Primary Site >> Biliary tract Cancer
Gene >> BCL2
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Ref: Immunohistochemical detection of bcl-2 protein in normal and pathological human liver. PMID: 8129031 |
Ref: Topographical immunohistochemical expression of bcl-2 protein in human liver lesions. PMID: 8687162 Ref: Expression of apoptosis, proliferating cell nuclear antigen, and apoptosis-related antigens (bcl-2, c-myc, Fas, Lewis(y) and p53) in human cholangiocarcinomas and hepatocellular carcinomas. PMID: 8916146 Ref: Spontaneous apoptosis in gallbladder carcinoma. Relationships with clinicopathologic factors, expression of E-cadherin, bcl-2 protooncogene, and p53 oncosuppressor gene. PMID: 8918403 |
Ref: Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line. PMID: 9328309 |
Ref: Association of Bcl-2 protein expression with gallbladder carcinoma differentiation and progression and its relation to apoptosis. PMID: 10023698 Ref: High levels of BCL-2 messenger RNA detected by in situ hybridization in human hepatocellular and cholangiocellular carcinomas. PMID: 10617275 |
Ref: Biliary dysplasia, cell proliferation and nuclear DNA-fragmentation in primary sclerosing cholangitis with and without cholangiocarcinoma. PMID: 11168786 Ref: Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas. PMID: 12120204 |
Ref: Expression of survivin, a novel inhibitor of apoptosis and cell cycle regulatory protein, in pancreatic adenocarcinoma. PMID: 11953819 Ref: Coexpression of neural cell adhesion molecules and bcl-2 in intrahepatic cholangiocarcinoma originated from viral hepatitis: relationship to atypical reactive bile ductule. PMID: 12031086 Ref: Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells. PMID: 12235080 |
Ref: Expression of Bcl-2 and Bax in extrahepatic biliary tract carcinoma and dysplasia. PMID: 14606101 |
Ref: Sarcomatoid carcinoma of common bile duct: a case report. PMID: 15011841 Ref: Antineoplastic effects of octreotide on human gallbladder cancer cells in vitro. PMID: 15052690 Ref: Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation. PMID: 15057907 Ref: Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells. PMID: 15150106 Ref: Detection of bcl-2 and bax expression and bcl-2/JH fusion gene in intrahepatic cholangiocarcinoma. PMID: 15484294 Ref: Immunohistochemical analysis of biliary tract lesions. PMID: 15551730 Ref: Telomerase activity and Bcl-2 expression in gallbladders of pancreaticobiliary maljunction patients: a preliminary study. PMID: 15754044 |
Ref: Prognostic value of Bax, Bcl-2, p53, and TUNEL staining in patients with radically resected ampullary carcinoma. PMID: 15677536 Ref: Mucosa-associated lymphoid tissue lymphoma of the extrahepatic bile duct. PMID: 15816435 Ref: Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis. PMID: 16024633 Ref: [Research on resveratrol's effects on suppressing growth and inducing apoptosis of GBC cells]. PMID: 16209266 Ref: Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. PMID: 16317687 Ref: [Effect of Bcl-2 antisense phosphorothioate oligodeoxynucleotides on bile duct carcinoma cell line QBC939]. PMID: 16320583 |
Ref: Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome. PMID: 16505435 Ref: [Anti-tumor mechanism of norcantharidin for the implanted tumors of human gallbladder carcinoma in nude mice in vivo]. PMID: 16784656 Ref: Arsenic trioxide induces gallbladder carcinoma cell apoptosis via downregulation of Bcl-2. PMID: 16904648 |
Ref: Bile duct cyst as precursor to biliary tract cancer. PMID: 17187167 Ref: Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro. PMID: 17287171 Ref: Histone deacetylase inhibitor MS-275 alone or combined with bortezomib or sorafenib exhibits strong antiproliferative action in human cholangiocarcinoma cells. PMID: 17724801 |
Ref: Expression of Etk/Bmx tyrosine kinase in intrahepatic cholangiocarcinoma. PMID: 18270973 Ref: Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas. PMID: 18854271 Ref: Biomarkers in carcinoma of the gallbladder. PMID: 23495740 |
