies to prion protein inhibit human colon cancer cell growth. PMID: 19521145 Ref: Autophagy-mediated anti-tumoral activity of imiquimod in Caco-2 cells. PMID: 19527683 Ref: [Inhibitory effect of resveratrol on the growth of human colon cancer ls174t cells and its subcutaneously transplanted tumor in nude mice and the mechanism of action]. PMID: 19538862 Ref: Relative resistance of SGK1 knockout mice against chemical carcinogenesis. PMID: 19548318 Ref: Antiproliferation and apoptosis induced by evodiamine in human colorectal carcinoma cells (COLO-205). PMID: 19551742 Ref: A putative role for human BFK in DNA damage-induced apoptosis. PMID: 19557800 Ref: In vitro studies on the inhibition of colon cancer by butyrate and carnitine. PMID: 19619983 Ref: Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. PMID: 19623659 Ref: Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. PMID: 19633423 Ref: Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer. PMID: 19661314 Ref: Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. PMID: 19735878 Ref: GHRH antagonist causes DNA damage leading to p21 mediated cell cycle arrest and apoptosis in human colon cancer cells. PMID: 19755849 Ref: Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapy. PMID: 19765849 Ref: A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. PMID: 19767770 Ref: Effects of Lipid Peroxidation-Derived Products on the Growth of Human Colorectal Cancer Cell Line HT-29. PMID: 19794925 Ref: Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells. PMID: 19801840 Ref: Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells. PMID: 19826421 Ref: Decreased polyunsaturated Fatty Acid content contributes to increased survival in human colon cancer. PMID: 19841681 Ref: MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells. PMID: 19843160 Ref: Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. PMID: 19846903 Ref: trans-10,cis-12 Conjugated linoleic acid induces depolarization of mitochondrial membranes in HT-29 human colon cancer cells: a possible mechanism for induction of apoptosis. PMID: 19857056 Ref: Factors influencing prognosis after neo-adjuvant chemoradiation therapy for rectal carcinoma. PMID: 19943591 Ref: beta-Glucan enhanced apoptosis in human colon cancer cells SNU-C4. PMID: 20090882 Ref: Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling. PMID: 20196786 |
Ref: Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell. PMID: 19139819 Ref: A novel protein fraction from Sesbania grandiflora shows potential anticancer and chemopreventive efficacy, in vitro and in vivo. PMID: 19183244 Ref: BCL2L12A localizes to the cell nucleus and induces growth inhibition through G2/M arrest in CHO cells. PMID: 19763795 Ref: Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation. PMID: 19798106 Ref: Combination of p53 codon 72 polymorphism and inactive p53 mutation predicts chemosensitivity to 5-fluorouracil in colorectal cancer. PMID: 19810096 Ref: Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis. PMID: 19900450 Ref: Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines. PMID: 19903580 Ref: The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells. PMID: 19949342 Ref: The ethyl acetate extract of Phellinus linteus grown on germinated brown rice induces G0/G1 cell cycle arrest and apoptosis in human colon carcinoma HT29 cells. PMID: 19998418 Ref: Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis. PMID: 20053782 Ref: Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. PMID: 20090905 Ref: Longan flower extract inhibits the growth of colorectal carcinoma. PMID: 20099197 Ref: Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells. PMID: 20104024 Ref: Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo. PMID: 20107900 Ref: [Effect of L-arginine on human colon carcinoma cell line LS174 through NO pathway and the mechanism]. PMID: 20117988 Ref: Antiproliferative effect of chitosan-added kimchi in HT-29 human colon carcinoma cells. PMID: 20136430 Ref: Subsite-specific differences of estrogen receptor beta expression in the normal colonic epithelium: implications for carcinogenesis and colorectal cancer epidemiology. PMID: 20173645 Ref: Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation. PMID: 20198313 Ref: Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression. PMID: 20206442 Ref: Tissue microarray constructs to predict a response to chemoradiation in rectal cancer. PMID: 20227932 Ref: Estrogen prevents sustained COLO-205 human colon cancer cell growth by inducing apoptosis, decreasing c-myb protein, and decreasing transcription of the anti-apoptotic protein bcl-2. PMID: 20237898 Ref: Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells. PMID: 20346929 Ref: Pleurospermum kamtschaticum extract induces apoptosis via mitochondrial pathway and NAG-1 expression in colon cancer cells. PMID: 20378978 Ref: Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells. PMID: 20392997 Ref: Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. PMID: 20398749 Ref: Epithelial-to-mesenchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells. PMID: 20406951 Ref: Expressions of the anti-apoptotic genes Bag-1 and Bcl-2 in colon cancer and their relationship. PMID: 20409521 Ref: Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. PMID: 20428773 Ref: HERG K+ channel related chemosensitivity to sparfloxacin in colon cancer cells. PMID: 20428834 Ref: Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network. PMID: 20433755 Ref: Chemopreventive role of etoricoxib (MK-0663) in experimental colon cancer: induction of mitochondrial proapoptotic factors. PMID: 20440209 Ref: Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). PMID: 20452335 Ref: Aurora-a is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells. PMID: 20460511 Ref: Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. PMID: 20509140 Ref: Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells. PMID: 20534983 Ref: Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells. PMID: 20536712 Ref: Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. PMID: 20540935 Ref: The effect of Longan seed polyphenols on colorectal carcinoma cells. PMID: 20561027 Ref: ABT-737 overcomes resistance to immunotoxin-mediated apoptosis and enhances the delivery of pseudomonas exotoxin-based proteins to the cell cytosol. PMID: 20587662 Ref: CD74 is a survival receptor on colon epithelial cells. PMID: 20614481 Ref: A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells. PMID: 20615460 Ref: Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1. PMID: 20653974 Ref: Induction of cell cycle arrest and apoptosis by the ethyl acetate fraction of Kalopanax pictus leaves in human colon cancer cells. PMID: 20659794 Ref: Tian Xian Liquid (TXL) induces apoptosis in HT-29 colon cancer cell in vitro and inhibits tumor growth in vivo. PMID: 20663169 Ref: Characterization of rectal, proximal and distal colon cancers based on clinicopathological, molecular and protein profiles. PMID: 20664940 Ref: Intrinsic mitochondrial membrane potential change and associated events mediate apoptosis in chemopreventive effect of diclofenac in colon cancer. PMID: 20681407 Ref: A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer. PMID: 20684596 Ref: Systematic assessment of protein phenotypes characterizing high-grade tumour budding in mismatch repair-proficient colorectal cancer. PMID: 20716165 Ref: Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors. PMID: 20721457 Ref: Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. PMID: 20726007 Ref: microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells. PMID: 20727858 Ref: Therapeutic potential of sulindac hydroxamic acid against human pancreatic and colonic cancer cells. PMID: 20801552 Ref: Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer. PMID: 20802524 Ref: Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules. PMID: 20803769 Ref: Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PMID: 20808790 Ref: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. PMID: 20837473 Ref: Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8. PMID: 20846456 Ref: Tumor necrosis is a new promising prognostic factor in colorectal cancer. PMID: 20869096 Ref: CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis. PMID: 20877573 Ref: Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells. PMID: 20878081 Ref: Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2. PMID: 20924970 Ref: Synthesis and anticancer activity of new 1-[(5 or 6-substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives. PMID: 20943401 Ref: Houttuynia cordata Thunb extract inhibits cell growth and induces apoptosis in human primary colorectal cancer cells. PMID: 20944136 Ref: Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities. PMID: 20951582 Ref: Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo. PMID: 21082859 Ref: Effect of erythropoietin, 5-fluorouracil and SN-38 on the growth of DLD-1 cells. PMID: 21098876 Ref: [Effect of APRIL on growth and apoptosis in transplanted tumor with human colorectal cancer cell line SW480 in nude mice]. PMID: 21122406 Ref: [Effect and mechanism of DNMT inhibitor on the reversal of multidrug resistance in human colon cancer cell line sw620/L-OHP]. PMID: 21265097 Ref: 20(S)-Ginsenoside Rg3-induced apoptosis in HT-29 colon cancer cells is associated with AMPK signaling pathway. PMID: 21472321 Ref: Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells. PMID: 21614182 Ref: Bax expression is a candidate prognostic and predictive marker of colorectal cancer. PMID: 22811811 Ref: Methylated BNIP3 gene in colorectal cancer prognosis. PMID: 22966396 |
Ref: The anti-proliferative effects of norcantharidin on human HepG2 cells in cell culture. PMID: 20333548 Ref: Chemopreventive effects of non-steroidal anti-inflammatory drugs in early neoplasm of experimental colorectal cancer: an apoptosome study. PMID: 20623380 Ref: Nuclear factor kappa-light chain-enhancer of activated B cells is activated by radiotherapy and is prognostic for overall survival in patients with rectal cancer treated with preoperative fluorouracil-based chemoradiotheraphy. PMID: 20630669 Ref: Bcl-2 family interaction with the mitochondrial morphogenesis machinery. PMID: 20671748 Ref: Loss of E-cadherin and MUC2 expressions correlated with poor survival in patients with stages II and III colorectal carcinoma. PMID: 20865330 Ref: Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. PMID: 20886344 Ref: Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells--involvement of ROS generation and polyamine depletion. PMID: 20940027 Ref: Induction of apoptosis in human colon carcinoma COLO 205 cells by the recombinant alpha subunit of C-phycocyanin. PMID: 21072562 Ref: Apoptosis-inducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines. PMID: 21122037 Ref: Impact of MTHFR gene C677T polymorphism on Bcl-2 gene methylation and protein expression in colorectal cancer. PMID: 21128871 Ref: Hedgehog signaling drives cellular survival in human colon carcinoma cells. PMID: 21135115 Ref: GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. PMID: 21156786 Ref: Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. PMID: 21194832 Ref: Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}. PMID: 21205744 Ref: High energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer. PMID: 21214291 Ref: Loss of E-cadherin independently predicts the lymph node status in colorectal cancer. PMID: 21233674 Ref: Early modulation of gene expression used as a biomarker for chemoprevention in a preclinical model of colon carcinogenesis. PMID: 21255184 Ref: Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways. PMID: 21271215 Ref: Prognostic significance of Bcl-xL gene expression in human colorectal cancer. PMID: 21277008 Ref: Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis. PMID: 21338095 Ref: SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. PMID: 21368833 Ref: Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells. PMID: 21370894 Ref: Ghrelin inhibits 5-fluorouracil-induced apoptosis in colonic cancer cells. PMID: 21375586 Ref: Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status. PMID: 21380817 Ref: Hypoxic human cancer cells are sensitized to BH-3 mimetic-induced apoptosis via downregulation of the Bcl-2 protein Mcl-1. PMID: 21393866 Ref: Oxaliplatin long-circulating liposomes improved therapeutic index of colorectal carcinoma. PMID: 21401960 Ref: Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer. PMID: 21403907 Ref: IL-32gamma inhibits cancer cell growth through inactivation of NF-kappaB and STAT3 signals. PMID: 21423208 Ref: Apoptotic Cell Death and Inhibition of Wnt/beta-Catenin Signaling Pathway in Human Colon Cancer Cells by an Active Fraction (HS7) from Taiwanofungus camphoratus. PMID: 21423639 Ref: MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. PMID: 21455217 Ref: PEG-liposomal oxaliplatin potentialization of antitumor efficiency in a nude mouse tumor-xenograft model of colorectal carcinoma. PMID: 21455585 Ref: Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells. PMID: 21462330 Ref: Synergistic killing of colorectal cancer cells by oxaliplatin and ABT-737. PMID: 21468686 Ref: Effects of Ginkgo biloba extract EGb761 on human colon adenocarcinoma cells. PMID: 21471711 Ref: Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. PMID: 21471712 Ref: LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression. PMID: 21491996 Ref: Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis. PMID: 21515332 Ref: Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells. PMID: 21519792 Ref: The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. PMID: 21524306 Ref: Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer. PMID: 21543155 Ref: Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53. PMID: 21557998 Ref: Folate receptor-alpha expression in resectable hepatic colorectal cancer metastases: patterns and significance. PMID: 21572402 Ref: Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. PMID: 