Primary Site >> Colorectal Cancer
Gene >> BAX
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Ref: Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. PMID: 8625322 Ref: Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells. PMID: 8668331 Ref: Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methylimidazo[4,5-f]quinoline. PMID: 8813112 Ref: Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines. PMID: 8938795 Ref: Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells. PMID: 9000137 Ref: The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. PMID: 9003774 Ref: Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide. PMID: 9018084 |
Ref: Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. PMID: 9020077 Ref: Expression of bcl-2, bax, and bcl-XL proteins in azoxymethane-induced rat colonic adenocarcinomas. PMID: 9180925 Ref: Suppression of nitric oxide-induced apoptosis by N-acetyl-L-cysteine through modulation of glutathione, bcl-2, and bax protein levels. PMID: 9210957 Ref: The polyproline region of p53 is required to activate apoptosis but not growth arrest. PMID: 9285684 Ref: Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype. PMID: 9331106 Ref: Apoptosis induced by hyperthermia and verapamil in vitro in a human colon cancer cell line. PMID: 9354939 Ref: Mechanisms underlying apoptosis induced by combination of 5-fluorouracil and interferon-gamma. PMID: 9388485 |
Ref: Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. PMID: 9443418 Ref: Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas. PMID: 9453486 Ref: Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factor-alpha (TNF-alpha) and/or interferon-gamma (IFN-gamma), resulting from down-modulation of Bcl-2 expression. PMID: 9472684 Ref: Microsatellite instability in Japanese hereditary non-polyposis colorectal cancer does not induce mutation of a simple repeat sequence of the bax gene. PMID: 9500210 Ref: Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. PMID: 9500462 Ref: Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. PMID: 9500552 Ref: The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium. PMID: 9563904 Ref: Apoptosis, proliferation, bax, bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal cancer. PMID: 9635706 Ref: Microsatellite instability and frameshift mutations in BAX and transforming growth factor-beta RII genes are very uncommon in acute lymphoblastic leukemia in vivo but not in cell lines. PMID: 9639521 Ref: Mutational analysis of Bax and Bcl-2 in childhood acute lymphoblastic leukaemia. PMID: 9645350 Ref: Morphology of sporadic colorectal cancer with DNA replication errors. PMID: 9659163 Ref: Absence of frameshift mutations in the bax gene in renal cell cancer (RCC) and transitional cell cancer (TCC). PMID: 9673385 Ref: Microsatellite instability in young patients with colorectal cancer. PMID: 9736405 Ref: Nuclear targeting of Bax during apoptosis in human colorectal cancer cells. PMID: 9747879 Ref: Induction of apoptosis in colon cancer cells by nonsteroidal anti-inflammatory drugs. PMID: 9752793 Ref: Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences. PMID: 9777938 Ref: Microsatellite instability and mutation of DNA mismatch repair genes in gliomas. PMID: 9777949 Ref: Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers. PMID: 9788444 Ref: 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins. PMID: 9792140 Ref: Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells. PMID: 9829751 Ref: Microsatellite instability and frameshift mutations in the Bax gene in hereditary nonpolyposis colorectal carcinoma. PMID: 9849580 Ref: Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal cancer. PMID: 9881495 Ref: Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate. PMID: 10200499 Ref: [Cellular apoptosis, proliferation and bcl-2 Bax expression in colorectal carcinoma and their association with tumor prognosis]. PMID: 11825479 |
Ref: Causes and consequences of microsatellite instability in endometrial carcinoma. PMID: 9927063 Ref: Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum. PMID: 9988229 Ref: Prognostic significance of Bcl-2, Bcl-xL/S, Bax and Bak expressions in colorectal carcinomas. PMID: 10023006 Ref: STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs. PMID: 10080945 Ref: Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases. PMID: 10334520 Ref: Germline hMSH2 and differential somatic mutations in patients with Turcot's syndrome. PMID: 10337989 Ref: Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. PMID: 10348818 Ref: Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity. PMID: 10360653 Ref: Expression of p53, p21/waf, bcl-2, bax, Rb and Ki67 proteins in colorectal adenocarcinomas. PMID: 10382939 Ref: DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs: a molecular case report. PMID: 10424776 Ref: Evaluation of the replication error phenotype in relation to molecular and clinicopathological features in hereditary and early onset colorectal cancer. PMID: 10448273 Ref: Regional reproducibility of microsatellite instability in sporadic colorectal cancer. PMID: 10469448 Ref: CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers. PMID: 10469457 Ref: Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. PMID: 10473109 Ref: Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability. PMID: 10485457 Ref: Genetic susceptibility to non-polyposis colorectal cancer. PMID: 10544223 Ref: Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability. PMID: 10597289 Ref: Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. PMID: 10637515 Ref: Apoptosis of human tumor cells by chemotherapeutic anthracyclines is enhanced by Bax overexpression. PMID: 10641488 Ref: CHML suppresses cell growth and induces apoptosis in multiple human tumor lines. PMID: 10652570 Ref: beta-lapachone induces cell cycle arrest and apoptosis in human colon cancer cells. PMID: 10656873 Ref: Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines. PMID: 10674020 Ref: Microsatellite instability and frameshift mutations in genes involved in cell cycle progression or apoptosis in ovarian cancer. PMID: 10757443 Ref: Association of increased radiocurability of murine carcinomas with low constitutive expression of p21(WAF1/CIP1) protein. PMID: 10760438 Ref: Sequence of molecular genetic events in colorectal tumorigenesis. PMID: 10772417 Ref: [Roles of bifidobacterium on prevention of experimental colorectal carcinoma and induction of apoptosis]. PMID: 11864503 Ref: [Significance of apoptosis status and apoptosis-associated antigen expression in human colorectal adenocarcinoma sequence]. PMID: 12212055 |
Ref: The effect of mismatch repair deficiency on tumourigenesis; microsatellite instability affecting genes containing short repeated sequences. PMID: 10601558 Ref: Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis. PMID: 10607839 Ref: Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta. PMID: 10660115 Ref: Absence of microsatellite instability in transitional cell carcinoma of the bladder. PMID: 10688097 Ref: Preoperative treatment with tegafur suppositories enhances apoptosis and reduces the intratumoral microvessel density of human colorectal carcinoma. PMID: 10699888 Ref: Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. PMID: 10728709 Ref: Aberrant splicing of the ATM gene associated with shortening of the intronic mononucleotide tract in human colon tumor cell lines: a novel mutation target of microsatellite instability. PMID: 10738255 Ref: Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas. PMID: 10782880 Ref: Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed. PMID: 10785598 Ref: Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy. PMID: 10786699 Ref: Synchronous multiple primary gastrointestinal cancer exhibits frequent microsatellite instability. PMID: 10797290 Ref: The role of p53 in gemcitabine-mediated cytotoxicity and radiosensitization. PMID: 10803919 Ref: Induction of apoptosis in human gastric cancer by sodium butyrate. PMID: 10810354 Ref: Genetic analysis of multiple sporadic colon carcinomas from a single patient. PMID: 10855548 Ref: DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. PMID: 10861262 Ref: Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. PMID: 10861263 Ref: Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict. PMID: 10911913 Ref: Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation. PMID: 10918391 Ref: Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer. PMID: 10934138 Ref: Mutations associated with microsatellite unstable colorectal carcinomas exhibit widespread intratumoral heterogeneity. PMID: 10959092 Ref: Genetic alterations of sporadic colorectal cancer with microsatellite instability, especially characteristics of primary multiple colorectal cancers. PMID: 10962455 Ref: Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution. PMID: 10984511 Ref: Specificity of mutations induced by the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine in colon cancer cell lines defective in mismatch repair. PMID: 10987307 Ref: Heterodimerization of Bcl-2 and Bcl-X(L) with Bax and Bad in colorectal cancer. PMID: 11041112 Ref: Apoptosis and its regulation in flat-type early colorectal carcinoma: comparison with that in polypoid-type early colorectal carcinoma. PMID: 11052474 Ref: Multiple factors other than p53 influence colon cancer sensitivity to paclitaxel. PMID: 11052631 Ref: Role of BAX in the apoptotic response to anticancer agents. PMID: 11062132 Ref: [Response of metastatic colorectal cancers to treatment with CPT11 (irinotecan): implications of the mismatched base repair system]. PMID: 11084429 Ref: Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. PMID: 11090257 Ref: TNF-alpha induced p21(WAF1) but not Bax in colon cancer cells WiDr with mutated p53: important role of protein stabilization. PMID: 11097743 Ref: Cytotoxic effect of gossypol on colon carcinoma cells. PMID: 11105982 Ref: Bax induction activates apoptotic cascade via mitochondrial cytochrome c release and Bax overexpression enhances apoptosis induced by chemotherapeutic agents in DLD-1 colon cancer cells. PMID: 11123425 Ref: Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates. PMID: 11417748 Ref: Change of apoptotic status in the human colorectal adenoma-carcinoma sequences and its correlation with carcinogenesis and prognosis. PMID: 11775833 Ref: Chemoprevention of tea on colorectal cancer induced by dimethylhydrazine in Wistar rats. PMID: 11819677 Ref: [Biomarkers in the studies on chemoprevention of colorectal cancer]. PMID: 12725091 |
