Primary Site >> Colorectal Cancer
Gene >> ASAH1
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Ref: Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide. PMID: 20735991 |
Ref: DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells. PMID: 22349266 |
Ref: Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. PMID: 23301156 Ref: [Identification of genes that predict lymph node metastasis in colorectal cancer cases]. PMID: 24693684 |
Ref: Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. PMID: 25839235 Ref: Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies. PMID: 26059437 |
Ref: Acid ceramidase is a novel drug target for pediatric brain tumors. PMID: 28445970 Ref: Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line. PMID: 28766347 Ref: Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency. PMID: 29348854 |
Ref: Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. PMID: 29518574 Ref: Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and beta1 integrin/FAK-mediated signalling. PMID: 29920241 |