21622155 Ref: Ki-67 and Bcl-2 in colorectal polyps with breast cancer. PMID: 21623079 Ref: Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-kappaB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells. PMID: 21656672 Ref: Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. PMID: 21664646 Ref: Site impact on colorectal cancer biological behavior in terms of clinicopathological and molecular features. PMID: 21674855 Ref: [Expression and clinical significance of COX-2 and BCL-2 in distal transitional mucosa adjacent to rectal carcinoma]. PMID: 21713707 Ref: A novel non-aromatic B-ring flavonoid: isolation, structure elucidation and its induction of apoptosis in human colon HT-29 tumor cell via the reactive oxygen species-mitochondrial dysfunction and MAPK activation. PMID: 21741427 Ref: Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. PMID: 21747117 Ref: Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells. PMID: 21785624 Ref: Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells. PMID: 21789651 Ref: Rectal hemangiopericytoma in a 37-year-old woman: a case report and review of the literature. PMID: 21819590 Ref: Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro. PMID: 21826595 Ref: Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects. PMID: 21836060 Ref: [Mechanism of polycomb Bmi1-targeted therapy for colorectal cancer]. PMID: 21866458 Ref: Cell cycle arrest and apoptosis induced by methyl 3,5-dicaffeoyl quinate in human colon cancer cells: Involvement of the PI3K/Akt and MAP kinase pathways. PMID: 21872580 Ref: A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA. PMID: 21878904 Ref: C086, a novel analog of curcumin, induces growth inhibition and down-regulation of NFkappaB in colon cancer cells and xenograft tumors. PMID: 21900746 Ref: Pien Tze Huang induced apoptosis in human colon cancer HT-29 cells is associated with regulation of the Bcl-2 family and activation of caspase 3. PMID: 21910070 Ref: Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. PMID: 21919647 Ref: Platinum-(IV)-derivative satraplatin induced G2/M cell cycle perturbation via p53-p21(waf1/cip1)-independent pathway in human colorectal cancer cells. PMID: 21927014 Ref: Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro. PMID: 21940310 Ref: The prognostic role of apoptosis mediators in rectal adenocarcinoma. PMID: 21940317 Ref: Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells. PMID: 21945981 Ref: Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to alpha5beta1 integrin and suppresses FAK/ERK/NF-kappaB signaling. PMID: 21963225 Ref: The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells. PMID: 22006676 Ref: Tissue microarrays in Chinese human rectal cancer: study of expressions of the tumor-associated genes. PMID: 22024062 Ref: [Study of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptotic and inflammatory gene expressions in colon cancer cell line]. PMID: 22030783 Ref: Relationship between ganglioside expression and anti-cancer effects of the monoclonal antibody against epithelial cell adhesion molecule in colon cancer. PMID: 22033101 Ref: Cancer chemopreventive ability of conjugated linolenic acids. PMID: 22174613 Ref: Apigenin suppresses the growth of colorectal cancer xenografts via phosphorylation and up-regulated FADD expression. PMID: 22870126 Ref: Valproate inhibits colon cancer growth through cell cycle modification in vivo and in vitro. PMID: 22977502 Ref: Predictive factors of the response of rectal cancer to neoadjuvant radiochemotherapy. PMID: 24212803 |
Ref: Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. PMID: 21520296 Ref: The use of molecular markers as a method to predict the response to neoadjuvant therapy for advanced stage rectal adenocarcinoma. PMID: 21689364 Ref: Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers. PMID: 21702037 Ref: The pro-apoptotic effect of quercetin in cancer cell lines requires ERbeta-dependent signals. PMID: 21732360 Ref: Ethanol Extract of Abnormal Savda Munziq, a Herbal Preparation of Traditional Uighur Medicine, Inhibits Caco-2 Cells Proliferation via Cell Cycle Arrest and Apoptosis. PMID: 21785650 Ref: Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells. PMID: 21809075 Ref: Apoptotic proteins as prognostic markers and indicators of radiochemosensitivity in stage II/III rectal cancers. PMID: 21848899 Ref: A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. PMID: 21919080 Ref: Anti-carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane-induced colonic aberrant crypt foci formation in rats. PMID: 21956158 Ref: B1, a novel topoisomerase II inhibitor, induces apoptosis and cell cycle G1 arrest in lung adenocarcinoma A549 cells. PMID: 22008852 Ref: Phenylarsine oxide induces apoptosis in Bax- and Bak-deficient cells through upregulation of Bim. PMID: 22048238 Ref: Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. PMID: 22056880 Ref: microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2. PMID: 22072615 Ref: Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins. PMID: 22138446 Ref: Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study. PMID: 22142698 Ref: Disparate clinicopathological correlations of p53 and Bcl-2 in colorectal cancer. PMID: 22143931 Ref: Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel. PMID: 22158036 Ref: COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines. PMID: 22159752 Ref: Targeting of colorectal cancer growth, metastasis, and anti-apoptosis in BALB/c nude mice via APRIL siRNA. PMID: 22170570 Ref: The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells. PMID: 22170686 Ref: Glucans from the edible mushroom Pleurotus pulmonarius inhibit colitis-associated colon carcinogenesis in mice. PMID: 22187166 Ref: Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. PMID: 22218594 Ref: MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. PMID: 22235338 Ref: Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells. PMID: 22264758 Ref: A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells. PMID: 22269384 Ref: Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. PMID: 22285227 Ref: Cells transformed by PLC-gamma 1 overexpression are highly sensitive to clostridium difficile toxin A-induced apoptosis and mitotic inhibition. PMID: 22297219 Ref: Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model. PMID: 22321733 Ref: MicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells. PMID: 22322955 Ref: Thermotherapy enhances oxaliplatin-induced cytotoxicity in human colon carcinoma cells. PMID: 22363135 Ref: Piroxicam and C-phycocyanin mediated apoptosis in 1,2-dimethylhydrazine dihydrochloride induced colon carcinogenesis: exploring the mitochondrial pathway. PMID: 22369161 Ref: Extract of fermented brown rice induces apoptosis of human colorectal tumor cells by activating mitochondrial pathway. PMID: 22389198 Ref: Role of Sulindac and Celecoxib in chemoprevention of colorectal cancer via intrinsic pathway of apoptosis: exploring NHE-1, intracellular calcium homeostasis and Calpain 9. PMID: 22390894 Ref: The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively. PMID: 22399804 Ref: Inhibitory effect and mechanisms of an anthocyanins- and anthocyanidins-rich extract from purple-shoot tea on colorectal carcinoma cell proliferation. PMID: 22404116 Ref: Perifosine sensitizes curcumin-induced anti-colorectal cancer effects by targeting multiple signaling pathways both in vivo and in vitro. PMID: 22438101 Ref: Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. PMID: 22465936 Ref: Upregulation of trefoil factor 3 (TFF3) after rectal cancer chemoradiotherapy is an adverse prognostic factor and a potential therapeutic target. PMID: 22516806 Ref: Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways. PMID: 22520577 Ref: The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors. PMID: 22526619 Ref: Overexpression of Dickkopf-3 induces apoptosis through mitochondrial pathway in human colon cancer. PMID: 22529687 Ref: Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro. PMID: 22546556 Ref: The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. PMID: 22552631 Ref: Elucidation of structure-activity relationship of 2-quinolone derivatives and exploration of their antitumor potential through Bax-induced apoptotic pathway. PMID: 22553933 Ref: Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells. PMID: 22559738 Ref: Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis. PMID: 22564437 Ref: Virosecurinine induces apoptosis by affecting Bcl-2 and Bax expression in human colon cancer SW480 cells. PMID: 22570942 Ref: Luffa echinata Roxb. induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway. PMID: 22592084 Ref: Preferential killing of p53-deficient cancer cells by reversine. PMID: 22592527 Ref: Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway. PMID: 22607196 Ref: SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than gemcitabine. PMID: 22617428 Ref: Deguelin, an Akt inhibitor, down-regulates NF-kappaB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. PMID: 22623043 Ref: Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis. PMID: 22624035 Ref: The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells. PMID: 22647378 Ref: Exercise training reduces inflammatory mediators in the intestinal tract of healthy older adult mice. PMID: 22647663 Ref: Effects of silk sericin on the proliferation and apoptosis of colon cancer cells. PMID: 22688983 Ref: Chemoprevention of azoxymethane-initiated colon cancer in rat by using a novel polymeric nanocarrier--curcumin. PMID: 22709992 Ref: Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. PMID: 22711167 Ref: Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis. PMID: 22735354 Ref: Diallyl trisulfide induces apoptosis in human primary colorectal cancer cells. PMID: 22736270 Ref: Anti-invasive effects and proapoptotic activity induction by the rexinoid IIF and valproic acid in combination on colon cancer cell lines. PMID: 22753748 Ref: Hedyotis diffusa Willd inhibits colorectal cancer growth in vivo via inhibition of STAT3 signaling pathway. PMID: 22754353 Ref: Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata Yaguchi, Nishim. & Udagawa. PMID: 22822525 Ref: Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. PMID: 22832932 Ref: Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses. PMID: 22869582 Ref: Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer. PMID: 22870247 Ref: Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells. PMID: 22877649 Ref: Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: evidence for the role of c-Jun N-terminal kinase activation. PMID: 22895172 Ref: Parthenolide suppresses tumor growth in a xenograft model of colorectal cancer cells by inducing mitochondrial dysfunction and apoptosis. PMID: 22895542 Ref: HRT, Herbal Formula, Induces G(2)/M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells. PMID: 22899960 Ref: Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats. PMID: 22916810 Ref: AEE788 potentiates celecoxib-induced growth inhibition and apoptosis in human colon cancer cells. PMID: 22922496 Ref: Adrenomedullin is involved in the progression of colonic adenocarcinoma. PMID: 22923200 Ref: High-mobility group A1 protein inhibits p53-mediated intrinsic apoptosis by interacting with Bcl-2 at mitochondria. PMID: 22932725 Ref: D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells. PMID: 22935404 Ref: Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner. PMID: 22941059 Ref: Anticancer effects of KI-10F: a novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer. PMID: 22941304 Ref: Effect of beta,beta-dimethylacrylshikonin on inhibition of human colorectal cancer cell growth in vitro and in vivo. PMID: 22942759 Ref: Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells. PMID: 22948973 Ref: Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins. PMID: 22965228 Ref: Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway. PMID: 22975518 Ref: The prognostic value of the immunohistochemical aspects of tumor suppressor genes p53, bcl-2, PTEN and nuclear proliferative antigen Ki-67 in resected colorectal carcinoma. PMID: 22990545 Ref: Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. PMID: 22992837 Ref: Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. PMID: 23027374 Ref: The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells. PMID: 23059827 Ref: Effects of ellagic acid on chemosensitivity to 5-fluorouracil in colorectal carcinoma cells. PMID: 23060566 Ref: Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells. PMID: 23064444 Ref: Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways. PMID: 23091557 Ref: Induction of apoptosis and cell cycle arrest in human colorectal carcinoma by Litchi seed extract. PMID: 23093841 Ref: Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. PMID: 23100468 Ref: Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. PMID: 23110215 Ref: Inhibition of Jak-STAT3 pathway enhances bufalin-induced apoptosis in colon cancer SW620 cells. PMID: 23110625 Ref: In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice. PMID: 23118721 Ref: Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. PMID: 23159854 Ref: Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. PMID: 23194063 Ref: Induction of apoptosis of SW480 human colon cancer cells by (-)-epicatechin isolated from Bulnesia sarmienti. PMID: 23225437 Ref: Inhibitory effects of meju prepared with mixed starter cultures on azoxymethane and dextran sulfate sodium-induced colon carcinogenesis in mice. PMID: 23230391 Ref: Beta-asarone induces LoVo colon cancer cell apoptosis by up-regulation of caspases through a mitochondrial pathway in vitro and in vivo. PMID: 23244151 Ref: (3S)-1,2,3,4-Tetrahydro-beta-carboline-3-carboxylic acid from Cichorium endivia. L induces apoptosis of human colorectal cancer HCT-8 cells. PMID: 23275050 Ref: Low Mmp 9 and VEGF levels predict good oncologic outcome in mid and low rectal cancer patients with neoadjuvant chemoradiation. PMID: 23276144 Ref: A chemoprotective fish oil/pectin diet enhances apoptosis via Bcl-2 promoter methylation in rat azoxymethane-induced carcinomas. PMID: 23354397 Ref: Glycogen Synthase Kinase 3beta Inhibitor (2'Z,3'E)-6-Bromo-indirubin- 3'-Oxime Enhances Drug Resistance to 5-Fluorouracil Chemotherapy in Colon Cancer Cells. PMID: 23359767 Ref: Chemotherapy and radiotherapy downregulate the activity and expression of DNA methyltransferase and enhance Bcl-2/E1B-19-kDa interacting protein-3-induced apoptosis in human colorectal cancer cells. PMID: 23364257 Ref: [Expression of Bcl-2, PD-L1 and its clinical significance in colorectal cancer]. PMID: 23387206 Ref: Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells. PMID: 23682426 Ref: The effect of the combined action of roscovitine and Paclitaxel on the apoptotic and cell cycle regulatory mechanisms in colon and anaplastic thyroid cancer cells. PMID: 25969761 Ref: Differential inhibition of human colon cancer cells by structurally similar flavonoids of citrus. PMID: 26434259 |
