Primary Site >> Colorectal Cancer
Gene >> ATG5
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Ref: DNA mismatch repair initiates 6-thioguanine--induced autophagy through p53 activation in human tumor cells. PMID: 17317843 |
Ref: Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. PMID: 19197948 |
Ref: Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death. PMID: 20930850 Ref: Induction of autophagy by dimethyl cardamonin is associated with proliferative arrest in human colorectal carcinoma HCT116 and LOVO cells. PMID: 21538483 Ref: Mutational and expressional analyses of ATG5, an autophagy-related gene, in gastrointestinal cancers. PMID: 21664058 Ref: Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. PMID: 21763418 |
Ref: Curcumin induces permanent growth arrest of human colon cancer cells: link between senescence and autophagy. PMID: 22613224 Ref: The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep? PMID: 22927544 Ref: Down-regulated expression of ATG5 in colorectal cancer. PMID: 22993366 Ref: Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells. PMID: 23226467 |
Ref: Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation. PMID: 23088850 Ref: Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy. PMID: 23461901 Ref: FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PMID: 23700428 Ref: A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells. PMID: 23907464 Ref: BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production. PMID: 24322755 |
Ref: Absence of autophagy-related proteins expression is associated with poor prognosis in patients with colorectal adenocarcinoma. PMID: 24723943 Ref: JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy. PMID: 24733045 Ref: Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. PMID: 24905352 Ref: Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells. PMID: 24956373 Ref: Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells. PMID: 25475140 Ref: Regulation of dimethyl-fumarate toxicity by proteasome inhibitors. PMID: 25482938 |
Ref: Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway. PMID: 25216025 Ref: Heterozygous deletion of ATG5 in Apc(Min/+) mice promotes intestinal adenoma growth and enhances the antitumor efficacy of interferon-gamma. PMID: 25695667 Ref: Nexavar/Stivarga and viagra interact to kill tumor cells. PMID: 25704960 Ref: Differential regulation of autophagy and cell viability by ceramide species. PMID: 25803131 Ref: The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death. PMID: 25935480 Ref: Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma. PMID: 26306675 Ref: Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress. PMID: 26496833 Ref: Autophagy in colorectal cancer: An important switch from physiology to pathology. PMID: 26600927 |
Ref: Niacin alleviates TRAIL-mediated colon cancer cell death via autophagy flux activation. PMID: 26517672 Ref: DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy. PMID: 26585906 Ref: Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity. PMID: 26871659 Ref: Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells. PMID: 27557491 |
Ref: Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells. PMID: 27737524 Ref: AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity. PMID: 28103582 Ref: CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk. PMID: 28131902 Ref: mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism. PMID: 28475179 Ref: Autophagy in aging and disease. PMID: 28523294 Ref: Synthetic lethal interaction of CDK inhibition and autophagy inhibition in human solid cancer cell lines. PMID: 28560460 Ref: Dual inhibition of BDNF/TrkB and autophagy: a promising therapeutic approach for colorectal cancer. PMID: 28597984 Ref: Transcription factor EB is involved in autophagy-mediated chemoresistance to doxorubicin in human cancer cells. PMID: 28603284 Ref: Mir-30d suppresses cell proliferation of colon cancer cells by inhibiting cell autophagy and promoting cell apoptosis. PMID: 28651493 Ref: AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells. PMID: 28837154 Ref: Identification of 7-(4'-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells. PMID: 28963527 Ref: Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells. PMID: 28981110 Ref: Traditional Chinese medicine Danggui Buxue Tang inhibits colorectal cancer growth through induction of autophagic cell death. PMID: 29179457 Ref: Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species. PMID: 29245915 |
Ref: Autophagy mediates cytotoxicity of human colorectal cancer cells treated with garcinielliptone FC. PMID: 28294332 Ref: Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells. PMID: 28933585 Ref: Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells. PMID: 28976622 Ref: CJK-7, a Novel Flavonoid from Paulownia tomentosa Triggers Cell Death Cascades in HCT-116 Human Colon Carcinoma Cells via Redox Signaling. PMID: 29076434 Ref: Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells. PMID: 29423046 Ref: Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner. PMID: 29492901 Ref: TIGAR knockdown enhanced the anticancer effect of aescin via regulating autophagy and apoptosis in colorectal cancer cells. PMID: 29769743 Ref: Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy. PMID: 29921885 Ref: Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells. PMID: 29928348 Ref: Opposite functions of GSN and OAS2 on colorectal cancer metastasis, mediating perineural and lymphovascular invasion, respectively. PMID: 30148861 Ref: Neratinib augments the lethality of [regorafenib + sildenafil]. PMID: 30203445 Ref: Knockdown of long noncoding RNA urothelial carcinoma associated 1 inhibits colorectal cancer cell proliferation and promotes apoptosis via modulating autophagy. PMID: 30362538 Ref: The Influence of Tumor Microenvironment on ATG4D Gene Expression in Colorectal Cancer Patients. PMID: 30374741 |