Ref: Antioxidants enhance the susceptibility of colon carcinoma cells to 5-fluorouracil by augmenting the induction of the bax protein. PMID: 11166918 Ref: Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells. PMID: 11169965 Ref: Butyric acid induces apoptosis by up-regulating Bax expression via stimulation of the c-Jun N-terminal kinase/activation protein-1 pathway in human colon cancer cells. PMID: 11208715 Ref: Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer. PMID: 11237386 Ref: Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer. PMID: 11290569 Ref: Bax protein expression in colorectal cancer: association with p53, bcl-2 and patterns of relapse. PMID: 11299743 Ref: 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. PMID: 11300326 Ref: Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells. PMID: 11313933 Ref: Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. PMID: 11358818 Ref: TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. PMID: 11408476 Ref: Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29. PMID: 11478840 Ref: Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. PMID: 11486001 Ref: The comparison of immunohistochemical proliferation and apoptosis markers in rectal carcinoma treated surgically or by preoperative radio-chemotherapy. PMID: 11505681 Ref: Relationship between grade of microsatellite instability and target genes of mismatch repair pathways in sporadic colorectal carcinoma. PMID: 11508658 Ref: A Fas-associated death domain protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell line. PMID: 11514566 Ref: Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer. PMID: 11515678 Ref: Alterations of repeated sequences in 5' upstream and coding regions in colorectal tumors from patients with hereditary nonpolyposis colorectal cancer and Turcot syndrome. PMID: 11526511 Ref: The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax. PMID: 11574543 Ref: Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer. PMID: 11687624 Ref: Molecular basis of colorectal cancer - role of gastrin and cyclooxygenase-2. PMID: 11687726 Ref: PTEN gene mutations in colorectal cancers displaying microsatellite instability. PMID: 11689295 Ref: Short-chain fatty acids inhibit invasive human colon cancer by modulating uPA, TIMP-1, TIMP-2, mutant p53, Bcl-2, Bax, p21 and PCNA protein expression in an in vitro cell culture model. PMID: 11694645 Ref: Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapse. PMID: 11745454 Ref: Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis. PMID: 11751493 Ref: Interleukin-15 expression is associated with malignant potential in colon cancer cells. PMID: 11752902 Ref: bcl-2/bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with rectal cancer. PMID: 11759059 |
Ref: Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by beta-carotene through down-regulation of cyclin A and Bcl-2 family proteins. PMID: 11756218 Ref: Bax expression decreases significantly from primary tumor to metastasis in colorectal cancer. PMID: 11821465 Ref: Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old. PMID: 11852336 Ref: Comparison of microsatellite instability and chromosomal instability in predicting survival of patients with T3N0 colorectal cancer. PMID: 11854698 Ref: Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. PMID: 11875499 Ref: Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. PMID: 11875713 Ref: An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. PMID: 11875737 Ref: Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases. PMID: 11896073 Ref: Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). PMID: 11912124 Ref: Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status. PMID: 11920608 Ref: Low mutation incidence in polymorphic noncoding short mononucleotide repeats in gastrointestinal cancer of the microsatellite mutator phenotype pathway. PMID: 11929811 Ref: Resistance to apoptosis is increased during metastatic dissemination of colon cancer. PMID: 11964082 Ref: Analysis of p53/BAX in primary colorectal carcinoma: low BAX protein expression is a negative prognostic factor in UICC stage III tumors. PMID: 11992551 Ref: Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer. PMID: 11996796 Ref: The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway. PMID: 12027451 Ref: Increased apoptosis in infiltrating mononuclear cells of colorectal cancer: a mechanism for tumor escape. PMID: 12033956 Ref: Colorectal carcinoma in Poland in 1975 and 1995: not only more, but also different. PMID: 12049310 Ref: Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. PMID: 12057899 Ref: Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis. PMID: 12082630 Ref: Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo. PMID: 12136424 Ref: Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. PMID: 12151395 Ref: The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. PMID: 12174820 Ref: Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells. PMID: 12203115 Ref: Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line. PMID: 12215894 Ref: Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. PMID: 12244568 Ref: Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma. PMID: 12372606 Ref: Prognostic implications of BAX and TGFBRII mutations in colon cancers with microsatellite instability. PMID: 12378532 Ref: Molecular mechanisms of sulfasalazine-induced T-cell apoptosis. PMID: 12381674 Ref: Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells. PMID: 12383351 Ref: Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells. PMID: 12384529 Ref: Requirement of BAX for efficient adenovirus-induced apoptosis. PMID: 12388688 Ref: [Genetic pathways in colorectal cancer: interest for the pathologist]. PMID: 12410150 Ref: Screening for microsatellite instability target genes in colorectal cancers. PMID: 12414815 Ref: The effects of acetylsalicylic acid on proliferation, apoptosis, and invasion of cyclooxygenase-2 negative colon cancer cells. PMID: 12423325 Ref: Frequent microsatellite instability in sporadic tumors of the upper urinary tract. PMID: 12460887 Ref: Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. PMID: 12477050 Ref: Incidence of apoptosis increases with age in colorectal cancer. PMID: 12559416 |
Ref: Apoptosis induced by cryo-injury in human colorectal cancer cells is associated with mitochondrial dysfunction. PMID: 12471619 Ref: Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine. PMID: 12473386 Ref: The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. PMID: 12482325 Ref: c-myc down-regulation induces apoptosis in human cancer cell lines exposed to RPR-115135 (C31H29NO4), a non-peptidomimetic farnesyltransferase inhibitor. PMID: 12490573 Ref: PUMA mediates the apoptotic response to p53 in colorectal cancer cells. PMID: 12574499 Ref: Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. PMID: 12589031 Ref: Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancer. PMID: 12591727 Ref: Restored T-cell activation mechanisms in human tumour-infiltrating lymphocytes from melanomas and colorectal carcinomas after exposure to interleukin-2. PMID: 12610520 Ref: Antisense protein kinase A RIalpha acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy. PMID: 12631623 Ref: Apoptosis induction in human cancer cells by sungucine from Strychnos icaja root. PMID: 12644898 Ref: Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines. PMID: 12661003 Ref: Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. PMID: 12663524 Ref: Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. PMID: 12670866 Ref: Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. PMID: 12670894 Ref: Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes. PMID: 12700659 Ref: Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability. PMID: 12712438 Ref: Anti-angiogenic and apoptotic effects of metabolites of sulindac on chick embryo chorioallantoic membrane. PMID: 12713691 Ref: Tumor necrosis factor-related apoptosis-inducing ligand gene on human colorectal cancer cell line HT29. PMID: 12717839 Ref: Effect of Bax deficiency on death receptor 5 and mitochondrial pathways during endoplasmic reticulum calcium pool depletion-induced apoptosis. PMID: 12730681 Ref: [Frequency of apoptotic cells and BAX positive cells in the lymph nodes of colorectal cancer patients with metastasis and micrometastasis]. PMID: 12806912 Ref: [Gene-regulating chemoprevention against cancer--as a model for "molecular-targeting prevention" of cancer]. PMID: 12806965 Ref: Induction of apoptosis by hydroxydibenzoylmethane through coordinative modulation of cyclin D3, Bcl-X(L), and Bax, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. PMID: 12822933 Ref: 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis. PMID: 12842827 Ref: Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity. PMID: 12855666 Ref: Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. PMID: 12885834 Ref: Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells. PMID: 12888913 Ref: Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK. PMID: 12898509 Ref: Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. PMID: 12902349 Ref: The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. PMID: 12902978 Ref: Microsatellite instability and mutations in DNA mismatch repair genes in sporadic colorectal cancers. PMID: 12907901 Ref: TR3/Nur77 in colon cancer cell apoptosis. PMID: 14500374 Ref: The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. PMID: 14506747 Ref: Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. PMID: 14522894 Ref: Frameshift mutations in the bax gene are not involved in development of ovarian endometrioid carcinoma. PMID: 14559989 Ref: Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis. PMID: 14581351 Ref: Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells. PMID: 14612938 Ref: Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. PMID: 14645705 Ref: Induction of apoptosis by p53, bax, bcl-2, and p21 expressed in colorectal cancer. PMID: 14663636 Ref: Differential apoptotic response to the proteasome inhibitor Bortezomib [VELCADE, PS-341] in Bax-deficient and p21-deficient colon cancer cells. PMID: 14688479 Ref: Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. PMID: 14695142 Ref: Genetic analysis of radiation-associated rectal cancer. PMID: 14714259 Ref: [Studies on cancer chemoprevention by tea pigments]. PMID: 14963910 |
Ref: Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. PMID: 14712090 Ref: Low extracellular pH augments TRAIL-induced apoptotic death through the mitochondria-mediated caspase signal transduction pathway. PMID: 14729063 Ref: Transcriptional regulation of TNF family receptors and Bcl-2 family by chemotherapeutic agents in murine CT26 cells. PMID: 14743399 Ref: Deleted in oral cancer-1 expression upregulates proapoptosis elements in microsatellite-unstable human colorectal cancer. PMID: 14761923 Ref: Therapeutic synergy between irinotecan and 5-fluorouracil against human tumor xenografts. PMID: 14871992 Ref: Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect. PMID: 14985457 Ref: [Transforming growth factor beta receptor II mutations in RER positive colorectal cancers]. PMID: 14989920 Ref: Genomic instability and colon cancer. PMID: 15000146 Ref: Diosgenin-3-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway. PMID: 15008458 Ref: Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. PMID: 15024076 Ref: [Alterations of p53 gene and microsatellite instability in ulcerative colitis and ulcerative colitis-associated colorectal cancer]. PMID: 15067728 Ref: Dietary conjugated linoleic acid increases the mRNA ratio of Bax/Bcl-2 in the colonic mucosa of rats. PMID: 15068816 Ref: beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate. PMID: 15073048 Ref: BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability. PMID: 15088110 Ref: Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms. PMID: 15120327 Ref: Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. PMID: 15155747 Ref: Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation. PMID: 15205314 Ref: Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. PMID: 15205359 Ref: Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis. PMID: 15219941 Ref: Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells. PMID: 15226295 Ref: Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria. PMID: 15229226 Ref: Induction of p53-dependent apoptosis in HCT116 tumor cells by RNA viruses and possible implications in virus-mediated oncolysis. PMID: 15254403 Ref: Colon cancer: genomics and apoptotic events. PMID: 15255176 Ref: Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. PMID: 15259066 Ref: Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways. PMID: 15262986 Ref: Astilbic acid induced COLO 205 cell apoptosis by regulating Bcl-2 and Bax expression and activating caspase-3. PMID: 15301745 Ref: Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat. PMID: 15312680 Ref: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. PMID: 15322075 Ref: Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA. PMID: 15334062 Ref: Multiple epithelial and nonepithelial tumors in hereditary nonpolyposis colorectal cancer: characterization of germline and somatic mutations of the MSH2 gene and heterogeneity of replication error phenotypes. PMID: 15350299 Ref: Molecular differences between RER+ and RER- sporadic endometrial carcinomas in a large population-based series. PMID: 15361209 Ref: Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: special reference to tumor proliferation and apoptosis. PMID: 15375710 Ref: Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis. PMID: 15377997 Ref: Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. PMID: 15453709 Ref: Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. PMID: 15488634 Ref: Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells. PMID: 15520193 Ref: [The occurrence and significance of apoptosis in tumors]. PMID: 15520871 Ref: Dietary corn oil promotes colon cancer by inhibiting mitochondria-dependent apoptosis in azoxymethane-treated rats. PMID: 15522837 Ref: Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells. PMID: 15545975 Ref: Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. PMID: 15570007 Ref: Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. PMID: 15623604 Ref: Apoptosis inducing effects of 6-methoxydihydrosanguinarine in HT29 colon carcinoma cells. PMID: 15646800 Ref: Expression of the insulin-like growth factor-I receptor and proapoptotic Bax and Bak proteins in human colorectal cancer. PMID: 15659820 Ref: Coptidis rhizoma induces apoptosis in human colorectal cancer cells SNU-C4. PMID: 15673193 Ref: Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy. PMID: 15790545 |