Ref: miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal carcinoma cells. PMID: 22121083 Ref: MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. PMID: 22824797 Ref: Diffusion-weighted MR imaging in liver metastases of colorectal cancer: reproducibility and biological validation. PMID: 23001604 Ref: Immunohistological expression of HIF-1alpha, GLUT-1, Bcl-2 and Ki-67 in consecutive biopsies during chemoradiotherapy in patients with rectal cancer. PMID: 23030583 Ref: The influence of tissue ischemia on biomarker expression in colorectal cancer. PMID: 23060299 Ref: The beta6-integrin-ERK/MAP kinase pathway contributes to chemo resistance in colon cancer. PMID: 23073477 Ref: Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells. PMID: 23117412 Ref: Relationship between the expression of the extracellular matrix genes SPARC, SPP1, FN1, ITGA5 and ITGAV and clinicopathological parameters of tumor progression and colorectal cancer dissemination. PMID: 23128103 Ref: Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells. PMID: 23135489 Ref: Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells. PMID: 23188704 Ref: Involvement of PKCalpha activation in TF/VIIa/PAR2-induced proliferation, migration, and survival of colon cancer cell SW620. PMID: 23233043 Ref: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling. PMID: 23233484 Ref: The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance. PMID: 23234544 Ref: Anti-tumorigenicity of dietary alpha-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites. PMID: 23239542 Ref: Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway. PMID: 23246487 Ref: Anticancer potential of an ethanol extract of Asiasari radix against HCT-116 human colon cancer cells in vitro. PMID: 23255939 Ref: Bamboo salt has in vitro anticancer activity in HCT-116 cells and exerts anti-metastatic effects in vivo. PMID: 23256441 Ref: Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. PMID: 23269238 Ref: The green algae Ulva fasciata Delile extract induces apoptotic cell death in human colon cancer cells. PMID: 23299316 Ref: Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: results from a pilot, randomized, and controlled trial. PMID: 23303903 Ref: bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PMID: 23326480 Ref: Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy. PMID: 23329644 Ref: 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. PMID: 23345169 Ref: 6 Iodo-delta-lactone: a derivative of arachidonic acid with antitumor effects in HT-29 colon cancer cells. PMID: 23375358 Ref: Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. PMID: 23392123 Ref: Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model. PMID: 23409104 Ref: Development of method for three-point data estimation and SVR-QSAR model to screen anti cancer leads. PMID: 23410041 Ref: Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells. PMID: 23411276 Ref: Analgesic-antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells. PMID: 23420047 Ref: Induction of apoptosis and suppression of ERCC1 expression by the potent amonafide analogue 8-c in human colorectal carcinoma cells. PMID: 23426174 Ref: Tandutinib inhibits the Akt/mTOR signaling pathway to inhibit colon cancer growth. PMID: 23427297 Ref: Chemopreventive effect of cactus (Opuntia humifusa) extracts: radical scavenging activity, pro-apoptosis, and anti-inflammatory effect in human colon (SW480) and breast cancer (MCF7) cells. PMID: 23435602 Ref: Micropropagation effect on the anti-carcinogenic activitiy of polyphenolics from Mexican oregano (Poliomintha glabrescens Gray) in human colon cancer cells HT-29. PMID: 23435631 Ref: Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by arraybased comparative genomic hybridization. PMID: 23440507 Ref: Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling. PMID: 23441183 Ref: Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives. PMID: 23472133 Ref: Decrease of survivin, p53 and Bcl-2 expression in chemorefractory colorectal liver metastases may be predictive of radiosensivity radiosensivity after radioembolization with yttrium-90 resin microspheres. PMID: 23497522 Ref: Synergistic antitumor effect of 5-fluorouracil in combination with parthenolide in human colorectal cancer. PMID: 23507557 Ref: Methanolic extracts of bitter melon inhibit colon cancer stem cells by affecting energy homeostasis and autophagy. PMID: 23533514 Ref: Resveratrol inhibits proliferation, angiogenesis and induces apoptosis in colon cancer cells: calorie restriction is the force to the cytotoxicity. PMID: 23536519 Ref: Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin alpha6beta4-dependent Akt, GSK-3beta, and HSF-1 in mesenchymal stem cells. PMID: 23538444 Ref: Evaluation of apoptotic activity of new condensed pyrazole derivatives. PMID: 23568979 Ref: Practical value of the new system for Maspin assessment, in colorectal cancer. PMID: 23581409 Ref: Citrus limonoids and curcumin additively inhibit human colon cancer cells. PMID: 23584140 Ref: Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21). PMID: 23620673 Ref: Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells. PMID: 23624503 Ref: RU486, a glucocorticoid receptor antagonist, induces apoptosis in U937 human lymphoma cells through reduction in mitochondrial membrane potential and activation of p38 MAPK. PMID: 23624748 Ref: Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction. PMID: 23660334 Ref: The novel BH3 alpha-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. PMID: 23680104 Ref: FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PMID: 23700428 Ref: Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells. PMID: 23712032 Ref: Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. PMID: 23732517 Ref: miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer. PMID: 23744359 Ref: Patrinia scabiosaefolia induces mitochondrial-dependent apoptosis in a mouse model of colorectal cancer. PMID: 23754194 Ref: Ilex kudingcha C.J. Tseng (Kudingcha) has in vitro anticancer activities in MCF-7 human breast adenocarcinoma cells and exerts anti-metastatic effects in vivo. PMID: 23760150 Ref: 2-deprenyl-rheediaxanthone B isolated from Metaxya rostrata induces active cell death in colorectal tumor cells. PMID: 23776538 Ref: Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway. PMID: 23800091 Ref: Maytenus ilicifolia dry extract protects normal cells, induces apoptosis and regulates Bcl-2 in human cancer cells. PMID: 23828591 Ref: Molecular pathways: MERTK signaling in cancer. PMID: 23833304 Ref: HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells. PMID: 23840275 Ref: Aristolochia debilis Sieb. et Zucc. induces apoptosis and reactive oxygen species in the HT-29 human colon cancer cell line. PMID: 23848946 Ref: Chemoprevention of colon and small intestinal tumorigenesis in APC(min/+) mice by SHetA2 (NSC721689) without toxicity. PMID: 23852423 Ref: Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells. PMID: 23859040 Ref: APRIL depletion induces cell cycle arrest and apoptosis through blocking TGF-beta1/ERK signaling pathway in human colorectal cancer cells. PMID: 23867993 Ref: Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress. PMID: 23881281 Ref: MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway. PMID: 23886157 Ref: Sodium selenite induces apoptosis in colon cancer cells via Bax-dependent mitochondrial pathway. PMID: 23893182 Ref: The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity. PMID: 23898060 Ref: A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells. PMID: 23907464 Ref: Flaxseed (Linum usitatissimum L.) and its total non-digestible fraction influence the expression of genes involved in azoxymethane-induced colon cancer in rats. PMID: 23907590 Ref: Preparation, preliminary characterization and inhibitory effect on human colon cancer HT-29 cells of an acidic polysaccharide fraction from Stachys floridana Schuttl. ex Benth. PMID: 23911803 Ref: Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species. PMID: 23916687 Ref: Anti-proliferative effects of a new docosapentaenoic acid monoacylglyceride in colorectal carcinoma cells. PMID: 23932824 Ref: Cadmium modifies the cell cycle and apoptotic profiles of human breast cancer cells treated with 5-fluorouracil. PMID: 23941782 Ref: Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells. PMID: 23959101 Ref: Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway. PMID: 23970102 Ref: Antitumour activity on extrinsic apoptotic targets of the triterpenoid maslinic acid in p53-deficient Caco-2 adenocarcinoma cells. PMID: 23973282 Ref: The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters. PMID: 23983126 Ref: [Abnormal expression of APRIL in colorectal cancer cells promotes tumor growth and metastasis]. PMID: 23985251 Ref: Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737. PMID: 24030153 Ref: Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue. PMID: 24055891 Ref: Plant-derived mAbs have effective anti-cancer activities by increasing ganglioside expression in colon cancers. PMID: 24078119 Ref: [Study on functions and mechanism of curcumin in inducing colorectal carcinoma cells LoVo apoptosis]. PMID: 24079252 Ref: Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. PMID: 24098503 Ref: Luteolin induces growth arrest in colon cancer cells through involvement of Wnt/beta-catenin/GSK-3beta signaling. PMID: 24099426 Ref: Soy soluble polysaccharide induces apoptosis in HCT116 human colon cancer cells via reactive oxygen species generation. PMID: 24126443 Ref: Effects of matrine on the proliferation of HT29 human colon cancer cells and its antitumor mechanism. PMID: 24137393 Ref: The prognostic value of the apoptosis pathway in colorectal cancer: a review of the literature on biomarkers identified by immunohistochemistry. PMID: 24179395 Ref: Anti-colorectal cancer activity of macrostemonoside A mediated by reactive oxygen species. PMID: 24211203 Ref: The interplay between epigenetic silencing, oncogenic KRas and HIF-1 regulatory pathways in control of BNIP3 expression in human colorectal cancer cells. PMID: 24211581 Ref: Characterization of oleanolic acid derivative for colon cancer targeting with positron emission tomography. PMID: 24219340 Ref: A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway. PMID: 24241351 Ref: Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via beta-catenin/GSK-3beta modulation in colorectal carcinoma. PMID: 24303084 Ref: Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment. PMID: 24308647 Ref: ART1 silencing enhances apoptosis of mouse CT26 cells via the PI3K/Akt/NF-kappaB pathway. PMID: 24335275 Ref: In vitro investigation of cytotoxic and apoptotic effects of Cynara L. species in colorectal cancer cells. PMID: 24377607 Ref: Inhibition of Wnt/beta-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. PMID: 24399733 Ref: Fermented Pu-erh tea increases in vitro anticancer activities in HT-29 cells and has antiangiogenetic effects on HUVECs. PMID: 24579782 Ref: The Study of DNA Methylation of bax Gene Promoter in Breast and Colorectal Carcinoma Cell Lines. PMID: 25250112 |
