Primary Site >> Colorectal Cancer

Gene >> ARG1

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Ref: Partial purification of a liver-derived tumor cell growth inhibitor that differentially inhibits poorly-liver metastasizing cell lines: identification as an active subunit of arginase.
PMID: 11592308
Ref: The redox state of the glutathione/glutathione disulfide couple mediates intracellular arginase activation in HCT-116 colon cancer cells.
PMID: 19997976
Ref: Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.
PMID: 21216893
Ref: Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo.
PMID: 22926062
Ref: Blockade of Myd88 signaling induces antitumor effects by skewing the immunosuppressive function of myeloid-derived suppressor cells.
PMID: 23184679
Ref: Complement 5a Enhances Hepatic Metastases of Colon Cancer via Monocyte Chemoattractant Protein-1-mediated Inflammatory Cell Infiltration.
PMID: 25739439
Ref: Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma.
PMID: 25818600
Ref: Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer.
PMID: 25869209
Ref: HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region.
PMID: 26030248
Ref: IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4(+) T cells.
PMID: 26759006
Ref: Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells.
PMID: 27683110
Ref: Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients.
PMID: 28008330
Ref: The MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment.
PMID: 28807001
Ref: Role of Kupffer cells in the progression of CRC liver metastases after the first stage of ALPPS.
PMID: 29795479
Ref: Increased number of arginase 1-positive cells in the stroma of carcinomas compared to precursor lesions and nonneoplastic tissues.
PMID: 29970307
Ref: Embelin impairs the accumulation and activation of MDSCs in colitis-associated tumorigenesis.
PMID: 30377563