Ref: Quinoxaline 1,4-dioxides induce G2/M cell cycle arrest and apoptosis in human colon cancer cells. PMID: 15538569 Ref: Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells. PMID: 15560738 Ref: Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. PMID: 15596295 Ref: Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. PMID: 15618392 Ref: Low BAX protein expression correlates with disease recurrence in preoperatively irradiated rectal carcinoma. PMID: 15629598 Ref: Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. PMID: 15661804 Ref: Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability. PMID: 15676142 Ref: Low daunomycin concentrations protect colorectal cancer cells from hypoxia-induced apoptosis. PMID: 15688011 Ref: Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. PMID: 15695406 Ref: Citri Reticulatae Viride Pericarpium extract induced apoptosis in SNU-C4, human colon cancer cells. PMID: 15707758 Ref: Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175. PMID: 15726367 Ref: Microsatellite instability of selective target genes in HNPCC-associated colon adenomas. PMID: 15735733 Ref: Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. PMID: 15741050 Ref: Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability. PMID: 15743744 Ref: PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells. PMID: 15753358 Ref: The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. PMID: 15767553 Ref: Connexin 26 correlates with Bcl-xL and Bax proteins expression in colorectal cancer. PMID: 15770735 Ref: Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors. PMID: 15824729 Ref: Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin). PMID: 15831530 Ref: Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. PMID: 15855171 Ref: Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma. PMID: 15891997 Ref: Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. PMID: 15896711 Ref: Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells. PMID: 15905197 Ref: Mechanisms of mitochondrial apoptosis induced by peripheral benzodiazepine receptor ligands in human colorectal cancer cells. PMID: 15907803 Ref: Expression of tumour necrosis factor-related apoptosis-inducing ligand death receptors in sporadic and hereditary colorectal tumours: potential targets for apoptosis induction. PMID: 15911244 Ref: Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. PMID: 15929791 Ref: Molecular markers that predict response to colon cancer therapy. PMID: 15934813 Ref: Expression of cell survival/death genes: Bcl-2 and Bax at the rate of colon cancer prognosis. PMID: 15955446 Ref: The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax. PMID: 15963994 Ref: Apoptosis induced by aspirin and 5-fluorouracil in human colonic adenocarcinoma cells. PMID: 15986848 Ref: Potent antitumor activity of oncolytic adenovirus expressing mda-7/IL-24 for colorectal cancer. PMID: 16000066 Ref: Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers. PMID: 16000315 Ref: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. PMID: 16052481 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: Bcl-xL/Bax ratio is altered by IFNgamma in TNFalpha- but not in TRAIL-induced apoptosis in colon cancer cell line. PMID: 16085058 Ref: Effects of genistein on the polyamine metabolism and cell growth in DLD-1 human colon cancer cells. PMID: 16091008 Ref: Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4. PMID: 16094708 Ref: Cancer-specific gene therapy. PMID: 16096014 Ref: Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines. PMID: 16103097 Ref: CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy. PMID: 16115938 Ref: Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells. PMID: 16127422 Ref: Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells. PMID: 16143316 Ref: Irreversible pan-ErbB tyrosine kinase inhibitor CI-1033 induces caspase-independent apoptosis in colorectal cancer DiFi cell line. PMID: 16151650 Ref: Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo. PMID: 16158974 Ref: Prognostic value of multimarker analysis in stage III colorectal cancer: one step forward towards an individualized therapy decision. PMID: 16160402 Ref: Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells. PMID: 16204075 Ref: Photodynamic therapy-induced death of HCT 116 cells: Apoptosis with or without Bax expression. PMID: 16215676 Ref: Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. PMID: 16227396 Ref: WMC-79, a potent agent against colon cancers, induces apoptosis through a p53-dependent pathway. PMID: 16227412 Ref: [Effects of genistein on proliferation and apoptosis in HT-29 cells]. PMID: 16329599 Ref: The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAIL-mediated apoptosis. PMID: 16382051 Ref: Gene targeting approach to selectively kill colon cancer cells, with hyperactive K-Ras pathway. PMID: 16507412 |
Ref: Inhibition of DLX4 promotes apoptosis in choriocarcinoma cell lines. PMID: 15975650 Ref: Induction of apoptosis by puerarin in colon cancer HT-29 cells. PMID: 16055262 Ref: Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells. PMID: 16106401 Ref: Tetracycline analogues (doxycycline and COL-3) induce caspase-dependent and -independent apoptosis in human colon cancer cells. PMID: 16152604 Ref: Apoptotic effect of red wine polyphenols on human colon cancer SNU-C4 cells. PMID: 16243419 Ref: Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. PMID: 16280330 Ref: Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy. PMID: 16324817 Ref: An overview of apoptosis and the prevention of colorectal cancer. PMID: 16326109 Ref: Methylation-induced silencing of ASC and the effect of expressed ASC on p53-mediated chemosensitivity in colorectal cancer. PMID: 16331272 Ref: Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells. PMID: 16353131 Ref: Peritoneal metastasis inhibition by linoleic acid with activation of PPARgamma in human gastrointestinal cancer cells. PMID: 16362414 Ref: Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers. PMID: 16380996 Ref: in vitro synergistic antitumor activity of a combination of 5-fluorouracil and irinotecan in human colon cancer. PMID: 16391804 Ref: Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. PMID: 16407454 Ref: An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells. PMID: 16413114 Ref: Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer. PMID: 16421660 Ref: Crude extract of garlic induced caspase-3 gene expression leading to apoptosis in human colon cancer cells. PMID: 16433033 Ref: Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. PMID: 16434969 Ref: Analysis of neuroendocrine differentiation and the p53/BAX pathway in UICC stage III colorectal carcinoma identifies patients with good prognosis. PMID: 16485142 Ref: Mechanisms of cardiotoxin lll-induced apoptosis in human colorectal cancer colo205 cells. PMID: 16487259 Ref: Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. PMID: 16500682 Ref: c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-beta-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. PMID: 16505115 Ref: Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop. PMID: 16518869 Ref: Bax and Bak are the critical complementary effectors of colorectal cancer cell apoptosis by chemopreventive resveratrol. PMID: 16550006 Ref: Microsatellite instability in colorectal cancer. PMID: 16555243 Ref: Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells. PMID: 16563722 Ref: Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members. PMID: 16574665 Ref: Dietary trans-10, cis-12 and cis-9,trans-11 conjugated linoleic acids induce apoptosis in the colonic mucosa of rats treated with 1,2-dimethylhydrazine. PMID: 16579724 Ref: PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells. PMID: 16608847 Ref: Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol. PMID: 16617056 Ref: Complete elimination of colorectal tumor xenograft by combined manganese superoxide dismutase with tumor necrosis factor-related apoptosis-inducing ligand gene virotherapy. PMID: 16618754 Ref: hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. PMID: 16619047 Ref: [Impact of STAT6 signaling pathway blockade on apoptosis of human colon cancer cells]. PMID: 16620708 Ref: Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy. PMID: 16686938 Ref: Birt-Hogg-Dube gene mutations in human endometrial carcinomas with microsatellite instability. PMID: 16691634 Ref: Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway. PMID: 16697692 Ref: Octahedral Pt(IV) complex K101 induces apoptosis via ERK1/2 activation and the p53 pathway in human colon cancer cells. PMID: 16702812 Ref: Apoptosis induced by short hairpin RNA-mediated STAT6 gene silencing in human colon cancer cells. PMID: 16732981 Ref: RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis. PMID: 16737913 Ref: Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells. PMID: 16827117 Ref: Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells. PMID: 16847458 Ref: Caspase independence of radio-induced cell death. PMID: 16862186 Ref: p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L). PMID: 16863993 Ref: Antiangiogenic effect of sulindac sulfide could be secondary to induction of apoptosis and cell cycle arrest. PMID: 16886631 Ref: 5-Fluorouracil-related enhancement of adenoviral infection is Coxsackievirus-adenovirus receptor independent and associated with morphological changes in lipid membranes. PMID: 16937527 Ref: Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors. PMID: 16949053 Ref: Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells. PMID: 16964520 Ref: Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. PMID: 17007015 Ref: Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells. PMID: 17016662 Ref: [Effect of ceramide on apoptosis of human colon cancer HT-29 cells]. PMID: 17086696 Ref: [Influence and significance of preoperative intraarterial infusion chemotherapy combined with radiotherapy on survivin, p53 and Bax expression in low rectal carcinoma]. PMID: 17094914 Ref: Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. PMID: 17121918 Ref: Effect of ligand troglitazone on peroxisome proliferator-activated receptor gamma expression and cellular growth in human colon cancer cells. PMID: 17143939 Ref: Modulation of the cell cycle and induction of apoptosis in human cancer cells by synthetic bile acids. PMID: 17168673 Ref: 3 Beta-hydroxyolean-12-en-27-oic acid: a cytotoxic, apoptosis-inducing natural drug against COLO-205 cancer cells. PMID: 17193218 Ref: Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3. PMID: 17201150 Ref: Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. PMID: 17201158 Ref: Down-regulation of FHIT inhibits apoptosis of colorectal cancer: mechanism and clinical implication. PMID: 17382535 |