Ref: IL-32gamma enhances TNF-alpha-induced cell death in colon cancer. PMID: 23255489 Ref: Crude extract of Rheum palmatum L induced cell death in LS1034 human colon cancer cells acts through the caspase-dependent and -independent pathways. PMID: 23315830 Ref: In vitro anti-proliferative effects of Zuojinwan on eight kinds of human cancer cell lines. PMID: 23397442 Ref: Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells. PMID: 23503458 Ref: Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors. PMID: 23670891 Ref: Interaction of omega-3 polyunsaturated fatty acids with radiation therapy in two different colorectal cancer cell lines. PMID: 23672803 Ref: mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. PMID: 24163374 Ref: Caffeine inhibits paclitaxelinduced apoptosis in colorectal cancer cells through the upregulation of Mcl1 levels. PMID: 24173825 Ref: Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells. PMID: 24177748 Ref: P7 peptides targeting bFGF sensitize colorectal cancer cells to CPT-11. PMID: 24190390 Ref: A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-kappaB in HCT116 human colon cancer cells. PMID: 24190633 Ref: Total alkaloids of Tripterygium hypoglaucum (levl.) Hutch inhibits tumor growth both in vitro and in vivo. PMID: 24212079 Ref: MicroRNA-192 suppresses liver metastasis of colon cancer. PMID: 24213572 Ref: Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways. PMID: 24231788 Ref: Expression of apoptosis regulating proteins identifies stage II and III colon cancer patients with high risk of recurrence. PMID: 24249458 Ref: DMPPQA, a novel angiogenesis inhibitor, induces apoptosis in human colon cancer HCT-116 cells and HUVECs. PMID: 24293112 Ref: MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2. PMID: 24293274 Ref: Distinct roles of Akt1 in regulating proliferation, migration and invasion in HepG2 and HCT 116 cells. PMID: 24297510 Ref: Chloroform fraction of Scutellaria barbata D. Don promotes apoptosis and suppresses proliferation in human colon cancer cells. PMID: 24337216 Ref: TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak. PMID: 24362790 Ref: Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway. PMID: 24384683 Ref: Chemoprevention of colonic aberrant crypt foci by Gynura procumbens in rats. PMID: 24393787 Ref: Inhibitory effects of Dendrobium candidum Wall ex Lindl. on azoxymethane- and dextran sulfate sodium-induced colon carcinogenesis in C57BL/6 mice. PMID: 24396476 Ref: Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. PMID: 24412611 Ref: MHY-449, a novel dihydrobenzofuro[4,5-b][1,8] naphthyridin-6-one derivative, induces apoptotic cell death through modulation of Akt/FoxO1 and ERK signaling in PC3 human prostate cancer cells. PMID: 24424889 Ref: Role of paxillin in colorectal carcinoma and its relationship to clinicopathological features. PMID: 24451945 Ref: Matrine inhibits proliferation and induces apoptosis of human colon cancer LoVo cells by inactivating Akt pathway. PMID: 24452711 Ref: Corosolic acid induces apoptotic cell death in HCT116 human colon cancer cells through a caspase-dependent pathway. PMID: 24481288 Ref: PI3K/Akt pathway involving into apoptosis and invasion in human colon cancer cells LoVo. PMID: 24496855 Ref: Usefulness of selective COX-2 inhibitors as therapeutic agents against canine mammary tumors. PMID: 24503782 Ref: Genistein modulates the anti-tumor activity of cisplatin in MCF-7 breast and HT-29 colon cancer cells. PMID: 24504162 Ref: Myricetin induces cell death of human colon cancer cells via BAX/BCL2-dependent pathway. PMID: 24511002 Ref: Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway. PMID: 24519064 Ref: Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival. PMID: 24556425 Ref: Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes. PMID: 24584270 Ref: Targeting cell death signaling in colorectal cancer: current strategies and future perspectives. PMID: 24587670 Ref: CELLFOOD induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways. PMID: 24598211 Ref: Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells. PMID: 24602180 Ref: Swietenia macrophylla King induces mitochondrial-mediated apoptosis through p53 upregulation in HCT116 colorectal carcinoma cells. PMID: 24613274 Ref: Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats. PMID: 24618844 Ref: Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells. PMID: 24619662 Ref: Lack of M30 expression correlates with factors reflecting tumor progression in rectal cancer with preoperative chemoradiotherapy. PMID: 24649315 Ref: TNF-alpha promotes gallbladder cancer cell growth and invasion through autocrine mechanisms. PMID: 24676340 Ref: Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells. PMID: 24682388 Ref: Apoptotic cascade inspired lipid nanovesicles show synergism with encapsulated paclitaxel in chemoresistant colon carcinoma. PMID: 24702739 Ref: BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737. PMID: 24709422 Ref: A novel small-molecule YLT205 induces apoptosis in human colorectal cells via mitochondrial apoptosis pathway in vitro and inhibits tumor growth in vivo. PMID: 24713812 Ref: HIF-1alpha activation under glucose deprivation plays a central role in the acquisition of anti-apoptosis in human colon cancer cells. PMID: 24718784 Ref: Heated and humidified CO(2) pneumoperitoneum inhibits tumour cell proliferation, migration and invasion in colon cancer. PMID: 24720439 Ref: JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy. PMID: 24733045 Ref: Expression profiling using a cDNA array and immunohistochemistry for the extracellular matrix genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in colorectal carcinoma progression and dissemination. PMID: 24737953 Ref: Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability. PMID: 24743574 Ref: Gender-related differences in pathological and clinical tumor response based on immunohistochemical proteins expression in rectal cancer patients treated with short course of preoperative radiotherapy. PMID: 24756926 Ref: Antichemosensitizing effect of resveratrol in cotreatment with oxaliplatin in HCT116 colon cancer cell. PMID: 24761411 Ref: Laminarin-induced apoptosis in human colon cancer LoVo cells. PMID: 24765209 Ref: Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3-dependent pathway. PMID: 24765211 Ref: Aspirin inhibits proliferation and induces apoptosis of multiple myeloma cells through regulation of Bcl-2 and Bax and suppression of VEGF. PMID: 24766194 Ref: LGR5 is required for the maintenance of spheroid-derived colon cancer stem cells. PMID: 24789370 Ref: Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage. PMID: 24814047 Ref: Can a biomarker-based scoring system predict pathologic complete response after preoperative chemoradiotherapy for rectal cancer? PMID: 24819099 Ref: The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells. PMID: 24829158 Ref: Arsenic trioxide induces apoptosis of human gastrointestinal cancer cells. PMID: 24833880 Ref: Chemical characterization and antitumor activities of polysaccharide extracted from Ganoderma lucidum. PMID: 24857920 Ref: Cracking the cytotoxicity code: apoptotic induction of 10-acetylirciformonin B is mediated through ROS generation and mitochondrial dysfunction. PMID: 24857964 Ref: Differences in telomerase activity between colon and rectal cancer. PMID: 24869613 Ref: Lack of relation of AKAP12 with p53 and Bcl-2 in colorectal carcinoma. PMID: 24870731 Ref: Combination of gefitinib and DNA methylation inhibitor decitabine exerts synergistic anti-cancer activity in colon cancer cells. PMID: 24874286 Ref: Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcmediated phosphorylation of EGF receptor tyrosine kinase. PMID: 24890449 Ref: Multiple regression analysis of mRNA-miRNA associations in colorectal cancer pathway. PMID: 24895601 Ref: Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways. PMID: 24930757 Ref: Sorbitol induces apoptosis of human colorectal cancer cells via p38 MAPK signal transduction. PMID: 24932277 Ref: Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. PMID: 24936217 Ref: Expression of apoptotic proteins in human colorectal cancer and metastatic lymph nodes. PMID: 24939147 Ref: In vitro antitumor effects of the cold-water extracts of Mediterranean species of genus Pleurotus (higher Basidiomycetes) on human colon cancer cells. PMID: 24940904 Ref: Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer. PMID: 24957706 Ref: S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-beta signaling pathway in cancer cells. PMID: 24970681 Ref: The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. PMID: 25023051 Ref: Anti cancer effects of Cnidium officinale Makino extract mediated through apoptosis and cell cycle arrest in the HT-29 human colorectal cancer cell line. PMID: 25040960 Ref: Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway. PMID: 25040975 Ref: DNA methylation of apoptosis genes in rectal cancer predicts patient survival and tumor recurrence. PMID: 25064172 Ref: 6-Acetonyldihydrochelerythrine Is a Potent Inducer of Apoptosis in HCT116 and SW620 Colon Cancer Cells. PMID: 25066282 Ref: Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells. PMID: 25070748 Ref: Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46. PMID: 25082959 Ref: Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells. PMID: 25096910 Ref: Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway. PMID: 25113506 Ref: Activation of JNK/p38 pathway is responsible for alpha-methyl-n-butylshikonin induced mitochondria-dependent apoptosis in SW620 human colorectal cancer cells. PMID: 25124618 Ref: Automated quantitative analysis of tissue microarray of 443 patients with colorectal adenocarcinoma: low expression of Bcl-2 predicts poor survival. PMID: 25127509 Ref: Apoptotic effect of genistein on human colon cancer cells via inhibiting the nuclear factor-kappa B (NF-kappaB) pathway. PMID: 25128065 Ref: The p38 MAPK-regulated PKD1/CREB/Bcl-2 pathway contributes to selenite-induced colorectal cancer cell apoptosis in vitro and in vivo. PMID: 25128071 Ref: Suppressive effect of sinomenine combined with 5-fluorouracil on colon carcinoma cell growth. PMID: 25169518 Ref: PEG-liposomal oxaliplatin combined with nuclear factor-kappaB inhibitor (PDTC) induces apoptosis in human colorectal cancer cells. PMID: 25174808 Ref: Tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of Bak and Bax, leading to mitochondria-dependent apoptosis in human colon cancer HCT116 cells. PMID: 25179905 Ref: Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer. PMID: 25187386 Ref: Kefir exhibits antiproliferative and proapoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion. PMID: 25189203 Ref: Doenjang prepared with mixed starter cultures attenuates azoxymethane and dextran sulfate sodium-induced colitis-associated colon carcinogenesis in mice. PMID: 25191137 Ref: Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells. PMID: 25192188 Ref: Annona muricata leaves induce G(1) cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells. PMID: 25195082 Ref: Preventive effects of Dendrobium candidum Wall ex Lindl. on the formation of lung metastases in BALB/c mice injected with 26-M3.1 colon carcinoma cells. PMID: 25202430 Ref: Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer cells and enhances the therapeutic efficacy of BH3 mimetics. PMID: 25208882 Ref: miR-204-5p expression in colorectal cancer: an autophagy-associated gene. PMID: 25209181 Ref: Piceatannol promotes apoptosis via up-regulation of microRNA-129 expression in colorectal cancer cell lines. PMID: 25218158 Ref: PROX1 promotes metabolic adaptation and fuels outgrowth of Wnt(high) metastatic colon cancer cells. PMID: 25242332 Ref: Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer. PMID: 25275062 Ref: Verbascoside promotes apoptosis by regulating HIPK2-p53 signaling in human colorectal cancer. PMID: 25282590 Ref: Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling. PMID: 25287946 Ref: SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo. PMID: 25301449 Ref: Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak. PMID: 25304383 Ref: [Impact of preoperative chemotherapy on the expression of apoptosis factors in colorectal cancer liver metastases]. PMID: 25306620 Ref: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. PMID: 25321483 Ref: Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE(2) synthesis and COX-2 expression. PMID: 25322760 Ref: D. candidum has in vitro anticancer effects in HCT-116 cancer cells and exerts in vivo anti-metastatic effects in mice. PMID: 25324926 Ref: Pro-apoptotic activities of polyphenolics from acai (Euterpe oleracea Martius) in human SW-480 colon cancer cells. PMID: 25329001 Ref: Mechanisms underlying cancer growth and apoptosis by DEK overexpression in colorectal cancer. PMID: 25340858 Ref: Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway. PMID: 25342273 Ref: Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination. PMID: 25386076 Ref: Achyranthes aspera root extracts induce human colon cancer cell (COLO-205) death by triggering the mitochondrial apoptosis pathway and S phase cell cycle arrest. PMID: 25401123 Ref: Celecoxib prevents colitis associated colon carcinogenesis: an upregulation of apoptosis. PMID: 25443739 Ref: Cochlioquinone derivatives with apoptosis-inducing effects on HCT116 colon cancer cells from the phytopathogenic fungus Bipolaris luttrellii L439. PMID: 25491333 Ref: [miR-15a and miR-16 modulate drug resistance by targeting bcl-2 in human colon cancer cells]. PMID: 25623762 |
Ref: Modulation of imatinib cytotoxicity by selenite in HCT116 colorectal cancer cells. PMID: 24930392 Ref: Role of miR-15/16 in CLL. PMID: 24971479 Ref: [10]-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells. PMID: 25148824 Ref: 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells. PMID: 25178491 Ref: Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis. PMID: 25187324 Ref: Growth inhibition of various human cancer cell lines by imperatorin and limonin from poncirus trifoliata rafin. Seeds. PMID: 25244913 Ref: Acetylamine derivative of diospyrin, a plant-derived binaphthylquinonoid, inhibits human colon cancer growth in Nod-Scid mice. PMID: 25262983 Ref: GRP78 mediates the therapeutic efficacy of curcumin on colon cancer. PMID: 25277658 Ref: A novel oxaliplatin derivative, Ht-2, triggers mitochondrion-dependent apoptosis in human colon cancer cells. PMID: 25307448 Ref: Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer. PMID: 25323586 Ref: Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma. PMID: 25335113 Ref: Transformer 2beta and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA. PMID: 25342468 Ref: Dichloroacetate affects proliferation but not survival of human colorectal cancer cells. PMID: 25344893 Ref: Ethyl acetate extract from Glycosmis parva leaf induces apoptosis and cell-cycle arrest by decreasing expression of COX-2 and altering BCL-2 family gene expression in human colorectal cancer HT-29 cells. PMID: 25356658 Ref: Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1alpha/miR-210/Bcl-2 pathway in colon cancer cells. PMID: 25385144 Ref: BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer. PMID: 25388617 Ref: Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis. PMID: 25418925 Ref: Prodigiosin isolated from cell wall of Serratia marcescens alters expression of apoptosis-related genes and increases apoptosis in colorectal cancer cells. PMID: 25429836 Ref: The HMGB1 protein sensitizes colon carcinoma cells to cell death triggered by pro-apoptotic agents. PMID: 25434832 Ref: Involvement of heat shock protein a4/apg-2 in refractory inflammatory bowel disease. PMID: 25437815 Ref: Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-kappaB