Primary Site >> Liver Cancer
Gene >> APC
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Ref: Cell and molecular biology of gastrointestinal tract cancer. PMID: 1324739 |
Ref: The putative tumor suppressor gene on chromosome 5q for hepatocellular carcinoma is distinct from the MCC and APC genes. PMID: 8402727 |
Ref: [Aberrations of tumor suppressor genes in hepatocellular carcinomas]. PMID: 7868063 Ref: Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China. PMID: 7903205 Ref: Loss of heterozygosity in spontaneous and chemically induced tumors of the B6C3F1 mouse. PMID: 8055644 |
Ref: Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53. PMID: 9041254 Ref: Relationship between loss of heterozygosity of tumor suppressor genes and histologic differentiation in hepatocellular carcinoma. PMID: 9307185 |
Ref: Hepatocellular carcinoma in children associated with Gardner syndrome or familial adenomatous polyposis. PMID: 9628444 Ref: Microsatellite instability and loss of heterozygosity at DNA mismatch repair gene loci occurs during hepatic carcinogenesis. PMID: 9657101 Ref: Metallothionein and apoptosis in primary human hepatocellular carcinoma (HCC) from northern China. PMID: 9891538 Ref: Absence of APC gene mutation in the mutation cluster region in hepatocellular carcinoma. PMID: 10381126 |
Ref: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. PMID: 10201372 Ref: beta-catenin expression in primary and metastatic colorectal carcinoma. PMID: 10404062 Ref: Mutational analysis of three tumor suppressor genes in two models of rat hepatocarcinogenesis. PMID: 10411141 Ref: Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity. PMID: 10435629 Ref: Analysis of beta-catenin gene mutations in pancreatic tumors. PMID: 10545724 Ref: Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. PMID: 10595907 Ref: Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas. PMID: 10597262 Ref: The role of the E-cadherin/catenin complex in gastrointestinal cancer. PMID: 10692769 |
Ref: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. PMID: 10700176 |
Ref: Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli. PMID: 11466687 Ref: [Application of the IFN-gamma ELISPOT assay for monitoring CD8(+) T cell response to specific antigen from hepatocellular carcinoma patients]. PMID: 11825525 |
Ref: Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. PMID: 11809809 Ref: Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. PMID: 11929813 Ref: Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin. PMID: 12036951 Ref: Association of hTcf-4 gene expression and mutation with clinicopathological characteristics of hepatocellular carcinoma. PMID: 12378619 Ref: P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells. PMID: 12439747 Ref: Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells. PMID: 12460462 Ref: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. PMID: 12481159 |
Ref: Loss of beta-catenin expression in metastatic gastric cancer. PMID: 12721245 Ref: Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survival. PMID: 12827550 Ref: Alteration of the fragile histidine triad gene in intrahepatic cholangiocarcinoma. PMID: 12867802 Ref: Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice. PMID: 12893427 Ref: Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. PMID: 12937151 Ref: Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. PMID: 14507645 |
Ref: Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. PMID: 14660579 Ref: PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma. PMID: 15064734 Ref: Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas. PMID: 15067328 Ref: Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells: Possible correlation with specific caspase-dependent cleavage of beta-catenin and inhibition of beta-catenin-mediated transactivation. PMID: 15067380 Ref: Alpha-fetoprotein impairs APC function and induces their apoptosis. PMID: 15265907 Ref: Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. PMID: 15563600 |
Ref: [Study on loss of heterozygosity and microsatellite instability in hepatocellular carcinoma]. PMID: 15842799 Ref: Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling. PMID: 15897561 Ref: Dendritic cells pulsed with gp96-peptide complexes derived from human hepatocellular carcinoma (HCC) induce specific cytotoxic T lymphocytes. PMID: 15965645 |
Ref: Wnt/Frizzled signaling in hepatocellular carcinoma. PMID: 16368566 Ref: [Role of Wnt/beta-catenin signaling transduction pathway in rat hepatocarcinogenesis]. PMID: 16806007 Ref: APC and CTNNB1 mutations are rare in sporadic ependymomas. PMID: 16843107 Ref: Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report. PMID: 16897741 Ref: Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer. PMID: 17030191 Ref: Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. PMID: 17106265 |
Ref: R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells. PMID: 17275129 Ref: Eradication of hepatoma and colon cancer in mice with Flt3L gene therapy in combination with 5-FU. PMID: 17361437 Ref: The burden of liver cancer in Asians and Pacific Islanders in the Greater San Francisco Bay Area, 1990 through 2004. PMID: 17385214 Ref: Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. PMID: 17675336 Ref: Autogeneic rna-electroporated CD40-ligand activated b-cells from hepatocellular carcinoma patients induce CD8+ T-cell responses ex vivo. PMID: 17704747 Ref: Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer. PMID: 17895985 |
Ref: Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations. PMID: 17962810 Ref: Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. PMID: 18161048 Ref: RNA-electroporated CD40-activated B cells induce functional T-cell responses against HepG2 cells. PMID: 18485013 Ref: APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. PMID: 18585699 Ref: Wnt signaling in renal cancer. PMID: 18673245 Ref: Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma. PMID: 18937283 Ref: [Aberrant methylation of multiple genes and its clinical implication in hepatocellular carcinoma]. PMID: 19173828 |
Ref: Mutations in the AXIN1 gene in advanced prostate cancer. PMID: 18514389 Ref: Rapid and quantitative detection of CpG-methylation status using TaqMan PCR combined with methyl-binding-domain polypeptide. PMID: 19332050 Ref: Methylation of multiple genes as molecular markers for diagnosis of a small, well-differentiated hepatocellular carcinoma. PMID: 19384946 Ref: [Effect of transcatheter arterial chemoembolization on HBV DNA level in primary liver cancer patients]. PMID: 19624882 Ref: A novel immunotherapy to hepatocellular carcinoma: CD40-activated B lymphocytes transfected with AFPmRNA. PMID: 19632790 Ref: SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis. PMID: 19686743 Ref: Altered microRNA Expression Patterns in Hepatoblastoma Patients. PMID: 19701500 |
Ref: High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCV-associated hepatocellular carcinoma. PMID: 20165882 Ref: Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. PMID: 20736025 |
Ref: Optimizing scan timing of hepatic arterial phase by physiologic pharmacokinetic analysis in bolus-tracking technique by multi-detector row computed tomography. PMID: 20872188 Ref: Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice. PMID: 21147764 Ref: Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. PMID: 21711587 Ref: Quantitative analysis of multiple methylated genes in plasma for the diagnosis and prognosis of hepatocellular carcinoma. PMID: 21884695 Ref: SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. PMID: 22014574 Ref: Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma. PMID: 22073196 |
Ref: Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. PMID: 22407776 Ref: Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma. PMID: 22505239 Ref: The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis. PMID: 22796152 Ref: Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines. PMID: 22943463 Ref: [Analysis and prediction of liver cancer incidence in China]. PMID: 22943911 Ref: [Trends in the mortality of liver cancer in Qidong, China: an analysis of fifty years]. PMID: 22967473 |
Ref: Early mitotic inhibitor-1, an anaphase-promoting complex/cyclosome inhibitor, can control tumor cell proliferation in hepatocellular carcinoma: correlation with Skp2 stability and degradation of p27(Kip1). PMID: 22995332 Ref: miR-106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma. PMID: 23087084 Ref: Multifocal hepatic neoplasia in 3 children with APC gene mutation. PMID: 23715166 |