Ref: Birt-Hogg-Dube (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability. PMID: 16870330 Ref: Kruppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage. PMID: 17016435 Ref: Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53. PMID: 17056233 Ref: In vivo evaluation of the role of DNp73alpha protein in regulating the p53-dependent apoptotic pathway after treatment with cytotoxic drugs. PMID: 17096333 Ref: Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D. PMID: 17116725 Ref: Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7beta-hydroxysitosterol and 7beta-hydroxycholesterol triggered apoptosis in human colon cancer cells. PMID: 17136497 Ref: Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. PMID: 17182797 Ref: Pinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells. PMID: 17186548 Ref: Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status. PMID: 17192871 Ref: Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells. PMID: 17201910 Ref: Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. PMID: 17218778 Ref: Berry phenolic extracts modulate the expression of p21(WAF1) and Bax but not Bcl-2 in HT-29 colon cancer cells. PMID: 17243699 Ref: Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells. PMID: 17250644 Ref: E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation. PMID: 17263886 Ref: Early apoptosis and cell death induced by ATX-S10Na (II)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells. PMID: 17278191 Ref: Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. PMID: 17278192 Ref: Recombinant human erythropoietin alpha modulates the effects of radiotherapy on colorectal cancer microvessels. PMID: 17299396 Ref: Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer. PMID: 17332927 Ref: A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells. PMID: 17363499 Ref: Decreased fragile histidine triad expression in colorectal cancer and its association with apoptosis inhibition. PMID: 17373735 Ref: [Fragile histidine triad protein expression and correlation with apoptosis in rectal carcinoma]. PMID: 17380463 Ref: Gene profile analysis of colorectal cancer cell lines by cDNA macroarray. PMID: 17390045 Ref: Significant coexpression of GLUT-1, Bcl-xL, and Bax in colorectal cancer. PMID: 17404017 Ref: Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX. PMID: 17426704 Ref: Sulindac treatment in hereditary non-polyposis colorectal cancer. PMID: 17434727 Ref: 4- [3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induced fas expression and activated caspase-3 and -8 in a DLD-1 colon cancer cell line. PMID: 17436592 Ref: p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells. PMID: 17440101 Ref: Rosiglitazone enhances fluorouracil-induced apoptosis of HT-29 cells by activating peroxisome proliferator-activated receptor gamma. PMID: 17461445 Ref: NF-kappaB and apoptosis in colorectal tumourigenesis. PMID: 17461988 Ref: 4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells. PMID: 17462534 Ref: Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer. PMID: 17487413 Ref: The growth-inhibitory effects of tomatoes digested in vitro in colon adenocarcinoma cells occur through down regulation of cyclin D1, Bcl-2 and Bcl-xL. PMID: 17490506 Ref: Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM. PMID: 17510082 Ref: Nanosecond pulsed electric fields induce apoptosis in p53-wildtype and p53-null HCT116 colon carcinoma cells. PMID: 17520193 Ref: Microsatellite instability in Ewing tumor is not associated with loss of mismatch repair protein expression. PMID: 17530287 Ref: P53 dependent and independent apoptosis induced by lidamycin in human colorectal cancer cells. PMID: 17534142 Ref: Cumulative expression of HIF-1-alpha, Bax, Bcl-xL and P53 in human colorectal cancer. PMID: 17558861 Ref: Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. PMID: 17575153 Ref: Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. PMID: 17578896 Ref: Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. PMID: 17603079 Ref: Gene expression profiling reveals two separate mechanisms regulating apoptosis in rectal carcinomas in vivo. PMID: 17610066 Ref: Bone morphogenetic protein-4 inhibits heat-induced apoptosis by modulating MAPK pathways in human colon cancer HCT116 cells. PMID: 17640799 Ref: Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. PMID: 17656449 Ref: Change in expression of apoptosis genes after hyperthermia, chemotherapy and radiotherapy in human colon cancer transplanted into nude mice. PMID: 17708613 Ref: Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells. PMID: 17721042 Ref: Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. PMID: 17855695 Ref: Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. PMID: 17938270 Ref: Role of insulin-like growth factor binding protein-4 in prevention of colon cancer. PMID: 17988381 Ref: Evaluation of apoptosis in nasal and buccal cells of septic patients. PMID: 18019433 Ref: Anti-proliferate and pro-apoptotic effects of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyranone through inactivation of NF-kappaB in human colon cancer cells. PMID: 18087815 Ref: Induction of apoptosis in HT-29 colon cancer cells by phloretin. PMID: 18158826 Ref: n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved. PMID: 18220742 Ref: Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer. PMID: 24557667 |
Ref: Casiopeina III-ia induces apoptosis in HCT-15 cells in vitro through caspase-dependent mechanisms and has antitumor effect in vivo. PMID: 17390215 Ref: Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. PMID: 17700538 Ref: Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4. PMID: 17897817 Ref: Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins. PMID: 17936584 Ref: 1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. PMID: 17957723 Ref: Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. PMID: 17999988 Ref: Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. PMID: 18033773 Ref: p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells. PMID: 18036557 Ref: The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction. PMID: 18056990 Ref: Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29). PMID: 18084318 Ref: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. PMID: 18097482 Ref: Hyperthermic CO2 pneumoperitoneum induces apoptosis in human colon cancer cells through Bax-associated mitochondrial pathway. PMID: 18097578 Ref: BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. PMID: 18098337 Ref: Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. PMID: 18160396 Ref: SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release. PMID: 18172320 Ref: Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts. PMID: 18189352 Ref: PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death. PMID: 18215742 Ref: Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway. PMID: 18218619 Ref: Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps. PMID: 18239078 Ref: Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB. PMID: 18241858 Ref: Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer. PMID: 18245490 Ref: Effects of recombinant MAP30 on cell proliferation and apoptosis of human colorectal carcinoma LoVo cells. PMID: 18246454 Ref: Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2. PMID: 18292181 Ref: IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells. PMID: 18294957 Ref: CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. PMID: 18325984 Ref: Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity. PMID: 18339878 Ref: Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. PMID: 18357373 Ref: Growth associated proteins in tumor cells and stroma related to disease progression of colon cancer accounting for tumor tissue PGE2 content. PMID: 18360718 Ref: Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. PMID: 18377871 Ref: Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells. PMID: 18377873 Ref: Signaling and regulatory mechanisms of integrin alphavbeta6 on the apoptosis of colon cancer cells. PMID: 18381232 Ref: 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. PMID: 18384088 Ref: Methylation alterations are not a major cause of PTTG1 misregulation. PMID: 18426563 Ref: Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells. PMID: 18430410 Ref: The bisphosphonate zoledronic acid inhibits the growth of HCT-116 colon carcinoma cells and induces tumor cell apoptosis. PMID: 18437576 Ref: Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax. PMID: 18444140 Ref: Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. PMID: 18455702 Ref: Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis. PMID: 18464289 Ref: [Expression change of apoptosis-associated genes after hyperthermia, chemotherapy and radiotherapy in human colon cancer-transplanted nude mice]. PMID: 18478475 Ref: Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. PMID: 18497955 Ref: Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). PMID: 18507053 Ref: Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone. PMID: 18593931 Ref: Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells. PMID: 18607570 Ref: Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480. PMID: 18636671 Ref: Preoperative radiochemotherapy is successful also in patients with locally advanced rectal cancer who have intrinsically high apoptotic tumours. PMID: 18664561 Ref: Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent. PMID: 18665601 Ref: Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells. PMID: 18695877 Ref: Synergism of CPT-11 and Apo2L/TRAIL against two differentially sensitive human colon tumor xenografts. PMID: 18714167 Ref: Composition and chemopreventive effect of polysaccharides from common beans (Phaseolus vulgaris L.) on azoxymethane-induced colon cancer. PMID: 18754663 Ref: Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin. PMID: 18771933 Ref: Anti colon cancer components from Lebanese sage (Salvia libanotica) essential oil: Mechanistic basis. PMID: 18787402 Ref: c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs. PMID: 18802399 Ref: Molecular mechanism of protection against chemically and gamma-radiation induced apoptosis in human colon cancer cells. PMID: 18812638 Ref: Hexane/ethanol extract of Glycyrrhiza uralensis licorice suppresses doxorubicin-induced apoptosis in H9c2 rat cardiac myoblasts. 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PMID: 25202430 Ref: Piceatannol promotes apoptosis via up-regulation of microRNA-129 expression in colorectal cancer cell lines. PMID: 25218158 Ref: Methanol extract of Flacourtia indica aerial parts induces apoptosis via generation of ROS and activation of caspases in human colon cancer HCT116 cells. PMID: 25227831 Ref: Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. PMID: 25232957 Ref: Verbascoside promotes apoptosis by regulating HIPK2-p53 signaling in human colorectal cancer. PMID: 25282590 Ref: Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway. PMID: 25285768 Ref: SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo. PMID: 25301449 Ref: [Impact of preoperative chemotherapy on the expression of apoptosis factors in colorectal cancer liver metastases]. PMID: 25306620 Ref: Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE(2) synthesis and COX-2 expression. PMID: 25322760 Ref: D. candidum has in vitro anticancer effects in HCT-116 cancer cells and exerts in vivo anti-metastatic effects in mice. PMID: 25324926 Ref: Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway. PMID: 25342273 Ref: Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach. PMID: 25360158 Ref: Garlic-derived compound S-allylmercaptocysteine inhibits cell growth and induces apoptosis via the JNK and p38 pathways in human colorectal carcinoma cells. PMID: 25364433 Ref: Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination. PMID: 25386076 Ref: Achyranthes aspera root extracts induce human colon cancer cell (COLO-205) death by triggering the mitochondrial apoptosis pathway and S phase cell cycle arrest. PMID: 25401123 Ref: Growth suppression of colorectal cancer by plant-derived multiple mAb CO17-1A x BR55 via inhibition of ERK1/2 phosphorylation. PMID: 25405740 Ref: [Relationship between multi-gene proteins in colorectal carcinoma complicated with chronic schistosomiasis: an immunohistochemical study by using tissue microarray techniques]. PMID: 25434139 Ref: Celecoxib prevents colitis associated colon carcinogenesis: an upregulation of apoptosis. PMID: 25443739 Ref: Mini profile of potential anticancer properties of propofol. PMID: 25502773 Ref: The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines. PMID: 26461322 |