inactivation on colitis-associated colon tumorigenesis in mice. PMID: 25449198 Ref: Design, synthesis and in vitro antitumor activity of novel N-substituted-4-phenyl/benzylphthalazin-1-ones. PMID: 25462265 Ref: Biosynthesis of silver nanoparticles using ethanolic petals extract of Rosa indica and characterization of its antibacterial, anticancer and anti-inflammatory activities. PMID: 25481491 Ref: Predictive markers of response to neoadjuvant therapy in rectal cancer. PMID: 25481527 Ref: Khz (fusion product of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis in human colon carcinoma HCT116 cells, accompanied by an increase in reactive oxygen species, activation of caspase 3, and increased intracellular Ca(2)(+). PMID: 25489715 Ref: Parthenolide enhances sensitivity of colorectal cancer cells to TRAIL by inducing death receptor 5 and promotes TRAIL-induced apoptosis. PMID: 25502339 Ref: The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells. PMID: 25542230 Ref: Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. PMID: 25548100 Ref: Non-genomic effects of the NR4A1/Nur77/TR3/NGFIB orphan nuclear receptor. PMID: 25555471 Ref: Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-kappaB pathway. PMID: 25555669 Ref: DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by Ruta graveolens in human colon cancer cells. PMID: 25576270 Ref: Stachyose-induced apoptosis of Caco-2 cells via the caspase-dependent mitochondrial pathway. PMID: 25578308 Ref: miRNA expression in human intestinal Caco-2 cells is comparably regulated by cis- and trans-fatty acids. PMID: 25612549 Ref: Circadian gene hClock enhances proliferation and inhibits apoptosis of human colorectal carcinoma cells in vitro and in vivo. PMID: 25625359 Ref: Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancer. PMID: 25628923 Ref: Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line. PMID: 25634350 Ref: Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer. PMID: 25644785 Ref: BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs. PMID: 25649765 Ref: Hydroquinone analog 4-[(Tetrahydro-2H-pyran-2yl) oxy] phenol induces C26 colon cancer cell apoptosis and inhibits tumor growth in vivo. PMID: 25651526 Ref: Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway. PMID: 25652758 Ref: BAD-mediated apoptotic pathway is associated with human cancer development. PMID: 25653146 Ref: CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo. PMID: 25663456 Ref: Intracellular Acidosis Promotes Mitochondrial Apoptosis Pathway: Role of EMMPRIN Down-regulation via Specific Single-chain Fv Intrabody. PMID: 25663946 Ref: Design, synthesis and in vitro antiproliferative activity of novel isatin-quinazoline hybrids. PMID: 25664631 Ref: Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. PMID: 25684945 Ref: Dihydroartemisinin-Induced Apoptosis is Associated with Inhibition of Sarco/Endoplasmic Reticulum Calcium ATPase Activity in Colorectal Cancer. PMID: 25701954 Ref: BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. PMID: 25715028 Ref: Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells. PMID: 25746954 Ref: Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation. PMID: 25752481 Ref: Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells. PMID: 25761243 Ref: The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression. PMID: 25767680 Ref: Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer. PMID: 25782664 Ref: HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion. PMID: 25800793 Ref: In vitro and in vivo evaluation of novel cinnamyl sulfonamide hydroxamate derivative against colon adenocarcinoma. PMID: 25824412 Ref: Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87. PMID: 25826088 Ref: Histochemical and immunohistochemical evidence of tumor heterogeneity in colorectal cancer. PMID: 25826503 Ref: Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling. PMID: 25833196 Ref: Terpenoids Isolated From the Shoot of Plectranthus hadiensis Induces Apoptosis in Human Colon Cancer Cells Via the Mitochondria-Dependent Pathway. PMID: 25837437 Ref: Genetic dissimilarity between primary colorectal carcinomas and their lymph node metastases: ploidy, p53, bcl-2, and c-myc expression--a pilot study. PMID: 25840688 Ref: The chemopotential effect of Annona muricata leaves against azoxymethane-induced colonic aberrant crypt foci in rats and the apoptotic effect of Acetogenin Annomuricin E in HT-29 cells: a bioassay-guided approach. PMID: 25860620 Ref: Elephantopus scaber induces apoptosis through ROS-dependent mitochondrial signaling pathway in HCT116 human colorectal carcinoma cells. PMID: 25861953 Ref: Is Bax/Bcl-2 ratio considered as a prognostic marker with age and tumor location in colorectal cancer? PMID: 25864810 Ref: Biocompatible iota-carrageenan-gamma-maghemite nanocomposite for biomedical applications - synthesis, characterization and in vitro anticancer efficacy. PMID: 25890231 Ref: The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells. PMID: 25892545 Ref: [Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells]. PMID: 25907934 Ref: Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene. PMID: 25914533 Ref: Characterization of the apoptotic response induced by the cyanine dye D112: a potentially selective anti-cancer compound. PMID: 25927702 Ref: [Co-inhibition effect of 17-DMAG and oxaliplatin on proliferation and invasion of colorectal cancer cells]. PMID: 25940182 Ref: Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002. PMID: 25945059 Ref: Mushroom Extracts Induce Human Colon Cancer Cell (COLO-205) Death by Triggering the Mitochondrial Apoptosis Pathway and Go/G1-Phase Cell Cycle Arrest. PMID: 25959910 Ref: A novel class I histone deacetylase inhibitor, I-7ab, induces apoptosis and arrests cell cycle progression in human colorectal cancer cells. PMID: 25960218 Ref: MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells. PMID: 25970424 Ref: AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells. PMID: 25974027 Ref: The polymorphic terminal-loop of pre-miR-1307 binding with MBNL1 contributes to colorectal carcinogenesis via interference with Dicer1 recruitment. PMID: 25977444 Ref: The BH3-mimetic obatoclax reduces HIF-1alpha levels and HIF-1 transcriptional activity and sensitizes hypoxic colon adenocarcinoma cells to 5-fluorouracil. PMID: 25979228 Ref: MHY218-induced apoptotic cell death is enhanced by the inhibition of autophagy in AGS human gastric cancer cells. PMID: 26043797 Ref: Functional characterization of the nitrogen permease regulator-like-2 candidate tumor suppressor gene in colorectal cancer cell lines. PMID: 26044952 Ref: Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects. PMID: 26054686 Ref: Shogaol overcomes TRAIL resistance in colon cancer cells via inhibiting of survivin. PMID: 26063410 Ref: Study on the molecular regulatory mechanism of MicroRNA-195 in the invasion and metastasis of colorectal carcinoma. PMID: 26064276 Ref: Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer. PMID: 26074733 Ref: Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. PMID: 26078354 Ref: Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by p53/p21-cdc2/cdc25A Crosstalk. PMID: 26119958 Ref: Balsalazide Potentiates Parthenolide-Mediated Inhibition of Nuclear Factor-kappaB Signaling in HCT116 Human Colorectal Cancer Cells. PMID: 26130998 Ref: Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer. PMID: 26134786 Ref: Enterobacter Strains Might Promote Colon Cancer. PMID: 26143056 Ref: Aldose Reductase Inhibitor Fidarestat as a Promising Drug Targeting Autophagy in Colorectal Carcinoma: a Pilot Study. PMID: 26163626 Ref: Triphala Extract Suppresses Proliferation and Induces Apoptosis in Human Colon Cancer Stem Cells via Suppressing c-Myc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio. PMID: 26167492 Ref: Chemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats. PMID: 26201720 Ref: Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth. PMID: 26206332 Ref: Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells. PMID: 26214321 Ref: Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy. PMID: 26229035 Ref: New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway. PMID: 26235743 Ref: Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29). PMID: 26248310 Ref: The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats. PMID: 26251570 Ref: miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1. PMID: 26297542 Ref: Colchicine induces apoptosis in HT29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways. PMID: 26299305 Ref: Chemopreventive effects of Strobilanthes crispus leaf extract on azoxymethane-induced aberrant crypt foci in rat colon. PMID: 26307342 Ref: Curcumol Inhibits Growth and Induces Apoptosis of Colorectal Cancer LoVo Cell Line via IGF-1R and p38 MAPK Pathway. PMID: 26307972 Ref: LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging. PMID: 26318819 Ref: Correlation study of Bcl-2, B7-H1, EGFR, VEGF and colorectal cancer. PMID: 26328258 Ref: TKTL1 promotes cell proliferation and metastasis in esophageal squamous cell carcinoma. PMID: 26349965 Ref: ApoG2 inhibits the antiapoptotic protein, Mcl1, and induces mitochondriadependent apoptosis in human colorectal cancer cells. PMID: 26352605 Ref: Lysophosphatidic Acid Inhibits Apoptosis Induced by Cisplatin in Cervical Cancer Cells. PMID: 26366416 Ref: Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers. PMID: 26392303 Ref: Synthetic Bichalcone TSWU-BR23 Induces Apoptosis of Human Colon Cancer HT-29 Cells by p53-Mediated Mitochondrial Oligomerization of BAX/BAK and Lipid Raft Localization of CD95/FADD. PMID: 26408703 Ref: Methionine adenosyltransferase alpha2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells. PMID: 26416353 Ref: A sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis. PMID: 26417363 Ref: Deregulation of miR-126 expression in colorectal cancer pathogenesis and its clinical significance. PMID: 26455548 Ref: Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis. PMID: 26457107 Ref: Oleanolic acid modulates multiple intracellular targets to inhibit colorectal cancer growth. PMID: 26459864 Ref: Molecular mechanisms underlying the antitumor activity of (E)-N-hydroxy-3-(1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acry lamide in human colorectal cancer cells in vitro and in vivo. PMID: 26462017 Ref: The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway. PMID: 26464652 Ref: Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity. PMID: 26472352 Ref: DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer. PMID: 26482433 Ref: Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PMID: 26492315 Ref: Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway. PMID: 26503559 Ref: Identification of a novel compound (beta-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin. PMID: 26521943 Ref: Polyunsaturated fatty acids trigger apoptosis of colon cancer cells through a mitochondrial pathway. PMID: 26528354 Ref: p-Methoxycinnamic acid, an active phenylpropanoid induces mitochondrial mediated apoptosis in HCT-116 human colon adenocarcinoma cell line. PMID: 26546748 Ref: MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer. PMID: 26564107 Ref: Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells. PMID: 26580615 Ref: Antitumor Activities and Apoptosis-regulated Mechanisms of Fermented Wheat Germ Extract in the Transplantation Tumor Model of Human HT-29 Cells in Nude Mice. PMID: 26582094 Ref: Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling. PMID: 26585594 Ref: Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth. PMID: 26586936 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 Ref: Evaluation of chemopreventive potential of Strobilanthes crispus against colon cancer formation in vitro and in vivo. PMID: 26608653 Ref: Scutellaria barbata D. Don inhibits growth and induces apoptosis by suppressing IL-6-inducible STAT3 pathway activation in human colorectal cancer cells. PMID: 26622533 Ref: Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-kappaB Transcription Factors and the Induction of Cytoprotective Genes. PMID: 26625825 Ref: Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors. PMID: 26673922 Ref: Exosome-Carried microRNA-375 Inhibits Cell Progression and Dissemination via Bcl-2 Blocking in Colon Cancer. PMID: 26697569 Ref: Effect of survivin on tumor growth of colorectal cancer in vivo. PMID: 26722528 Ref: Epieriocalyxin A Induces Cell Apoptosis Through JNK and ERK1/2 Signaling Pathways in Colon Cancer Cells. PMID: 27352353 |