Ref: Expression and clinical significance of cell cycle regulatory proteins in gallbladder and extrahepatic bile duct cancer. PMID: 18979138 Ref: The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma. PMID: 19070389 Ref: Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis. PMID: 19358267 |
Ref: Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C>T, BCL2-938C>A, MCL1-386C>G) in extrahepatic cholangiocarcinoma. PMID: 19968497 Ref: Arsenic trioxide inhibits cholangiocarcinoma cell growth and induces apoptosis. PMID: 20012722 Ref: Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines. PMID: 20458760 Ref: Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo. PMID: 20688607 Ref: Prostate apoptosis response-4 is expressed in normal cholangiocytes, is down-regulated in human cholangiocarcinoma, and promotes apoptosis of neoplastic cholangiocytes when induced pharmacologically. PMID: 20724592 |
Ref: The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid. PMID: 20473610 Ref: mda-7/IL-24 induces apoptosis in human GBC-SD gallbladder carcinoma cells via mitochondrial apoptotic pathway. PMID: 21109977 Ref: Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. PMID: 21130731 Ref: Apoptosis of human cholangiocarcinoma cell lines induced by beta-escin through mitochondrial caspase-dependent pathway. PMID: 21394804 Ref: Overexpression of LAPTM4B-35 attenuates epirubucin-induced apoptosis of gallbladder carcinoma GBC-SD cells. PMID: 21429547 Ref: [Expression of WW domain containing oxidoreductase gene in cholangiocarcinoma and its effect on the biological behavior of cancer cell line RBE]. PMID: 21612698 |
Ref: Effects of matrine on proliferation and apoptosis in gallbladder carcinoma cells (GBC-SD). PMID: 22162124 Ref: Apoptosis mechanism of human cholangiocarcinoma cells induced by bile extract from crocodile. PMID: 22194052 Ref: Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways. PMID: 22213475 Ref: Lobaplatin induces apoptosis and arrests cell cycle progression in human cholangiocarcinoma cell line RBE. PMID: 22425181 Ref: Altered expression of cellular Bcl-2 in the progression of hamster cholangiocarcinogenesis. PMID: 22654601 Ref: [The role of tissue factor pathway inhibitor-2 gene in gallbladder cancer]. PMID: 23336488 |
Ref: Xanthogranulomatous cholecystitis: a clinicopathological study of its association with gallbladder carcinoma. PMID: 23134201 Ref: Icariin potentiates the antitumor activity of gemcitabine in gallbladder cancer by suppressing NF-kappaB. PMID: 23274410 Ref: NK4 regulates 5-fluorouracil sensitivity in cholangiocarcinoma cells by modulating the intrinsic apoptosis pathway. PMID: 23619566 Ref: Antiproliferative and apoptosis-inducing activity of curcumin against human gallbladder adenocarcinoma cells. PMID: 23645731 Ref: Curcumin induces apoptosis in gallbladder carcinoma cell line GBC-SD cells. PMID: 23802572 |
Ref: Expression of cell cycle-related proteins, p16, p53 and p63 as important prognostic markers in gallbladder adenocarcinoma. PMID: 24178677 Ref: Inhibitory effects of deleted in liver cancer 1 gene on gallbladder cancer growth through induction of cell cycle arrest and apoptosis. PMID: 24329682 Ref: Mycoepoxydiene induces apoptosis and inhibits TPA-induced invasion in human cholangiocarcinoma cells via blocking NF-kappaB pathway. PMID: 24486723 Ref: Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells. PMID: 24566325 Ref: Baicalin induces apoptosis of gallbladder carcinoma cells in vitro via a mitochondrial-mediated pathway and suppresses tumor growth in vivo. PMID: 24568162 Ref: Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-kappaB pathways in human cholangiocarcinomas both in vitro and in vivo. PMID: 24603952 Ref: Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway. PMID: 24655726 Ref: TNF-alpha promotes gallbladder cancer cell growth and invasion through autocrine mechanisms. PMID: 24676340 Ref: UHRF1 depletion suppresses growth of gallbladder cancer cells through induction of apoptosis and cell cycle arrest. PMID: 24756644 Ref: Effects of oxymatrine on the apoptosis and proliferation of gallbladder cancer cells. PMID: 24869760 Ref: Luteolin arrests cell cycling, induces apoptosis and inhibits the JAK/STAT3 pathway in human cholangiocarcinoma cells. PMID: 