Ref: [10]-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells. PMID: 25148824 Ref: 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells. PMID: 25178491 Ref: Growth inhibition of various human cancer cell lines by imperatorin and limonin from poncirus trifoliata rafin. Seeds. PMID: 25244913 Ref: Acetylamine derivative of diospyrin, a plant-derived binaphthylquinonoid, inhibits human colon cancer growth in Nod-Scid mice. PMID: 25262983 Ref: GRP78 mediates the therapeutic efficacy of curcumin on colon cancer. PMID: 25277658 Ref: A novel oxaliplatin derivative, Ht-2, triggers mitochondrion-dependent apoptosis in human colon cancer cells. PMID: 25307448 Ref: Dichloroacetate affects proliferation but not survival of human colorectal cancer cells. PMID: 25344893 Ref: Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells. PMID: 25355159 Ref: Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis. PMID: 25418925 Ref: Prodigiosin isolated from cell wall of Serratia marcescens alters expression of apoptosis-related genes and increases apoptosis in colorectal cancer cells. PMID: 25429836 Ref: Design, synthesis and in vitro antitumor activity of novel N-substituted-4-phenyl/benzylphthalazin-1-ones. PMID: 25462265 Ref: Biosynthesis of silver nanoparticles using ethanolic petals extract of Rosa indica and characterization of its antibacterial, anticancer and anti-inflammatory activities. PMID: 25481491 Ref: Effect of sun ginseng potentiation on epirubicin and paclitaxel-induced apoptosis in human cervical cancer cells. PMID: 25535473 Ref: The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells. PMID: 25542230 Ref: Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. PMID: 25548100 Ref: DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by Ruta graveolens in human colon cancer cells. PMID: 25576270 Ref: DNA damage and ER stress contribute to oblongifolin C-induced cell killing in Bax/Bak-deficient cells. PMID: 25576357 Ref: Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway. PMID: 25577197 Ref: Stachyose-induced apoptosis of Caco-2 cells via the caspase-dependent mitochondrial pathway. PMID: 25578308 Ref: Effects of supplemental vitamin D and calcium on normal colon tissue and circulating biomarkers of risk for colorectal neoplasms. PMID: 25597952 Ref: Regional Bias of Intratumoral Genetic Heterogeneity of Apoptosis-Related Genes BAX, APAF1, and FLASH in Colon Cancers with High Microsatellite Instability. PMID: 25599959 Ref: Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells. PMID: 25618598 Ref: NOB1 is essential for the survival of RKO colorectal cancer cells. PMID: 25624720 Ref: Induction of apoptosis in HCT-116 colon cancer cells by polysaccharide of Larimichthys crocea swim bladder. PMID: 25624917 Ref: Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line. PMID: 25634350 Ref: Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer. PMID: 25644785 Ref: Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway. PMID: 25652758 Ref: CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo. PMID: 25663456 Ref: Design, synthesis and in vitro antiproliferative activity of novel isatin-quinazoline hybrids. PMID: 25664631 Ref: Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. PMID: 25684945 Ref: Tumor suppression by resistant maltodextrin, Fibersol-2. PMID: 25692338 Ref: Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. PMID: 25695595 Ref: Dihydroartemisinin-Induced Apoptosis is Associated with Inhibition of Sarco/Endoplasmic Reticulum Calcium ATPase Activity in Colorectal Cancer. PMID: 25701954 Ref: Microsatellite instability: an update. PMID: 25701956 Ref: BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. PMID: 25715028 Ref: Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients. PMID: 25742468 Ref: Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells. PMID: 25746954 Ref: HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion. PMID: 25800793 Ref: Mismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters. PMID: 25816162 Ref: In vitro and in vivo evaluation of novel cinnamyl sulfonamide hydroxamate derivative against colon adenocarcinoma. PMID: 25824412 Ref: Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway. PMID: 25829782 Ref: Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses. PMID: 25834404 Ref: Terpenoids Isolated From the Shoot of Plectranthus hadiensis Induces Apoptosis in Human Colon Cancer Cells Via the Mitochondria-Dependent Pathway. PMID: 25837437 Ref: The chemopotential effect of Annona muricata leaves against azoxymethane-induced colonic aberrant crypt foci in rats and the apoptotic effect of Acetogenin Annomuricin E in HT-29 cells: a bioassay-guided approach. PMID: 25860620 Ref: Elephantopus scaber induces apoptosis through ROS-dependent mitochondrial signaling pathway in HCT116 human colorectal carcinoma cells. PMID: 25861953 Ref: Is Bax/Bcl-2 ratio considered as a prognostic marker with age and tumor location in colorectal cancer? PMID: 25864810 Ref: Isolation, identification and cytotoxicity of a new noroleanane-type triterpene saponin from Salicornia bigelovii Torr. PMID: 25867827 Ref: The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells. PMID: 25892545 Ref: Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene. PMID: 25914533 Ref: Extracellular Ca(2+)-dependent enhancement of cytocidal potency of zoledronic acid in human oral cancer cells. PMID: 25934567 Ref: The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death. PMID: 25935480 Ref: [Co-inhibition effect of 17-DMAG and oxaliplatin on proliferation and invasion of colorectal cancer cells]. PMID: 25940182 Ref: Mushroom Extracts Induce Human Colon Cancer Cell (COLO-205) Death by Triggering the Mitochondrial Apoptosis Pathway and Go/G1-Phase Cell Cycle Arrest. PMID: 25959910 Ref: A novel class I histone deacetylase inhibitor, I-7ab, induces apoptosis and arrests cell cycle progression in human colorectal cancer cells. PMID: 25960218 Ref: PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer. PMID: 25965911 Ref: AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells. PMID: 25974027 Ref: Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells. PMID: 26030884 Ref: MHY218-induced apoptotic cell death is enhanced by the inhibition of autophagy in AGS human gastric cancer cells. PMID: 26043797 Ref: Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects. PMID: 26054686 Ref: Shogaol overcomes TRAIL resistance in colon cancer cells via inhibiting of survivin. PMID: 26063410 Ref: Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer. PMID: 26074733 Ref: The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma. PMID: 26077911 Ref: Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. PMID: 26078354 Ref: Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis. PMID: 26141646 Ref: Triphala Extract Suppresses Proliferation and Induces Apoptosis in Human Colon Cancer Stem Cells via Suppressing c-Myc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio. PMID: 26167492 Ref: Chemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats. PMID: 26201720 Ref: Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth. PMID: 26206332 Ref: Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells. PMID: 26214321 Ref: [BAX as a susceptibility factor in hereditary non polyposis colorectal cancer]. PMID: 26228962 Ref: Ponicidin suppresses HT29 cell growth via the induction of G1 cell cycle arrest and apoptosis. PMID: 26239027 Ref: Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29). PMID: 26248310 Ref: The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats. PMID: 26251570 Ref: Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest. PMID: 26287184 Ref: Colchicine induces apoptosis in HT29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways. PMID: 26299305 Ref: Curcumol Inhibits Growth and Induces Apoptosis of Colorectal Cancer LoVo Cell Line via IGF-1R and p38 MAPK Pathway. PMID: 26307972 Ref: Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells. PMID: 26318418 Ref: ApoG2 inhibits the antiapoptotic protein, Mcl1, and induces mitochondriadependent apoptosis in human colorectal cancer cells. PMID: 26352605 Ref: Dietary cocoa inhibits colitis associated cancer: a crucial involvement of the IL-6/STAT3 pathway. PMID: 26355019 Ref: MicroRNA-203-mediated posttranscriptional deregulation of CPEB4 contributes to colorectal cancer progression. PMID: 26361147 Ref: Lysophosphatidic Acid Inhibits Apoptosis Induced by Cisplatin in Cervical Cancer Cells. PMID: 26366416 Ref: Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells. PMID: 26383537 Ref: Synthetic Bichalcone TSWU-BR23 Induces Apoptosis of Human Colon Cancer HT-29 Cells by p53-Mediated Mitochondrial Oligomerization of BAX/BAK and Lipid Raft Localization of CD95/FADD. PMID: 26408703 Ref: A sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis. PMID: 26417363 Ref: Insulin-Like Growth Factor-2 Is Induced Following 5-Aminolevulinic Acid-Mediated Photodynamic Therapy in SW620 Human Colon Cancer Cell Line. PMID: 26445041 Ref: Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis. PMID: 26457107 Ref: Oleanolic acid modulates multiple intracellular targets to inhibit colorectal cancer growth. PMID: 26459864 Ref: The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway. PMID: 26464652 Ref: Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity. PMID: 26472352 Ref: The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. PMID: 26510776 Ref: Polyunsaturated fatty acids trigger apoptosis of colon cancer cells through a mitochondrial pathway. PMID: 26528354 Ref: p-Methoxycinnamic acid, an active phenylpropanoid induces mitochondrial mediated apoptosis in HCT-116 human colon adenocarcinoma cell line. PMID: 26546748 Ref: Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B. PMID: 26561202 Ref: Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells. PMID: 26580615 Ref: Antitumor Activities and Apoptosis-regulated Mechanisms of Fermented Wheat Germ Extract in the Transplantation Tumor Model of Human HT-29 Cells in Nude Mice. PMID: 26582094 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 Ref: Evaluation of chemopreventive potential of Strobilanthes crispus against colon cancer formation in vitro and in vivo. PMID: 26608653 Ref: Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-kappaB Transcription Factors and the Induction of Cytoprotective Genes. PMID: 26625825 Ref: Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways. PMID: 26770191 Ref: Epieriocalyxin A Induces Cell Apoptosis Through JNK and ERK1/2 Signaling Pathways in Colon Cancer Cells. PMID: 27352353 Ref: Detection of Bax Microsatellite Mutations and BaxDelta2 Isoform in Human Buccal Cells. PMID: 29302381 |