Ref: Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model. PMID: 25773652 Ref: Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells. PMID: 25777538 Ref: Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer. PMID: 25994220 Ref: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. PMID: 26152521 Ref: Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines. PMID: 26183715 Ref: Nexrutine inhibits azoxymethane-induced colonic aberrant crypt formation in rat colon and induced apoptotic cell death in colon adenocarcinoma cells. PMID: 26259065 Ref: Inhibition of human 67-kDa laminin receptor sensitizes multidrug resistance colon cancer cell line SW480 for apoptosis induction. PMID: 26293895 Ref: Tubb3 regulation by the Erk and Akt signaling pathways: a mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells. PMID: 26373733 Ref: Purification, partial characterization and antitumor effect of an exopolysaccharide from Rhizopus nigricans. PMID: 26449531 Ref: Crataegus azarolus Leaves Induce Antiproliferative Activity, Cell Cycle Arrest, and Apoptosis in Human HT-29 and HCT-116 Colorectal Cancer Cells. PMID: 26495895 Ref: Regulatory effects of DeltaFosB on proliferation and apoptosis of MCF-7 breast cancer cells. PMID: 26608367 Ref: Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway. PMID: 26614430 Ref: A novel quinazolinone chalcone derivative induces mitochondrial dependent apoptosis and inhibits PI3K/Akt/mTOR signaling pathway in human colon cancer HCT-116 cells. PMID: 26615871 Ref: Sodium orthovanadate induces the apoptosis of SH-SY5Y cells by inhibiting PIWIL2. PMID: 26647781 Ref: A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells. PMID: 26673746 Ref: Guarana a Caffeine-Rich Food Increases Oxaliplatin Sensitivity of Colorectal HT-29 Cells by Apoptosis Pathway Modulation. PMID: 26673759 Ref: Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells. PMID: 26677729 Ref: Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells. PMID: 26702744 Ref: Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro. PMID: 26707712 Ref: Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition. PMID: 26716648 Ref: Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy. PMID: 26717967 Ref: MiR-331-3p inhibits proliferation and promotes apoptosis by targeting HER2 through the PI3K/Akt and ERK1/2 pathways in colorectal cancer. PMID: 26718987 Ref: A novel PI3K axis selective molecule exhibits potent tumor inhibition in colorectal carcinogenesis. PMID: 26764221 Ref: The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer. PMID: 26771233 Ref: Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line. PMID: 26774143 Ref: Cytotoxic Compounds from Juglans sinensis Dode Display Anti-Proliferative Activity by Inducing Apoptosis in Human Cancer Cells. PMID: 26805799 Ref: Long non-coding RNA AK027294 involves in the process of proliferation, migration, and apoptosis of colorectal cancer cells. PMID: 26820130 Ref: Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells. PMID: 26821367 Ref: miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells. PMID: 26824186 Ref: Synergistic anti-tumor activity and mechanisms of total glycosides from Cimicifuga dahurica in combination with cisplatin. PMID: 26825081 Ref: Segmental distribution of some common molecular markers for colorectal cancer (CRC): influencing factors and potential implications. PMID: 26842924 Ref: Silencing Bag-1 gene via magnetic gold nanoparticle-delivered siRNA plasmid for colorectal cancer therapy in vivo and in vitro. PMID: 26846101 Ref: Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway. PMID: 26847477 Ref: Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro. PMID: 26848703 Ref: Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity. PMID: 26871659 Ref: Low toxic and high soluble camptothecin derivative 2-47 effectively induces apoptosis of tumor cells in vitro. PMID: 26879138 Ref: Diffuse large B-cell lymphoma in colon confounded by prior history of colorectal cancer: A case report and literature review. PMID: 26893766 Ref: Expression analysis and association of RBBP6 with apoptosis in colon cancers. PMID: 26905308 Ref: In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition. PMID: 26915975 Ref: Chalcone derivatives cause accumulation of colon cancer cells in the G2/M phase and induce apoptosis. PMID: 26916824 Ref: Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells. PMID: 26921340 Ref: SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy. PMID: 26940565 Ref: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. PMID: 27004568 Ref: Goniothalamin prevents the development of chemically induced and spontaneous colitis in rodents and induces apoptosis in the HT-29 human colon tumor cell line. PMID: 27016270 Ref: Bakuchiol sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins. PMID: 27033605 Ref: Inhibition of histone deacetylases by trans-cinnamic acid and its antitumor effect against colon cancer xenografts in athymic mice. PMID: 27035417 Ref: LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p. PMID: 27046651 Ref: Inflammatory bowel disease, colorectal cancer and type 2 diabetes mellitus: The links. PMID: 27051585 Ref: CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis. PMID: 27058823 Ref: Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells. PMID: 27064730 Ref: Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice. PMID: 27085036 Ref: Induction of ROS Overload by Alantolactone Prompts Oxidative DNA Damage and Apoptosis in Colorectal Cancer Cells. PMID: 27089328 Ref: The Herbal Medicine Utrica Dioica Inhibits Proliferation of Colorectal Cancer Cell Line by Inducing Apoptosis and Arrest at the G2/M Phase. PMID: 27090648 Ref: Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells. PMID: 27098859 Ref: 5-Hydroxy-7-Methoxyflavone Triggers Mitochondrial-Associated Cell Death via Reactive Oxygen Species Signaling in Human Colon Carcinoma Cells. PMID: 27116119 Ref: The prognostic significance of p53, Bax, Bcl-2 and cyclin E protein overexpression in colon cancer - an immunohistochemical study using the tissue microarray technique. PMID: 27151692 Ref: Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment. PMID: 27166181 Ref: miR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1. PMID: 27173050 Ref: Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo. PMID: 27180010 Ref: JNK1 Inhibition Attenuates Hypoxia-Induced Autophagy and Sensitizes to Chemotherapy. PMID: 27216154 Ref: Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway. PMID: 27221553 Ref: Harmal Extract Induces Apoptosis of HCT116 Human Colon Cancer Cells, Mediated by Inhibition of Nuclear Factor-kappaB and Activator Protein-1 Signaling Pathways and Induction of Cytoprotective Genes. PMID: 27221880 Ref: miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2. PMID: 27244080 Ref: 5,7,4'-Trihydroxy-6,8-diprenylisoflavone and lupalbigenin, active components of Derris scandens, induce cell death on breast cancer cell lines. PMID: 27261599 Ref: Three components of cigarette smoke altered the growth and apoptosis of metastatic colon cancer cells via inducing the synthesis of reactive oxygen species and endoplasmic reticulum stress. PMID: 27262990 Ref: Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study. PMID: 27268964 Ref: Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. PMID: 27271587 Ref: Data on clinical significance of GAS2 in colorectal cancer cells. PMID: 27284567 Ref: Boletus edulis ribonucleic acid - a potent apoptosis inducer in human colon adenocarcinoma cells. PMID: 27302173 Ref: Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC). PMID: 27302926 Ref: Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings. PMID: 27322552 Ref: Transforming Growth Factor beta Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer. PMID: 27330076 Ref: Effect of PLCepsilon gene silencing on inhibiting the cancerous transformation of ulcerative colitis. PMID: 27347072 Ref: Cytotoxicity and Apoptotic Effects of Polyphenols from Sugar Beet Molasses on Colon Carcinoma Cells in Vitro. PMID: 27347927 Ref: Enhanced TLR4 Expression on Colon Cancer Cells After Chemotherapy Promotes Cell Survival and Epithelial-Mesenchymal Transition Through Phosphorylation of GSK3beta. PMID: 27354597 Ref: Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed omega-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs. PMID: 27368132 Ref: Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation. PMID: 27372405 Ref: Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cells. PMID: 27378626 Ref: 5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-beta-synthase in colon cancer cells lacking p53. PMID: 27385096 Ref: DNA methylation based biomarkers in colorectal cancer: A systematic review. PMID: 27385266 Ref: Enhanced colon cancer chemoprevention of curcumin by nanoencapsulation with whey protein. PMID: 27404761 Ref: The Effect of (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-Olide (LS-1) from Lobophyyum sp. on the Apoptosis Induction of SNU-C5 Human Colorectal Cancer Cells. PMID: 27469141 Ref: Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer. PMID: 27472952 Ref: Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation. PMID: 27512955 Ref: IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis. PMID: 27520705 Ref: Tumor markers used in monitoring the tumor recurrence in patients with colorectal cancer. PMID: 27547057 Ref: The omega-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of beta-catenin complex, inhibiting COX-2 through repressing NF-kappaB, and inducing 15-prostaglandin dehydrogenase. PMID: 27566583 Ref: Possible Mechanisms of Ethanol-Mediated Colorectal Carcinogenesis: The Role of Cytochrome P4502E1, Etheno-DNA Adducts, and the Anti-Apoptotic Protein Mcl-1. PMID: 27581253 Ref: Correlation of multiple proteins with clinic-pathological features and its prognostic significance in colorectal cancer with signet-ring cell component. PMID: 27608893 Ref: Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model. PMID: 27612418 Ref: (3'R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells. PMID: 27616029 Ref: BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells. PMID: 27628414 Ref: Study of apoptosis-related interactions in colorectal cancer. PMID: 27629291 Ref: Effect of Schiff base Cu(II) complexes on signaling pathways in HT-29 cells. PMID: 27633628 Ref: The Association of CXC Receptor 4 Mediated Signaling Pathway with Oxaliplatin-Resistant Human Colorectal Cancer Cells. PMID: 27668882 Ref: Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway. PMID: 27671231 Ref: Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells. PMID: 27698814 Ref: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action. PMID: 27716288 Ref: Novel quercetin derivative TEF induces ER stress and mitochondria-mediated apoptosis in human colon cancer HCT-116 cells. PMID: 27721177 Ref: Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. PMID: 27748879 Ref: Salidroside induces apoptosis and autophagy in human colorectal cancer cells through inhibition of PI3K/Akt/mTOR pathway. PMID: 27748934 Ref: [Overexpression of aplysia Ras homolog I (ARHI) increases apoptosis in colon cancer SW480 cells]. PMID: 27774944 Ref: Pre-clinical characterization of PKC412, a multi-kinase inhibitor, against colorectal cancer cells. PMID: 27780925 Ref: Curcumin analog EF24 induces apoptosis via ROS-dependent mitochondrial dysfunction in human colorectal cancer cells. PMID: 27787644 Ref: Evaluation of a furochromone from the halophyte Corydalis heterocarpa for cytotoxic activity against human gastric cancer (AGS) cells. PMID: 27808331 Ref: Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles. PMID: 27835895 Ref: Bamboo Salt Suppresses Colon Carcinogenesis in C57BL/6 Mice with Chemically Induced Colitis. PMID: 27845862 Ref: RhoA regulates resistance to irinotecan by regulating membrane transporter and apoptosis signaling in colorectal cancer. PMID: 27888624 Ref: HSP90 inhibitor enhances anti-proliferative and apoptotic effects of celecoxib on HT-29 colorectal cancer cells via increasing BAX/BCL-2 ratio. PMID: 27894402 Ref: Combination effects of sorafenib with PI3K inhibitors under hypoxia in colorectal cancer. PMID: 27995152 Ref: Silencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating Hedgehog signaling pathway in colorectal cancer. PMID: 28032859 Ref: Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. PMID: 28035994 Ref: Effect of ethanol extract of HPRS, a Traditional Chinese Medicine formula, on HCT116 cell Line. PMID: 29949709 |
Ref: FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. PMID: 27399335 Ref: BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers. PMID: 27447746 Ref: BCL-2 system analysis identifies high-risk colorectal cancer patients. PMID: 27663504 Ref: Betalains increase vitexin-2-O-xyloside cytotoxicity in CaCo-2 cancer cells. PMID: 27719921 Ref: Anacyclus Pyrethrum Extract Exerts Anticancer Activities on the Human Colorectal Cancer Cell Line (HCT) by Targeting Apoptosis, Metastasis and Cell Cycle Arrest. PMID: 27796737 Ref: Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. PMID: 27840966 Ref: Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice. PMID: 27845068 Ref: Koelreuteria Formosana Extract Induces Growth Inhibition and Cell Death in Human Colon Carcinoma Cells via G2/M Arrest and LC3-II Activation-Dependent Autophagy. PMID: 27880045 Ref: A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice. PMID: 27888812 Ref: Thioridazine elicits potent antitumor effects in colorectal cancer stem cells. PMID: 28000884 Ref: Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy. PMID: 28017891 Ref: MC37, a new mono-carbonyl curcumin analog, induces G2/M cell cycle arrest and mitochondria-mediated apoptosis in human colorectal cancer cells. PMID: 28024945 Ref: [Overexpression of N-myc downstream regulated gene 2 (NDRG2) inhibits proliferation, migration and promotes apoptosis in SW480 rectal cancer cells]. PMID: 28031114 Ref: Autophagy inhibition enhances photocytotoxicity of Photosan-II in human colorectal cancer cells. PMID: 28031534 Ref: Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. PMID: 28035355 Ref: The BAX gene as a candidate for negative autophagy-related genes regulator on mRNA levels in colorectal cancer. PMID: 28035578 Ref: Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration. PMID: 28049506 Ref: Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis. PMID: 28055016 Ref: Inhibitory Effects of Probiotic Lactobacillus on the Growth of Human Colonic Carcinoma Cell Line HT-29. PMID: 28075415 Ref: Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. PMID: 28096658 Ref: Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells. PMID: 28103302 Ref: Association of single nucleotide polymorphisms in the coding region of Bcl-2 with the occurrence and prognosis of colorectal cancer: A case-control study. PMID: 28106544 Ref: Knockdown of TCTN1 Strongly Decreases Growth of Human Colon Cancer Cells. PMID: 28123172 Ref: Synthesis of C5-tethered indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors. PMID: 28131777 Ref: Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF. PMID: 28182330 Ref: S100A8(+) stroma cells predict a good prognosis and inhibit aggressiveness in colorectal carcinoma. PMID: 28197382 Ref: Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. PMID: 28202514 Ref: Discovery of Mieap-regulated mitochondrial quality control as a new function