24998588 Ref: A rare collision tumor composed of follicular lymphoma and adenocarcinoma in the ampulla of vater: a case report. PMID: 25002984 Ref: Tetrandrine induces apoptosis in gallbladder carcinoma in vitro. PMID: 25074868 Ref: Cordycepin induces S phase arrest and apoptosis in human gallbladder cancer cells. PMID: 25090123 Ref: Schisandrin B induces apoptosis and cell cycle arrest of gallbladder cancer cells. PMID: 25165862 Ref: Aberrant expression of NF-kappaB in liver fluke associated cholangiocarcinoma: implications for targeted therapy. PMID: 25170898 Ref: Expression of epidermal growth factor receptor, p53, Bcl2, vascular endothelial growth factor, cyclooxygenase-2, cyclin D1, human epidermal receptor-2 and Ki-67: Association with clinicopathological profiles and outcomes in gallbladder carcinoma. PMID: 25225463 Ref: FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling. PMID: 25344679 |
Ref: Maslinic acid potentiates the antitumor activities of gemcitabine in vitro and in vivo by inhibiting NF-kappaB-mediated survival signaling pathways in human gallbladder cancer cells. PMID: 25633045 Ref: ABT737 enhances cholangiocarcinoma sensitivity to cisplatin through regulation of mitochondrial dynamics. PMID: 25936772 Ref: MiR-138 Suppresses Cell Proliferation by Targeting Bag-1 in Gallbladder Carcinoma. PMID: 25962180 Ref: Cholangiocarcinoma: from molecular biology to treatment. PMID: 26427701 |
Ref: Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells. PMID: 26470769 Ref: The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine. PMID: 26870236 Ref: Scabraside D Extracted from Holothuria scabra Induces Apoptosis and Inhibits Growth of Human Cholangiocarcinoma Xenografts in Mice. PMID: 26925636 Ref: Anoikis-resistant cholangiocarcinoma cells display aggressive characteristics and increase STAT3 activation. PMID: 27107220 Ref: Scabraside D Derived from Sea Cucumber Induces Apoptosis and Inhibits Metastasis via iNOS and STAT-3 Expression in Human Cholangiocarcinoma Xenografts. PMID: 27221911 Ref: Schisandrin B inhibits cell proliferation and induces apoptosis in human cholangiocarcinoma cells. PMID: 27499090 |
Ref: Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells. PMID: 28070171 Ref: miR-125b-5p enhances chemotherapy sensitivity to cisplatin by down-regulating Bcl2 in gallbladder cancer. PMID: 28256505 Ref: Primary hepatic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type: A case report and literature review. PMID: 28353562 Ref: Chloride intracellular channel 1 regulates the antineoplastic effects of metformin in gallbladder cancer cells. PMID: 28378944 Ref: Long Noncoding RNA MNX1-AS1 Knockdown Inhibits Cell Proliferation and Migration in Ovarian Cancer. PMID: 28414551 Ref: Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkappaB pathways in cholangiocarcinoma cells. PMID: 28670110 Ref: Therapeutic effects of long-circulating miR-135a-containing cationic immunoliposomes against gallbladder carcinoma. PMID: 28729631 Ref: Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway. PMID: 28766687 Ref: Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma. PMID: 28902342 Ref: Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma. PMID: 29235470 |
Ref: Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway. PMID: 29170841 Ref: Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma. PMID: 29408314 Ref: Tea polyphenols induce S phase arrest and apoptosis in gallbladder cancer cells. PMID: 29513793 Ref: Intrahepatic cholangiocarcinoma after Fontan procedure in an adult with visceral heterotaxy. PMID: 29559246 Ref: Anti-cancer activity of asiatic acid against human cholangiocarcinoma cells through inhibition of proliferation and induction of apoptosis. PMID: 30084792 Ref: Phytochemical analysis and antioxidant and anticancer activities of mastic gum resin from Pistacia atlantica subspecies kurdica. PMID: 30122948 Ref: Dihydroartemisinin induces apoptosis and autophagy-dependent cell death in cholangiocarcinoma through a DAPK1-BECLIN1 pathway. PMID: 30136419 Ref: The long noncoding RNA TPTE2P1 promotes the viability of colorectal cancer cells. PMID: 30382596 |