Ref: Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells. PMID: 25689151 Ref: Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells. PMID: 25880142 Ref: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. PMID: 26152521 Ref: Nexrutine inhibits azoxymethane-induced colonic aberrant crypt formation in rat colon and induced apoptotic cell death in colon adenocarcinoma cells. PMID: 26259065 Ref: Inhibition of human 67-kDa laminin receptor sensitizes multidrug resistance colon cancer cell line SW480 for apoptosis induction. PMID: 26293895 Ref: Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells. PMID: 26392056 Ref: Purification, partial characterization and antitumor effect of an exopolysaccharide from Rhizopus nigricans. PMID: 26449531 Ref: Crataegus azarolus Leaves Induce Antiproliferative Activity, Cell Cycle Arrest, and Apoptosis in Human HT-29 and HCT-116 Colorectal Cancer Cells. PMID: 26495895 Ref: Chemopreventive effect of oleuropein in colitis-associated colorectal cancer in c57bl/6 mice. PMID: 26502315 Ref: A novel quinazolinone chalcone derivative induces mitochondrial dependent apoptosis and inhibits PI3K/Akt/mTOR signaling pathway in human colon cancer HCT-116 cells. PMID: 26615871 Ref: Insulin-induced gene 2 expression correlates with colorectal cancer metastasis and disease outcome. PMID: 26662938 Ref: A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells. PMID: 26673746 Ref: Guarana a Caffeine-Rich Food Increases Oxaliplatin Sensitivity of Colorectal HT-29 Cells by Apoptosis Pathway Modulation. PMID: 26673759 Ref: Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells. PMID: 26677729 Ref: Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells. PMID: 26702744 Ref: Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro. PMID: 26707712 Ref: Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway. PMID: 26714930 Ref: MiR-331-3p inhibits proliferation and promotes apoptosis by targeting HER2 through the PI3K/Akt and ERK1/2 pathways in colorectal cancer. PMID: 26718987 Ref: Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells. PMID: 26751572 Ref: A novel PI3K axis selective molecule exhibits potent tumor inhibition in colorectal carcinogenesis. PMID: 26764221 Ref: Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line. PMID: 26774143 Ref: Anti-oxidant and anti-cancer activities of Angelica dahurica extract via induction of apoptosis in colon cancer cells. PMID: 26776960 Ref: An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis. PMID: 26785732 Ref: Knockdown of MACC1 expression increases cisplatin sensitivity in cisplatin-resistant epithelial ovarian cancer cells. PMID: 26794135 Ref: Cytotoxic Compounds from Juglans sinensis Dode Display Anti-Proliferative Activity by Inducing Apoptosis in Human Cancer Cells. PMID: 26805799 Ref: Synergistic anti-tumor activity and mechanisms of total glycosides from Cimicifuga dahurica in combination with cisplatin. PMID: 26825081 Ref: The hypoxia-mimetic agent CoCl(2) induces chemotherapy resistance in LOVO colorectal cancer cells. PMID: 26846577 Ref: Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway. PMID: 26847477 Ref: Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells. PMID: 26847687 Ref: Piperlongumine exerts cytotoxic effects against cancer cells with mutant p53 proteins at least in part by restoring the biological functions of the tumor suppressor. PMID: 26848023 Ref: Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro. PMID: 26848703 Ref: Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-kappaB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways. PMID: 26870201 Ref: Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity. PMID: 26871659 Ref: Low toxic and high soluble camptothecin derivative 2-47 effectively induces apoptosis of tumor cells in vitro. PMID: 26879138 Ref: The Activation of ERK1/2 and JNK MAPK Signaling by Insulin/IGF-1 Is Responsible for the Development of Colon Cancer with Type 2 Diabetes Mellitus. PMID: 26901856 Ref: In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition. PMID: 26915975 Ref: Chalcone derivatives cause accumulation of colon cancer cells in the G2/M phase and induce apoptosis. PMID: 26916824 Ref: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. PMID: 27004568 Ref: Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease. PMID: 27005424 Ref: Goniothalamin prevents the development of chemically induced and spontaneous colitis in rodents and induces apoptosis in the HT-29 human colon tumor cell line. PMID: 27016270 Ref: Luffa echinata Roxb. Induced Apoptosis in Human Colon Cancer Cell (SW-480) in the Caspase-dependent Manner and Through a Mitochondrial Apoptosis Pathway. PMID: 27019558 Ref: Antiproliferative effects on colon adenocarcinoma cells induced by co-administration of vitamin K1 and Lactobacillus rhamnosus GG. PMID: 27035094 Ref: Inhibition of histone deacetylases by trans-cinnamic acid and its antitumor effect against colon cancer xenografts in athymic mice. PMID: 27035417 Ref: Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis. PMID: 27053107 Ref: Abrin P2 suppresses proliferation and induces apoptosis of colon cancer cells via mitochondrial membrane depolarization and caspase activation. PMID: 27055473 Ref: Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells. PMID: 27064730 Ref: Hyperoside and rutin of Nelumbo nucifera induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells. PMID: 27073499 Ref: Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells. PMID: 27082059 Ref: Induction of ROS Overload by Alantolactone Prompts Oxidative DNA Damage and Apoptosis in Colorectal Cancer Cells. PMID: 27089328 Ref: Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells. PMID: 27098859 Ref: 5-Hydroxy-7-Methoxyflavone Triggers Mitochondrial-Associated Cell Death via Reactive Oxygen Species Signaling in Human Colon Carcinoma Cells. PMID: 27116119 Ref: The prognostic significance of p53, Bax, Bcl-2 and cyclin E protein overexpression in colon cancer - an immunohistochemical study using the tissue microarray technique. PMID: 27151692 Ref: Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment. PMID: 27166181 Ref: Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo. PMID: 27180010 Ref: Apoptosis-Mediated Chemoprevention by Different Ratios of Fish Oil in Experimental Colon Carcinogenesis. PMID: 27191482 Ref: The UVB1 Vitamin D analogue inhibits colorectal carcinoma progression. PMID: 27208626 Ref: HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells. PMID: 27220399 Ref: Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway. PMID: 27221553 Ref: Harmal Extract Induces Apoptosis of HCT116 Human Colon Cancer Cells, Mediated by Inhibition of Nuclear Factor-kappaB and Activator Protein-1 Signaling Pathways and Induction of Cytoprotective Genes. PMID: 27221880 Ref: Apoptotic effect of eugenol envolves G2/M phase abrogation accompanied by mitochondrial damage and clastogenic effect on cancer cell in vitro. PMID: 27235711 Ref: 5,7,4'-Trihydroxy-6,8-diprenylisoflavone and lupalbigenin, active components of Derris scandens, induce cell death on breast cancer cell lines. PMID: 27261599 Ref: Three components of cigarette smoke altered the growth and apoptosis of metastatic colon cancer cells via inducing the synthesis of reactive oxygen species and endoplasmic reticulum stress. PMID: 27262990 Ref: Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. PMID: 27271587 Ref: Butyrate-mediated acquisition of chemoresistance by human colon cancer cells. PMID: 27277338 Ref: Boletus edulis ribonucleic acid - a potent apoptosis inducer in human colon adenocarcinoma cells. PMID: 27302173 Ref: Cytotoxicity and Apoptotic Effects of Polyphenols from Sugar Beet Molasses on Colon Carcinoma Cells in Vitro. PMID: 27347927 Ref: Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation. PMID: 27372405 Ref: Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cells. PMID: 27378626 Ref: 5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-beta-synthase in colon cancer cells lacking p53. PMID: 27385096 Ref: Engineering of caveolae-specific self-micellizing anticancer lipid nanoparticles to enhance the chemotherapeutic efficacy of oxaliplatin in colorectal cancer cells. PMID: 27395829 Ref: Enhanced colon cancer chemoprevention of curcumin by nanoencapsulation with whey protein. PMID: 27404761 Ref: Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. PMID: 27421828 Ref: Crocodile blood extract induces the apoptosis of lung cancer cells through PTEN activity. PMID: 27431918 Ref: [Mechanism of colon cancer cell apoptosis induced by telocinobufagin: role of oxidative stress and apoptosis pathway]. PMID: 27435769 Ref: Depletion of UBA protein 2-like protein inhibits growth and induces apoptosis of human colorectal carcinoma cells. PMID: 27456362 Ref: The anti-oncogenic influence of ellagic acid on colon cancer cells in leptin-enriched microenvironment. PMID: 27460082 Ref: The Effect of (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-Olide (LS-1) from Lobophyyum sp. on the Apoptosis Induction of SNU-C5 Human Colorectal Cancer Cells. PMID: 27469141 Ref: Chemopreventive effect of Phaleria macrocarpa on colorectal cancer aberrant crypt foci in vivo. PMID: 27492327 Ref: Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. PMID: 27496966 Ref: Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis. PMID: 27506388 Ref: Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation. PMID: 27512955 Ref: The omega-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of beta-catenin complex, inhibiting COX-2 through repressing NF-kappaB, and inducing 15-prostaglandin dehydrogenase. PMID: 27566583 Ref: Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. PMID: 27622714 Ref: BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells. PMID: 27628414 Ref: Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells. PMID: 27633085 Ref: Effect of Schiff base Cu(II) complexes on signaling pathways in HT-29 cells. PMID: 27633628 Ref: Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway. PMID: 27671231 Ref: Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression. PMID: 27693317 Ref: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action. PMID: 27716288 Ref: Salidroside induces apoptosis and autophagy in human colorectal cancer cells through inhibition of PI3K/Akt/mTOR pathway. PMID: 27748934 Ref: Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer. PMID: 27765849 Ref: Curcumin analog EF24 induces apoptosis via ROS-dependent mitochondrial dysfunction in human colorectal cancer cells. PMID: 27787644 Ref: Evaluation of a furochromone from the halophyte Corydalis heterocarpa for cytotoxic activity against human gastric cancer (AGS) cells. PMID: 27808331 Ref: Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles. PMID: 27835895 Ref: Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity. PMID: 27841296 Ref: Bamboo Salt Suppresses Colon Carcinogenesis in C57BL/6 Mice with Chemically Induced Colitis. PMID: 27845862 Ref: MicroRNA-455-3p Inhibits Tumor Cell Proliferation and Induces Apoptosis in HCT116 Human Colon Cancer Cells. PMID: 27861461 Ref: RhoA regulates resistance to irinotecan by regulating membrane transporter and apoptosis signaling in colorectal cancer. PMID: 27888624 Ref: HSP90 inhibitor enhances anti-proliferative and apoptotic effects of celecoxib on HT-29 colorectal cancer cells via increasing BAX/BCL-2 ratio. PMID: 27894402 Ref: Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer PMID: 28032729 Ref: Sorbus rufopilosa Extract Exhibits Antioxidant and Anticancer Activities by Inducing Cell Cycle Arrest and Apoptosis in Human Colon Adenocarcinoma HT29 Cells. PMID: 28053959 Ref: LncRNA-LINC00152 down-regulated by miR-376c-3p restricts viability and promotes apoptosis of colorectal cancer cells. PMID: 28078002 Ref: Naphthazarin suppresses cell proliferation and induces apoptosis in human colorectal cancer cells via the B-cell lymphoma 2/B-cell associated X protein signaling pathway. PMID: 28101239 Ref: Anticancer Properties of Chrysin on Colon Cancer Cells, In vitro and In vivo with Modulation of Caspase-3, -9, Bax and Sall4. PMID: 28959334 Ref: Effect of ethanol extract of HPRS, a Traditional Chinese Medicine formula, on HCT116 cell Line. PMID: 29949709 |