of tumor suppressor p53. PMID: 28222492 Ref: The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target. PMID: 28223542 Ref: Antitumor Activities and Apoptosis-regulated Mechanisms of Fermented Barley Extract in the Transplantation Tumor Model of Human HT-29 Cells in Nude Mice. PMID: 28245895 Ref: miR-195 enhances the radiosensitivity of colorectal cancer cells by suppressing CARM1. PMID: 28255246 Ref: Epigenome-wide discovery and evaluation of leukocyte DNA methylation markers for the detection of colorectal cancer in a screening setting. PMID: 28270869 Ref: Blockage of Glyoxalase I Inhibits Colorectal Tumorigenesis and Tumor Growth via Upregulation of STAT1, p53, and Bax and Downregulation of c-Myc and Bcl-2. PMID: 28282916 Ref: In vitro evaluation of cytotoxicity, possible alteration of apoptotic regulatory proteins, and antibacterial activity of synthesized copper oxide nanoparticles. PMID: 28285257 Ref: ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29. PMID: 28306533 Ref: Anti-Cancerous Potential of Polysaccharide Fractions Extracted from Peony Seed Dreg on Various Human Cancer Cell Lines Via Cell Cycle Arrest and Apoptosis. PMID: 28316571 Ref: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer. PMID: 28341962 Ref: Apoptosis mediated chemosensitization of tumor cells to 5-fluorouracil on supplementation of fish oil in experimental colon carcinoma. PMID: 28349837 Ref: MTA3 regulates malignant progression of colorectal cancer through Wnt signaling pathway. PMID: 28351306 Ref: LRG1 promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation. PMID: 28376129 Ref: [Inhibitory effect of apatinib on HCT-116 cells and its mechanism]. PMID: 28377354 Ref: Effects of Hylomecon vernalis ethanol extracts on cell cycle and apoptosis of colon cancer cells. PMID: 28393197 Ref: The suppressing effects of BTG3 expression on aggressive behaviors and phenotypes of colorectal cancer: An in vitro and vivo study. PMID: 28407690 Ref: Eco-friendly synthesis of novel cyanopyridine derivatives and their anticancer and PIM-1 kinase inhibitory activities. PMID: 28431341 Ref: Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway. PMID: 28432271 Ref: Effects of Scutellaria barbata polysaccharide on the proliferation, apoptosis and EMT of human colon cancer HT29 Cells. PMID: 28433181 Ref: Apoptosis-induced effects of extract from Artemisia annua Linne by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells. PMID: 28454566 Ref: Cisatracurium-induced proliferation impairment and death of colorectal cancer cells, HCT116 is mediated by p53 dependent intrinsic apoptotic pathway in vitro. PMID: 28463795 Ref: Vitex rotundifolia Fruit Extract Induces Apoptosis Through the Downregulation of ATF3-Mediated Bcl-2 Expression in Human Colorectal Cancer Cells. PMID: 28468511 Ref: Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS-12, induces apoptosis pathways in human colorectal cancer cell lines. PMID: 28477945 Ref: Hepatoprotective Effect of Carboxymethyl Pachyman in Fluorouracil-Treated CT26-Bearing Mice. PMID: 28481246 Ref: Apoptotic Activity of Lactobacillus plantarum DGK-17-Fermented Soybean Seed Extract in Human Colon Cancer Cells via ROS-JNK Signaling Pathway. PMID: 28488794 Ref: The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo. PMID: 28492347 Ref: Chloroform fraction of Scutellaria barbata D. Don inhibits the growth of colorectal cancer cells by activating miR34a. PMID: 28498458 Ref: Curcumin loading potentiates the chemotherapeutic efficacy of selenium nanoparticles in HCT116 cells and Ehrlich's ascites carcinoma bearing mice. PMID: 28499854 Ref: Mammea longifolia Planch. and Triana Fruit Extract Induces Cell Death in the Human Colon Cancer Cell Line, SW480, via Mitochondria-Related Apoptosis and Activation of p53. PMID: 28504908 Ref: Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy. PMID: 28507280 Ref: Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cells. PMID: 28522946 Ref: Isofraxidin inhibited proliferation and induced apoptosis via blockage of Akt pathway in human colorectal cancer cells. PMID: 28531803 Ref: N-myc downstream-regulated gene 1 promotes oxaliplatin-triggered apoptosis in colorectal cancer cells via enhancing the ubiquitination of Bcl-2. PMID: 28537875 Ref: Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. PMID: 28551635 Ref: The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations. PMID: 28560697 Ref: In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. PMID: 28573788 Ref: Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival. PMID: 28586030 Ref: The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway. PMID: 28597038 Ref: Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells. PMID: 28618116 Ref: Down-regulation of liver-intestine cadherin enhances noscapine-induced apoptosis in human colon cancer cells. PMID: 28622054 Ref: 8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells. PMID: 28627461 Ref: Targeted CDX2 expression inhibits aggressive phenotypes of colon cancer cells in vitro and in vivo. PMID: 28627695 Ref: Evaluation of in vitro cytotoxicity, biocompatibility, and changes in the expression of apoptosis regulatory proteins induced by cerium oxide nanocrystals. PMID: 28634498 Ref: Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma. PMID: 28656255 Ref: Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2. PMID: 28663269 Ref: Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU. PMID: 28671249 Ref: Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer. PMID: 28672935 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and mitochondrial apoptosis. PMID: 28675857 Ref: Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells. PMID: 28706417 Ref: Photo-catalytic, anti-bacterial, and anti-cancer properties of phyto-mediated synthesis of silver nanoparticles from Artemisia tournefortiana Rchb extract. PMID: 28711019 Ref: Spica Prunellae extract suppresses the growth of human colon carcinoma cells by targeting multiple oncogenes via activating miR-34a. PMID: 28713966 Ref: Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. PMID: 28714374 Ref: MHY451 induces cell cycle arrest and apoptosis by ROS generation in HCT116 human colorectal cancer cells. PMID: 28731136 Ref: Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway. PMID: 28737825 Ref: YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway. PMID: 28740556 Ref: Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim. PMID: 28744911 Ref: Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice. PMID: 28751809 Ref: Cellular expression, in-vitro and in-vivo confirmation of GAEC1 oncogenic properties in colon cancer. PMID: 28764863 Ref: Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11. PMID: 28781653 Ref: Antitumor activity of beta-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. PMID: 28782499 Ref: High expression of anti-apoptotic protein Bcl-2 is a good prognostic factor in colorectal cancer: Result of a meta-analysis. PMID: 28785155 Ref: microRNA630 promotes cell proliferation and inhibits apoptosis in the HCT116 human colorectal cancer cell line. PMID: 28791386 Ref: Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells. PMID: 28791416 Ref: Gender-related prognostic significance of clinical and biological tumor features in rectal cancer patients receiving short-course preoperative radiotherapy. PMID: 28794690 Ref: Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies. PMID: 28802125 Ref: Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase-3beta/beta-catenin pathway. PMID: 28803443 Ref: Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis. PMID: 28816773 Ref: Scutellaria barbata D. Don inhibits 5-fluorouracil resistance in colorectal cancer by regulating PI3K/AKT pathway. PMID: 28849113 Ref: Sanggenon C induces apoptosis of colon cancer cells via inhibition of NO production, iNOS expression and ROS activation of the mitochondrial pathway. PMID: 28849234 Ref: Ginkgo biloba L. leaf extract offers multiple mechanisms in bridling N-methylnitrosourea - mediated experimental colorectal cancer. PMID: 28858737 Ref: [Role of PpIX-based photodynamic therapy in promoting the damage and apoptosis of colorectal cancer cell and its mechanisms]. PMID: 28872077 Ref: Identification of hub genes, key miRNAs and potential molecular mechanisms of colorectal cancer. PMID: 28902367 Ref: Smad4 re-expression increases the sensitivity to parthenolide in colorectal cancer. PMID: 28902368 Ref: Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway. PMID: 28903386 Ref: Antiproliferative Effects of Bacillus coagulans Unique IS2 in Colon Cancer Cells. PMID: 28910156 Ref: The Immune-microenvironment Confers Chemoresistance of Colorectal Cancer through Macrophage-Derived IL6. PMID: 28928161 Ref: PPA1 regulates tumor malignant potential and clinical outcome of colon adenocarcinoma through JNK pathways. PMID: 28938583 Ref: Sulforaphane induces p53deficient SW480 cell apoptosis via the ROSMAPK signaling pathway. PMID: 28944886 Ref: SN38-PEG-PLGA-verapamil nanoparticles inhibit proliferation and downregulate drug transporter ABCG2 gene expression in colorectal cancer cells. PMID: 28948511 Ref: The BET-Bromodomain Inhibitor JQ1 synergized ABT-263 against colorectal cancer cells through suppressing c-Myc-induced miR-1271-5p expression. PMID: 28950657 Ref: Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect. PMID: 28955240 Ref: Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PMID: 28968471 Ref: Human colorectal cancer cells induce vascular smooth muscle cell apoptosis in an exocrine manner. PMID: 28977925 Ref: Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells. PMID: 28981607 Ref: Chemoprevention by artesunate in a preclinical model of colorectal cancer involves down regulation of beta-catenin, suppression of angiogenesis, cellular proliferation and induction of apoptosis. PMID: 29031619 Ref: In vitro investigation of the effect of matrix molecules on the behavior of colon cancer cells under the effect of geldanamycin derivative. PMID: 29034805 Ref: Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b. PMID: 29036788 Ref: The preclinical analysis of TW-37 as a potential anti-colorectal cancer cell agent. PMID: 29065135 Ref: Phosphoinositide-specific phospholipase Cgamma1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells. PMID: 29066806 Ref: [Role of aquaporin-5 in regulating colorectal cancer cell growth in vitro]. PMID: 29070462 Ref: Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance. PMID: 29130100 Ref: Expression of CD40/CD40L in colon cancer, and its effect on proliferation and apoptosis of SW48 colon cancer cells. PMID: 29155517 Ref: Exome and transcriptome sequencing identifies loss of PDLIM2 in metastatic colorectal cancers. PMID: 29184442 Ref: Molecular characterization of pro-metastatic functions of beta4-integrin in colorectal cancer. PMID: 29190919 Ref: Anticancer effect of dentatin and dentatin-hydroxypropyl-beta-cyclodextrin complex on human colon cancer (HT-29) cell line. PMID: 29200826 Ref: Genistein induces apoptosis of colon cancer cells by reversal of epithelial-to-mesenchymal via a Notch1/NF-kappaB/slug/E-cadherin pathway. PMID: 29202800 Ref: Ampelopsin-induced reactive oxygen species enhance the apoptosis of colon cancer cells by activating endoplasmic reticulum stress-mediated AMPK/MAPK/XAF1 signaling. PMID: 29250183 Ref: Knockdown of Rhotekin 2 expression suppresses proliferation and induces apoptosis in colon cancer cells. PMID: 29250187 Ref: Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador. PMID: 29258490 Ref: Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric. PMID: 29311914 Ref: Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer. PMID: 29312593 Ref: Clinical significance of LMO1 in gastric cancer tissue and its association with apoptosis of cancer cells. PMID: 29344115 Ref: Cyclin-dependent kinase 2 inhibitor SU9516 increases sensitivity of colorectal carcinoma cells Caco-2 but not HT29 to BH3 mimetic ABT-737. PMID: 29372687 Ref: Dishevelled1-3 contribute to multidrug resistance in colorectal cancer via activating Wnt/beta-catenin signaling. PMID: 29383202 Ref: Establishment of optimal regulatory network of colorectal cancer based on p42.3 protein. PMID: 29551923 |
