Primary Site >> Colorectal Cancer
Gene >> BAK1
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Ref: Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. PMID: 8625322 Ref: Increased intestinal Bak expression results in apoptosis. PMID: 8660371 |
Ref: 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins. PMID: 9792140 Ref: Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells. PMID: 9829751 Ref: Perillyl alcohol: applications in oncology. PMID: 9855569 Ref: Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal cancer. PMID: 9881495 |
Ref: NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen species. PMID: 9990295 Ref: Prognostic significance of Bcl-2, Bcl-xL/S, Bax and Bak expressions in colorectal carcinomas. PMID: 10023006 Ref: Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro. PMID: 10394957 Ref: Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic BAK and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP). PMID: 10467346 |
Ref: Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy. PMID: 10786699 Ref: Induction of apoptosis in human gastric cancer by sodium butyrate. PMID: 10810354 Ref: Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase. PMID: 10811474 |
Ref: Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors. PMID: 11159736 Ref: p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. PMID: 11313989 Ref: Comparison of calcium supplementation or low-fat dairy foods on epithelial cell proliferation and differentiation. PMID: 12094618 |
Ref: Butyrate and aspirin in combination have an enhanced effect on apoptosis in human colorectal cancer cells. PMID: 12131661 Ref: Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line. PMID: 12215894 Ref: Requirement of BAX for efficient adenovirus-induced apoptosis. PMID: 12388688 Ref: Incidence of apoptosis increases with age in colorectal cancer. PMID: 12559416 |
Ref: Apoptosis induced by cryo-injury in human colorectal cancer cells is associated with mitochondrial dysfunction. PMID: 12471619 Ref: Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. PMID: 12818369 Ref: Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK. PMID: 12898509 Ref: Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. PMID: 12902349 Ref: The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. PMID: 12902978 Ref: Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis. PMID: 14581351 Ref: Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. PMID: 14645705 |
Ref: Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers. PMID: 14654970 Ref: CD44 negatively regulates apoptosis in murine colonic epithelium via the mitochondrial pathway. PMID: 15126101 Ref: CD44 promotes resistance to apoptosis in human colon cancer cells. PMID: 15215046 Ref: Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis. PMID: 15219941 Ref: Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA. PMID: 15334062 Ref: Dietary corn oil promotes colon cancer by inhibiting mitochondria-dependent apoptosis in azoxymethane-treated rats. PMID: 15522837 Ref: Conjugated docosahexaenoic acid is a potent inducer of cell cycle arrest and apoptosis and inhibits growth of colo 201 human colon cancer cells. PMID: 15572300 Ref: Expression of the insulin-like growth factor-I receptor and proapoptotic Bax and Bak proteins in human colorectal cancer. PMID: 15659820 |
Ref: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. PMID: 15547111 Ref: Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. PMID: 15661804 Ref: Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors. PMID: 15824729 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2. PMID: 16083714 Ref: CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy. PMID: 16115938 |
Ref: Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. PMID: 16500682 Ref: Bax and Bak are the critical complementary effectors of colorectal cancer cell apoptosis by chemopreventive resveratrol. PMID: 16550006 Ref: Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol. PMID: 16617056 Ref: Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells. PMID: 16847458 Ref: Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells. PMID: 17016662 |
Ref: Gender-specific modulation of markers for premalignancy by nutritional soy and calcium in the mouse colon. PMID: 17182828 Ref: Strain-specific homeostatic responses during early stages of Azoxymethane-induced colon tumorigenesis in mice. PMID: 17786315 |
Ref: The antiapoptotic role of pregnane X receptor in human colon cancer cells. PMID: 18096695 Ref: Malignant transformation of normal enterocytes following downregulation of Bak expression. PMID: 18349538 Ref: Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone. PMID: 18593931 Ref: Evaluation of the immunohistochemical stain patterns of survivin, Bak and Bag-1 in colorectal cancers and comparison with polyps situated in the colon. PMID: 18795671 Ref: Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737. PMID: 19088028 |
Ref: Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4alpha. PMID: 19048623 Ref: Sodium butyrate sensitizes human colon adenocarcinoma COLO 205 cells to both intrinsic and TNF-alpha-dependent extrinsic apoptosis. PMID: 19130237 Ref: Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential. PMID: 19154411 Ref: 3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin. PMID: 19470789 Ref: A putative role for human BFK in DNA damage-induced apoptosis. PMID: 19557800 Ref: In vitro studies on the inhibition of colon cancer by butyrate and carnitine. PMID: 19619983 Ref: Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. PMID: 19633423 Ref: Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PMID: 19798419 Ref: Relationships of P53 and Bak with EPO and EPOR in human colorectal cancer. PMID: 19846965 |