Ref: BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers. PMID: 27447746 Ref: Activation of CXCL12/CXCR4 renders colorectal cancer cells less sensitive to radiotherapy via up-regulating the expression of survivin. PMID: 27798120 Ref: Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. PMID: 27840966 Ref: A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice. PMID: 27888812 Ref: Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis. PMID: 27924057 Ref: CD44-shRNA recombinant adenovirus inhibits cell proliferation, invasion, and migration, and promotes apoptosis in HCT116 colon cancer cells. PMID: 27959393 Ref: Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells. PMID: 27959417 Ref: Salvianolic acid B reverses multidrug resistance in HCT8/VCR human colorectal cancer cells by increasing ROS levels. PMID: 28000873 Ref: Thioridazine elicits potent antitumor effects in colorectal cancer stem cells. PMID: 28000884 Ref: MC37, a new mono-carbonyl curcumin analog, induces G2/M cell cycle arrest and mitochondria-mediated apoptosis in human colorectal cancer cells. PMID: 28024945 Ref: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. PMID: 28030835 Ref: [Overexpression of N-myc downstream regulated gene 2 (NDRG2) inhibits proliferation, migration and promotes apoptosis in SW480 rectal cancer cells]. PMID: 28031114 Ref: Autophagy inhibition enhances photocytotoxicity of Photosan-II in human colorectal cancer cells. PMID: 28031534 Ref: Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. PMID: 28035355 Ref: The BAX gene as a candidate for negative autophagy-related genes regulator on mRNA levels in colorectal cancer. PMID: 28035578 Ref: Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration. PMID: 28049506 Ref: Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis. PMID: 28055016 Ref: Ku70, Ku80, and sClusterin: A Cluster of Predicting Factors for Response to Neoadjuvant Chemoradiation Therapy in Patients With Locally Advanced Rectal Cancer. PMID: 28068245 Ref: Inhibitory Effects of Probiotic Lactobacillus on the Growth of Human Colonic Carcinoma Cell Line HT-29. PMID: 28075415 Ref: Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. PMID: 28096658 Ref: Carboxamide analog ITR-284 evokes apoptosis and inhibits migration ability in human lung adenocarcinoma A549 cells. PMID: 28098885 Ref: Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells. PMID: 28103302 Ref: Calreticulin is a fine tuning molecule in epibrassinolide-induced apoptosis through activating endoplasmic reticulum stress in colon cancer cells. PMID: 28112451 Ref: Synthesis of C5-tethered indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors. PMID: 28131777 Ref: Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis. PMID: 28169543 Ref: Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells. PMID: 28197625 Ref: Antitumor and Immunomodulatory Effect of Gastrodia elata on Colon Cancer In Vitro and In Vivo. PMID: 28231745 Ref: Antitumor Activities and Apoptosis-regulated Mechanisms of Fermented Barley Extract in the Transplantation Tumor Model of Human HT-29 Cells in Nude Mice. PMID: 28245895 Ref: miR-195 enhances the radiosensitivity of colorectal cancer cells by suppressing CARM1. PMID: 28255246 Ref: The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA. PMID: 28272349 Ref: Blockage of Glyoxalase I Inhibits Colorectal Tumorigenesis and Tumor Growth via Upregulation of STAT1, p53, and Bax and Downregulation of c-Myc and Bcl-2. PMID: 28282916 Ref: Mus81 knockdown sensitizes colon cancer cells to chemotherapeutic drugs by activating CHK1 pathway. PMID: 28291626 Ref: ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29. PMID: 28306533 Ref: Anti-Cancerous Potential of Polysaccharide Fractions Extracted from Peony Seed Dreg on Various Human Cancer Cell Lines Via Cell Cycle Arrest and Apoptosis. PMID: 28316571 Ref: A PPAR-gamma agonist protects from radiation-induced intestinal toxicity. PMID: 28344789 Ref: Apoptosis mediated chemosensitization of tumor cells to 5-fluorouracil on supplementation of fish oil in experimental colon carcinoma. PMID: 28349837 Ref: MTA3 regulates malignant progression of colorectal cancer through Wnt signaling pathway. PMID: 28351306 Ref: Pro-apoptotic and anti-proliferative effects of corn silk extract on human colon cancer cell lines. PMID: 28356987 Ref: LRG1 promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation. PMID: 28376129 Ref: [Inhibitory effect of apatinib on HCT-116 cells and its mechanism]. PMID: 28377354 Ref: Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells. PMID: 28412728 Ref: Eco-friendly synthesis of novel cyanopyridine derivatives and their anticancer and PIM-1 kinase inhibitory activities. PMID: 28431341 Ref: Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway. PMID: 28432271 Ref: Effects of Scutellaria barbata polysaccharide on the proliferation, apoptosis and EMT of human colon cancer HT29 Cells. PMID: 28433181 Ref: Apoptosis-induced effects of extract from Artemisia annua Linne by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells. PMID: 28454566 Ref: Cisatracurium-induced proliferation impairment and death of colorectal cancer cells, HCT116 is mediated by p53 dependent intrinsic apoptotic pathway in vitro. PMID: 28463795 Ref: Hepatoprotective Effect of Carboxymethyl Pachyman in Fluorouracil-Treated CT26-Bearing Mice. PMID: 28481246 Ref: Apoptotic Activity of Lactobacillus plantarum DGK-17-Fermented Soybean Seed Extract in Human Colon Cancer Cells via ROS-JNK Signaling Pathway. PMID: 28488794 Ref: The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo. PMID: 28492347 Ref: Nitric oxide-releasing derivatives of brefeldin A as potent and highly selective anticancer agents. PMID: 28494251 Ref: Curcumin loading potentiates the chemotherapeutic efficacy of selenium nanoparticles in HCT116 cells and Ehrlich's ascites carcinoma bearing mice. PMID: 28499854 Ref: Mammea longifolia Planch. and Triana Fruit Extract Induces Cell Death in the Human Colon Cancer Cell Line, SW480, via Mitochondria-Related Apoptosis and Activation of p53. PMID: 28504908 Ref: A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53. PMID: 28526414 Ref: Isofraxidin inhibited proliferation and induced apoptosis via blockage of Akt pathway in human colorectal cancer cells. PMID: 28531803 Ref: Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. PMID: 28551635 Ref: The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations. PMID: 28560697 Ref: Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice. PMID: 28565805 Ref: In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. PMID: 28573788 Ref: Physicochemical characterization and antitumour activity of exopolysaccharides produced by Lactobacillus casei SB27 from yak milk. PMID: 28578968 Ref: Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival. PMID: 28586030 Ref: The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway. PMID: 28597038 Ref: Down-regulation of liver-intestine cadherin enhances noscapine-induced apoptosis in human colon cancer cells. PMID: 28622054 Ref: 8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells. PMID: 28627461 Ref: Differences in telomerase activity and the effects of AZT in aneuploid and euploid cells in colon cancer. PMID: 28627647 Ref: Targeted CDX2 expression inhibits aggressive phenotypes of colon cancer cells in vitro and in vivo. PMID: 28627695 Ref: Evaluation of in vitro cytotoxicity, biocompatibility, and changes in the expression of apoptosis regulatory proteins induced by cerium oxide nanocrystals. PMID: 28634498 Ref: Secondary metabolites from endophytic fungus Chaetomium sp. induce colon cancer cell apoptotic death. PMID: 28652012 Ref: Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma. PMID: 28656255 Ref: Induction of apoptosis by Dae-Hwang-Mok-Dan-Tang in HCT-116 colon cancer cells through activation of caspases and inactivation of the phosphatidylinositol 3-kinase/Akt signaling. PMID: 28664141 Ref: Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and mitochondrial apoptosis. PMID: 28675857 Ref: Photo-catalytic, anti-bacterial, and anti-cancer properties of phyto-mediated synthesis of silver nanoparticles from Artemisia tournefortiana Rchb extract. PMID: 28711019 Ref: MHY451 induces cell cycle arrest and apoptosis by ROS generation in HCT116 human colorectal cancer cells. PMID: 28731136 Ref: Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway. PMID: 28737825 Ref: Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim. PMID: 28744911 Ref: Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice. PMID: 28751809 Ref: Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11. PMID: 28781653 Ref: Treatment mechanism of matrine in combination with irinotecan for colon cancer. PMID: 28781667 Ref: Antitumor activity of beta-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. PMID: 28782499 Ref: Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites. PMID: 28790461 Ref: Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells. PMID: 28791416 Ref: Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies. PMID: 28802125 Ref: MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma. PMID: 28802228 Ref: Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase-3beta/beta-catenin pathway. PMID: 28803443 Ref: Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis. PMID: 28816773 Ref: Leuconostoc mesenteroides-derived anticancer pharmaceuticals hinder inflammation and cell survival in colon cancer cells by modulating NF-kappaB/AKT/PTEN/MAPK pathways. PMID: 28821160 Ref: Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells by arresting cell cycle progression and inducing apoptosis. PMID: 28849005 Ref: Scutellaria barbata D. Don inhibits 5-fluorouracil resistance in colorectal cancer by regulating PI3K/AKT pathway. PMID: 28849113 Ref: The apoptotic impact of nisin as a potent bacteriocin on the colon cancer cells. PMID: 28867631 Ref: [Role of PpIX-based photodynamic therapy in promoting the damage and apoptosis of colorectal cancer cell and its mechanisms]. PMID: 28872077 Ref: Smad4 re-expression increases the sensitivity to parthenolide in colorectal cancer. PMID: 28902368 Ref: Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway. PMID: 28903386 Ref: Antiproliferative Effects of Bacillus coagulans Unique IS2 in Colon Cancer Cells. PMID: 28910156 Ref: Bax is involved in the anticancer activity of Velcade in colorectal cancer. PMID: 28912868 Ref: In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells. PMID: 28923355 Ref: Synthesis, structure-activity relationships and preliminary mechanism of action of novel water-soluble 4-quinolone-3-carboxamides as antiproliferative agents. PMID: 28942112 Ref: Sulforaphane induces p53deficient SW480 cell apoptosis via the ROSMAPK signaling pathway. PMID: 28944886 Ref: SN38-PEG-PLGA-verapamil nanoparticles inhibit proliferation and downregulate drug transporter ABCG2 gene expression in colorectal cancer cells. PMID: 28948511 Ref: Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect. PMID: 28955240 Ref: Arsenic Trioxide Induces Apoptosis via Specific Signaling