Ref: MicroRNA-184 inhibits proliferation and promotes apoptosis of human colon cancer SW480 and HCT116 cells by downregulating C-MYC and BCL-2. PMID: 28782841 Ref: Effects of Glut1 gene silencing on proliferation, differentiation, and apoptosis of colorectal cancer cells by targeting the TGF-beta/PI3K-AKT-mTOR signaling pathway. PMID: 28884839 Ref: Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. PMID: 28937686 Ref: Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway. PMID: 28965196 Ref: Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor. PMID: 29063678 Ref: Antitumor activity of Lepidium latifolium and identification of the epithionitrile 1-cyano-2,3-epithiopropane as its major active component. PMID: 29073716 Ref: Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human gammadeltaT cells against colon cancer. PMID: 29104081 Ref: Hedyotis diffusa Willd inhibits proliferation and induces apoptosis of 5FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway. PMID: 29115462 Ref: Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-alpha-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells. PMID: 29115534 Ref: Cepharanthine exhibits a potent anticancer activity in p53-mutated colorectal cancer cells through upregulation of p21Waf1/Cip1. PMID: 29138869 Ref: The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells. PMID: 29222016 Ref: Musa paradisiaca inflorescence induces human colon cancer cell death by modulating cascades of transcriptional events. PMID: 29243757 Ref: Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122. PMID: 29253766 Ref: Down-regulation of FN1 inhibits colorectal carcinogenesis by suppressing proliferation, migration, and invasion. PMID: 29274284 Ref: Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest, and Antimigratory Effects in SW480 Colorectal Cancer Cells. PMID: 29276946 Ref: Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK4 signaling pathway. PMID: 29288563 Ref: Induction of apoptosis by pyrazolo[3,4-d]pyridazine derivative in lung cancer cells via disruption of Bcl-2/Bax expression balance. PMID: 29290491 Ref: BaxDelta2 sensitizes colorectal cancer cells to proteasome inhibitor-induced cell death. PMID: 29291406 Ref: Cytotoxic Effects and Anti-Angiogenesis Potential of Pistachio (Pistacia vera L.) Hulls against MCF-7 Human Breast Cancer Cells. PMID: 29303970 Ref: Acylated and unacylated ghrelin inhibit apoptosis in myoblasts cocultured with colon carcinoma cells. PMID: 29328480 Ref: Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines. PMID: 29337231 Ref: Inhibition of autophagy potentiates the apoptosis-inducing effects of photodynamic therapy on human colon cancer cells. PMID: 29355734 Ref: Eupatorin and Salvigenin Potentiate Doxorubicin-Induced Apoptosis and Cell Cycle Arrest in HT-29 and SW948 Human Colon Cancer Cells PMID: 29373904 Ref: The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. PMID: 29374142 Ref: DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. PMID: 29394130 Ref: Modified miR-15a has therapeutic potential for improving treatment of advanced stage colorectal cancer through inhibition of BCL2, BMI1, YAP1 and DCLK1. PMID: 29416778 Ref: Silencing long noncoding RNA PVT1 inhibits tumorigenesis and cisplatin resistance of colorectal cancer. PMID: 29423000 Ref: Chemoprevention by Probiotics During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats. PMID: 29427224 Ref: A novel small molecular STAT3 inhibitor, 5Br-6b, induces apoptosis and inhibits migration in colorectal cancer cells. PMID: 29438179 Ref: Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer. PMID: 29442390 Ref: Molecular chemoprevention by morin - A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer. PMID: 29453046 Ref: Scutellarein from Scutellaria barbata induces apoptosis of human colon cancer HCT116 cells through the ROS-mediated mitochondria-dependent pathway. PMID: 29457739 Ref: Drug-like dietary vanilloids induce anticancer activity through proliferation inhibition and regulation of bcl-related apoptotic proteins. PMID: 29464796 Ref: Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen). PMID: 29464799 Ref: Selenium-Enriched Saccharomyces cerevisiae Reduces the Progression of Colorectal Cancer. PMID: 29468612 Ref: Upregulation of AKAP12 with HDAC3 depletion suppresses the progression and migration of colorectal cancer. PMID: 29484387 Ref: Overexpression of secretagogin promotes cell apoptosis and inhibits migration and invasion of human SW480 human colorectal cancer cells. PMID: 29499408 Ref: miR-34a increases the sensitivity of colorectal cancer cells to 5-fluorouracil in vitro and in vivo. PMID: 29511598 Ref: Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway. PMID: 29519997 Ref: A new glycoprotein SPG-8700 isolated from sweet potato with potential anti-cancer activity against colon cancer. PMID: 29527942 Ref: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. PMID: 29531808 Ref: An Asparagus polysaccharide fraction inhibits MDSCs by inducing apoptosis through toll-like receptor 4. PMID: 29532545 Ref: Wnt/catenin beta1/microRNA 183 predicts recurrence and prognosis of patients with colorectal cancer. PMID: 29541213 Ref: Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K/AKT/mTOR/p70S6K signaling pathway. PMID: 29541215 Ref: A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-kappaB Signaling in KRAS-Mutant Colon Cancer Cells. PMID: 29545333 Ref: Interferon-gamma induces autophagy-associated apoptosis through induction of cPLA2-dependent mitochondrial ROS generation in colorectal cancer cells. PMID: 29551681 Ref: The study of sclareol in inhibiting proliferation of osteosarcoma cells by apoptotic induction and loss of mitochondrial membrane potential. PMID: 29562495 Ref: Extracted metabolite from Streptomyces Levis ABRIINW111 altered the gene expression in colon cancer. PMID: 29564063 Ref: Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells. PMID: 29568348 Ref: Deciphering the molecular mechanism and apoptosis underlying the in-vitro and in-vivo chemotherapeutic efficacy of vanadium luteolin complex in colon cancer. PMID: 29574863 Ref: Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells. PMID: 29587241 Ref: Ferula pseudalliacea induces apoptosis in human colorectal cancer HCT-116 cells via mitochondria-dependent pathway. PMID: 29587544 Ref: Design and synthesis of novel pyrrolo[2,3-a]carbazoles: 7-Chloro-2-oxo-3a-(2'-oxo-2',3'-dihydro-1'H-indol-3'-yl)-2,3,3a,4,5,10-hexahydro- pyrrolo[3,2-a]carbazole-1-carbonitrile as an efficient anticancer agent. PMID: 29597168 Ref: Effects of secreted frizzled-related protein 1 on proliferation, migration, invasion, and apoptosis of colorectal cancer cells. PMID: 29610564 Ref: betaarrestin2 promotes 5FUinduced apoptosis via the NFkappaB pathway in colorectal cancer. PMID: 29620228 Ref: p38 inhibitor inhibits the apoptosis of cowanin-treated human colorectal adenocarcinoma cells. PMID: 29620273 Ref: The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-kappaB translocation. PMID: 29636600 Ref: miR-206 regulates 5-FU resistance by targeting Bcl-2 in colon cancer cells. PMID: 29636622 Ref: Shikonin Prevents Early Phase Inflammation Associated with Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer and Induces Apoptosis in Human Colon Cancer Cells. PMID: 29642242 Ref: Erythropoietin Intensifies the Proapoptotic Activity of LFM-A13 in Cells and in a Mouse Model of Colorectal Cancer. PMID: 29690619 Ref: Knockdown of long noncoding RNA PVT1 reverses multidrug resistance in colorectal cancer cells. PMID: 29693171 Ref: Natural Hypoxia is Not a Limiting Factor in Evaluating the Novel Arylidene Derivative MLT-401 Against an In Vitro Colorectal Cancer Model. PMID: 29723868 Ref: Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway. PMID: 29745074 Ref: Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest. PMID: 29745075 Ref: Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A. PMID: 29761838 Ref: 1,2,3,4,6-Penta-O-galloyl-beta-d-glucose suppresses colon cancer through induction of tumor suppressor. PMID: 29778287 Ref: C-glycosyl flavone from Urginea indica inhibits proliferation & angiogenesis & induces apoptosis via cyclin-dependent kinase 6 in human breast, hepatic & colon cancer cell lines. PMID: 29806604 Ref: The NK1 receptor antagonist NKP608 inhibits proliferation of human colorectal cancer cells via Wnt signaling pathway. PMID: 29843798 Ref: Vicenin-2 inhibits Wnt/beta-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line. PMID: 29849451 Ref: Expression profile of NF-kappaB regulated genes in sporadic colorectal cancer patients. PMID: 29849793 Ref: Bufalin and 5-fluorouracil synergistically induce apoptosis in colorectal cancer cells. PMID: 29849804 Ref: Angiodrastic Chemokines in Colorectal Cancer: Clinicopathological Correlations. PMID: 29850390 Ref: Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells. PMID: 29860266 Ref: L-carnosine induces apoptosis/cell cycle arrest via suppression of NF-kappaB/STAT1 pathway in HCT116 colorectal cancer cells. PMID: 29869056 Ref: NUDCD1 promotes metastasis through inducing EMT and inhibiting apoptosis in colorectal cancer. PMID: 29888104 Ref: Cytotoxic, Anti-Proliferative and Apoptosis Activity of l-Amino Acid Oxidase from Malaysian Cryptelytrops purpureomaculatus (CP-LAAO) Venom on Human Colon Cancer Cells. PMID: 29890640 Ref: [Role of allograft inflammatory factor-1 in regulating the proliferation, migration and apoptosis of colorectal cancer cells]. PMID: 29891445 Ref: Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway. PMID: 29892198 Ref: Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. PMID: 29895675 Ref: Artesunate induces apoptosis and autophagy in HCT116 colon cancer cells, and autophagy inhibition enhances the artesunateinduced apoptosis. PMID: 29901098 Ref: Cytotoxic, Antiproliferative and Apoptosis-inducing Activity of L-Amino Acid Oxidase from Malaysian Calloselasma rhodostoma on Human Colon Cancer Cells. PMID: 29908095 Ref: Ellagitannins from Pomegranate Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Rats while Enhancing Its Chemotoxicity against HT-29 Colorectal Cancer Cells through Intrinsic Apoptosis Induction. PMID: 29920075 Ref: MACC1 silencing inhibits cell proliferation and induces cell apoptosis of lung adenocarcinoma cells through the beta-catenin pathway. PMID: 29940751 Ref: Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies. PMID: 29944015 Ref: Tumour suppressor properties of miR-15a and its regulatory effects on BCL2 and SOX2 proteins in colorectal carcinomas. PMID: 29958837 Ref: Anti-inflammatory and anticancer effects of p-methoxycinnamic acid, an active phenylpropanoid, against 1,2-dimethylhydrazine-induced rat colon carcinogenesis. PMID: 29980883 Ref: Anticancer activity of safranal against colon carcinoma is due to induction of apoptosis and G2/M cell cycle arrest mediated by suppression of mTOR/PI3K/Akt pathway. PMID: 30003721 Ref: Antitumor effects of emodin in CACO-2 human colon carcinoma cells are mediated via apoptosis, cell cycle arrest and downregulation of PI3K/AKT signalling pathway. PMID: 30003723 Ref: Impairing Powerhouse in Colon Cancer Cells by Hydrazide-Hydrazone-Based Small Molecule. PMID: 30023806 Ref: Polymeric chitosan-glycolipid nanocarriers for an effective delivery of marine carotenoid fucoxanthin for induction of apoptosis in human colon cancer cells (Caco-2 cells). PMID: 30033314 Ref: Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer. PMID: 30038258 Ref: MiR-629-5p promotes colorectal cancer progression through targetting CXXC finger protein 4. PMID: 30042169 Ref: Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation. PMID: 30056019 Ref: Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. PMID: 30056083 Ref: Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin. PMID: 30061214 Ref: Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer. PMID: 30066888 Ref: Synthesis, Computational Docking Study, and Biological Evaluation of a Library of Heterocyclic Curcuminoids with Remarkable Antitumor Activity. PMID: 30079563 Ref: Induction of HT-29 Colon Cancer Cells Apoptosis by Pyrogallol with Growth Inhibiting Efficacy Against Drug Resistant Helicobacter pylori. PMID: 30081791 Ref: A natural flavonoid lawsonaringenin induces cell cycle arrest and apoptosis in HT-29 colorectal cancer cells by targeting multiple signalling pathways. PMID: 30088202 Ref: Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities. PMID: 30088538 Ref: Evaluation of potential anti-cancer activity of cationic liposomal nanoformulated Lycopodium clavatum in colon cancer cells. PMID: 30104445 Ref: LINC00473 promotes the Taxol resistance via miR-15a in colorectal cancer. PMID: 30126852 Ref: Lysosomal permeabilization and endoplasmic reticulum stress mediate the apoptotic response induced after photoactivation of a lipophilic zinc(II) phthalocyanine. PMID: 30130653 Ref: Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3. PMID: 30135654 Ref: Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-3beta signaling pathway. PMID: 30142548 Ref: Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer. PMID: 30144515 Ref: Antitumor Ability of KT2 Peptide Derived from Leukocyte Peptide of Crocodile Against Human HCT116 Colon Cancer Xenografts. PMID: 30150436 Ref: Repurposing of mTOR Complex inhibitors Attenuates MCL-1 and sensitizes to PARP inhibition. PMID: 30201826 Ref: Matricellular protein periostin promotes colitis-associated colon tumorigenesis in mice. PMID: 30204842 Ref: Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer. PMID: 30219719 Ref: Silencing of cadherin-17 enhances apoptosis and inhibits autophagy in colorectal cancer cells. PMID: 30227326 Ref: Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development. PMID: 30235866 Ref: Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity. PMID: 30266650 Ref: Long noncoding RNA FAL1 promotes proliferation and inhibits apoptosis of human colon cancer cells. PMID: 30290064 Ref: FAK alleviates radiation-induced rectal injury by decreasing apoptosis. PMID: 30292832 Ref: PTBP1 promotes tumorigenesis by regulating apoptosis and cell cycle in colon cancer. PMID: 30309622 Ref: Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line. PMID: 30314650 Ref: Induction of apoptotic but not autophagic cell death by Cinnamomum cassia extracts on human oral cancer cells. PMID: 30317581 Ref: Signal transducer and activator of transcription 3 inhibition enhances vemurafenib sensitivity in colon cancers harboring the BRAF(V600E) mutation. PMID: 30320916 Ref: An Intrinsic Mitochondrial Pathway Is Required for Phytic Acid-Chitosan-Iron Oxide Nanocomposite (Phy-CS-MNP) to Induce G(0)/G(1) Cell Cycle Arrest and Apoptosis in the Human Colorectal Cancer (HT-29) Cell Line. PMID: 30360519 Ref: Bio-Effects of TiO2 Nanoparticles on Human Colorectal Cancer and Umbilical Vein Endothelial Cell Lines PMID: 30361551 Ref: alpha-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-kappaB Signaling in Colon Cancer Cells. PMID: 30363706 Ref: Galla Rhois water extract inhibits lung metastasis by inducing AMPKmediated apoptosis and suppressing metastatic properties of colorectal cancer cells. PMID: 30365120 Ref: Nrf2 is a key factor in the reversal effect of curcumin on multidrug resistance in the HCT8/5Fu human colorectal cancer cell line. PMID: 30365132 Ref: Folate/Vitamin B12 Supplementation Combats Oxidative Stress-Associated Carcinogenesis in a Rat Model of Colon Cancer. PMID: 30372163 Ref: The long noncoding RNA TPTE2P1 promotes the viability of colorectal cancer cells. PMID: 30382596 Ref: Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1. PMID: 30382763 Ref: ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells. PMID: 30384048 Ref: Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. PMID: 30387805 |