Ref: Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways. PMID: 19686703 Ref: Bax deficiency mediated drug resistance can be reversed by endoplasmic reticulum stress induced death signaling. PMID: 20138027 Ref: Fucoidan present in brown algae induces apoptosis of human colon cancer cells. PMID: 20727207 Ref: Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line. PMID: 20950428 |
Ref: Bcl-2 family interaction with the mitochondrial morphogenesis machinery. PMID: 20671748 Ref: Oxaliplatin sensitizes human colon cancer cells to TRAIL through JNK-dependent phosphorylation of Bcl-xL. PMID: 21683075 Ref: Novel selective Cox-2 inhibitors induce apoptosis in Caco-2 colorectal carcinoma cell line. PMID: 21939759 Ref: Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro. PMID: 21940310 Ref: Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer. PMID: 22171132 Ref: [Hepatic intra-arterial infusion of BAK immune cells to treat metastatic liver cancer]. PMID: 22202430 |
Ref: Phenylarsine oxide induces apoptosis in Bax- and Bak-deficient cells through upregulation of Bim. PMID: 22048238 Ref: Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. PMID: 22056880 Ref: Targeting colorectal cancer stem cells with inducible caspase-9. PMID: 22223359 Ref: Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. PMID: 22285227 Ref: Cellular apoptosis susceptibility (chromosome segregation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer. PMID: 22450763 Ref: Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo. PMID: 22470139 Ref: Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. PMID: 23100468 Ref: [Hepatic intra-arterial infusion of biological response modifier (BRM)-activated killer immune lymphocytes to treat liver cancer]. PMID: 23267895 |
Ref: Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation. PMID: 23088850 Ref: Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy. PMID: 23329644 Ref: The novel BH3 alpha-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. PMID: 23680104 Ref: Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells. PMID: 23959101 Ref: Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors. PMID: 23966164 Ref: hClock gene expression in human colorectal carcinoma. PMID: 23970287 Ref: Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue. PMID: 24055891 |
Ref: In vitro anti-proliferative effects of Zuojinwan on eight kinds of human cancer cell lines. PMID: 23397442 Ref: TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak. PMID: 24362790 Ref: Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival. PMID: 24556425 Ref: Bax protein may influence the invasion of colorectal cancer. PMID: 24574804 Ref: Expression of apoptotic proteins in human colorectal cancer and metastatic lymph nodes. PMID: 24939147 Ref: Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer. PMID: 24957706 Ref: ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells. PMID: 24970817 Ref: Activation of JNK/p38 pathway is responsible for alpha-methyl-n-butylshikonin induced mitochondria-dependent apoptosis in SW620 human colorectal cancer cells. PMID: 25124618 Ref: Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells. PMID: 25156145 Ref: Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway. PMID: 25285768 Ref: Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak. PMID: 25304383 |
Ref: Ethyl acetate extract from Glycosmis parva leaf induces apoptosis and cell-cycle arrest by decreasing expression of COX-2 and altering BCL-2 family gene expression in human colorectal cancer HT-29 cells. PMID: 25356658 Ref: Effect of sun ginseng potentiation on epirubicin and paclitaxel-induced apoptosis in human cervical cancer cells. PMID: 25535473 Ref: The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells. PMID: 25542230 Ref: Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. PMID: 25548100 Ref: DNA damage and ER stress contribute to oblongifolin C-induced cell killing in Bax/Bak-deficient cells. PMID: 25576357 Ref: Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway. PMID: 25577197 Ref: BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs. PMID: 25649765 Ref: BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. PMID: 25715028 Ref: The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death. PMID: 25935480 Ref: Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer. PMID: 26074733 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 |
Ref: Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells. PMID: 25689151 Ref: Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis. PMID: 27053107 Ref: Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells. PMID: 27082059 Ref: miR410 regulates apoptosis by targeting Bak1 in human colorectal cancer cells. PMID: 27177325 Ref: Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. PMID: 27271587 Ref: Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. PMID: 27421828 Ref: Protocatechualdehyde Induces S-Phase Arrest and Apoptosis by Stimulating the p27(KIP1)-Cyclin A/D1-CDK2 and Mitochondrial Apoptotic Pathways in HT-29 Cells. PMID: 27447597 Ref: TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. PMID: 27818144 |
Ref: Effects of Scutellaria barbata polysaccharide on the proliferation, apoptosis and EMT of human colon cancer HT29 Cells. PMID: 28433181 Ref: Apoptosis-induced effects of extract from Artemisia annua Linne by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells. PMID: 28454566 |
Ref: Chitosan oligosaccharides with degree of polymerization 2-6 induces apoptosis in human colon carcinoma HCT116 cells. PMID: 29155028 Ref: The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. PMID: 29374142 Ref: A452, an HDAC6-selective inhibitor, synergistically enhances the anticancer activity of chemotherapeutic agents in colorectal cancer cells. PMID: 29917295 Ref: Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer. PMID: 30066888 Ref: Matricellular protein periostin promotes colitis-associated colon tumorigenesis in mice. PMID: 30204842 |