Pathways in HT-29 Colon Cancer Cells. PMID: 28966729 Ref: Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PMID: 28968471 Ref: Human colorectal cancer cells induce vascular smooth muscle cell apoptosis in an exocrine manner. PMID: 28977925 Ref: Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer. PMID: 28979133 Ref: Chemoprevention by artesunate in a preclinical model of colorectal cancer involves down regulation of beta-catenin, suppression of angiogenesis, cellular proliferation and induction of apoptosis. PMID: 29031619 Ref: Quercetrin from Toona sinensis leaves induces cell cycle arrest and apoptosis via enhancement of oxidative stress in human colorectal cancer SW620 cells. PMID: 29039609 Ref: Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression. PMID: 29042944 Ref: The ethanol extracts of sporoderm-broken spores of Ganoderma lucidum inhibit colorectal cancer in vitro and in vivo. PMID: 29048673 Ref: [Role of aquaporin-5 in regulating colorectal cancer cell growth in vitro]. PMID: 29070462 Ref: Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines. PMID: 29078261 Ref: Grape seed proanthocyanidins induce mitochondrial pathway-mediated apoptosis in human colorectal carcinoma cells. PMID: 29113217 Ref: Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance. PMID: 29130100 Ref: beta-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells. PMID: 29141249 Ref: Expression of CD40/CD40L in colon cancer, and its effect on proliferation and apoptosis of SW48 colon cancer cells. PMID: 29155517 Ref: Mismatch Repair Protein hMLH1, but not hMSH2, Enhances Estrogen-Induced Apoptosis of Colon Cancer Cells. PMID: 29158795 Ref: Histone Methyltransferase SETDB1 Promotes the Progression of Colorectal Cancer by Inhibiting the Expression of TP53. PMID: 29158805 Ref: Citrinin induces apoptosis in human HCT116 colon cancer cells through endoplasmic reticulum stress. PMID: 29165056 Ref: Inonotus obliquus extract induces apoptosis in the human colorectal carcinoma's HCT-116 cell line. PMID: 29174853 Ref: Anticancer effect of dentatin and dentatin-hydroxypropyl-beta-cyclodextrin complex on human colon cancer (HT-29) cell line. PMID: 29200826 Ref: Genistein induces apoptosis of colon cancer cells by reversal of epithelial-to-mesenchymal via a Notch1/NF-kappaB/slug/E-cadherin pathway. PMID: 29202800 Ref: Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum. PMID: 29204990 Ref: Knockdown of Rhotekin 2 expression suppresses proliferation and induces apoptosis in colon cancer cells. PMID: 29250187 Ref: Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador. PMID: 29258490 Ref: Clinical significance of LMO1 in gastric cancer tissue and its association with apoptosis of cancer cells. PMID: 29344115 Ref: In vivo and in vitro induction of the apoptotic effects of oxysophoridine on colorectal cancer cells via the Bcl-2/Bax/caspase-3 signaling pathway. PMID: 29344242 Ref: Establishment of optimal regulatory network of colorectal cancer based on p42.3 protein. PMID: 29551923 |
Ref: CD155 knockdown promotes apoptosis via AKT/Bcl-2/Bax in colon cancer cells. PMID: 28816021 Ref: Effects of Glut1 gene silencing on proliferation, differentiation, and apoptosis of colorectal cancer cells by targeting the TGF-beta/PI3K-AKT-mTOR signaling pathway. PMID: 28884839 Ref: Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway. PMID: 28965196 Ref: Expression of KLF6-SV2 in colorectal cancer and its impact on proliferation and apoptosis. PMID: 29084019 Ref: Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration. PMID: 29086459 Ref: Hedyotis diffusa Willd inhibits proliferation and induces apoptosis of 5FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway. PMID: 29115462 Ref: Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-alpha-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells. PMID: 29115534 Ref: Synthesis and biological evaluation of sulfur-containing shikonin oxime derivatives as potential antineoplastic agents. PMID: 29174813 Ref: The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells. PMID: 29222016 Ref: Musa paradisiaca inflorescence induces human colon cancer cell death by modulating cascades of transcriptional events. PMID: 29243757 Ref: Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122. PMID: 29253766 Ref: Down-regulation of FN1 inhibits colorectal carcinogenesis by suppressing proliferation, migration, and invasion. PMID: 29274284 Ref: Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest, and Antimigratory Effects in SW480 Colorectal Cancer Cells. PMID: 29276946 Ref: Induction of apoptosis by pyrazolo[3,4-d]pyridazine derivative in lung cancer cells via disruption of Bcl-2/Bax expression balance. PMID: 29290491 Ref: Modulated electro-hyperthermia induced loco-regional and systemic tumor destruction in colorectal cancer allografts. PMID: 29290768 Ref: BaxDelta2 sensitizes colorectal cancer cells to proteasome inhibitor-induced cell death. PMID: 29291406 Ref: Cytotoxic Effects and Anti-Angiogenesis Potential of Pistachio (Pistacia vera L.) Hulls against MCF-7 Human Breast Cancer Cells. PMID: 29303970 Ref: Acylated and unacylated ghrelin inhibit apoptosis in myoblasts cocultured with colon carcinoma cells. PMID: 29328480 Ref: Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines. PMID: 29337231 Ref: MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC). PMID: 29338680 Ref: In Vivo Double Targeting of C26 Colon Carcinoma Cells and Microenvironmental Protumor Processes Using Liposomal Simvastatin. PMID: 29344291 Ref: Inhibition of autophagy potentiates the apoptosis-inducing effects of photodynamic therapy on human colon cancer cells. PMID: 29355734 Ref: Eupatorin and Salvigenin Potentiate Doxorubicin-Induced Apoptosis and Cell Cycle Arrest in HT-29 and SW948 Human Colon Cancer Cells PMID: 29373904 Ref: The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. PMID: 29374142 Ref: Dioscin inhibits colon cancer cells' growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways. PMID: 29389802 Ref: Silencing long noncoding RNA PVT1 inhibits tumorigenesis and cisplatin resistance of colorectal cancer. PMID: 29423000 Ref: Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells. PMID: 29423046 Ref: Chemoprevention by Probiotics During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats. PMID: 29427224 Ref: Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer. PMID: 29442390 Ref: Molecular chemoprevention by morin - A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer. PMID: 29453046 Ref: Scutellarein from Scutellaria barbata induces apoptosis of human colon cancer HCT116 cells through the ROS-mediated mitochondria-dependent pathway. PMID: 29457739 Ref: Drug-like dietary vanilloids induce anticancer activity through proliferation inhibition and regulation of bcl-related apoptotic proteins. PMID: 29464796 Ref: Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen). PMID: 29464799 Ref: Ganoderma applanatum secondary metabolites induced apoptosis through different pathways: In vivo and in vitro anticancer studies. PMID: 29494964 Ref: Overexpression of secretagogin promotes cell apoptosis and inhibits migration and invasion of human SW480 human colorectal cancer cells. PMID: 29499408 Ref: Long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) promote cell proliferation in colorectal cancer by affecting P53. PMID: 29509245 Ref: Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway. PMID: 29519997 Ref: A new glycoprotein SPG-8700 isolated from sweet potato with potential anti-cancer activity against colon cancer. PMID: 29527942 Ref: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. PMID: 29531808 Ref: An Asparagus polysaccharide fraction inhibits MDSCs by inducing apoptosis through toll-like receptor 4. PMID: 29532545 Ref: Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K/AKT/mTOR/p70S6K signaling pathway. PMID: 29541215 Ref: Interferon-gamma induces autophagy-associated apoptosis through induction of cPLA2-dependent mitochondrial ROS generation in colorectal cancer cells. PMID: 29551681 Ref: The study of sclareol in inhibiting proliferation of osteosarcoma cells by apoptotic induction and loss of mitochondrial membrane potential. PMID: 29562495 Ref: Deciphering the molecular mechanism and apoptosis underlying the in-vitro and in-vivo chemotherapeutic efficacy of vanadium luteolin complex in colon cancer. PMID: 29574863 Ref: Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells. PMID: 29587241 Ref: Ferula pseudalliacea induces apoptosis in human colorectal cancer HCT-116 cells via mitochondria-dependent pathway. PMID: 29587544 Ref: betaarrestin2 promotes 5FUinduced apoptosis via the NFkappaB pathway in colorectal cancer. PMID: 29620228 Ref: p38 inhibitor inhibits the apoptosis of cowanin-treated human colorectal adenocarcinoma cells. PMID: 29620273 Ref: The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-kappaB translocation. PMID: 29636600 Ref: Detection of pro-apoptotic Bax2 proteins in the human cerebellum. PMID: 29663074 Ref: Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells. PMID: 29668110 Ref: Erythropoietin Intensifies the Proapoptotic Activity of LFM-A13 in Cells and in a Mouse Model of Colorectal Cancer. PMID: 29690619 Ref: Natural Hypoxia is Not a Limiting Factor in Evaluating the Novel Arylidene Derivative MLT-401 Against an In Vitro Colorectal Cancer Model. PMID: 29723868 Ref: Dihydroartemisinin potentiates antitumor activity of 5-fluorouracil against a resistant colorectal cancer cell line. PMID: 29738772 Ref: Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway. PMID: 29745074 Ref: Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest. PMID: 29745075 Ref: Carboxymethyl pachyman (CMP) reduces intestinal mucositis and regulates the intestinal microflora in 5-fluorouracil-treated CT26 tumour-bearing mice. PMID: 29756138 Ref: Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A. PMID: 29761838 Ref: Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK. PMID: 29783958 Ref: FAM188B enhances cell survival via interaction with USP7. PMID: 29795372 Ref: C-glycosyl flavone from Urginea indica inhibits proliferation & angiogenesis & induces apoptosis via cyclin-dependent kinase 6 in human breast, hepatic & colon cancer cell lines. PMID: 29806604 Ref: The NK1 receptor antagonist NKP608 inhibits proliferation of human colorectal cancer cells via Wnt signaling pathway. PMID: 29843798 Ref: Vicenin-2 inhibits Wnt/beta-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line. PMID: 29849451 Ref: Bufalin and 5-fluorouracil synergistically induce apoptosis in colorectal cancer cells. PMID: 29849804 Ref: Lactobacillus casei Variety rhamnosus Probiotic Preventively Attenuates 5-Fluorouracil/Oxaliplatin-Induced Intestinal Injury in a Syngeneic Colorectal Cancer Model. PMID: 29867884 Ref: L-carnosine induces apoptosis/cell cycle arrest via suppression of NF-kappaB/STAT1 pathway in HCT116 colorectal cancer cells. PMID: 29869056 Ref: Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis. PMID: 29875662 Ref: [Role of allograft inflammatory factor-1 in regulating the proliferation, migration and apoptosis of colorectal cancer cells]. PMID: 29891445 Ref: Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway. PMID: 29892198 Ref: Ellagitannins from Pomegranate Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Rats while Enhancing Its Chemotoxicity against HT-29 Colorectal Cancer Cells through Intrinsic Apoptosis Induction. PMID: 29920075 Ref: Cardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF-kappaB pathway in vitro. PMID: 29928339 Ref: MACC1 silencing inhibits cell proliferation and induces cell apoptosis of lung adenocarcinoma cells through the beta-catenin pathway. PMID: 29940751 Ref: Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies. 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